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Original Article

Effects of local hyperthermia on the tissue levels and toxicity of three radiosensitizers in mice

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Pages 321-328 | Received 18 Feb 1991, Accepted 21 Oct 1991, Published online: 09 Jul 2009

References

  • Adams G. E. Hypoxia-mediated drugs for radiation and chemotherapy. Cancer 1981; 48: 696–707
  • Allen J. G., Dische S., Lenox-Smith I., Malcolm S. L., Saunders M. I. The pharmacokinetics of a new radiosensitizer Ro-03–8799 in humans. European Journal of Clinical Pharmacology 1984; 27: 483–489
  • Bleehen N. M., Walton M. I., Workman P. Interactions of hyperthermia with hypoxic cell sensitizers. Recent Results in Cancer Research 1988; 109: 136–148
  • Dische S. Chemical sensitizers for hypoxic cells: a decade of experiences in clinical radiotherapy. Radiotherapy and Oncology 1985; 3: 97–115
  • Fujimoto S., Shrestha R. D., Kokobun M., Ohta M., Takahashi M., Kobayashi K., Kiuchi S., Okui K., Miyoshi T., Arimizu N. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding. Annals of Surgery 1988; 208: 36–41
  • George K. C., Streffer C., Pelzer T. Combined effects of X-rays, Ro 03–8799, and hyperthermia on growth, necrosis, and cell proliferation in a mouse tumor. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1119–1122
  • Haveman J., Wondergem J. Thermal enhancement of the cell killing effect of X-irradiation in mammalian cells in vitro and in a transplantable mouse tumour: influence of pH, thermotolerance, hypoxia, or misonidazole. Recent Results in Cancer Research 1988; 109: 149–160
  • Honess D. J., Workman P., Morgan J. E., Bleehen N. M. Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetised mouse. British Journal of Cancer 1980; 41: 529–540
  • Lierke E. G., Schlemm H. Technische Aspekte der Entwicklung eines Ultraschallgerätes zur Lokalhyperthermie tiefliegender Tumoren. Lokale Hyperthermia, C. Streffer, M. Herbst, H. Schwabe. Deutscher Ärzte Verlage, Köln 1986; 75–90
  • Lierke E. G., Grossbach H., Sudhof W., Muller-Klieser W., Vaupel P. A feedback control system for localized ultrasound hyperthermia in tumours. 1. Technical and functional description of equipment. Strahlentherapie 1982; 158: 386
  • Overgaard J. Effect of local hyperthermia on the acute toxicity of misonidazole in mice. British Journal of Cancer 1979; 39: 96–98
  • Roberts J. T., Bleehen N. M., Walton M. I., Workman P. A clinical Phase I toxicity study of Ro 03–8799: Plasma, urine, tumour and normal brain pharmacokinetics. British Journal of Radiology 1986; 59: 107–112
  • Smithen C. E., Clarke E. D., Dale J. A., Jacobs R. S., Wardman P., Watts M. E., Woodcock M. Novel (nitro-l-imidazolyl)-alkanolamines as potential radio-sensitizers with improved therapeutic properties. Radiation Sensitizers, L. Brady. Masson, New York 1980; 22–32
  • Tamulevicius P., Bamberg M., Scherer E., Streffer C. Misonidazole as a radio-sensitizer in the radiotherapy of glioblastomas and oesophageal cancer. Pharmacokinetic and clinical studies. British Journal of Radiology 1981; 54: 318–324
  • Tamulevicius P., Messner H., Streffer C. Metabolism and metabolic effects of misonidazole in mice. Radiosensitization Newsletter 1982; 1: 5
  • Tamulevicius P., Luscher G., Streffer C. Effects on intermediary metabolism in mouse tissues by Ro-03–8799. British Journal of Cancer 1987; 56: 315–320
  • Walton M. I., Bleehen N. M., Workman P. The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro-03–8799 in mice. British Journal of Cancer 1987; 55: 469–476
  • Walton M. I., Bleehen N. M., Workman P. Effects of localised tumour hyperthermia on pimonidazole (Ro 03–8799) pharmacokinetics in mice. British Journal of Cancer 1989a; 59: 667–673
  • Walton M. I., Bleehen N. M., Workman P. Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction. Cancer Chemotherapy and Pharmacology 1989b; 24: 172–176
  • Walton M. I., Bleehen N. M., Workman P. Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice. Cancer Research 1989c; 49: 2351–2355

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