Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

References

• Kaul S. Myocardial contrast echocardiography: A 25-year retrospective. Circulation 2008;118:291–308
   PubMed Web of Science ®Google Scholar
• Alzaraa A, Gravante G, Chung WY, Al-Leswas D, Morgan B, Dennison A, et al. Contrast-enhanced ultrasound in the preoperative, intraoperative and postoperative assessment of liver lesions. Hepatol Res 2013;43:809–19
   PubMed Web of Science ®Google Scholar
• Klibanov AL. Ultrasound contrast materials in cardiovascular medicine: From perfusion assessment to molecular imaging. J Cardiovasc Transl Res 2013;6:729–39
   PubMed Web of Science ®Google Scholar
• Correas JM, Helenon O, Pourcelot L, Moreau JF. Ultrasound contrast agents. Examples of blood pool agents. Acta Radiol Suppl 1997;412:101–12
   PubMedGoogle Scholar
• Greis C. Ultrasound contrast agents as markers of vascularity and microcirculation. Clin Hemorheol Microcirc 2009;43:1–9
   PubMed Web of Science ®Google Scholar
• Kooiman K, Vos HJ, Versluis M, de Jong N. Acoustic behavior of microbubbles and implications for drug delivery. Adv Drug Deliv Rev 2014;72:28–48
   PubMed Web of Science ®Google Scholar
• Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008;60:1153–66
   PubMed Web of Science ®Google Scholar
• Wu H, Rognin NG, Krupka TM, Solorio L, Yoshiara H, Guenette G, et al. Acoustic characterization and pharmacokinetic analyses of new nanobubble ultrasound contrast agents. Ultrasound Med Biol 2013;39:2137–46
   PubMed Web of Science ®Google Scholar
• Wang L, Li L, Guo Y, Tong H, Fan X, Ding J, et al. Construction and in vitro/in vivo targeting of PSMA-targeted nanoscale microbubbles in prostate cancer. Prostate 2013;73:1147–58
   PubMed Web of Science ®Google Scholar
• Kooiman K, Foppen-Harteveld M, van der Steen AF, de Jong N. Sonoporation of endothelial cells by vibrating targeted microbubbles. J Control Release 2011;154:35–41
   PubMed Web of Science ®Google Scholar
• Alzaraa A, Gravante G, Chung WY, Al-Leswas D, Bruno M, Dennison AR, et al. Targeted microbubbles in the experimental and clinical setting. Am J Surg 2012;204:355–66
   PubMed Web of Science ®Google Scholar
• Unnikrishnan S, Klibanov AL. Microbubbles as ultrasound contrast agents for molecular imaging: Preparation and application. Am J Roentgenol 2012;199:292–9
   PubMed Web of Science ®Google Scholar
• Kooiman K, Kokhuis TJA, van Rooij T, Skachkov I, Nigg A, Bosch JG, et al. DSPC or DPPC as main shell component influences ligand distribution and binding area of lipid-coated targeted microbubbles. Eur J Lipid Sci Technol 2014;116:1217–27
   Google Scholar
• van Rooij T, Luan Y, Renaud GGJ, van der Steen AFW, De Jong N, Kooiman K. Acoustical response of DSPC versus DPPC lipid-coated microbubbles. Proc IEEE Ultrason Symp 2013; 2013 July 22–25; Prague, Czech Republic. pp 310–13
   Google Scholar
• Myrset AH, Fjerdingstad HB, Bendiksen R, Arbo BE, Bjerke RM, Johansen JH, et al. Design and characterization of targeted ultrasound microbubbles for diagnostic use. Ultrasound Med Biol 2011;37:136–50
   PubMed Web of Science ®Google Scholar
• Marsh D, Bartucci R, Sportelli L. Lipid membranes with grafted polymers: Physicochemical aspects. Biochim Biophys Acta 2003;2:1–2
   Google Scholar
• Ottoboni S, Short RE, Kerby MB, Tickner EG, Steadman E, Ottoboni TB. Characterization of the in vitro adherence behavior of ultrasound responsive double-shelled microspheres targeted to cellular adhesion molecules. Contrast Media Mol Imaging 2006;1:279–90
   PubMed Web of Science ®Google Scholar
• Chen CC, Borden MA. The role of poly(ethylene glycol) brush architecture in complement activation on targeted microbubble surfaces. Biomaterials 2011;32:6579–87
   PubMed Web of Science ®Google Scholar
• Kiessling F, Fokong S, Bzyl J, Lederle W, Palmowski M, Lammers T. Recent advances in molecular, multimodal and theranostic ultrasound imaging. Adv Drug Deliv Rev 2014;72:15–27
   PubMed Web of Science ®Google Scholar
• Hernot S, Unnikrishnan S, Du Z, Shevchenko T, Cosyns B, Broisat A, et al. Nanobody-coupled microbubbles as novel molecular tracer. J Control Release 2012;158:346–53
   PubMed Web of Science ®Google Scholar
• Nakatsuka MA, Mattrey RF, Esener SC, Cha JN, Goodwin AP. Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging. Adv Mater 2012;24:6010–16
   PubMed Web of Science ®Google Scholar
• Wheatley MA, Lathia JD, Oum KL. Polymeric ultrasound contrast agents targeted to integrins: Importance of process methods and surface density of ligands. Biomacromolecules 2007;8:516–22
   PubMed Web of Science ®Google Scholar
• Paganelli G, Belloni C, Magnani P, Zito F, Pasini A, Sassi I, et al. Two-step tumour targetting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin. Eur J Nucl Med 1992;19:322–9
   PubMedGoogle Scholar
• Wei X, Li Y, Zhang S, Gao X, Luo Y, Gao M. Ultrasound targeted apoptosis imaging in monitoring early tumor response of trastuzumab in a murine tumor xenograft model of her-2-positive breast cancer. Transl Oncol 2014;7:284–91
   PubMed Web of Science ®Google Scholar
• Pochon S, Tardy I, Bussat P, Bettinger T, Brochot J, von Wronski M, et al. BR55: A lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis. Invest Radiol 2010;45:89–95
