Tumour microcirculation as a target for hyperthermia

References

• Algire G. H., Legallis F. Y. Vascular reactions of normal and malignant tissues in vivo. IV. The effect of peripheral hypotension on transplanted tumors. Journal of the National Cancer Institute 1952; 12: 399–408
   Google Scholar
• Von Ardenne M., Krüger W. The use of hyperthermia within the frame of cancer multistep therapy. Annals of the New York Academy of Sciences 1980; 335: 356–361
   PubMedGoogle Scholar
• Von Ardenne M., Reitnauer P. G. Selective inhibition of microcirculation in tumour tissue. Naturwissenschaften 1980; 61: S154
   Google Scholar
• Von Ardenne Hd., Reitnauer P. G. Die manipulierte selektive Hemmung der Mikrozikkulation im Krebsgewebe. Journal of Cancer Research and Clinical Oncology 1982; 103: 269–279
   Google Scholar
• Batws C. F., DeWitt D. P., Voorhees W. D., McCaw J. S., Chan R. C. Theoretical feasibility of vasodilator-enhanced local tumor heating. European Journal of Cancer and Clinical Oncology 1982; 18: 1137–1146
   Google Scholar
• Hadylak S. F., Babbs C. F., Skojac T. M., Voorhees W. D., Richardson R. C. Hyperthermia-induced vascular injury in normal and neoplastic tissue. Cancer 1985; 56: 991–1000
   Google Scholar
• Beer-Gabel M., Yerushalmi A. Altered glucose metabolism in intact and tumor bearing rats subjected to local hyperthermia. Bulletin du Cancer 1981; 68: 321–327
   Google Scholar
• Van den Berg-Blok A. E., Reinhold H. S. Time-temperature relationship for hyperthermia induced stoppage of the microcirculation in tumors. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 737–740
   PubMed Web of Science ®Google Scholar
• Berg A. P., Van den Wike-Hooley J. L., Berg-Blok A. E., Van den Zee J., Van der Reinhold H. S. Turnour pH in human mammary carcinoma. European Journal of Cancer and Clinical Oncology 1982; 18: 457–462
   Google Scholar
• Bicher H. I. Impact of microcirculation and physiologic considerations on clinical hyperthermia. Proceedings of the 13th International Cancer Congress, Part D, Research and Treatment. Alan R. Liss, New York 1983; 235–245
   Google Scholar
• Bicher H. I., Hetzel F. W., Sandhu T. S., Frinak S., Vaupei P., O'Hara M. D., O'Brian T. Effects of hyperthermia on normal and tumour microenvironment. Hadiology 1980; 137: 523–530
   Google Scholar
• Bicher H. I., Mitagvaria N. Circulatory responses of malignant tumors during hyperthermia. Microvascular Research 1981; 21: 19–26
   PubMed Web of Science ®Google Scholar
• Bicher H. I., Mitagvaria N. P. Changes in tumor tissue oxygenation during microwave hyperthermia. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1985; 169–172
   Google Scholar
• Bicher H. I., Sandhu T. S., Vaupel P., Hetzel F. W. Effect of localized microwave hyperthermia on physiological responses. National Cancer Institute Monograph 1982; 61: 217–219
   Google Scholar
• Calderwood S. K., Dickson J. A. Inhibition of tumour blood flow at high blood sugar levels: Effects on tumor pH and hyperthermia. National Cancer Institute Monograph 1982; 61: 221–223
   Google Scholar
• Calderwood S. K., Dickson J. A. pH and tumor response to hyperthermia. Advances in Radiation Biology 1983; 10: 135–186
   Google Scholar
• Cater D. B., Silver I. A., Watkinson D. A. Combined therapy with 220 kV Roentgen and 10 cm microwave heating in rat hepatoma. Acta Radiologica: Therapy, Physics, Biology 1964; 2: 321–336
   PubMed Web of Science ®Google Scholar
• Copley A. L. Fibrinogen gel clotting, pH and cancer therapy. Thrombosis Research 1980; 18: 1–6
   Google Scholar
