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Research Article

Release kinetics of liposome-encapsulated ganciclovir after intravitreal injection in rabbits

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Pages 473-480 | Received 19 Jun 1995, Accepted 24 Jul 1995, Published online: 27 Sep 2008

References

  • Akula S. K., Ma P. E., Peyman G. A., Rahimy M. H., Hyslop N. E., Janney A., Ashton P. Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS. British Journal of Ophthalmology 1994; 78: 677–680
  • Anand R., Font R. L., Fish R. H., Nightingale S. D. Pathology of cytomegalovirus retinitis treated with sustained release intravitreal ganciclovir. Ophthalmology 1993; 100: 1032–1039
  • Ashton P., Brown J. D., Pearson P. A., Blandford D. L., Smith T. J., Anand R., Nightingale S. D., Sanborn G. E. Intravitreal ganciclovir pharmacokinetics in rabbits and man. Journal of Ocular Pharmacology 1992; 8: 343–347
  • Cantrill W. H., Henry K., Melroe N. H., Knobloch W. H., Ramsey R. C., Baldour H. H. Treatment of CMV retinitis with intravitreal ganciclovir: long term results. Ophthalmology 1989; 96: 367–374
  • Diaz-Llopis. Liposomally-encapsulated ganciclovir for the treatment of cytomegalovirus retinitis in AIDS patients-Experimental toxicity and pharmokinetics, and clinical trials. Documenta Ophthalmologica 1992; 82: 297–305
  • Faulds D., Heel R. C. Ganciclovir: A review of its antivitrial activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs 1990; 39: 597–638
  • Heinemann H. H. Long term intrivitrial ganciclovir therapy for cytomegalovirus retinopathy. Archives of ophthalmology 1989; 110: 255–258
  • Henry K., Canrtrill H., Fletcher C., Chinnock B. J., Balfour H. H. Use of intravitreal ganciclovir for cytomegalovirus retinitis in a patient with AIDS. American Journal of Ophthalmology 1987; 103: 17–23
  • Peyman G. A., Khoobehi B., Tawakol M. E., Schulman J. A., Mortada H. A., Alkan H. M., Fiscella R. Intravireal injection of liposome-encapsulated ganciclovir in a rabbit model. Retina 1987; 7: 227–229
  • Pulido J., Peyman G. A., Lesar T. Intravitreal toxicity of hydroxycyclovir (BW-B759U): a new antiviral agent. Archives of Ophthalmology 1985; 103: 840–841
  • Sanborn G. E., Anand R., Torti R. E., Nightinggale S. D., Cal S. X., Yates B., Ashton P., Smith T. Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis-Use of an intravitreal device. Archives of Ophthalmology 1992; 110: 188–195
  • Saran B. R., Maguire A. M. Restinal toxicity of high dose intravitreal ganciclovir. Retina 1994; 14: 248–252
  • Shakiba S., Assil K. K., Listhaus A. D., Munguia D., Flores-Aguilar M., Vuong C., Wiley C. A., Tolman R. L., Karkas J. D. Evaluation of retinal toxicity and liposome encapsulation of the anti-CMV drug 2-nor-cyclic GMP. Investigative Ophthalmology and Visual Science 1993; 34: 2903–2910
  • Smith T. J., Pearson P. A., Blandford D. L., Brown J. D., Goins K. A., Hollins J. L., Schmeisser E. T., Glavinos P., Baldwin L. B., Ashton P. Intravitreal sustained-release ganciclovir. Archives Ophthalmology 1992; 110: 255–258
  • Szoka F., Olson F., Heath T., Vail W., Mayhew E., Papahadjopoulos D. Preparations of unilamellar liposomes of intermediate size (0·1–0·2μm) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes. Biochimica et Biophysica Acta 1980; 601: 559–571
  • Ussery F. M., Gibson S. R., Conklin R. H., Piot D. F., Stool E. W., Conklin A. J. Intravitreal ganciclovir in the treatment of AIDS-associated cytomegalovirus retinitis. Ophthalmology 1988; 95: 640–648
  • Wiltink E. H., Stekkinger P., Brakenhoff J., Danner S. Determination of DHPG in biological fluids by reverse-phase high pressure liquid chromatography. Pharmaceutish Weekblad Scientific Edition 1987; 9: 261–264
  • Yoshizumi M. O., Lee D., Vinci V., Fajardo S. Ocular toxicity of multiple intravitreal DHPG injections. Greafes Archives for Clinical and Experimental Ophthalmology 1990; 228: 350–355

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