   PubMed Web of Science ®Google Scholar
• Fokong S, Fragoso A, Rix A, Curaj A, Wu Z, Lederle W, et al. Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide. Invest Radiol 2013;48:843–50
   PubMed Web of Science ®Google Scholar
• Willmann JK, Lutz AM, Paulmurugan R, Patel MR, Chu P, Rosenberg J, et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology 2008;248:936–44
   PubMed Web of Science ®Google Scholar
• Jun HY, Park SH, Kim HS, Yoon KH. Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. Acad Radiol 2010;17:54–60
   PubMed Web of Science ®Google Scholar
• Otani K, Yamahara K. Feasibility of lactadherin-bearing clinically available microbubbles as ultrasound contrast agent for angiogenesis. Mol Imaging Biol 2013;15:534–41
   PubMed Web of Science ®Google Scholar
• Wijkstra HSM, Rosette JJ, de la Pochon S, Tranquart F. Targeted microbubble prostate cancer imaging with BR55. 17th Eur Symp Ultrasound Imaging; 2012 January 1920; Rotterdam, the Netherlands. pp 6–7
   Google Scholar
• Kaufmann BA, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation 2007;116:276–84
   PubMed Web of Science ®Google Scholar
• Kaufmann BA, Lewis C, Xie A, Mirza-Mohd A, Lindner JR. Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography. Eur Heart J 2007;28:2011–17
   PubMed Web of Science ®Google Scholar
• Kim H, Moody MR, Laing ST, Kee PH, Huang SL, Klegerman ME, et al. In vivo volumetric intravascular ultrasound visualization of early/inflammatory arterial atheroma using targeted echogenic immunoliposomes. Invest Radiol 2010;45:685–91
   PubMed Web of Science ®Google Scholar
• Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, et al. Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease. Arterioscler Thromb Vasc Biol 2010;30:54–9
   PubMed Web of Science ®Google Scholar
• Wen Q, Wan S, Liu Z, Xu S, Wang H, Yang B. Ultrasound contrast agents and ultrasound molecular imaging. J Nanosci Nanotechnol 2014;14:190–209
   PubMed Web of Science ®Google Scholar
• Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release 2006;114:288–99
   PubMed Web of Science ®Google Scholar
• Wang X, Hagemeyer CE, Hohmann JD, Leitner E, Armstrong PC, Jia F, et al. Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice. Circulation 2012;125:3117–26
   PubMed Web of Science ®Google Scholar
• Schumann PA, Christiansen JP, Quigley RM, McCreery TP, Sweitzer RH, Unger EC, et al. Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi. Invest Radiol 2002;37:587–93
   PubMed Web of Science ®Google Scholar
• Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, et al. Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis 2007;195:225–35
   PubMed Web of Science ®Google Scholar
• Nakatsuka MA, Barback CV, Fitch KR, Farwell AR, Esener SC, Mattrey RF, et al. In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive contrast agents. Biomaterials 2013;34:9559–65
   PubMed Web of Science ®Google Scholar
• Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level < or = 4.0 ng per milliliter. N Engl J Med 2004;350:2239–46
   PubMed Web of Science ®Google Scholar
• Perner S, Hofer MD, Kim R, Shah RB, Li H, Moller P, et al. Prostate-specific membrane antigen expression as a predictor of prostate cancer progression. Hum Pathol 2007;38:696–701
   PubMed Web of Science ®Google Scholar
• Sanna V, Pintus G, Bandiera P, Anedda R, Punzoni S, Sanna B, et al. Development of polymeric microbubbles targeted to prostate-specific membrane antigen as prototype of novel ultrasound contrast agents. Mol Pharm 2011;8:748–57
   PubMed Web of Science ®Google Scholar
• Tsuruta JK, Klauber-DeMore N, Streeter J, Samples J, Patterson C, Mumper RJ, et al. Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma. PLoS One 2014;9:e86642
   PubMed Web of Science ®Google Scholar
• Lutz AM, Bachawal SV, Drescher CW, Pysz MA, Willmann JK, Gambhir SS. Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model. Clin Cancer Res 2014;20:1313–22
   PubMed Web of Science ®Google Scholar
• Foygel K, Wang H, Machtaler S, Lutz AM, Chen R, Pysz M, et al. Detection of pancreatic ductal adenocarcinoma in mice by ultrasound imaging of thymocyte differentiation antigen 1. Gastroenterology 2013;145:885–94 e3
   PubMed Web of Science ®Google Scholar
• Knowles JA, Heath CH, Saini R, Umphrey H, Warram J, Hoyt K, et al. Molecular targeting of ultrasonographic contrast agent for detection of head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2012;138:662–8
   PubMedGoogle Scholar
• Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994;84:1415–20
   PubMed Web of Science ®Google Scholar
• Ferrante EA, Pickard JE, Rychak J, Klibanov A, Ley K. Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. J Control Release 2009;140:100–7
   PubMed Web of Science ®Google Scholar
• Warram JM, Sorace AG, Saini R, Umphrey HR, Zinn KR, Hoyt K. A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature. J Ultrasound Med 2011;30:921–31
   PubMed Web of Science ®Google Scholar
• Ham AS, Klibanov AL, Lawrence MB. Action at a distance: Lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticles. Langmuir 2009;25:10038–44
   PubMed Web of Science ®Google Scholar