• Copley A. L., King R. G. A survey of surface hemorheological experiments on the inhibition of fibrinogenin formation employing surface layers of fibrinogen systems with heparins arid other substances. A contribution on antithrombogenic action. Thrombosis Research 1984; 35: 231–256
   Google Scholar
• Crandall E. D., Critz A. M., Osher A. S., Kelio D. J., Fowrter R. E. Influence of pff on elastic deformability of the human erythrocyte membrane. American Journal of Physiology 1978; 235: 269–278
   Google Scholar
• Dewhirst M., Gross J. F., Sim D., Arnold P., Boyer D. The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. Biorheology 1984; 21: 539–558
   PubMed Web of Science ®Google Scholar
• Dewhirst M. W., Sim D. A., Gross J., Kundrat M. A. b, Effect of heating rate on tumour and normal tissue microcirculatory function. Hyperthermic Oncology 1984, Vol. I, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 177–180
   Google Scholar
• Dickson J. A., Calderwood S. K. Effect of hyperglycemia and hyperthermia on the pH, glycolysis, and respiration of the Yoshia sarcoma. in vivo. Journal of the National Cancer Institute 1979; 63: 1371–1381
   PubMedGoogle Scholar
• Dickson J. A., Calderwood S. K. Temperature range and selective sensitivity of tumors to hyperthermia: A critical review. Annals of the New York Academy of Sciences 1980; 335: 180–205
   PubMedGoogle Scholar
• Dudar T. E., Jain R. K. Differential response of normal and tumor micro-circulation to hyperthermia. Cancer Research 1984; 44: 605–612
   PubMed Web of Science ®Google Scholar
• Durand R. E. Potentiation of radiation lethality by hyperthermia in a tumor model: Effects of sequence, degree, and duration of heating. International Journal of Radiation, Oncology, Biology, Physics 1978; 4: 401–405
   PubMed Web of Science ®Google Scholar
• Eddy H. A. Alterations in tumor microvasculature during hyperthermia. Radiology 1980; 137: 515–521
   PubMed Web of Science ®Google Scholar
• Emami B., Nussbaum G. H., Hahn N., Piro A. J., Dritschilo A., Quimby F. Histopathological study on the effects of hyperthermia on microvasculature. Inter national Journal of Radiation, Oncology, Biology, Physics 1981; 7: 343–348
   PubMed Web of Science ®Google Scholar
• Emami B., Nussbaum G. H., TenHaken R. K., Hughes W. L. Physiological effects of hyperthermia: Response of capillary blood flow and structure to local tumor heating. Radiology 1980; 137: 805–809
   PubMed Web of Science ®Google Scholar
• Emami B., Song C. W. Physiological mechanisms in hyperthermia: A review. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 289–295
   PubMed Web of Science ®Google Scholar
• Endrich B. Mikrozirkulation maligner Tumoren, Ph.D. Thesis. University of Heidelberg. 1984
   Google Scholar
• Endrich B., Hammersen F. Hyperthermia induced changes on capillary ultra-structure. International Journal of Microcirculation: Clinical and Experimental 1984; 3: 498
   Google Scholar
• Endrich B., Hammersen F. Morphologic and Hemodynamic alterations in capillaries during hyperthermia. Hyperthermia in Cancer Treatment, Vol. II, L. J. Anghileri, J. Robert. CRC Press, Boca Raton, Florida 1985, (in the press)
   Google Scholar
• Endrich B., Messmer K. Quantitative analysis of the microcirculation in the awake animal. Handbook of Microsurgery, W. L. Oleszweski. CRC Press, Boca Raton, Florida 1984; 79–105
   Google Scholar
• Endrich B., Schosser R., Messmer K. Blood flow measurements by means of radioactive microspheres. A useful technique in malignant tumors. European Journal of Cancer and Clinical Oncology 1981; 17: 1349–1351
   PubMedGoogle Scholar
• Endrich B., Voges J., Lehmann A. The microcirculation of the amelanotic melanoma A-Mel-3 during hyperthermia. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 137–140
