52
Views
110
CrossRef citations to date
0
Altmetric
Original Article

Rationale for use of local hyperthermia with radiation therapy and selected anticancer drugs in locally advanced human malignancies

, , , , &
Pages 143-158 | Received 17 Aug 1987, Published online: 09 Jul 2009

References

  • Adams G. E., Stratford E. J., Rajaratnam S. Interaction of the cytotoxic and sensitizing effects of electron-affinic drugs and hyperthermia. National Cancer Institute Monograph 1982; 61: 27–35
  • Arcangeli G., Cividalli A., Mauro F., Nervi C., Pavin G. Enhanced effectiveness of Adriamycin and Bleomycin combined with local hyperthermia in neck node metastases from head and neck cancers. Tumori 1979; 65: 481–486
  • Arcangeli G., Barocas P., Mauro F., Nervi C., Spano M., Tabocchini A. Multiple daily fraction (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clinical results. Cancer 1980; 45: 2707–2711
  • Baker D., Sager H., Constable W., Goodchild N. Response of previously irradiated skin to combinations of X-radiation, hyperthermia and cis-diamminedichloroplatinum. Cancer Investigations 1984; 2: 15–19
  • Bicher H. F., Hetzel F. W., Sandu T. S., Frinck S., Vaupel P., O'Hara M. D., O'Brian T. Effects of hyperthermia on normal and tumour microenvironment. Radiology 1980; 137: 523–533
  • Bowman H. F., Burns J. K., Edelle D. J., Weaver J. C. (1985) Temperatures, SDR, perfusion and oxygen profilometer. Presented at 5th Annual Meeting of NAHG, Los Angeles, CA, 3-7 May, 1985
  • Bull J. M., Lees D., Schuette W., Whang Pang J., Smith R., Bynum G., Atkinson E. R., Gottdiener J. S., Gralnick H. R., Shawker T. H., Devita V. T. Whole body hyperthermia: a Phase I trial of potential adjuvant chemotherapy. Annals of Internal Medicine 1979; 90: 317–322
  • Dahl O. Hyperthermia and drugs. Hyperthermia, D. J. Wathmong, W. M. Ross. Blackie, Glasgow 1986; 121–153
  • Dahl O., Mella O. The effect of timing and sequence of hyperthermia and cyclophosphamide on a neurogenic rat tumor (BT4A) in vivo. Cancer 1983; 52: 983–987
  • Dahl O., Mella O. Timing of combined hyperthermia and 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-diamminedichloroplatinum in BD IX rats with BT4A tumors. Anticancer Research 1985; 5: 259–265
  • Dean J. C., Salamon S. E. Prevention of doxirubicin-induced hair loss with scalp hypothermia. New England Journal of Medicine 1979; 301: 1427–1429
  • Denekemp J. Testing of hypoxic cell radiosensitizers in vivo. Cancer Clinical Trials 1980; 3: 139–148
  • Dethlefsen L. A., Riley R. M. Adriamycin effects and the interactions of adriamycin with X irradiation on murine mammary tumors. Radiation Research 1982; 90: 165–172
  • Dewey W. C. Interaction of heat with radiation and chemotherapy. Cancer Research 1984; 44: 4714–4720
  • Dewhirst M. W., Sim D. A., Grochowski K. J. Thermal influence on radiation induced complications versus tumor response in a Phase III randomized trial. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984a; Vol. 1: 313–316
  • Dewhirst M. W., Sim D. A., Gross J., Kundrat M. A. Effect of heating rate in tumor and normal tissue microcirculatory function. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984b; Vol. 1: 77–180
  • Dewit L. Combined treatment of radiation and cis-diamminedichloroplatinum (II): a review of experimental and clinical data. International Journal of Radiation Oncology, Biology and Physics 1987; 13: 403–426
  • Donaldson S., Gordon L., Hahn G. M. Protective effect of hyperthermia against the cytotoxicity of actinomycin D in Chinese hamster cells. Cancer Treatment Reports 1978; 62: 1489–1495
  • Eddy A. A., Sutherland R. M. Chimielewski tumor microvascular response: Hyperthermia and radiation combinations. National Cancer Institute Monograph 1982; 61: 225–229
  • Englehardt R. Hyperthermia and drugs. Recent Results in Cancer Research 1987; 104: 133–203
