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Journal of Microencapsulation
Micro and Nano Carriers
Volume 7, 1990 - Issue 4
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Research Article

Ibuprofen-loaded ethylcellulose microspheres: Release studies and analysis of the matrix structure through the Higuchi model

C. Dubernet Laboratoire de Pharmacie Galénique et Biopharmacie, URA CNRS 1218, Université de Paris Sud, 5 rue J. B. Clement, 92296, Chaˇtenay-Malabry cedex, France
,
J. P. Benoit Laboratoire de Pharmacie Galénique et Biopharmacie, URA CNRS 1218, Université de Paris Sud, 5 rue J. B. Clement, 92296, Chaˇtenay-Malabry cedex, France
,
N. A. Peppas School of Chemical Engineering, Purdue University, West Lafayette
&
F. Puisieux Laboratoire de Pharmacie Galénique et Biopharmacie, URA CNRS 1218, Université de Paris Sud, 5 rue J. B. Clement, 92296, Chaˇtenay-Malabry cedex, France
Pages 555-565 | Published online: 27 Sep 2008

References

  • Albert K. S., Gernaat C. M. Pharmacokinetics of ibuprofen. American Journal of Medicine 1984; 13(July)40–46
  • Au D. S. L., Kuo T. H., Mederski-Samora J. B., Lee C. S. Disposition of ibuprofen in nephrectomized dogs. Journal of Pharmaceutical Sciences 1984; 73(5)705–708
  • Crank J. The Mathematics of Diffusion, 2nd edn. Oxford University Press. 1975
  • Dubernet C., Benoit J. P., Rouland J. C., Thies C. A physicochemical study of the morphology of ibuprofen-loaded microspheres. Symposium on Controlled Release Bioactive Materials 1987; 14: 236–237
  • Dubernet C., Rouland J. C., Benoit J. P. Ibuprofen-loaded ethylcellulose microspheres: analysis of the matrix structure by thermal analysis. Journal of Pharmaceutical Sciences 1990
  • Harland R. S., Dubernet C., Benoit J. P., Peppas N. A. A model of dissolution-controlled, diffusional drug release from non-swellable polymeric microspheres. Journal of Controlled Release 1988; 7: 207–215
  • Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Journal of Pharmaceutical Sciences 1963; 52(12)1145–1149
  • Lustig S. R., Peppas N. A. Scaling laws for solute diffusion in equilibrium swollen gels. Polymer Preprints 1985; 26(2)72

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