   Google Scholar
• Endrich B., Zweifach B. W., Reinhold H. S., Intaglietta M. Quantitative studies of microcirculatory function in malignant tissue: influence of temperature on microvascular hemodynamics during the early growth of the BA1112 rat sarcoma. International Journal of Radiation, Oncology, Biology, Physics 1979; 5: 2021–2030
   PubMed Web of Science ®Google Scholar
• Evanochko W. T., Ng T. C., Lilly M. B., Lawson A. J., Corbett T. H., Durant J. R., Glickson J. D. In vivo 31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, X-irradiation and hyperthermia. Proceedings of the National Academy of Sciences, USA. 1983; 80: 334–338
   PubMedGoogle Scholar
• Faithfull N. S., Reinhold H. S., Berg A. P., Van den Rhoon G. C., Van Zee J., Wike-Hooley J. L. Cardiovascular changes during whole body hyperthermia treatment of advanced malignancy. European Journal of Applied Physiology 1984; 53: 274–281
   PubMed Web of Science ®Google Scholar
• Fajardo L. F., Egbert B., Marmor J., Hahn G. M. Effects of hyperthermia in a malignant tumor. Cancer 1980; 45: 613–623
   PubMed Web of Science ®Google Scholar
• Fajardo L. F., Schreiber A. B., Kelly N. I., Hahn G. M. Thermal sensitivity of endothelial cells. Radiation Research 1985; 103: 276–285
   PubMed Web of Science ®Google Scholar
• Falk P. The effect of elevated temperature on the vasculature of mouse jejunum. British Journal of Radiology 1983; 56: 41–49
   PubMed Web of Science ®Google Scholar
• Field S. B., Bleehen N. M. Hyperthermia in the treatment of cancer. Cancer Treatment Reviews 1979; 6: 63–94
   PubMed Web of Science ®Google Scholar
• Gerweck L. E. M. Modification of cell lethality at elevated temperatures. The pH effect. Radiation Research 1977; 10: 224–235
   Google Scholar
• Gerweck L. E. Environmental and vascular effects. Hyperthermic Oncology 1984, Vol. 2, Review Lectures, Symposium Summaries and Workshop Summaries, J. Overgaard. Taylor & Francis, London, Philadelphia 1985; 253–262
   Google Scholar
• Gullino P. M. Influence of blood supply on thermal properties and metabolism of mammary carcinoma. Thermal characteristics of tumors: applications in detection and treatment. Annals of the New York Academy of Sciences 1980; 335: 1–18
   PubMedGoogle Scholar
• Gullino P. M., Jain R. K., Grantham F. H. Temperture gradients and local perfusion in a mammary carcinoma. Journal of the National Cancer Institute 1982; 68: 519–533
   Google Scholar
• Gullino P. M., Pon-Nyong Y., Grantham F. H. Relationship between temperature and blood supply or consumption of oxygen and glucose by rat mammary carcinomas. Journal of the National Cancer Institute 1978; 60: 835–847
   PubMedGoogle Scholar
• Hammersen F., Endrich B., Messmer K. a, The fine structure of tumor blood vessels. 1. Participation of non-endothelial cells in tumor angiogenesis. International Journal of Microcirculation: Clinical and Experimental 1083; 4: 31–43
   Google Scholar
• Hammersen F., Osterkamp-Baust U., Endrich B. b, Ein Beitrag zum Feinbau terminale Strombahnen und ihrer Entstellung in bosartigen Tumoren. Mikrozirk, Forsch. Klin. 1983; 2: 15–51
   Google Scholar
• Haveman J. Influence of pH and thermotolerance on the enhancement of X-ray induced inactivation of cultured mammalian cells by hyperthermia. International Journal of Radiation Biology 1983; 43: 281–289
   Web of Science ®Google Scholar
• Hill S. A., Denekamp J. The effect of vascular occlusion on the thermal sensitization of a mouse tumour. British Journal of Cancer 1978; 51: 997–1002
   Google Scholar
