siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells

References

• Hall SF, Walker H, Siemens R, Schneeberg A. Increasing detection and increasing incidence in thyroid cancer. World J Surg 2009; 12: 2567–2571
   Google Scholar
• Riesco-Eizaguirre G, Santisteban P. New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy. Endocr Relat Cancer 2007; 14: 957–977
   PubMedGoogle Scholar
• Jereb B, Stjernsward J, Lowhagen T. Anaplastic giant-cell carcinoma of the thyroid. A study of treatment and prognosis. Cancer 1975; 35: 1293–1295
   PubMed Web of Science ®Google Scholar
• Tan RK, 3 rd Finley RK, Driscoll D, Bakamjian V, Hicks WL, Jr, Shedd DP. Anaplastic carcinoma of the thyroid: A 24-year experience. Head Neck 1995; 17: 41–47
   PubMed Web of Science ®Google Scholar
• Sweeney PJ, Haraf DJ, Recant W, Kaplan EL, Vokes EE. Anaplastic carcinoma of the thyroid. Ann Oncol 1996; 7: 739–744
   PubMedGoogle Scholar
• Taccaliti A, Boscaro M. Genetic mutations in thyroid carcinoma. Minerva Endocrinol 2009; 34: 11–28
   PubMedGoogle Scholar
• Kanata H, Yane K, Ota I, Miyahara H, Matsunaga T, Takahashi A, Ohnishi K, Ohnishi T, Hosoi H. CDDP induces p53-dependent apoptosis in tongue cancer cells. Int J Oncol 2000; 17: 513–517
   PubMedGoogle Scholar
• Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Yane K, Kanata H, Okamoto N, Hosoi H, Ohnishi T. Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene. Apoptosis 2004; 9: 853–859
   PubMedGoogle Scholar
• Ohnishi K, Ota I, Takahashi A, Yane K, Matsumoto H, Ohnishi T. Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck. Apoptosis 2002; 7: 367–372
   PubMedGoogle Scholar
• Asakawa I, Yoshimura H, Takahashi A, Ohnishi K, Nakagawa H, Ota I, Furusawa Y, Tamamoto T, Ohishi H, Ohnishi T. Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status. Anticancer Res 2002; 22: 2037–2043
   PubMed Web of Science ®Google Scholar
• Ota I, Ohnishi K, Takahashi A, Yane K, Kanata H, Miyahara H, Ohnishi T, Hosoi H. Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2000; 47: 495–501
   PubMed Web of Science ®Google Scholar
• Tamamoto T, Yoshimura H, Takahashi A, Asakawa I, Ota I, Nakagawa H, Ohnishi K, Ohishi H, Ohnishi T. Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53. Int J Hyperthermia 2003; 19: 590–597
   PubMed Web of Science ®Google Scholar
• Takahashi A, Matsumoto H, Nagayama K, Kitano M, Hirose S, Tanaka H, Mori E, Yamakawa N, Yasumoto J, Yuki K, et al. Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res 2004; 64: 8839–8845
   PubMed Web of Science ®Google Scholar
• Kaneko H, Igarashi K, Kataoka K, Miura M. Heat shock induces phosphorylation of histone H2AX in mammalian cells. Biochem Biophys Res Commun 2005; 328: 1101–1106
   PubMed Web of Science ®Google Scholar
• Takahashi A, Mori E, Somakos GI, Ohnishi K, Ohnishi T. Heat induces γH2AX foci formation in mammalian cells. Mutat Res 2008; 656: 88–92
   PubMed Web of Science ®Google Scholar
• Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of 125IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002; 158: 486–492
   PubMed Web of Science ®Google Scholar
• Rothkamm K, Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 2003; 100: 5057–5062
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohnishi T. Does γH2AX focus formation depend on the presence of DNA double strand breaks?. Cancer Lett 2005; 229: 171–179
   PubMed Web of Science ®Google Scholar
• Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair (Amst) 2007; 6: 923–935
   PubMed Web of Science ®Google Scholar
• Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 2002; 21: 8967–8980
   PubMed Web of Science ®Google Scholar
