KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia

References

• Szasz A, Szasz O, Szasz N. Physical background and technical realization of hyperthermia. Hyperthermia in cancer treatment: A primer, GF Baronzio, ED Hager. Springer, New York 2006; 25–57
   Google Scholar
• Roigas J, Wallen ES, Loening SA, Moseley PL. Effects of combined treatment of chemotherapeutics and hyperthermia on survival and the regulation of heat shock proteins in Dunning R3327 prostate carcinoma cells. Prostate 1998; 34: 195–202
   PubMedGoogle Scholar
• Koishi M, Yokota S, Mae T, Nishimura Y, Kanamori S, Horii N, Shibuya K, Sasai K, Hiraoka M. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res 2001; 7: 215–219
   PubMed Web of Science ®Google Scholar
• Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 2000; 92: 1564–1572
   PubMed Web of Science ®Google Scholar
• Samali A, Holmberg CI, Sistonen L, Orrenius S. Thermotolerance and cell death are distinct cellular responses to stress: Dependence on heat shock proteins. FEBS Lett 1999; 461: 306–310
   PubMed Web of Science ®Google Scholar
• Jakubowicz-Gil J, Rzymowska J, Gawron A. Quercetin, apoptosis, heat shock. Biochem Pharmacol 2002; 64: 1591–1595
   PubMed Web of Science ®Google Scholar
• Elia G, Santoro MG. Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem J 1994; 300: 201–209
   PubMed Web of Science ®Google Scholar
• Jones EL, Zhao MJ, Stevenson MA, Calderwood SK. The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia 2004; 20: 835–849
   PubMed Web of Science ®Google Scholar
• Larocca LM, Ranelletti FO, Maggiano N, Rutella S, La Barbera EO, Rumi C, Serra F, Voso MT, Piantelli M, Teofili L, et al. Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: Role of heat-shock protein-70. Int J Cancer 1997; 73: 75–83
   PubMed Web of Science ®Google Scholar
• Nakanoma T, Ueno M, Iida M, Hirata R, Deguchi N. Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Int J Urol 2001; 8: 623–630
   PubMed Web of Science ®Google Scholar
• Wachsberger PR, Burd R, Bhala A, Bobyock SB, Wahl ML, Owen CS, Rifat SB, Leeper DB. Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia. Int J Hyperthermia 2003; 19: 507–519
   PubMed Web of Science ®Google Scholar
• Piantelli M, Tatone D, Castrilli G, Savini F, Maggiano N, Larocca LM, Ranelletti FO, Natali PG. Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia. Melanoma Res 2001; 11: 469–476
   PubMed Web of Science ®Google Scholar
• Kudo M, Naito Z, Yokoyama M, Asano G. Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. Exp Mol Pathol 1999; 66: 66–75
   PubMed Web of Science ®Google Scholar
• Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res 2000; 60: 2942–2948
   PubMed Web of Science ®Google Scholar
• Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003; 304: 505–512
   PubMed Web of Science ®Google Scholar
• Fuller KJ, Issels RD, Slosman DO, Guillet JG, Soussi T, Polla BS. Cancer and the heat shock response. Eur J Cancer 1994; 30A: 1884–1891
   PubMed Web of Science ®Google Scholar
• Milani V, Lorenz M, Weinkauf M, Rieken M, Pastore A, Dreyling M, Issels R. Combination of hyperthermia and bortezomib results in additive killing in mantle cell lymphoma cells. Int J Hyperthermia 2009; 25: 262–272
   PubMed Web of Science ®Google Scholar
• Lloyd SN, Chalmers D, Leake RE, Kirk D. Local hyperthermia for prostatic disease: In vitro studies on human prostatic cancer cell lines. Br J Urol 1992; 70: 529–533
   PubMedGoogle Scholar
• Karlseder J, Wissing D, Holzer G, Orel L, Sliutz G, Auer H, Jaattela M, Simon MM. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochem Biophys Res Commun 1996; 220: 153–159
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hirayoshi K, Kudo H, Takechi H, Aoike A, Kawai K, Nagata K. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol Cell Biol 1992; 12: 3490–3498
   PubMed Web of Science ®Google Scholar
• Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. Embo J 1998; 17: 6124–6134
   PubMed Web of Science ®Google Scholar
• Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the APAF-1 apoptosome. Nat Cell Biol 2000; 2: 469–475
   PubMed Web of Science ®Google Scholar
• Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger JM, Garrido C, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001; 3: 839–843
   PubMed Web of Science ®Google Scholar
• Nonaka T, Akimoto T, Mitsuhashi N, Tamaki Y, Yokota S, Nakano T. Changes in the localization of heat shock protein 72 correlated with development of thermotolerance in human esophageal cancer cell line. Anticancer Res 2003; 23: 4677–4687
   PubMed Web of Science ®Google Scholar
• Ohnishi K, Takahashi A, Yokota S, Ohnishi T. Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status. Int J Radiat Biol 2004; 80: 607–614
   PubMed Web of Science ®Google Scholar
• Hansen RK, Oesterreich S, Lemieux P, Sarge KD, Fuqua SA. Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. Biochem Biophys Res Commun 1997; 239: 851–856
   PubMed Web of Science ®Google Scholar
• Nimmanapalli R, Gerbino E, Dalton WS, Gandhi V, Alsina M. Hsp70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma. Br J Haematol 2008; 142: 551–561
   PubMedGoogle Scholar
• Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A. Induction of apoptosis by quercetin: Involvement of heat shock protein. Cancer Res 1994; 54: 4952–4957
   PubMed Web of Science ®Google Scholar
• Fujita M, Nagai M, Murata M, Kawakami K, Irino S, Takahara J. Synergistic cytotoxic effect of quercetin and heat treatment in a lymphoid cell line (OZ) with low HSP70 expression. Leuk Res 1997; 21: 139–145
   PubMedGoogle Scholar
• Adachi S, Kokura S, Okayama T, Ishikawa T, Takagi T, Handa O, Naito Y, Yoshikawa T. Effect of hyperthermia combined with gemcitabine on apoptotic cell death in cultured human pancreatic cancer cell lines. Int J Hyperthermia 2009; 25: 210–219
   PubMed Web of Science ®Google Scholar