• Hofman P., Lagendijk J. J. W., Schipper J. The combination of radiotherapy with hyperthermia in protocolized clinical studies. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 379–382
   Google Scholar
• Hume S. P., Marigold J. C. L., Hirst D. G. The effect of hyperthermia on one aspect of the response of mesenteric blood vessels to radiation. International Journal of Radiation Biology 1981; 39: 321–327
   Google Scholar
• Jain R. K. Transport of macromolecules in tumor microcirculation. Biotechnology Progress 1985; 1: 81–94
   PubMed Web of Science ®Google Scholar
• Jain K. K., Grantham F. H., Gullino P. M. Blood flow and heat transfer in Walker 256 mammary carcinoma. Journal of the National Cancer Institute 1979; 62: 927–933
   PubMed Web of Science ®Google Scholar
• Jain R. K., Ward-Hartley K. Tumor blood flow—Characterization, modifications and role in hyperthermia. IEEE Transactions. Sonics and Ultrasonics 1984; 31: 504–526
   Web of Science ®Google Scholar
• Jain R. K., Ward-Hartley K., Dudar T. E., Shah S. A. Effects of hyperthermia and hyperglycemia on microcirculatory perfusion and interstitial pH of normal and neoplastic tissues. International Journal of Microcirculation: Clinical and Experimental 1984; 3: 570
   Google Scholar
• Johnson P. C. The myogenic response. Handbook of Physiology, Vol. II, Section 2, D. F. Bohr, A. P. Somlyo, H. V. Sparks. American Physiological Society, Bethesda, Maryland 1980; 409–442
   Google Scholar
• Johnson R. J. K. (1976) Effects of hyperthermia on tumor blood flow. Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation. 1976, J. E. Robinson, M. J. Wizenberg. American College of Radiology, 154–155
   Google Scholar
• Kallinowski F., Vaupel P., Schaefer C., Benzing H., Mueller-Schauen L. W., Fortmeyer H. P. Hyperthermia-induced blood flow changes in human mamary carcinomas itransplanted into nude (rnu/rnu) rats. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 133–136
   Google Scholar
• Kang M. S., Song C. W., Levitt S. H. Role of vascular function in response of tumors in vico to hyperthermia. Cancer Research 1980; 40: 1130–1135
   PubMed Web of Science ®Google Scholar
• Karino M., Koga S., Maeta M., Hamazoe K., Kumane T., Oda M. Experimental and clinical studies on effect of hyperthermia on tumor blood flow. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 173–176
   Google Scholar
• Lagendijk J. J. W. The influence of blood flow in large vessels on the temperature distribution in hyperthermia. Physics in Medicine and Biology 1982; 27: 11–23
   Google Scholar
• Lee S. Y., Song C. W., Levitt S. H. Change in fibrinogen uptake in tumors by hyperthermia. European Journal of Cancer and Clinical Oncology 1985; 21: 1507–1513
   PubMedGoogle Scholar
• Levin S., Hendrikse A., Nongalaza G., Fraser J., Blekkenhorst G. Tumour ischaemia plus hyperthermia and radiation in mouse tumours. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 305–308
   Google Scholar
• Lokshina A., Song C. W., Rhee J. G., Levitt S. H. Effect of fractionated heating on the blood flow in normal tissues. International Journal of Hyperthermia 1985; 1: 117–129
   PubMedGoogle Scholar
• Milligan A. J., Conran P. B., Ropar M. A., McCulloch H. A., Ahuja R. K., Dobelbower R. R. Predictions of blood flow from thermal clearance during regional hyperthermia. International Journal of Radiation, Oncology, Biology, Physics 1983; 9: 1335–1343
   PubMedGoogle Scholar
• Milligan A. J., Panjehpour M. Canine normal and tumor tissue estimated blood flow during fractionated hyperthermia. International Journal of Radiation, Oncology, Biology, Physics 1985; 11: 1679–1684
   PubMed Web of Science ®Google Scholar
