Modification of the hTERT promoter by heat shock elements enhances the efficiency and specificity of cancer targeted gene therapy

References

• Dorer DE, Nettelbeck DM. Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis. Adv Drug Deliver Rev 2009;61:554–71
   PubMed Web of Science ®Google Scholar
• Nettelbeck DM, Jerome V, Muller R. Gene therapy: Designer promoters for tumour targeting. Trends Genet 2000;16:174–81
   PubMed Web of Science ®Google Scholar
• Hildebrandt B, Wust P, Rau B, Schlag P, Riess H. Regional hyperthermia for rectal cancer. Lancet 2000;356:771–72
   PubMed Web of Science ®Google Scholar
• Sherar M, Liu FF, Pintilie M, Levin W, Hunt J, Hill R, et al. Relationship between thermal dose and outcome in thermoradiotherapy treatments for superficial recurrences of breast cancer: Data from a phase III trial. Int J Radiat Oncol Biol Phys 1997;39:371–80
   PubMed Web of Science ®Google Scholar
• Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol 2002;3:487–97
   PubMed Web of Science ®Google Scholar
• Walther W, Stein U. Heat-responsive gene expression for gene therapy. Adv Drug Deliv Rev 2009;61:641–9
   PubMed Web of Science ®Google Scholar
• Morimoto RI, Sarge KD, Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. J Biol Chem 1992;267:21987–90
   PubMed Web of Science ®Google Scholar
• Brade AM, Ngo D, Szmitko P, Li PX, Liu FF, Klamut HJ. Heat-directed gene targeting of adenoviral vectors to tumor cells. Cancer Gene Ther 2000;7:1566–74
   PubMed Web of Science ®Google Scholar
• Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011–15
   PubMed Web of Science ®Google Scholar
• Emiliusen L, Gough M, Bateman A, Ahmed A, Voellmy R, Chester J, et al. A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component. Gene Ther 2001;8:987–98
   PubMed Web of Science ®Google Scholar
• Cunniff NF, Morgan WD. Analysis of heat shock element recognition by saturation mutagenesis of the human HSP70.1 gene promoter. J Biol Chem 1993;268:8317–24
   PubMed Web of Science ®Google Scholar
• Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, et al. Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element. Proc Natl Acad Sci USA 2005;102:18437–42
   PubMed Web of Science ®Google Scholar
• Vekris A, Maurange C, Moonen C, Mazurier F, De Verneuil H, Canioni P, et al. Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter. J Gene Med 2000;2:89–96
   PubMed Web of Science ®Google Scholar
• Wang J, Yao M, Zhang Z, Gu J, Zhang Y, Li B, et al. Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation. FEBS Lett 2003;546:315–20
   PubMed Web of Science ®Google Scholar
• Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, et al. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Ther 2007;14:279–86
   PubMed Web of Science ®Google Scholar
• Lu B, Makhija SK, Nettelbeck DM, Rivera AA, Wang M, Komarova S, et al. Evaluation of tumor-specific promoter activities in melanoma. Gene Ther 2005;12:330–38
   PubMed Web of Science ®Google Scholar
• Ortner V, Kaspar C, Halter C, Töllner L, Mykhaylyk O, Walzer J, et al. Magnetic field-controlled gene expression in encapsulated cells. J Control Release 2012;158:424–32
   PubMed Web of Science ®Google Scholar
• Wang JH, Yao MZ, Gu JF, Sun LY, Shen YF, Liu XY. Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia. Biochem Biophys Res Commun 2002;290:1454–61
   PubMed Web of Science ®Google Scholar
• Lu Y, Zhang Y, Chang G, Zhang J. Comparison of prostate-specific promoters and the use of PSP-driven virotherapy for prostate cancer. Biomed Res Int 2013;2013:624–32
   Google Scholar
