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Journal of Microencapsulation
Micro and Nano Carriers
Volume 13, 1996 - Issue 6
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Research Article

Investigation of in-vitro release characteristics of NSAID-loaded polylactic acid microspheres

B. Guiziou Drug Delivery and Pharmaceutical Technology Research Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
,
D. J. Armstrong Drug Delivery and Pharmaceutical Technology Research Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
,
P. N. C. Elliott Drug Delivery and Pharmaceutical Technology Research Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
,
J. L. Ford Drug Delivery and Pharmaceutical Technology Research Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
&
C. Rostron Drug Delivery and Pharmaceutical Technology Research Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
Pages 701-708 | Received 02 Mar 1996, Accepted 26 Jun 1996, Published online: 27 Sep 2008

References

  • Armstrong D. J., Elliott P. N. C., Ford J. L., Gadsdon D., McCarthy G. P., Overend T., Rostron C., Worsley M. The acute effect of inhaled polylactic acid microspheres upon the lungs of rabbits. Proceedings of 11th Pharmaceutical Technological Conference (Manchester) 1992; 3: 29–52
  • Armstrong D. J., Elliott P. N. C., Ford J. L., Guiziou B., Rostron C. A comparison of the use of halothane and dichloromethane in the preparation of PLA microspheres by a solvent evaporation technique. Proceedings of 13th Pharmaceutical Technological Conference (Strasbourg) 1994; 1: 57–64
  • Armstrong D. J., Elliott P. N. C., Ford J. L., Guiziou B., Herwitker S., McCarthy G. P., Rostron C. Investigation of in vitro release of NSAIDs from PLA microspheres. Proceedings 14th Pharmaceutical Technological Conference, Barcelona, 1995; 1: 43–51
  • Bodmeier R., McGinity J. W. The preparation and evaluation of drug containing poly. (D,L-lactide) microspheres formed by the solvent evaporation technique. Pharmaceutical Research 1987; 4: 465–471
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  • Jalil R., Nixon J. R. Microencapsulation using poly(L-lactic acid) III. Effect of polymer molecular weight on the microcapsule properties. Journal of Microencapsulation 1990; 7: 41–52
  • Lalla J. K., Sapna K. Biodegradable microspheres of poly(D,L-lactic acid) containing piroxicam as a model drug for controlled release via the parenteral route. Journal of Microencapsulation 1993; 10: 449–460
  • Rosilio R., Benoit J. P., Deyme M., Thies C., Madelmout G. A physico-chemical study of the morphology of progesterone-loaded microspheres fabricated from poly(D,L-lactide-co-glycolide). Journal of Biomedical Material Research 1991; 25: 667–682
  • Schwope A. D., Wise D. L., Howes J. F. Lactic/glycolic acid polymers as narcotic antagonist delivery systems. Life Sciences 1975; 17: 187–188
  • Spenlehauer G., Benoit J. P., Veillard M. Formation and characterisation of poly(D,L-lactic acid) microspheres for chemoembolisation. Journal of Pharmaceutical Science 1986; 75: 750–755
  • Wise D. L., McCormick G. J., Willet G. P., Anderson L. C., Howes J. F. Sustained release of sulphadiazine. Journal of Pharmacy and Pharmacology 1978; 30: 686–689

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