  • Fisher G. A., Hahn G. M. Enhancement of cis-platinum(II) diamminedichloride cytotoxicity by hyperthermia. National Cancer Institute Monograph 1982; 61: 255–258
  • Fu K. K. Biological basis for the interaction of chemotherapeutic agents and radiation therapy. Cancer 1985; 55: 2123–2130
  • Fu K. K., Begg A. C., Kane L. J., Phillips T. L. Interaction of radiation and adriamycin on the EMT6 tumor as a function of tumor size and assay method. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 1249–1254
  • Gerweck L. E. Effect of microenvironmental factors on the response of cells to single and fractionated heat treatments. National Cancer Institute Monograph 1982; 61: 19–26
  • Ghussen F., Nagel K., Groth W., Muller I. M., Stutzer H. A prospective randomized study of regional extremity perfusion in patients with malignant melanoma. Annals of Surgery 1984; 200: 764–768
  • Goldfeder A., Brown D. M. Response of an experimental mammary carcinoma to fractionated x-irradiation with misonidazole and microwave hyperthermia. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 1287–1291
  • Goldfeder A., Newport S. Thermally-enhanced tumor regression in mice treated with melphalan. Anticancer Research 1984; 4: 17–22
  • Groos E., Walker L., Masters J. R. W. Intravesical chemotherapy: Studies on the relationship between pH and cytotoxicity. Cancer 1986; 58: 1199–1203
  • Gupta V., Costanzi J. J. Role of hypoxia in anticancer drug-induced cytotoxicity for Ehrlich ascites cells. Cancer Research 1987; 47: 2407–2412
  • Hahn G. M. Metabolic aspects of the role of hyperthermia in mammalian cell inactivation and their possible relevance to cancer treatment. Cancer Research 1974; 34: 3117–3123
  • Hahn G. M. Potential for therapy of drugs and hyperthermia. Cancer Research 1979; 39: 2264–2268
  • Hahn G. M. Hyperthermia and Cancer. Plenum Press, New York 1982; 1–285
  • Hahn G. M. Thermotolerance and drugs. Mechanisms of Thermotolerance, K. Henle. CRC Press, Boca Raton 1987, in press
  • Hahn G. M., Shiu E. C. Effect of pH and elevated temperatures on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro. Cancer Research 1983; 43: 5789–5791
  • Hahn G. M., Shiu E. C. Adaptation to low pH modifies thermal and thermo-chemical responses in mammalian cells. International Journal of Hyperthermia 1986; 2: 379–387
  • Hahn G. M., Strande D. P. Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. Journal of the National Cancer Institute 1976; 37: 1063–1067
  • Hall E. J., Miller R., Astor M., Rini F. The nitroimidazoles as radio-sensitizers and cytotoxic agents. British Journal of Cancer 1978; 37(Suppl. III)120–123
  • Harris J. W., Shrieve D. C. Effects of adriamycin and x-rays on euoxic and hypoxic EMT6 cells in vitro. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 1245–1248
  • Henle K. J. Sensitization to hyperthermia below 45°C induced by step-down heating. Journal of the National Cancer Institute 1980; 64: 1479–1483
  • Henle K. J., Roti Roti J. Time-temperature conversion in biological applications of hyperthermia. Radiation Research 1980; 82: 138–145
  • Herman T. S. Temperature dependence of adriamycin, cis-diamminedichloroplatinum, Bleomycin and 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in vitro. Cancer Research 1983a; 43: 517–520
  • Herman T. S. Effect of temperature of exposure on the cytotoxicity of three new anticancer drugs. Cancer Treatment Reports 1983b; 67: 1019–1022
  • Herman T S., Cress A. E., Sweets C. C., Gerner E. W. Reversal of methotrexate resistance by hyperthermia. Cancer Research 1981a; 41: 3840–3843
  • Herman T. S., Sweets C. C., Gerner E. W. Rate of heating as a determinant of hyperthermic cytotoxicity. Cancer Research 1981b; 41: 3519–3523
  • Herman T. S., Sweets C. C., White D. M., Gerner E. W. Effect of heating on lethality due to hyperthermia and selected chemotherapeutic drugs. Journal of the National Cancer Institute 1982a; 68: 487–491
