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Journal of Microencapsulation
Micro and Nano Carriers
Volume 14, 1997 - Issue 2
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Original Article

The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility

J. P. McGee United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA
,
M. Singh Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA
,
X. M. Li United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA
,
H. Qiu United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA
&
D. T. O'hagan Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA
Pages 197-210 | Received 04 Oct 1995, Accepted 19 Jan 1996, Published online: 26 Jun 2009

References

  • Aguado M. T., Lambert P. H. Controlled release vaccines—biodegradable polylactide/polyglycolide (PL/PG) microspheres as antigen vehicles. Immunobiology 1992; 184: 113–125
  • Allemann E., Doelker E., Gurny R. Drug loaded poly(lactic acid) nano-particles produced by a reversible salting out process: Purification of an injectable dosage form. European Journal of Pharmacy and Biopharmacy 1993; 39: 13–18
  • Burns R. A., Vitale J., Sanders L. M. Nafarelin controlled release injectable: theoretical clinical plasma profiles from multiple dosing and from mixtures of microspheres containing two per cent, four per cent and seven per cent Nafarelin. Journal of Microencapsulation 1990; 7: 397–413
  • Christel P., Chabot F., Leray L. F., Morin C., Vert M. Biomaterials, G. D. Winter, D. F. Giobonnes, H. Plenk. John Wiley, New York 1982; 271
  • Cutwright D. E., Perez E., Beasley J. D., Larson W. G., Posey W. R. Degradation of poly (lactic acid) polymer and co-polymers of Poly (glycolic acid). Journal of Oral Surgery 1974; 37: 132–142
  • Furr B. J. A. Pharmacological studies with zoladex, a novel luteinizing hormone-releasing hormone analogue. Zoladex: A New Treatment for Prostatic Cancer. Royal Society of Medicine International Congress and Symposium Series, G. D. Chisholm. 1987; 125: 1
  • Hora M. S., Rana R. K., Nunberg J. H., Tice T. R., Gilley R. M., Hudson M. E. Release of human serum albumin from poly(lactide-co-glycolide) micro-particles. Pharmaceutical Research 1990a; 7: 1190–1194
  • Hora M. S., Rana R. K., Nunberg J. H., Tice T. R., Gilley R. M., Hudson M. E. Controlled release of interleukin-2 from biodegradable microspheres. Biotechnology 1990b; 8: 755–758
  • Hutchinson F. G., Furr B. J. A. Biodegradable polymers in sustained release of polypeptides. Delivery Systems for Peptide Drugs, S. S. Davis, L. Ilium, E. Tomlinson. Plenum, New York 1986; 115–124
  • Jeffery H., Davis S. S., O'Hagan D. T. The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: oil-in-water emulsion solvent evaporation. International Journal of Pharmaceutics 1991; 77: 169–177
  • Jeffery H., Davis S. S., O'Hagan D. T. The preparation and characterization of poly(lactide-co-glycolide) microparticles: II the entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharmaceutical Research 1993; 10: 362–368
  • McGee J. P., Davis S. S., O'Hagan D. T. The immunogenicity of a model protein entrapped in poly (lactide-co-glycolide) microparticles prepared by a novel phase separation technique. Journal of Controlled Release 1994; 31: 55–60
  • McGee J. P., Davies M. C., Davis S. S., Scholes P. D., Leadley S. R., Jeffery H., O'Hagan D. T. Protein detection by SIMS and XPS in the surfaces of poly (D, L lactide-co-glycolide) microparticles. Journal of Controlled Release 1996, submitted
  • O'Hagan D. T. Intestinal translocation of particulates—implications for drug and antigen delivery. Advanced Drug Delivery Review 1990; 5: 265–285
  • O'Hagan D. T., Rahman D., McGee J. P., Jeffery H., Davies M. C., Williams P., Davis S. S., Challacombe S. J. Biodegradable microparticles as controlled release antigen delivery systems. Immunology 1991a; 73: 239–242
  • O'Hagan D. T., Jeffery H., Roberts M. J. J., McGee J. P., Davis S. S. Controlled release microparticles for vaccine development. Vaccine 1991b; 9: 768–771
  • Pitt C. G., Gratzl M. M., Kummel G. L., Surles J., Schindler A. Aliphatic polyesters. II: The degradation of poly (DL-lactide) and their co-polymers in vivo. Biomaterials 1981; 2: 215
  • Reul G. J. Use of Vicryl (polyglactin 910) sutures in general surgery and cardio-thoracic procedures. American Journal of Surgery 1977; 134: 197–199
  • Tabata Y., Ikada Y. Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophages. Biomaterials 1988; 9: 356–362
  • Tice T. R., Mason D. W., Gilley R. M. Clinical use and future of parenteral microsphere delivery systems. Novel Drug Delivery and its Therapeutic Applications, F. Prescott, W. S. Nimmo. John Wiley, ChichesterUK 1989, ch. 21
  • Vert M., Li S., Garreau H. More about the degradation of LA/GA-derived matrices in aqueous media. Journal of Controlled Release 1991; 16: 15–26
  • Wise D. L., Fellman T. D., Sanderson J. E., Wentworth R. L. Lactide/ glycolide polymers used in as surgical suture material, raw material for osteosynthesis and in sustained release forms of drugs. Drug Carriers in Medicine, G. Gregoriadis. Academic Press, London 1979; 237

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