• Tauchi H, Kobayashi J, Morishima K, van Gent DC, Shiraishi T, Verkaik NS, van Heems D, Ito E, Nakamura A, Sonoda E, et al. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 2002; 420: 93–98
   PubMed Web of Science ®Google Scholar
• Ito T, Seyama T, Mizuno T, Tsuyama N, Hayashi T, Hayashi Y, Dohi K, Nakamura N, Akiyama M. Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res 1992; 52: 1369–1371
   PubMed Web of Science ®Google Scholar
• Ohnishi K, Scuric Z, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T. siRNA Targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat Res 2006; 166: 454–462
   PubMed Web of Science ®Google Scholar
• Takahashi A, Yamakawa N, Kirita T, Omori K, Ishioka N, Hurusawa Y, Mori E, Ohnishi K, Ohnishi T. DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus. J Radiat Res (Tokyo) 2008; 49: 645–652
   PubMedGoogle Scholar
• Wu SY, McMillan NA. Lipidic systems for in vivo siRNA delivery. AAPS J 2009; 11: 639–652
   PubMed Web of Science ®Google Scholar
• Wall NR, Shi Y. Small RNA: Can RNA interference be exploited for therapy?. Lancet 2003; 362: 1401–1403
   PubMed Web of Science ®Google Scholar
• Ohnishi K, Scuric Z, Yau D, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T. Heat-induced phosphorylation of NBS1 in human skin fibroblast cells. J Cell Biochem 2006; 99: 1642–1650
   PubMedGoogle Scholar
• Li R, Sutphin PD, Schwartz D, Matas D, Almog N, Wolkowicz R, Goldfinger N, Pei H, Prokocimer M, Rotter V. Mutant p53 protein expression interferes with p53-independent apoptotic pathways. Oncogene 1998; 16: 3269–3277
   PubMedGoogle Scholar
• Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, et al. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res 2007; 67: 3010–3017
   PubMed Web of Science ®Google Scholar
• Laszlo A, Fleischer I. The heat-induced γH2AX response does not play a role in hyperthermic cell killing. Int J Hyperthermia 2009; 25: 199–209
   PubMed Web of Science ®Google Scholar
• Laszlo A, Fleischer I. Heat-induced perturbations of DNA damage signaling pathways are modulated by molecular chaperones. Cancer Res 2009; 69: 2042–2049
   PubMed Web of Science ®Google Scholar
• Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000; 10: 886–895
   PubMed Web of Science ®Google Scholar
• Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, Ito E, Masnada D, Delia D, Komatsu K. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50-hMRE11-NBS1 complex DNA repair activity. J Biol Chem 2001; 276: 12–15
   PubMed Web of Science ®Google Scholar
• Seno JD, Dynlacht JR. Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Phys 2004; 199: 157–170
   PubMed Web of Science ®Google Scholar
• Dynlacht JR, Xu M, Pandita RK, Wetzel EA, Roti Roti JL. Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells. Int J Hyperthermia 2004; 20: 144–156
   PubMed Web of Science ®Google Scholar
• Takahashi A, Mori E, Ohnishi T. Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment. Ann Cancer Res Ther 2007; 15: 50–53
   Google Scholar
• Takahashi A, Mori E, Ohnishi T. The foci of DNA double strand break-recognition proteins localize with γH2AX after heat treatment. J Radiat Res (Tokyo) 2010; 51: 91–95
   PubMed Web of Science ®Google Scholar
• Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 2000; 275: 9390–9395
   PubMed Web of Science ®Google Scholar
• Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001; 107: 241–246
   PubMed Web of Science ®Google Scholar
• LaCasse EC, Baird S, Korneluk RG, MacKenzie AE. A novel anti-apoptosis gene: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 1998; 17: 3247–3259
   PubMed Web of Science ®Google Scholar
• Yang MH, Chiang WC, Chou TY, Chang SY, Chen PM, Teng SC, Wu KJ. Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin Cancer Res 2006; 12: 507–515
   PubMedGoogle Scholar