• Maul TM, Dudgeon DD, Beste MT, Hammer DA, Lazo JS, Villanueva FS, et al. Optimization of ultrasound contrast agents with computational models to improve selection of ligands and binding strength. Biotechnol Bioeng 2010;107:854–64
   PubMed Web of Science ®Google Scholar
• Kawan S, Hiroshi W. Development of magnetic microbubbles for drug delivery system (DDS). Jpn J Appl Phys 2000;39:S3230–2
   Web of Science ®Google Scholar
• Stride E, Porter C, Prieto AG, Pankhurst Q. Enhancement of microbubble mediated gene delivery by simultaneous exposure to ultrasonic and magnetic fields. Ultrasound Med Biol 2009;35:861–8
   PubMed Web of Science ®Google Scholar
• Soetanto K, Watarai H. Ferromagnetic ultrasound microbubbles contrast agent. Engineering in Medicine and Biology Society, 2003 Proc 25th IEEE EMBS Annu Int Conf; 2013 September 17–21; Cancun, Mexico. pp 1226–9
   Google Scholar
• Owen J, Pankhurst Q, Stride E. Magnetic targeting and ultrasound mediated drug delivery: Benefits, limitations and combination. Int J Hyperthermia 2012;28:362–73
   PubMed Web of Science ®Google Scholar
• Torr GR. The acoustic radiation force. Am J Phys 1984;52:402–8
   Web of Science ®Google Scholar
• Borden MA, Sarantos MR, Stieger SM, Simon SI, Ferrara KW, Dayton PA. Ultrasound radiation force modulates ligand availability on targeted contrast agents. Mol Imaging 2006;5:139–47
   PubMed Web of Science ®Google Scholar
• Borden MA, Streeter JE, Sirsi SR, Dayton PA. In vivo demonstration of cancer molecular imaging with ultrasound radiation force and buried-ligand microbubbles. Mol Imaging 2013;12:1–8
   Web of Science ®Google Scholar
• Wang S, Hossack JA, Klibanov AL, Mauldin FW. Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force. Phys Med Biol 2014;59:465–84
   PubMed Web of Science ®Google Scholar
• Frinking PJ, Tardy I, Theraulaz M, Arditi M, Powers J, Pochon S, et al. Effects of acoustic radiation force on the binding efficiency of BR55, a VEGFR2-specific ultrasound contrast agent. Ultrasound Med Biol 2012;38:1460–9
   PubMed Web of Science ®Google Scholar
• Kokhuis TJA, Skachkov I, Naaijkens BA, Juffermans LJM, Kamp O, Kooiman K, et al. Intravital microscopy of localized stem cell delivery using microbubbles and acoustic radiation force. Biotechnol Bioeng 2014;112:220–7
   PubMed Web of Science ®Google Scholar
• Kim DH, Klibanov AL, Needham D. The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor−ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads. Langmuir 2000;16:2808–17
   Web of Science ®Google Scholar
• Sboros V, Glynos E, Ross JA, Moran CM, Pye SD, Butler M, et al. Probing microbubble targeting with atomic force microscopy. Colloids and Surfaces B 2010;80:12–17
   PubMed Web of Science ®Google Scholar
• Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release 2004;96:473–82
   PubMed Web of Science ®Google Scholar
• Kokhuis TJA, Garbin V, Kooiman K, Naaijkens BA, Juffermans LJM, Kamp O, et al. Secondary Bjerknes forces deform targeted microbubbles. Ultrasound Med Biol 2013;39:490–506
   PubMed Web of Science ®Google Scholar
• Garbin V, Cojoc D, Ferrari E, Di Fabrizio E, Overvelde MLJ, van der Meer SM, et al. Changes in microbubble dynamics near a boundary revealed by combined optical micromanipulation and high-speed imaging. Appl Phys Lett 2007;90:114103-1–3
   Web of Science ®Google Scholar
• Leighton TG. The Acoustic Bubble. London: Academic Press, 1994
   Google Scholar
• Chetty K, Stride E, Sennoga CA, Hajnal JV, Eckersley RJ. High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonation. IEEE Trans Ultrason Ferroelectr Freq Control 2008;55:1333–42
   PubMed Web of Science ®Google Scholar
• Faez T, Goertz D, De Jong N. Characterization of Definity ultrasound contrast agent at frequency range of 5–15 MHz. Ultrasound Med Biol 2011;37:338–42
   PubMed Web of Science ®Google Scholar
• Gorce JM, Arditi M, Schneider M. Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: A study of SonoVue. Invest Radiol 2000;35:661–71
   PubMed Web of Science ®Google Scholar
• Helfield BL, Goertz DE. Nonlinear resonance behavior and linear shell estimates for Definity and MicroMarker assessed with acoustic microbubble spectroscopy. J Acoust Soc Am 2013;13:1158–68
   Google Scholar
• Klibanov AL, Rasche PT, Hughes MS, Wojdyla JK, Galen KP, Wible JH, Jr et al. Detection of individual microbubbles of ultrasound contrast agents: Imaging of free-floating and targeted bubbles. Invest Radiol 2004;39:187–95
   PubMed Web of Science ®Google Scholar
• McKendry JE Grant CA, Johnson BRG, Coletta PL, Evans JA, Evans SD. Force spectroscopy of streptavidin conjugated lipid coated microbubbles. Bubble Sci Eng Technol. 2010;2:48–54
   Google Scholar
• Abou-Saleh RH, Peyman SA, Critchley K, Evans SD, Thomson NH. Nanomechanics of lipid encapsulated microbubbles with functional coatings. Langmuir 2013;29:4096–103
   PubMed Web of Science ®Google Scholar
• Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104:2107–12
   PubMed Web of Science ®Google Scholar
• van der Meer SM, Dollet B, Voormolen MM, Chin CT, Bouakaz A, de Jong N, et al. Microbubble spectroscopy of ultrasound contrast agents. J Acoust Soc Am 2007;121:648–56
   PubMed Web of Science ®Google Scholar
• Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, et al. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J Acoust Soc Am 2005;118:3499–505
   Web of Science ®Google Scholar
• Dieluweit S, Csiszar A, Rubner W, Fleischhauer J, Houben S, Merkel R. Mechanical properties of bare and protein-coated giant unilamellar phospholipid vesicles. A comparative study of micropipet aspiration and atomic force microscopy. Langmuir 2010;26:11041–9
   PubMed Web of Science ®Google Scholar
• Darst SA, Ahlers M, Meller PH, Kubalek EW, Blankenburg R, Ribi HO, et al. Two-dimensional crystals of streptavidin on biotinylated lipid layers and their interactions with biotinylated macromolecules. Biophys J 1991;59:387–96
   PubMed Web of Science ®Google Scholar
• Borden MA, Kruse DE, Caskey CF, Zhao S, Dayton PA, Ferrara KW. Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction. IEEE Trans Ultrason Ferroelectr Freq Control 2005;52:1992–2002
   PubMed Web of Science ®Google Scholar
• Overvelde M, Garbin V, Dollet B, de Jong N, Lohse D, Versluis M. Dynamics of coated microbubbles adherent to a wall. Ultrasound Med Biol 2011;37:1500–8
   PubMed Web of Science ®Google Scholar
• Voet D, Voet JG. Amino acids. In: Biochemistry. Somerset, NJ, USA: John Wiley and Sons, Inc.; 1995. pp 58–9
   Google Scholar
• Klibanov AL. Preparation of targeted microbubbles: Ultrasound contrast agents for molecular imaging. Med Biol Eng Comput 2009;47:875–82
   PubMed Web of Science ®Google Scholar
• Zhao S, Ferrara KW, Dayton PA. Asymmetric oscillation of adherent targeted ultrasound contrast agents. Appl Phys Lett 2005;87:134103-1–3
   Web of Science ®Google Scholar
• Zhao S, Kruse DE, Ferrara KW, Dayton PA. Acoustic response from adherent targeted contrast agents. J Acoust Soc Am 2006;120:EL63–9
   PubMed Web of Science ®Google Scholar
• Casey J, Sennoga C, Mulvana H, Hajnal JV, Tang MX, Eckersley RJ. Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound Med Biol 2013;39:903–14
   PubMed Web of Science ®Google Scholar
• Helfield BL, Cherin E, Foster FS, Goertz DE. The effect of binding on the subharmonic emissions from individual lipid-encapsulated microbubbles at transmit frequencies of 11 and 25 MHz. Ultrasound Med Biol 2013;39:345–59
   PubMed Web of Science ®Google Scholar
• Schmidt BJ, Sousa I, van Beek AA, Bohmer MR. Adhesion and ultrasound-induced delivery from monodisperse microbubbles in a parallel plate flow cell. J Control Release 2008;131:19–26
   PubMed Web of Science ®Google Scholar
• Cerroni B, Chiessi E, Margheritelli S, Oddo L, Paradossi G. Polymer shelled microparticles for a targeted doxorubicin delivery in cancer therapy. Biomacromolecules 2011;12:593–601
   PubMed Web of Science ®Google Scholar
• Grishenkov D, Kari L, Brodin LK, Brismar TB, Paradossi G. In vitro contrast-enhanced ultrasound measurements of capillary microcirculation: comparison between polymer- and phospholipid-shelled microbubbles. Ultrasonics 2011;51:40–8
   PubMed Web of Science ®Google Scholar
• de Jong N, Bouakaz A, Frinking P. Basic acoustic properties of microbubbles. Echocardiography 2002;19:229–40
   PubMed Web of Science ®Google Scholar
• Eller A, Flynn HG. Generation of subharmonics of order one-half by bubbles in a sound field. J Acoust Soc Am 1969;46:722–7
   Web of Science ®Google Scholar
• Chomas J, Dayton P, May D, Ferrara K. Nondestructive subharmonic imaging. IEEE Trans Ultrason Ferroelectr Freq Control 2002;49:883–92
   PubMed Web of Science ®Google Scholar
• Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, et al. Subharmonic contrast intravascular ultrasound for vasa vasorum imaging. Ultrasound Med Biol 2007;33:1859–72
   PubMed Web of Science ®Google Scholar
• Needles A, Goertz D, Karshafian R, Cherin E, Brown A, Burns P, et al. High-frequency subharmonic pulsed-wave Doppler and color flow imaging of microbubble contrast agents. Ultrasound Med Biol 2008;34:1139–51
   PubMed Web of Science ®Google Scholar
• Wu CY, Tsao J, Chou YH. An ultrasonic microbubble semi-intermodulated imaging technique. Ultrasound Med Biol 2005;31:1199–210
   PubMed Web of Science ®Google Scholar
• Deng CX, Lizzi FL, Kalisz A, Rosado A, Silverman RH, Coleman DJ. Study of ultrasonic contrast agents using a dual-frequency band technique. Ultrasound Med Biol 2000;26:819–31
   PubMed Web of Science ®Google Scholar
• Shi WT, Forsberg F. Ultrasonic characterization of the nonlinear properties of contrast microbubbles. Ultrasound Med Biol 2000;26:93–104
   PubMed Web of Science ®Google Scholar
• Chen S, Kinnick R, Greenleaf JF, Fatemi M. Difference frequency and its harmonic emitted by microbubbles under dual frequency excitation. Ultrasonics 2006;44:Se123–6
   Web of Science ®Google Scholar
• Burns PN, Powers JE, Simpson DH, Brezina A, Kolin A, Chin CT, et al. Harmonic power mode Doppler using microbubble contrast agents: an improved method for small vessel flow imaging. IEEE Proc Ultrason Symp; 31 October – 3 November 1994; Cannes, France. pp 1547–50
   Google Scholar
• Pi Hsien C, Shun KK, Shih-Jeh W, Levene HB. Second harmonic imaging and harmonic Doppler measurements with Albunex. IEEE Trans Ultrason Ferroelectr Freq Control 1995;42:1020–7
   Web of Science ®Google Scholar