  • Herman T. S., Zukoski C. F., Anderson R. M. Review of the current status of whole-body hyperthermia administered by water circulation techniques. Journal of the National Cancer Institute 1982b; 61: 365–369
  • Herman T. S., Henle K. T., Nagle W. A., Moss A. J., Monson T. P. Exposure to pretreatment hypothermia as a determinant of heat killing. Radiation Research 1984a; 98: 345–353
  • Herman T. S., Henle K. J., Nagle W. A., Moss A. J., Monson T. P. The effect of stepdown heating on the cytotoxicity of adriamycin, Bleomycin and cisplatinum. Cancer Research 1984b; 44: 1823–1826
  • Herman T. S., Teicher B. A., Coleman C. N. Potential for combined hyperthermia, radiation and chemotherapy treatment in locally advanced human malignancies. AAPM Monographs 1987, in press
  • Hofer K. G., Mackinnon A. R., Schubert A. L., Lehr J. E., Grimmett E. V. Radiosensitization of tumors and normal tissues by combined treatment with misonidazole and heat. Radiology 1981; 141: 801–809
  • Jain R. K., Grantham F. H., Gullino P. M. Blood flow and heat transfer in Walker 256 mammary carcinoma. Journal of the National Cancer Institute 1979; 62: 927–933
  • Kai H., Matsufuji H., Sugimachi K. O., Okudaira Y., Inokuchi K. Combined effects of hyperthermia, Bleomycin, and x-rays on Ehrlich ascites tumor. Journal of Surgical Research 1986; 41: 503–509
  • Kapp D. S., Bagshaw M. A., Meyer J. L., Hahn G. M., Samulski T. V., Fessenden P., Lee E. R., Lohrbach A. W. Hyperthermia as an adjuvant to radiation in the treatment of superficial metastases: a randomized trial of 2 vs. 6 heat treatments. Proceedings of the 34th Annual Meeting of the Radiation Research Meeting, Las Vegas NV, 1986, abstract Bf 4
  • Keyes S. R., Rockwell S., Sartorelli A. C. Porfiromycin as a bioreductive alkylating agent with selected toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Research 1985; 45: 3642–3645
  • Kim J. H., Kim S. H., Hahn E. W., Song C. W. 5-Thio-D-glucose selectivity potentiated hyperthermia killing of hypoxic tumor cells. Science 1978; 20: 206–207
  • Kohno F., Kaneshige E., Fujiwara K., Sekiba K. Thermochemotherapy for gynecological malignancies. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; Vol. 1: 753–756
  • Leeper D. B. Adjuvant hyperthermia in radiation therapy. Head and Neck Cancer 1985; 1: 338–345
  • Lele P. P. Scanned, focused, ultrasound for controlled, localized heating of deep tumors. Hyperthermia in Cancer Treatment, L. Anghileri, J. Roberts. CRC Press, Boca Raton 1984, in press
  • Lelieveld P., Scoles M. A., Brown J. M., Kallman R. F. The effect of treatment in fractionated schedules with the combination of x-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin. International Journal of Radiation Oncology, Biology and Physics 1985; 11: 111–121
  • Luk K. H., Frances M. E., Perez C. A., Johnson R. J. R. Radiation therapy and hyperthermia in the treatment of superficial lesions: Preliminary observations and directions for future clinical trials. International Journal of Radiation Oncology, Biology and Physics 1981; 6: 765–772
  • Luk K. H., Pajak T. F., Perez C. A., Johnson R. J., Connor N., Dobbins T. Prognostic factors for tumor response after hyperthermia and radiation. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; Vol. 1: 353–356
  • Ma F., Hiraoka M., Shiken J., Akuta K., Nishimura Y., Takahashi M., Abe M. Response of mammary tumors in C3H/He mice to hyperthermia and Bleomycin in vivo. Radiation Medicine 1985; 3: 230–233
  • Magun B. E. 1983, personal communication
  • Marmor J. B. Interactions of hyperthermia and chemotherapy in animals. Cancer Research 1979; 39: 2269–2276
  • Meyer J. L., Van Kersen I., Hahn G. M. Tumor responses following multiple hyperthermia and X-ray treatments: role of thermotolerance at the cellular level. Cancer Research 1986; 46: 5691–5695
