Advanced search
Publication Cover
Journal of Microencapsulation
Micro and Nano Carriers
Volume 7, 1990 - Issue 1
Submit an article Journal homepage
21
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Phase separation modulation and aggregation prevention: Mechanism of the non-solvent addition method in the presence and absence of polyisobutylene as an additive

M. Donbrow Department of Pharmacy, The School of Pharmacy The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem, 91120, Israel
,
A. Hoffman Department of Pharmacy, The School of Pharmacy The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem, 91120, Israel
&
S. Benita Department of Pharmacy, The School of Pharmacy The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem, 91120, Israel
Pages 1-15 | Received 22 Nov 1988, Accepted 04 Jan 1989, Published online: 27 Sep 2008

References

  • Albertsson P. Partition of Cell Particles and Macromolecules2nd ed. Almquist and Wiksell, Stockholm/Wiley, N.Y. 1971, Chapter 2
  • Bakan J. A. Microencapsulation of foods and related products. Food Technology 1973; 33–44
  • Bamford C. H., Tompa H. The theory of coacervation. Transactions of the Faraday Society 1950; 46: 310–316
  • Benita S., Donbrow M. Coacervation of ethyl cellulose: the role of polyisobutylene and the effect of its concentration. Journal of Colloid Interface Science 1980; 77: 102–109
  • Benita S., Donbrow M. Effect of polyisobutylene on ethyl cellulose-walled microcapsules: wall structure and thickness of salicylamide and theophylline microcapsules. Journal of Pharmaceutical Science 1982; 71: 205–210
  • Benita S., Hoffman A., Donbrow M. Microencapsulation of paracetamol using polyacrylate resins (Eudragit Retard), kinetics of drug release and evaluation of kinetic model. Journal of Pharmacy and Pharmacology 1985a; 37: 391–395
  • Benita S., Hoffman A., Donbrow M. Polyacrylate resin (Eudragit Retard) microcapsules as a controlled release drug delivery system improved non-solvent addition phase separation process. Journal of Microencapsulation 1985b; 2: 207–222
  • Chemtob C., Chamueil J. C., N'Dongo M. Microcencapsulation by ethyl cellulose phase separation: microcapsule characteristics. International Journal of Pharmaceutics 1986; 29: 1–7
  • Dobry A., Bover-Kawenoki F. Phase separation in polymer solution. Journal of Polymer Science 1947; 2: 90–100
  • Donbrow M., Benita S. The effect of polyisobutylene on the coacervation of ethyl cellulose and the formation of microcapsules. Journal of Pharmacy and Pharmacology 1977; 29(Suppl.)4P
  • Donbrow M., Benita A., Hoffman A. Microencapsulation of dichromate and aracetamol with Eudragit Retard polymers using phase separation by non-solvent addition. 5th Internal. Symposium on Microencapsulation including Artificial Cells, Montreal, Canada, 1983. Applied Biochemistry and Biotechnology 1984; 10: 245–249
  • Dragan D., Airinei A., Carpov A. Dissolution studies of microencapsulated 4-sulphonamidophenoxyacetic acid: effect of preparative variables on dissolution. Journal of Microencapsulation 1985; 2: 223–234
  • Flory P. J. Principles of Polymer Chemistry. Cornell University Press, Ithica, N.Y. 1953; 541–594
  • Ismail N., Harris M. S., Nixon J. R. Particle size analysis of gelatin-acacia coacervate and ethyl cellulose walled microcapsules. Journal of Microencapsulation 1984; 1: 9–19
  • Jalsenjak I., Nicolaidou C. F., Nixon J. R. The in vitro dissolution of phenobarbitone sodium from ethylcellulose microcapsules. Journal of Pharmacy and Pharmacology 1976; 28: 912–914
  • Kawashima Y., Lin S. Y., Kasai A., Takenaka H., Matsunami K., Nochida Y., Hirose H. Drug release properties of the microcapsules of adriamycin hydrochloride with ethyl cellulose prepared by a phase separation technique. Drug Development and Industrial Pharmacy 1984; 10: 467–479
  • Koida Y., Kobayashi M., Hirata G., Samejima M. Studies on microcapsules III. Influence of MW of polyisobutylene in the microencapsulation of ascorbic acid. Chemistry and Pharmacy Bulletin 1984; 32: 4971–4978
  • Koida Y., Kobayashi M., Samejima M. Studies on Microcapsules IV. Influence of properties of drugs on microencapsulation and dissolution behavior. Chemistry and Pharmacy Bulletin 1986; 34: 3354–3361
  • Lin S. Y. Influence of coacervation-inducing agents and cooling rates on the preparation and in vitro release of bleomycin hydrochloride microcapsules. Journal of Microencapsulation 1985; 2: 91–101
  • Miller R. E., Anderson J. L. Cyclic process-temperature sensitive. U.S. Patent 3155590, 1964
  • Nixon J. R., Meleka M. R. The preparation and characterization of ethyl cellulose-walled theophylline microcapsules. Journal of Microencapsulation 1984; 1: 53–64
  • Powell T. C., Steinle M. E., Yoncoskie R. A. Three-phase mutually incompatible system-nonionized. U.S. Patent, 3415758, 1968
  • Reyes Z. Water-ethyl cellulose-petroleum ether. U.S. Patent 3178878, 1965
  • Scott R. L. The thermodynamics of high polymer solutions IV. Phase equilibria in the ternary system: polymer-liquid 1-liquid 2. Journal of Chemical Physics 1949a; 17: 268–277
  • Scott R. L. The thermodynamics of high polymer solutions, V. Phase equilibria in the ternary system: Polymer I-polymer 2-solvent. Journal of Chemical Physics 1949b; 17: 279–284
  • Tompa H. Phase relationships in polymer solutions. Transactions of the Faraday Society 1949; 45: 1142–1152

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.