• Simpson DH, Burns PN. Pulse inversion Doppler: A new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Proc Ultrason Symp; 1997 October 5–8; Toronto, Ontario, Canada. pp 1597–600
   Google Scholar
• de Jong N, Frinking PJA, Bouakaz A, Ten Cate FJ. Detection procedures of ultrasound contrast agents. Ultrasonics 2000;38:87–92
   PubMed Web of Science ®Google Scholar
• Deng CX, Lizzi FL. A review of physical phenomena associated with ultrasonic contrast agents and illustrative clinical applications. Ultrasound Med Biol 2002;28:277–86
   PubMed Web of Science ®Google Scholar
• Foster FS, Hossack J, Adamson SL. Micro-ultrasound for preclinical imaging. Interface Focus 2011;1:576–601
   PubMed Web of Science ®Google Scholar
• Needles A, Arditi M, Rognin NG, Mehi J, Coulthard T, Bilan-Tracey C, et al. Nonlinear contrast imaging with an array-based micro-ultrasound system. Ultrasound Med Biol 2010;36:2097–106
   PubMed Web of Science ®Google Scholar
• Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med 2007;26:1575–86
   PubMed Web of Science ®Google Scholar
• Rychak J, Graba J, Cheung A, Mystry B, Lindner J, Kerbel R, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging 2007;6:289–96
   PubMed Web of Science ®Google Scholar
• Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology 2008;246:508–18
   PubMed Web of Science ®Google Scholar
• Moran CM, Watson RJ, Fox KA, McDicken WN. In vitro acoustic characterisation of four intravenous ultrasonic contrast agents at 30 MHz. Ultrasound Med Biol 2002;28:785–91
   PubMed Web of Science ®Google Scholar
• ten Kate GL, Renaud GG, Akkus Z, van den Oord SC, ten Cate FJ, Shamdasani V, et al. Far-wall pseudoenhancement during contrast-enhanced ultrasound of the carotid arteries: Clinical description and in vitro reproduction. Ultrasound Med Biol 2012;38:593–600
   PubMed Web of Science ®Google Scholar
• Tang M-X, Kamiyama N, Eckersley RJ. Effects of nonlinear propagation in ultrasound contrast agent imaging. Ultrasound Med Biol 2010;36:459–66
   PubMed Web of Science ®Google Scholar
• Renaud G, Bosch JG, De Jong N, van der Steen AW, Shamdasani V, Entrekin R. Counter-propagation interaction for contrast-enhanced ultrasound imaging. IEEE Int Ultrason Symp; 2012 October 7–10; Dresden, Germany. pp 1–4
   Google Scholar
• Yu H, Jang HJ, Kim TK, Khalili K, Williams R, Lueck G, et al. Pseudoenhancement within the local ablation zone of hepatic tumors due to a nonlinear artifact on contrast-enhanced ultrasound. Am J Roentgenol 2010;194:653–9
   PubMed Web of Science ®Google Scholar
• Thapar A, Shalhoub J, Averkiou M, Mannaris C, Davies AH, Leen EL. Dose-dependent artifact in the far wall of the carotid artery at dynamic contrast-enhanced US. Radiology 2012;262:672–9
   PubMed Web of Science ®Google Scholar
• Hansen R, Angelsen BAJ, Burns PN, Bouakaz A, Borsboom J, Versluis M, et al. Radial modulation imaging. Proc 10th Eur Symp Ultrasound Contrast Imaging; 2005 January 20–21; Rotterdam, the Netherlands. pp 90–1
   Google Scholar
• Frijlink ME, Goertz DE, Bouakaz A, van der Steen AF. A simulation study on tissue harmonic imaging with a single-element intravascular ultrasound catheter. J Acoust Soc Am 2006;120:1723–31
   PubMed Web of Science ®Google Scholar
• Jimenez-Fernandez J. Nonlinear response to ultrasound of encapsulated microbubbles. Ultrasonics 2012;52:784–93
   PubMed Web of Science ®Google Scholar
• Park J, Li X, Zhou Q, Shung KK. Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20–60 MHz phantom and ex vivo results. Ultrasonics 2013;53:369–76
   PubMed Web of Science ®Google Scholar
• Shen CC, Lin CH. Chirp-encoded excitation for dual-frequency ultrasound tissue harmonic imaging. IEEE Trans Ultrason Ferroelectr Freq Control 2012;59:2420–30
   PubMed Web of Science ®Google Scholar
• Park J, Huang Y, Chen R, Lee J, Cummins TM, Zhou Q, et al. Pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) of zebrafish heart using high frame rate ultrasound biomicroscopy. Ann Biomed Eng 2013;41:41–52
   PubMed Web of Science ®Google Scholar
• Novell A, Sennoga CA, Escoffre JM, Chaline J, Bouakaz A. Evaluation of chirp reversal power modulation sequence for contrast agent imaging. Phys Med Biol 2014;59:5101–17
   PubMed Web of Science ®Google Scholar
• Sprague MR, Cherin E, Goertz DE, Foster FS. Nonlinear emission from individual bound microbubbles at high frequencies. Ultrasound Med Biol 2010;36:313–24
   PubMed Web of Science ®Google Scholar
• Helfield BL, Cherin E, Foster FS, Goertz DE. The effect of binding on the subharmonic emissions from individual lipid-encapsulated microbubbles at transmit frequencies of 11 and 25 MHz. Ultrasound Med Biol 2013;39:345–59
   PubMed Web of Science ®Google Scholar
• Tjötta JN, Tjötta S. An analytical model for the nearfield of a baffled piston transducer. J Acoust Soc Am 1980;68:334–9
   Web of Science ®Google Scholar
• Faez T, Emmer M, Docter M, Sijl J, Versluis M, de Jong N. Characterizing the subharmonic response of phospholipid-coated microbubbles for carotid imaging. Ultrasound Med Biol 2011;37:958–70
   PubMed Web of Science ®Google Scholar
• Shankar PM, Krishna PD, Newhouse VL. Advantages of subharmonic over second harmonic backscatter for contrast-to-tissue echo enhancement. Ultrasound Med Biol 1998;24:395–9
   PubMed Web of Science ®Google Scholar