  • Meyn R. E., Corry P. M., Fletcher S. E., Demetriades M. Thermal enhancement of DNA strand breakage in mammalian cells treated with Bleomycin. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 1487–1489
  • Moffat F. L., Gilas T., Calhoun K., Falk M., Dalfen R., Rotstein L. E., Makowa L., Howard V., Laing D., Venturi D., Langer J. C., Falk J. A., Falk R. E. Further experience with regional radiofrequency hyperthermia and cytotoxic chemotherapy for unresectable hepatic neoplasia. Cancer 1985; 55: 1291–1295
  • Molin J., Sogaard P. E., Overgaard J. Experimental studies on the radiation-modifying effect of Bleomycin in malignant and normal tissue in vivo. Cancer Treatment Reports 1981; 65: 583–589
  • Morgan J. E., Howes D. J., Bleehan N. M. The interaction of thermotolerance with drug cytotoxicity in vitro. British Journal of Cancer 1979; 39: 422–428
  • Overgaard J. Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue. British Journal of Cancer 1980; 41: 10–21
  • Overgaard J. Rationale and problems in design of clinical studies. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1985; Vol. 2: 325–338
  • Overgaard J., Nielsen O. S. Influence of thermotolerance on the effect of multi-fractionated hyperthermia in a C3H mammary carcinoma in vivo. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1985; Vol. 2: 211–214
  • Perez C. A., Kuski R. R., Emami B., Fineberg B. Irradiation alone or combined with hyperthermia in the treatment of recurrent carcinoma of the breast in the chest wall: a nonrandomized comparison. International Journal of Hyperthermia 1986; 2: 179–182
  • Phillips T. L. Clinical and experimental alterations in the radiation therapeutic ratio caused by cytotoxic chemotherapy. Radiation Biology in Cancer Research, R. E. Meyn, H. R. Withers. Raven Press, New York 1980; 567–588
  • Pritsos C. A., Sartorelli A. C. Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Research 1986; 46: 3528–3532
  • Rajaratnam S., Adams G. E., Stratford I. J., Clarke C. Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electronaffinic relationship. British Journal of Cancer 1982; 46: 912–917
  • Redpath J. L., Zabilansky E., Colman M. Radiation, adriamycin and skin reactions: Effects of radiation and drug fractionation, hyperthermia and tetracycline. Radiation Research 1981; 86: 459–466
  • Reinhold H. S., Blackiewicz B., Berg-Blok A., Vanden A. Decrease in tumor microcirculation during hyperthermia. Cancer Therapy by Hyperthermia and Radiation, C. Streffer. Urban and Schwartzenberg, Baltimore, Munich 1978; 231–232
  • Reinhold H. S., Endrich B. Tumour microcirculation as a target for hyperthermia. International Journal of Hyperthermia 1986; 2: 111–137
  • Rockwell S., Kennedy K. A. Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 1673–1676
  • Roizin-Towle L., Hall E. J., Capauno L. Interaction of hyperthermia and cytotoxic agents. National Cancer Institute Monograph 1982; 61: 149–152
  • Rubin P. The Franz Buschke lecture: Late effects of chemotherapy and radiation therapy: a new hypothesis. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 5–34
  • Scott R. S. Hyperthermia in combination with radiation. International Journal of Radiation Oncology, Biology and Physics. 1987, submitted
  • Scott R. S., Johnson R. J. R., Storey K. V., Clery L. Local hyperthermia in combination with definitive radiotherapy: Increased tumor clearance reduced recurrence rate in extended follow-up. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 2119–2123
  • Sim D. A., Oleson J. R., Grochowski K. J. An update of the University of Arizona human clinical hyperthermia experience including estimates of therapeutic advantage. Hyperthermic Oncology 1984, J. Overgaard. Taylor & Francis, London, Philadelphia 1984; Vol. 1: 367–370
