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Original Article

Dependence of proton generation on aerobic or anaerobic metabolism and implications for tumour pH

Pages 495-499 | Received 21 Jul 1995, Accepted 18 Feb 1996, Published online: 09 Jul 2009

References

  • Boyer M. J., Tannock I. F. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Research 1992; 52: 4441–4447
  • Busa W., Nuccitelli R. Metabolic regulation via intracellular pH. American Journal of Physiology 1984; 246: R409–R438
  • Chu G. L., Dewey W. C. The role of low intracellular or extracellular pH in sensitization to hyperthermia. Radiation Research 1988; 114: 154–167
  • Cook J. A., Fox M. H. Effects of acute pH 6·6 and 42·0°C heating on the intracellular pH of Chinese hamster ovary cells. Cancer Research 1988; 48: 496–502
  • Engin K., Leeper D. B., Cater J. R., Thistlethwaite A. J., Tupchong L., McFarlane J. D. Extracellular pH distribution in human tumours. International Journal of Hyperthermia 1995; 11: 211–216
  • Fellenz M. P., Gerweck L. E. Influence of extracellular pH on intracellular pH and cell energy status. Radiation Research 1989; 116: 305–312
  • Gerweck L., Rhee J., Koutcher J., Song C. W., Urano M. Regulation of pH in murine tumor and muscle. Radiation Research 1991; 126: 206–209
  • Gevers W., Dowle E. The effect of pH on glycolysis in vitro. Clinical Science(Oxf) 1963; 25: 343–349
  • Griffiths J. R. Are cancer cells acidic. British Journal of Cancer 1991; 64: 425–427
  • Hahn G. M., Shiu E. Adaptation to low pH modifies thermal and thermochemical responses to mammalian cells. International Journal of Hyperthermia 1986; 2: 379–387
  • Halperin M. L., Connors H., Relman A. S., Karnovsky M. L. Factors that control the effect of pH on glycolysis in leukocytes. Journal of Biological Chemistry 1969; 244: 384–390
  • Hinkle P. C., Kumar M. A., Resetar A., Harris D. L. Mechanistic stoichiometry of mitochondrial oxidative phosphorylation. Biochemistry 1991; 30: 3576–3582
  • Hochachka P. W., Mommsen T. P. Protons and anaerobiosis. Science 1983; 219: 1391–1397
  • Hofer K., Mivechi N. Tumor cell sensitivity to hyperthermia as a function of extracellular pH and intracellular pH. Journal of the National Cancer Institute 1980; 65: 621–625
  • Kallinowski F., Vaupel P., Runkel S., Berg G., Fortmeyer H. P., Baessler K. H., Wagner K., Mueller-Klieser W., Walenta S. Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu and pH distributions in human breast cancer xenografts in nude rats. Cancer Research 1988; 48: 7264–7272
  • Kuin A., Smets L., Volk T., Paans A., Adams G., Atema A., Jaehde E., Maas A., Rajewsky M. F., Visser G., Wood P. Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Research 1994; 54: 3785–3792
  • Leeper D. B., Engin K., Thistlethwaite A. J., Hitchon H. D., Dover J. D., Li D. J., Tupchong L. Human tumor extracellular pH as a function of blood glucose concentration. International Journal of Radiation Oncology and Biological Physics 1994; 28: 935–943
  • Lyons J. C., Kim G., Song C. W. Modification of intracellular pH and thermosensitivity. Radiation Research 1992; 129: 79–87
  • Lyons J. C., Kim G., Song C. W. Killing of hypoxic cells by lowering the intracellular pH in combination with hyperthermia. Radiation Research 1995; 141: 216–218
  • Newell K., Franchi A., Pouyssegur J., Tannock I. Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proceedings of the National Academy of Science, USA 1993; 90: 1127–1131
  • Otsu K., Kinsella J. L., Heller P., Froehlich J. P. Sodium dependence of the Na+-H+ exchanger in the pre-steady state. Journal of Biology and Chemistry 1993; 268: 3184–3193
  • Sostman H. D., Prescott D., Dewhirst M., Dodge R. K., Thrall D. E., Page R. L., Tucker J. A., Harrelson J. M., Reece G., Leopold K. A., Oleson J. R., Charles H. C. MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas. Radiology 1994; 190: 269–275
  • Stryer L. Biochemistry, 4th edition. W.H. Freeman, New York 1995; 551–552
  • Tannock I. F., Rotin D. Acid pH in tumors and its potential for exploitation. Cancer Research 1989; 49: 4373–4384
  • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Research 1989; 49: 6449–6465
  • Voet D., Voet J. G. Biochemistry. Wiley & Sons, New York 1990; 36
  • Wike-Hooley J. L., Haveman J., Reinhold H. S. The relevance of tumor pH to the treatment of malignant disease. Radiothermal Oncology 1984; 2: 343–366

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