• Forsberg F, Liu JB, Shi WT, Furuse J, Shimizu M, Goldberg BB. In vivo pressure estimation using subharmonic contrast microbubble signals: Proof of concept. IEEE Trans Ultrason Ferroelectr Freq Control 2005;52:581–3
   PubMed Web of Science ®Google Scholar
• Zhang D, Gong Y, Gong X, Liu Z, Tan K, Zheng H. Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique. Phys Med Biol 2007;52:5531–44
   PubMed Web of Science ®Google Scholar
• Daeichin V, Faez T, Renaud G, Bosch JG, van der Steen AF, de Jong N. Effect of self-demodulation on the subharmonic response of contrast agent microbubbles. Phys Med Biol 2012;57:3675–91
   PubMed Web of Science ®Google Scholar
• Zheng H, Mukdadi O, Kim H, Hertzberg JR, Shandas R. Advantages in using multifrequency excitation of contrast microbubbles for enhancing echo particle image velocimetry techniques: Initial numerical studies using rectangular and triangular waves. Ultrasound Med Biol 2005;31:99–108
   PubMed Web of Science ®Google Scholar
• Biagi E, Breschi L, Vannacci E, Masotti L. Subharmonic emissions from microbubbles: Effect of the driving pulse shape. IEEE Trans Ultrason Ferroelectr Freq Control 2006;53:2174–82
   PubMed Web of Science ®Google Scholar
• Masotti L, Biagi E, Breschi L, Vannacci E. Study and characterization of subharmonic emissions by using shaped ultrasonic driving pulse. In: André MP, Akiyama I, Andre M, Arnold W, Bamber J, Burov V, et al., editors. Acoustical imaging. Dordrecht, Netherlands: Springer; 2007. pp 307–15
   Google Scholar
• Zhang D, Xi X, Zhang Z, Gong X, Chen G, Wu J. A dual-frequency excitation technique for enhancing the sub-harmonic emission from encapsulated microbubbles. Phys Med Biol 2009;54:4257–72
   PubMed Web of Science ®Google Scholar
• Streeter JE, Gessner R, Miles I, Dayton PA. Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: In vivo studies. Mol Imaging 2010;9:87–95
   PubMed Web of Science ®Google Scholar
• Zhao S, Kruse DE, Ferrara KW, Dayton PA. Selective imaging of adherent targeted ultrasound contrast agents. Phys Med Biol 2007;52:2055–72
   PubMed Web of Science ®Google Scholar
• Hu X, Zheng H, Kruse DE, Sutcliffe P, Stephens DN, Ferrara KW. A sensitive TLRH targeted imaging technique for ultrasonic molecular imaging. IEEE Trans Ultrason Ferroelectr Freq Control 2010;57:305–16
   PubMed Web of Science ®Google Scholar
• Needles A, Couture O, Foster F. A method for differentiating targeted microbubbles in real time using subharmonic micro-ultrasound and interframe filtering. Ultrasound Med Biol 2009;35:1564–73
   PubMed Web of Science ®Google Scholar
• Mauldin FW, Jr Dhanaliwala AH, Patil AV, Hossack JA. Real-time targeted molecular imaging using singular value spectra properties to isolate the adherent microbubble signal. Phys Med Biol 2012;57:5275–93
   PubMed Web of Science ®Google Scholar
• Pysz MA, Gambhir SS, Willmann JK. Molecular imaging: Current status and emerging strategies. Clin Radiol 2010;65:500–16
   PubMed Web of Science ®Google Scholar
• Sorace AG, Saini R, Mahoney M, Hoyt K. Molecular ultrasound imaging using a targeted contrast agent for assessing early tumor response to antiangiogenic therapy. J Ultrasound Med 2012;31:1543–50
   PubMed Web of Science ®Google Scholar
• Streeter JE, Gessner RC, Tsuruta J, Feingold S, Dayton PA. Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography. Mol Imaging 2011;10:460–8
   PubMed Web of Science ®Google Scholar
• Stieger SM, Dayton PA, Borden MA, Caskey CF, Griffey SM, Wisner ER, et al. Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents. Contrast Media Mol Imaging 2008;3:9–18
   PubMed Web of Science ®Google Scholar
• Piedra M, Allroggen A, Lindner JR. Molecular imaging with targeted contrast ultrasound. Cerebrovasc Dis 2009;2:66–74
   Google Scholar
• Dayton PA, Rychak JJ. Molecular ultrasound imaging using microbubble contrast agents. Front Biosci 2007;12:5124–42
   PubMed Web of Science ®Google Scholar
• Anderson CR, Hu X, Zhang H, Tlaxca J, Decleves AE, Houghtaling R, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol 2011;46:215–24
   PubMed Web of Science ®Google Scholar
• Itani M, Mattrey RF. The effect of inhaled gases on ultrasound contrast agent longevity in vivo. Mol Imaging Biol 2012;14:40–6
   PubMed Web of Science ®Google Scholar
• Wible JH, Jr Wojdyla JK, Bales GL, McMullen WN, Geiser EA, Buss DD. Inhaled gases affect the ultrasound contrast produced by Albunex in anesthetized dogs. J Am Soc Echocardiogr 1996;9:442–51
   PubMedGoogle Scholar
• McDannold N, Zhang Y, Vykhodtseva N. Blood–brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocol. Ultrasound Med Biol 2011;37:1259–70
   PubMed Web of Science ®Google Scholar
• Mullin L, Gessner R, Kwan J, Kaya M, Borden MA, Dayton PA. Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats. Contrast Media Mol Imaging 2011;6:126–31
   PubMed Web of Science ®Google Scholar
• Pysz MA, Guracar I, Tian L, Willmann JK. Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer. Quant Imaging Med Surg 2012;2:68–80
   PubMedGoogle Scholar
• Daeichin V, Akkus Z, Hoogi A, Bosch JG, Needles A, Kooiman K, et al. Quantification of targeted microbubbles in contrast enhanced ultrasound. IEEE Int Ultrason Symp; 2013 July 21–25; Prague, Czech Republic. pp 1825–8