• Ginn SL, Alexander IE, Edelstein ML, Abedi MR, Wixon J. Gene therapy clinical trials worldwide to 2012 – an update. J Gene Med 2013;15:65–77
   PubMed Web of Science ®Google Scholar
• Walther W, Stein U. Heat-responsive gene expression for gene therapy. Adv Drug Deliver Rev 2009;61:641–49
   PubMed Web of Science ®Google Scholar
• Kabu S, Gao Y, Kwon BK, Labhasetwar V. Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. J Control Release 2015;219:141–54
   PubMed Web of Science ®Google Scholar
• Osaki T, Tanio Y, Tachibana I, Hosoe S, Kumagai T, Kawase I, et al. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 1994;54:5258–61
   PubMed Web of Science ®Google Scholar
• Jin S, Lin X, Guan H, Wu J. Cell-specific expression of the analgesic-antitumor peptide coding sequence under the control of the human alpha-fetoprotein gene promoter and enhancer. Exp Ther Med 2015;9:863–67
   PubMed Web of Science ®Google Scholar
• Gazit G, Kane SE, Nichols P, Lee AS. Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo. Cancer Res 1995;55:1660–63
   PubMed Web of Science ®Google Scholar
• Lu MH, Liao ZL, Zhao XY, Fan YH, Lin XL, Fang DC, et al. hTERT-based therapy: A universal anticancer approach (Review). Oncol Rep 2012;28:1945–52
   PubMed Web of Science ®Google Scholar
• Mocna M. Hyperthermia in Oncology. In: AIP Conference Proceedings, vol. 958. New York: American Institute of Physics, 2007. pp. 256–7
   Google Scholar
• Giménez Ortiz A, Montalar Salcedo J. Heat shock proteins as targets in oncology. Clin Transl Oncol 2010;12:166–73
   PubMed Web of Science ®Google Scholar
• Krepp J, Gelmedin V, Hawdon JM. Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation. Int J Parasitol 2011;41:533–43
   PubMed Web of Science ®Google Scholar
• Min JN, Huang L, Zimonjic DB, Moskophidis D, Mivechi NF. Selective suppression of lymphomas by functional loss of HSF1 in a p53-deficient mouse model for spontaneous tumors. Oncogene 2007;26:5086–97
   PubMed Web of Science ®Google Scholar
• Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem 2006;281:782–91
   PubMed Web of Science ®Google Scholar
• Ikuta K, Urakawa H, Kozawa E, Hamada S, Ota T, Kato R, et al. In vivo heat-stimulus-triggered osteogenesis. Int J Hyperthermia 2015;31:58–66
   PubMed Web of Science ®Google Scholar
• Verhaart RF, Verduijn GM, Fortunati V, Rijnen Z, van Walsum T, Veenland JF, et al. Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations. Int J Hyperthermia 2015;31:686–92
   PubMed Web of Science ®Google Scholar
• Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol 2002;3:487–97
   PubMed Web of Science ®Google Scholar
• Giombini A, Giovannini V, Di Cesare A, Pacetti P, Ichinoseki-Sekine N, Shiraishi M, et al. Hyperthermia induced by microwave diathermy in the management of muscle and tendon injuries. Br Med Bull 2007;83:379–96
   PubMed Web of Science ®Google Scholar
• Rohmer S, Mainka A, Knippertz I, Hesse A, Nettelbeck DM. Insulated hsp70B' promoter: Stringent heat-inducible activity in replication-deficient, but not replication-competent adenoviruses. J Gene Med 2008;10:340–54
   PubMed Web of Science ®Google Scholar
• Guilhon E, Voisin P, de Zwart JA, Quesson B, Salomir R, Maurange C, et al. Spatial and temporal control of transgene expression in vivo using a heat-sensitive promoter and MRI-guided focused ultrasound. J Gene Med 2003;5:333–42
   PubMed Web of Science ®Google Scholar
• Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jaattela M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 2005;19:570–82
   PubMed Web of Science ®Google Scholar