• Müeller-Klieser W., Manz R., Otte J., Vaupel P. Effect of localized hyperthermia on tumor blood flow and oxygenation. Recent Advances in Medical Thermology, E. F. J. Ring. Plenum, New York 1984; 669–676
   Google Scholar
• Müller-Klieser W., Vaupel P. Effect of hyperthermia on tumor blood flow. Biorheology 1984; 21: 529–538
   PubMed Web of Science ®Google Scholar
• Olch A. J., Kaiser L. R., Silberman A. W., Storm F. K., Graham L. S., Morton D. L. Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model. Journal of Surgical Oncology 1983; 23: 125–132
   PubMed Web of Science ®Google Scholar
• Overgaard J. Effect of hyperthermia on the hypoxic fraction in an experimental mammary carcinoma. in vivo. British Journal of Radiology 1981; 54: 245–249
   PubMed Web of Science ®Google Scholar
• Overgaard J., Bichel P. The influence of hypoxia and acidity on the hyperthermic response of malignant cells. in vitro. Radiology 1977; 123: 511–514
   PubMed Web of Science ®Google Scholar
• Overgaard J., Nielsen O. S. The role of tissue environmental factors on the kinetics and morphology of tumor cells exposed to hyperthermia. Annals of the New York Academy of Sciences 1980; 335: 254–278
   PubMedGoogle Scholar
• Paskins-Hurlburt A. J., Hollenberg N. K., Abrams H. L. Tumor perfusion in relation to the rapid growth phase and necrosis: studies on the Walker carcinoma in the rat testicle. Microvascular Research 1982; 24: 15–24
   PubMed Web of Science ®Google Scholar
• Peck J. W., Gibbs F. A. Capillary blood flow in murine tumors, feet and intestines during localized hyperthermia. Radiation Research 1983; 96: 65–81
   Google Scholar
• Rappaport D. S., Song C. W. Blood flow and intravascular volume of mammary adenocarcinoma 13726A and normal tissues of rat during and following hyperthermia. International Journal of Radiation, Oncology, Biology, Physics 1983; 9: 539–547
   PubMed Web of Science ®Google Scholar
• Reinhold H. S., Blachiewicz B., Van den Berg-Blok A. Decrease in tumor microcirculation during hyperthermia. Cancer Therapy by Hyperthermia and Radiation, C. Streffer. Urban and Schwarzenberg, Baltimore, Munich 1978; 231–232
   Google Scholar
• Reinhold H. S., Van den Berg-Blok A. E. Enhancement of thermal damage to the microcirculation of ‘sandwich” tumours by additional treatment. European Journai of Cancer and Clinical Oncology 1981; 11: 781–795
   Google Scholar
• Reinhold H. S., Van den Berg-Blok A. E. Hyperthermia-induced alteration in erythrocyte velocity in tumors. International Journal of Microcirculation: Clinical and Experimental 1983; 2: 285–295
   PubMedGoogle Scholar
• Reinhold H. S., Van den Berg-Blok A. E. Heat-induced microcirculatory stoppage strongly enhances tumour control by radiation. Hyperthermic Oncology 1984, Vol. 1, Summary Papers, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 149–152
   Google Scholar
• Khee J. G., Kim T. H., Levitt S. H., Song C. W. Changes in acidity of mouse tumor by hyperthermia. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 393–399
   Google Scholar
• Krwe J. G., Song C. W. Thermosensitivity of bovine aortic cells in cultures in vitro clonogenicity study. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; 157–160
   Google Scholar
• Robinson J. E., McCulloch D., McCready W. A. Blood perfusion of murine tumors at normal and hyperthermal temperatures. National Cancer Institute Monographs 1982; 61: 211–215
   Google Scholar
• Kuu K. H. L., Song C. W., Kang M. S., Levitt S. H. Changes in lactic acid content in tumors by hyperthermia. Radiation Research 1982; 91: 319–320
   Google Scholar