   Google Scholar
• Liu H, Wang X, Tan KB, Liu P, Zhuo ZX, Liu Z, et al. Molecular imaging of vulnerable plaques in rabbits using contrast-enhanced ultrasound targeting to vascular endothelial growth factor receptor-2. J Clin Ultrasound 2011;39:83–90
   PubMed Web of Science ®Google Scholar
• Hamilton A, Huang SL, Warnick D, Stein A, Rabbat M, Madhav T, et al. Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: Studies in a new experimental model. Circulation 2002;105:2772–8
   PubMed Web of Science ®Google Scholar
• Deshpande N, Needles A, Willmann JK. Molecular ultrasound imaging: Current status and future directions. Clin Radiol 2010;65:567–81
   PubMed Web of Science ®Google Scholar
• Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 2007;13:323–30
   PubMed Web of Science ®Google Scholar
• Deshpande N, Ren Y, Foygel K, Rosenberg J, Willmann JK. Tumor angiogenic marker expression levels during tumor growth: Longitudinal assessment with molecularly targeted microbubbles and US imaging. Radiology 2011;258:804–11
   PubMed Web of Science ®Google Scholar
• Ellegala DB, Leong-Poi H, Carpenter JE, Klibanov AL, Kaul S, Shaffrey ME, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003;108:336–41
   PubMed Web of Science ®Google Scholar
• Barua A, Yellapa A, Bahr JM, Machado SA, Bitterman P, Basu S, et al. Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: A preclinical model of spontaneous ovarian cancer. Int J Gynecol Cancer 2014;24:19–28
   PubMed Web of Science ®Google Scholar
• Kuliszewski MA, Fujii H, Liao C, Smith AH, Xie A, Lindner JR, et al. Molecular imaging of endothelial progenitor cell engraftment using contrast-enhanced ultrasound and targeted microbubbles. Cardiovasc Res 2009;83:653–62
   PubMed Web of Science ®Google Scholar
• Bachawal SV, Jensen KC, Lutz AM, Gambhir SS, Tranquart F, Tian L, et al. Earlier detection of breast cancer with ultrasound molecular imaging in a transgenic mouse model. Cancer Res 2013;73:1689–98
   PubMed Web of Science ®Google Scholar
• Grouls C, Hatting M, Rix A, Pochon S, Lederle W, Tardy I, et al. Liver dysplasia: US molecular imaging with targeted contrast agent enables early assessment. Radiology 2013;267:487–95
   PubMed Web of Science ®Google Scholar
• Khanicheh E, Mitterhuber M, Xu L, Haeuselmann SP, Kuster GM, Kaufmann BA. Noninvasive ultrasound molecular imaging of the effect of statins on endothelial inflammatory phenotype in early atherosclerosis. PLoS One 2013;8:e58761
   PubMed Web of Science ®Google Scholar
• Khanicheh E, Qi Y, Xie A, Mitterhuber M, Xu L, Mochizuki M, et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. Arterioscler Thromb Vasc Biol 2013;33:2187–92
   PubMed Web of Science ®Google Scholar
• Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK. Antiangiogenic cancer therapy: Monitoring with molecular US and a clinically translatable contrast agent (BR55). Radiology 2010;256:519–27
   PubMed Web of Science ®Google Scholar
• Baron Toaldo M, Salvatore V, Marinelli S, Palama C, Milazzo M, Croci L, et al. Use of VEGFR-2 targeted ultrasound contrast agent for the early evaluation of response to sorafenib in a mouse model of hepatocellular carcinoma. Mol Imaging Biol 2014; in press
   Google Scholar
• Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 2007;13:323–30
   PubMed Web of Science ®Google Scholar
• Palmowski M, Huppert J, Ladewig G, Hauff P, Reinhardt M, Mueller MM, et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: Early assessment of antiangiogenic therapy effects. Mol Cancer Ther 2008;7:101–9
   PubMed Web of Science ®Google Scholar
• Sirsi SR, Flexman ML, Vlachos F, Huang J, Hernandez SL, Kim HK, et al. Contrast ultrasound imaging for identification of early responder tumor models to anti-angiogenic therapy. Ultrasound Med Biol 2012;38:1019–29
   PubMed Web of Science ®Google Scholar
• Streeter JE, Herrera-Loeza SG, Neel NF, Yeh JJ, Dayton PA. A comparative evaluation of ultrasound molecular imaging, perfusion imaging, and volume measurements in evaluating response to therapy in patient-derived xenografts. Technol Cancer Res Treat 2013;12:311–21
   PubMed Web of Science ®Google Scholar
• Flisikowska T, Kind A, Schnieke A. The new pig on the block: Modelling cancer in pigs. Transgenic Res 2013;22:673–80
   PubMed Web of Science ®Google Scholar
• Kim H, Britton GL, Peng T, Holland CK, McPherson DD, Huang SL. Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage. Int J Nanomedicine 2014;9:155–65
   PubMed Web of Science ®Google Scholar
• Chadderdon SM, Belcik JT, Bader L, Kirigiti MA, Peters DM, Kievit P, et al. Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insulin resistance. Circulation 2014;129:471–8
   PubMed Web of Science ®Google Scholar
• Davidson BP, Chadderdon SM, Belcik JT, Gupta S, Lindner JR. Ischemic memory imaging in nonhuman primates with echocardiographic molecular imaging of selectin expression. J Am Soc Echocardiogr 2014;27:786–93
   PubMed Web of Science ®Google Scholar
• Streeter JE, Gessner RC, Tsuruta J, Feingold S, Dayton PA. Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography. Mol Imaging 2011;10:460–8
   PubMed Web of Science ®Google Scholar
