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Journal of Microencapsulation
Micro and Nano Carriers
Volume 7, 1990 - Issue 3
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Research Article

Nafarelin controlled release injectable: theoretical clinical plasma profiles from multiple dosing and from mixtures of microspheres containing 2 per cent, 4 per cent and 7 per cent Nafarelin

Ramon A. Burns Syntex Research, 3401 Hillview Ave, Palo Alto, CA, 94304, USA
,
Karen Vitale Syntex Research, 3401 Hillview Ave, Palo Alto, CA, 94304, USA
&
Lynda M. Sanders Syntex Research, 3401 Hillview Ave, Palo Alto, CA, 94304, USA
Pages 397-413 | Received 31 May 1989, Accepted 13 Nov 1989, Published online: 27 Sep 2008

References

  • Anik S. T., Sanders L. M., Chaplin M. D., Kushinsky S., Nerenberg C. Delivery systems for LHRH and analogs. LHRH and Its Analogs, B. H. Vickery, J. J. Nestor, Jr., E. S. E. Hafez. MTP Press. 1984; 421–435
  • Bauer L. A., Gibaldi M. Computation of model-independent pharmacokinetic parameters during multiple dosing. Journal of Pharmaceutical Sciences 1983; 72: 978–979
  • Benet L. Z., Galeazzi R. L. Noncompartmental determination of the steady-state volume of distribution. Journal of Pharmaceutical Sciences 1979; 68: 1071–1074
  • Hoerl A. E., Nashed M. Z., McKetta J. J., Silberberg I. H. Mathematics. Perry's Chemical Engineering Handbook, R. H. Perry, D. Green. McGraw Hill Book Company. 1984; 2–16
  • Kent J. S., Lewis D. H., Sanders L. M., Tice T. R. United States Patent Number. 4,675,189, 1987
  • Kent J. S., Sanders L. M., Tice T. R., Lewis D. H. Microencapsulation of the peptide nafarelin acetate for controlled release. Long-Acting Contraceptive Delivery Systems, G. I. Zatuchni, A. Goldsmith, J. D. Shelton, J. J. Sciarra. Harper and Row Publishers. 1984; 169–179
  • Perrier D., Mayersohn M. Noncompartmental determination of the steady-state volume of distribution for any mode of administration. Journal of Pharmaceutical Sciences 1982; 71: 372–373
  • Pfeffer M. Estimation of mean residence time from data obtained when multiple-dosing steady state has been reached. Journal of Pharmaceutical Sciences 1984; 73: 854–856
  • Sanders L. M., Burns R. A., Vitale K. M., Hoffman P. Clinical performance of nafarelin controlled release injectable: influence of formulation parameters on release kinetics and duration of efficacy. Proceedings International Symposium on Controlled Release Bioactive Materials. 1988; 15: 62–63
  • Sanders L. M., Kent J. S., McRae G. I., Vickery B. H., Tice T. R., Lewis D. H. Controlled release of a luteinizing hormone releasing hormone analogue from poly (d,l-lactide-co-glycolide) microspheres. Journal of Pharmaceutical Sciences 1984; 73: 1294–1299
  • Sanders L. M., McRae G. I., Vitale K. M., Kell B. A. Controlled delivery of an LHRH analogue from biodegradable injectable microspheres. Journal of Controlled Release 1985; 2: 187–195

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