• Schein P. Funktionale Besonderheiten der Mikrozirkulation im Karzinom. Bibliotheca Anatomica 1961; 1: 327–335
   Google Scholar
• Schmid-Schönbein H., Volger E., Weiss J., Brandhuber M. Effect of O-β-hydroxyethyl)-Rutosides on the microrheology of human blood under defined flow conditions. Vasa, Zeitschrift für Gefässkrankheiten 1975; 4: 263–210
   PubMedGoogle Scholar
• Schmid-Schönbein H., Singh M., Malotta H., Leschke D., Teitel P., Driessen G., Scheidt-Bleichert H. Subpopulations of rigid red cells in hyperthermia and acidosis: Effect on filtrability in vitro and on nutritive capillary perfusion in the mesenterjc microcirculation. International Journal of Microcirculation: Clinical and Experimental 1984; 3: 497
   Google Scholar
• Shrivastav S., Kaelin W. G., Jr, Joines W. T., Jirtle R. L. Microwave hyperthermia and its effect on tumor blood flow in rats. Cancer Research 1983; 43: 4665–4669
   PubMed Web of Science ®Google Scholar
• Simpson J. G., Fraser R. A. Angiogenese in malignen Tumoren. Progress in Applied Microcirculation 1983; 2: 1–14
   Google Scholar
• Song C. W. Effect of hyperthermia on vascular functions of normal tissues and experimental tumors: brief communication. Journal of the National Cancer Institute 1978; 60: 711–713
   PubMedGoogle Scholar
• Song C. W., Kang M. S., Rhee J. G., Levitt S. H. a, Vascular damage and delayed cell death in tumours after hyperthermia. British Journal of Cancer 1980; 41: 309–312
   PubMed Web of Science ®Google Scholar
• Song C. W., Kang M. S., Rhee J. G., Levitt S. H. b, Effect of hyperthermia on vascular function in normal arid neoplastic tissues. Annals of the New York Academy of Sciences 1980; 335: 35–41
   PubMedGoogle Scholar
• Song C. W., Kang M. S., Rhee J. G., Levitt S. H. c, The effect of hyperthermia on vascular function, pH, and cell survival. Radiology 1980; 137: 795–803
   PubMed Web of Science ®Google Scholar
• Song C. W., Kang M. S., Rhee J. G., Levitt S. H. d, Blood flow in normal tissues and tumors during hyperthermia. Journal of the National Cancer Institute 1980; 64: 119–124
   PubMedGoogle Scholar
• Song C. W., Lokshina A., Rhee J. G., Patten M., Levitt S. H. Implication of blood flow in hyperthermic treatment of tumors. IEEE Transactions. Biomedical Engineering 1984; 31: 9–16
   PubMed Web of Science ®Google Scholar
• Song C. W., Rhee J. G., Levitt S. H. Effect of hyperthermia on hypoxic cell fraction in tumor. International Journal of Radiation, Oncology, Biology, Physics 1982; 8: 851–856
   PubMed Web of Science ®Google Scholar
• Stewart F., Begg A. Blood flow changes in transplanted mouse tumours and skin after mild hyperthermia. British Journal of Radiology 1983; 56: 477–482
   PubMedGoogle Scholar
• Stfwart J. R., Gibbs F. A., Jr, Lehman C. M., Peck J. W., Egger M. J. Change in the in vivo hyperthermic response resulting from the metabolic effects of temporary vascular occlusion. International Journal of Radiation, Oncology, Biology, Physics 1983; 9: 197–201
   Google Scholar
• Storm F. K., Harrison W. H., Elliott R. S., Morton R. L. Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials. Cancer Research 1979; 39: 2245–2251
   PubMed Web of Science ®Google Scholar
• Streffer C. Metabolic changes during and after hyperthermia. International Journal of Hyperthermia 1985; 1: 305–319
   PubMedGoogle Scholar
• Streffer C., Hengstebeck S., Tamulevicius P. Metabolic studies in an experimental tumor and iiver of mice after hyperthermia and glucose. Strahlentherapie 1981; 157: 623
   Google Scholar
• Sutton C. H. Necrosis and altered blood flow produced by microwave-induced tumor hyperthermia in a murine glioma. Proceedings of the 12th Annual Meeting of the American Society for Clinical Oncology 1976; 11: 63
