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Journal of Microencapsulation
Micro and Nano Carriers
Volume 12, 1995 - Issue 5
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Research Article

Development of digoxin dry elixir as a novel dosage form using a spray-drying technique

C. K. Kim College of Pharmacy, Seoul National University, San 56–1, Shimlim-Dong, Kwanak-Gu, Seoul, 151-742, Korea
&
Y. S. Yoon College of Pharmacy, Seoul National University, San 56–1, Shimlim-Dong, Kwanak-Gu, Seoul, 151-742, Korea
Pages 547-556 | Received 25 May 1994, Accepted 10 Nov 1994, Published online: 27 Sep 2008

References

  • Ampoulsuk C., Mauro J. V., Nyhuis A. A., Shah N., Jarowski C. I. Influence of dispersion method on dissolution rate of digoxin-lactose and hydrocorti-sone-lactose triturations I. Journal of Pharmaceutical Sciences 1974; 63: 117–118
  • Chiou W. L., Riegelman S. Increasing dissolution rates of water-insoluble cardiac glycosides and steroids via solid dispersions in polyethylene glycol 6000. Journal of Pharmaceutical Sciences 1971; 60: 1569–1571
  • Chiou W. L., Kyle L. E. Differential thermal, solubility and aging studies on various sources of digoxin and digitoxin powder: Biopharmaceutical implication. Journal of Pharmaceutical Sciences 1979; 68: 1224–1229
  • Glbaldi M., Perrier D. Pharmacokinetics, 2nd ed. Marcel Dekker InC., NY 1982
  • Higuchi T., Ikeda M. Rapidly dissolving forms of digoxin: Hydroquinone complex. Journal of Pharmaceutical Sciences 1974; 63: 809–811
  • Kim C. K., Choi J. Y., Yoon Y. S., Gong J. P., Choi H. G., Gong J. Y., Lee B. J. Preparation and evaluation of dry elixir for the enhancement of dissolution rate of poorly water-soluble drugs. International Journal of Pharmaceutics 1994; 106: 25–32
  • Khalil S. A. H., El-Masry S. Instability of digoxin in acid medium using a nonisotropic method. Journal of Pharmaceutical Sciences 1978; 67: 327–330
  • Klink P. R., Poust R. I., Colaizzi J. L., McDonald R. H., Jr. Bioavailability and dissolution properties of two commercial digoxin tablets. Journal of Pharmaceutical Sciences 1974; 63: 1231–1234
  • MentinC L. C., Hoogstad B., Thijssen H. A. C. Diffusion coefficient of water and organic volatiles in carbohydrate-water system. Journal of Food Technology 1970; 5: 111–126
  • Reynolds J. E. F., Prasad A. B. Martindale, The Extra Pharmacopoeia, 28th ed. The Pharmaceutical Press, London 1982; 531–546
  • Uekama K., Shaw U., Fujinaga T., Hirayama F., Tsuruoka M. Improvement of oral bioavailability of digitalis glycosides by cyclodextrin complexation. Journal of Pharmaceutical Sciences 1983; 72: 1338–1341
  • Yoon Y. S. Design and evaluation of dry elixir as a novel dosage form for poorly water-soluble drugs. PhD Thesis. Seoul National University, SeoulKorea 1994

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