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International Journal of Hyperthermia Volume 7, 1991 - Issue 3
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Original Article

Effect of hyperthermia on the in vitro hydrolysis of melphalan

J. E. Riviere Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA
,
R. L. Page Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA
,
D. P. Aucoin Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA
,
R. A. Rogers Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA
&
P. L. Williams Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA
Pages 527-529 | Received 19 Dec 1989, Accepted 08 Nov 1990, Published online: 09 Jul 2009

References

  • Alberts D. S., Chang S. Y., Chen G., Evans T. L., Moon T. E. Oral melphalan kinetics. Clinical Pharmacology and Therapeutics 1979a; 26: 737–745
  • Alberts D. S., Chang S. Y., Chen G., Moon T. E., Evans T. L., Furner R. L., Himmelstein K., Gross J. F. Kinetics of intravenous melphalan. Clinical Pharmacology and Therapeutics 1979b; 26: 73–80
  • Alberts D. S., Chen H.-S. G., Benz D., Mason N. L. Effect of renal dysfunction in dogs on the disposition and marrow toxicity of melphalan. British Journal of Cancer 1981; 43: 330–334
  • Bosanquet A. G. Stability of melphalan solutions during preparation and storage. Journal of Pharmaceutical Sciences 1985; 74: 348–351
  • Chang S. Y., Alberts D. S., Melnick L. R. HPLC analysis of L-phenylalanine mustard in biological fluids. Journal of Pharmaceutical Sciences 1978; 67: 679–681
  • Choi K. E., Ratain M. J., Williams S. F., Golick J. A., Beschorner J. C., Fullem L. J., Bitran J. D. Plasma pharmacokinetics of high-dose oral melphalan in patients treated with trialkylator chemotherapy and autologous bone marrow reinfusion. Cancer Research 1989; 49: 1318–1321
  • Furner R. L., Brown R. K. L-phenylalanine mustard (L-PAM): the first 25 years. Cancer Treatment Reports 1979; 64: 559–574
  • Honess D. J., Bleehan N. M. Potentiation of rnelphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumors. International Journal of Hyperthemia 1985; 1: 57–68
  • Honess D. J., Donaldson J., Workman P., Bleehen N. M. The effect of systemic perthermia on melphalan pharmacokinetics in mice. British Journal of Cancer 1985; 51: 77–45
  • Loos U., Musch E., Engel M., Hartlapp J. H., Hugl E., Dengler H. J. The pharmacokinetics of melphalan during intermittent therapy of multiple myeloma. European Journal of Clinical Pharmacology 1988; 35: 187–193
  • Stehlin J. S., Giovanella B. C., De Ipolyi P. D., Muenz L. R., Anderson R. F. Results of hyperthermic perfusion for melanoma of the extremities. Surgery, Gynecology and Obstetrics 1975; 140: 339–348
  • Tabibi S., Cradock J. C. Stability of melphalan in infusion fluids. American Journal of Hospital Pharmacy 1984; 41: 1380–1382

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