   Google Scholar
• Tanaka Y., Hasegawa T., Murata T. Effect of radiation and hyperthermia on vascular function in normal and tumor tissue. Hyperthermic Oncology 1984, J. Overgaard. Taylor and Francis, London, Philadelphia 1984; 145–148
   Google Scholar
• Thistlethwaite A. J., Leeper D. B., Moylan D. J., Nerlinger R. E. pH distribution in human tumors. International Journal of Radiation, Oncology, Biology, Physics 1985; 11: 1647–1652
   PubMed Web of Science ®Google Scholar
• Urano M., Montoya V., Booth A. Effect of hyperglycemia on the thermal response of murine normal and tumor tissues. Cancer Research 1983; 43: 453–455
   PubMed Web of Science ®Google Scholar
• Vaupel P. Einfluss einer lokalisierten Mikrowellen-Hyperthermie auf die pH-Verteilung in bosartigen Tumoren. Strahlentherapie 1982; 158: 168–173
   Google Scholar
• Vaupel P. W., Frinak S., Bicher H. I. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma. Cancer Research 1981; 41: 2008–2013
   PubMed Web of Science ®Google Scholar
• Vaupel P., Frinak S., Mueller-Klieser W., Bicher H. I. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. National Cancer Institute Monograph 1982; 61: 207–209
   Google Scholar
• Vaupel P., Müller-Klieser W., Otte J., Manz R., Kallinowski F. Blood flow, tissue oxygenation, and pH distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses. Strahlentherapie 1983; 159: 73–81
   PubMedGoogle Scholar
• Vaupel P., Ostheimer K., Müller-Klieser W. Circulatory and metabolic responses of malignant tumors during localized hyperthermia. Journal of Cancer Research and Clinical Oncology 1980; 98: 15–29
   PubMed Web of Science ®Google Scholar
• Vaupel P., Ostheimer K., Thome H. Blood flow, vascular resistance, and oxygen consumption of malignant tumors during normothermia and hyperthermia. Microvascular Research 1977; 13: 272
   Google Scholar
• Voorhees W. D., III, Babbs C. F. Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs. European Journal of Cancer and Clinical Oncology 1982; 18: 1027–1033
   PubMedGoogle Scholar
• Warren B. A. Tumor angiogenesis. Tumor Blood Circulation, H. I. Peterson. CRC Press, Boca Raton 1979; 49–75
   Google Scholar
• Waterman F. M. Personal communication 1986
   Google Scholar
• Wiig H., Tveit E., Hultborn R., Reed R. K., Weiss L. Interstitial fluid pressure in DMBA-induced rat mammary tumors. Scandinavian Journal of Clinical Laboratory Investigation 1982; 42: 159–164
   PubMed Web of Science ®Google Scholar
• Wike-Hooley J. L., Haveman J., Reinhold H. S. The relevance of tumour pH to the treatment of malignant disease. Radiotherapy and Oncology 1984a; 2: 343–366
   PubMed Web of Science ®Google Scholar
• Wike-Hooley J. L., Berg A. P., Van den Zee J., Reinhold H. S. Human tumour pH and its variation. European Journal of Cancer and Clinical Oncology 1985; 21: 785–791
   PubMedGoogle Scholar
• Wike-Hooley J. L., Van der Zee J., Van Rhoon G. C., Van den Berg A. P., Reinhold H. S. Human tumour pH changes following hyperthermia and radiation therapy. European Journal of Cancer and Clinical Oncology 1984b; 20: 619–623
   PubMedGoogle Scholar
• Young J. S., Lumsden C. E., Stalker A. L. The significance of the ‘tissue pressure” of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. Journal of Pathology and Bacteriology 1950; 62: 313–335
   PubMedGoogle Scholar
• Van der Zee J., Rhoon G. C., Van Wike-Hooley J. L., FaithFull N. S., Reinhold H. S. Whole-body hyperthermia in cancer therapy: a report of a phase I-II study. European Journal of Cancer and Clinical Oncology 1983; 19: 1189–1200
   PubMedGoogle Scholar