• Streeter JE, Dayton PA. An in vivo evaluation of the effect of repeated administration and clearance of targeted contrast agents on molecular imaging signal enhancement. Theranostics 2013;3:93–8
   PubMed Web of Science ®Google Scholar
• Bzyl J, Palmowski M, Rix A, Arns S, Hyvelin JM, Pochon S, et al. The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55). Eur Radiol 2013;23:468–75
   PubMed Web of Science ®Google Scholar
• Hu X, Caskey CF, Mahakian LM, Kruse DE, Beegle JR, Decleves AE, et al. In vivo validation and 3D visualization of broadband ultrasound molecular imaging. Am J Nucl Med Mol Imaging 2013;3:336–49
   PubMedGoogle Scholar
• Lentacker I, De Cock I, Deckers R, De Smedt SC, Moonen CT. Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms. Adv Drug Deliv Rev 2014;72:49–64
   PubMed Web of Science ®Google Scholar
• Bao S, Thrall BD, Miller DL. Transfection of a reporter plasmid into cultured cells by sonoporation in vitro. Ultrasound Med Biol 1997;23:953–9
   PubMed Web of Science ®Google Scholar
• McLaughlan J, Ingram N, Smith PR, Harput S, Coletta PL, Evans S, et al. Increasing the sonoporation efficiency of targeted polydisperse microbubble populations using chirp excitation. IEEE Trans Ultrason Ferroelectr Freq Control 2013;60:2511–20
   PubMed Web of Science ®Google Scholar
• Skachkov I, Ying L, van der Steen AFW, de Jong N, Kooiman K. Targeted microbubble mediated sonoporation of endothelial cells in vivo. IEEE Trans Ultrason Ferroelectr Freq Control 2014;61:1661–7
   PubMed Web of Science ®Google Scholar
• Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA. Intravascular ultrasound detection and delivery of molecularly targeted microbubbles for gene delivery. IEEE Trans Ultrason Ferroelectr Freq Control 2012;59:1596–601
   PubMed Web of Science ®Google Scholar
• Chang S, Guo J, Sun J, Zhu S, Yan Y, Zhu Y, et al. Targeted microbubbles for ultrasound mediated gene transfection and apoptosis induction in ovarian cancer cells. Ultrason Sonochem 2013;20:171–9
   PubMed Web of Science ®Google Scholar
• Xie A, Belcik T, Qi Y, Morgan TK, Champaneri SA, Taylor S, et al. Ultrasound-mediated vascular gene transfection by cavitation of endothelial-targeted cationic microbubbles. JACC Cardiovasc Imaging 2012;5:1253–62
   PubMed Web of Science ®Google Scholar
• Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizzaro TT, et al. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release 2013;165:216–25
   PubMed Web of Science ®Google Scholar
• Liu H, Chang S, Sun J, Zhu S, Pu C, Zhu Y, et al. Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells. Mol Pharm 2014;11:40–8
   PubMed Web of Science ®Google Scholar
• Yan F, Li X, Jin Q, Jiang C, Zhang Z, Ling T, et al. Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells. Ultrasound Med Biol 2011;37:768–79
   PubMed Web of Science ®Google Scholar
• Pu C, Chang S, Sun J, Zhu S, Liu H, Zhu Y, et al. Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles for the treatment of intraperitoneal ovarian cancer xenografts. Mol Pharm 2014;11:49–58
   PubMed Web of Science ®Google Scholar
• Fan CH, Ting CY, Liu HL, Huang CY, Hsieh HY, Yen TC, et al. Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment. Biomaterials 2013;34:2142–55
   PubMed Web of Science ®Google Scholar
• McLaughlan J, Ingram N, Smith P, Harput S, Coletta P, Evans S, et al. Increasing the sonoporation efficiency of targeted polydisperse microbubble populations using chirp excitation. IEEE Trans Ultrason Ferroelectr Freq Control 2013;60:2511–20
   PubMed Web of Science ®Google Scholar
• Fan Z, Kumon RE, Park J, Deng CX. Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles. J Control Release 2010;142:31–9
   PubMed Web of Science ®Google Scholar
• van Wamel A, Kooiman K, Harteveld M, Emmer M, ten Cate FJ, Versluis M, et al. Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation. J Control Release 2006;112:149–55
   PubMed Web of Science ®Google Scholar
• Kotopoulis S, Postema M. Microfoam formation in a capillary. Ultrasonics 2010;50:260–8
   PubMed Web of Science ®Google Scholar
• Hu X, Kheirolomoom A, Mahakian LM, Beegle JR, Kruse DE, Lam KS, et al. Insonation of targeted microbubbles produces regions of reduced blood flow within tumor vasculature. Invest Radiol 2012;47:398–405
   PubMed Web of Science ®Google Scholar
• Wood AK, Schultz SM, Lee WM, Bunte RM, Sehgal CM. Antivascular ultrasound therapy extends survival of mice with implanted melanomas. Ultrasound Med Biol 2010;36:853–7
   PubMed Web of Science ®Google Scholar
• Rask-Andersen M, Zhang J, Fabbro D, Schioth HB. Advances in kinase targeting: Current clinical use and clinical trials. Trends Pharmacol Sci 2014;35:604–20
   Google Scholar
• Joo Ha H, Crum LA. Current status of clinical high-intensity focused ultrasound. IEEE EMBC 2009 Annu Int Conf; 2009 September 3–6; Minneapolis, MN, USA. pp 130–3
   Google Scholar
• Xiaoping L, Leizhen Z. Advances of high intensity focused ultrasound (HIFU) for pancreatic cancer. Int J Hyperthermia 2013;29:678–82
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang Z, Chen Y, Shen H, Luo Z, Li A, et al. Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors. Adv Mater 2013;25:4123–30
   PubMed Web of Science ®Google Scholar