  • Song C. W. Physiological factors in hyperthermia of tumors. Physical Aspects of Hyperthermia, G. Nussbaum. American Institute of Physics, New York 1982; 43–62
  • Song C. W., Clement J. J., Levitt S. W. Cytotoxic and radiosensitizing effect of 5-thio-D-glucose on hypoxic cells. Radiology 1971; 123: 201–205
  • Song C. W., Clement J. J., Levitt S. W. Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells. Journal of the National Cancer Institute 1976; 57: 603–605
  • Song C. W., Kang M. S., Rhee J. G., Levitt S. H. The effect of hyperthermia on vascular function, pH and cell survival. Radiology 1980; 137: 795–803
  • Spencer T. L., Jehninger A. L. L-Lactate transplant in Ehrlich ascites tumour cells. Biochemical Journal 1976; 154: 405–414
  • Stehlin J. S., Giovenella B. C., de Ipolyi P. D., Anderson R. F. Results of eleven years of experience with heated perfusion for melanoma of the extremities. Cancer Research 1979; 39: 2255–2257
  • Storm F. K., Kaiser L. R., Goodnight J. E., Harrison W. H., Elliott R. S., Gomes A. S., Morton D. L. Thermochemotherapy for melanoma metastases in liver. Cancer 1982; 49: 1243–1248
  • Sugimachi K., Inokuchi K., Kai H., Ueo H., Kuwano H., Matsufuji H. Preoperative hyperthermo-chemo-radiotherapy effective for carcinoma of the esophagus. Journal of Surgical Oncology 1984; 27: 199–204
  • Tannock I. Response of aerobic and hypoxic cells in a solid tumor to adriamcyin and cyclophosphamide and interaction of the drugs with radiation. Cancer Research 1982; 42: 4291–4296
  • Teicher B. A., Kowal C. D., Kennedy K. A., Sartorelli A. C. Enhancement by hyperthermia of the invitro cytotoxicity of mitomycin C toward hypoxic tumor cells. Cancer Research 1981a; 41: 1096–1099
  • Teicher B. A., Lazo J. S., Sartorelli A. C. Classification of antineoplastic agents by their selective toxicities toward ocygenated and hypoxic tumor cells. Cancer Research 1981b; 41: 73–81
  • Trott K. R. Radiation-chemotherapy interactions. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1409–1413
  • Urano M., Kim M. S., Kahn J., Kenton L. A., Li M. L. Effect of thermo-chemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration in a murine fibrosarcoma. Cancer Research 1985; 45: 4162–4166
  • Vaupel P., Frinak S., Mueller-Klieser W., Bicher H. I. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. National Cancer Institute Monograph 1982; 61: 207–209
  • Von der Maase H. Experimental studies on interactions of radiation and cancer chemotherapeutic drugs in normal tissues and a solid tumor. Radiotherapy Oncology 1986; 7: 47–68
  • Von der Maase H., Overgaard J. Interactions of radiation and cancer chemotherapeutic drugs in a C3H mouse mammary carcinoma. Acta Radiologica Oncologica 1985; 24: 181–187
  • Walker M. D., Alexander E., Hunt W. E., MacCarty C. S., Mahaley M. S., Mealey J., Norrell H. A., Owens G., Ransohoff J., Wilson C. B., Gehan E. A., Strike T. A. Evaluation of BCNU and/with radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. Journal of Neurosurgery 1978; 49: 333–343
  • Wallner K. E., Banda M., Li G. C. Hyperthermic enhancement of cell killing by mitomycin C in mitomycin C-resistant Chinese hamster ovary cells. Cancer Research 1987; 47: 1308–1312
  • Westermark H. The effect of heat upon rat tumors. Scandinavian Archives of Physiology 1927; 52: 257–322
  • Wike-Hooley J. L., Haveman J., Reinhold H. S. The relevance of tumour pH to the treatment of malignant disease. Radiotherapy Oncology 1984; 2: 343–366
  • Wondergem J., Haveman J., Van der Schueren E., Van den Hoeven H., Breur K. Effect of hyperthermia and misonidazole on the radiosensitivity of a transplantable murine tumor: influence of factors modifying the fraction of hypoxic cells. International Journal of Radiation Oncology, Biology and Physics 1982; 8: 1323–1331

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.