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Original Article

Garlic preserves patency and delays hyperthermia-induced thrombosis in pial microcirculation

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Pages 513-525 | Received 12 Jul 1995, Accepted 15 Mar 1996, Published online: 09 Jul 2009

References

  • Ali M., Mohammed S. Y. Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandins, Leukotrienes and Medicine 1986; 25: 139–146
  • Apitz-Castro R., Badimon J. J., Badimon L. Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Thrombosis Research 1992; 68: 145–155
  • Apitz-Castro R., Badimon J. J., Badimon L. A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model. Thrombosis Research 1994; 75: 243–249
  • Ariga T., Oshiba S., Tamada T. Platelet aggregation inhibitor in garlic. Lancet 1981; 1: (January 17), 150–151
  • Chao T. C. Post-mortem findings of heat stroke. Heat Stress: Physical Exertion and Environment, J. R. S. Hales, D. A. B. Richards. Elsevier Science, Amsterdam 1987; 297–302
  • Deboer L. W., Folts J. D. Garlic extract prevents acute platelet thrombus formation in stenosed canine coronary arteries. American Heart Journal 1989; 117: 973–975
  • El-Sabban F., Fahim M. A. Local hyperthermia induces spontaneous thrombosis and arteriolar constriction in the pia mater of the mouse. International Journal of Biometerology 1995; 38: 92–97
  • El-Sabban F., Fahim M. A., Mustafa K. Y. Aspirin influences mouse pial microvascular responses to regional hyperthermia. Pathophysiology 1995a; 2: 217–222
  • El-Sabban F., Fahim M. A., van Homsi M. F., Singh S. Dehydration and food deprivation exacerbate mouse cerebral responses to local hyperthermia. Journal of Thermal Biology 1995b; 20: 469–476
  • Fahim M. A., El-Sabban F. Hyperthermia induces ultrastructural changes in mouse pial microvessels. The Anatomical Record 1995; 242: 77–82
  • Harenberg J., Giese C., Zimmermann R. Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis 1988; 74: 247–249
  • Jung E. M., Jung F., Mrowietz C., Kiesewetter H., Pindur G., Wenzel E. Influence of garlic powder on cutaneous microcirculation. A randomized placebo-controlled double-blind cross-over study in apparently healthy subjects. Arzneimittel Forschung 1991; 41: 626–630
  • Kawakishi S., Morimitsu Y. New inhibition of platelet aggregation in onion. Lancet 1988; 2: 330, August 6
  • Kiesewetter H., Jung F., Pindur G., Jung E. M., Mrowietz C., Welzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. International Journal of Clinical Pharmacology, Therapy and Toxicology 1991; 29: 151–155
  • Legnani C., Frascaro M., Guazzaloca G., van Dovici S., Cesarano G., Coccheri S. Effects of dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. Arzneimittel-Forschung 1993; 43: 119–122
  • Makheja A. N., Vanderhoek J. Y., Bailey J. M. Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. Prostaglandins, Leukotrienes and Medicine 1979; 2: 413–424
  • Makheja A. N., Vanderhoek J. Y., Bryant R. W., Baily J. M. Altered arachidonic acid metabolism in platelets inhibited by onion or garlic extracts. Advances in Prostaglandin and Thromboxane Research 1980; 6: 309–312
  • Mayeux P. R., Agarwal K. C., Tou J. S., King B. T., Lipton H. L., Hyman A. L., Kadowitz P. J., McNamara D. B. The pharmacological effects of allicin, a constituent of garlic oil. Agents and actions 1988; 25: 182–190
  • McMahon F. G., Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993; 13: 406–407
  • Mohammed S. F., Woodward S. C. Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (Garlic). Thrombosis Research 1986; 44: 793–806
  • Mustafa K. Y., Omer O., Khogali M., Jamjoom A., Gumaa K. A., Abu El Nasr N., Gader M. A. Blood coagulation and fibrinolysis in heat stroke. British Journal of Haematology 1985; 63: 517–523
  • Okuyama T., Fujita K., Shibata S., Hoson M., Kawada T., Masaki M., Yamate N. Effects of Chinese drugs “xiebai” and “dasuan” on human platelet aggregation (Allium bakeri, A. sativum). Planta Medica 1989; 55: 242–244
  • Rosenblum W. I., El-Sabban F. Platelet aggregation in cerebral microcirculation: effect of aspirin and other agents. Circulation Resarch 1977; 40: 320–328
  • Srivastava K. C. Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomedica Biochimia Acta 1984; 43: S335–336
  • Srivastava K. C. Onion exerts anti aggregatory effects by altering arachidonic acid metabolism in platelets. Prostaglandins, Leukotrienes and Medicine 1986a; 24: 43–50
  • Srivastava K. C. Evidence for the mechanism by which garlic inhibits platelet aggregation. Prostaglandins, Leukotrienes and Medicine 1986b; 22: 313–321
  • Vanderhoek J. Y., Makheja A. N., Bailey J. M. Inhibition of fatty acid oxygenases by onion and garlic oils. Evidence for the mechanism by which these oils inhibit platelet aggregation. Biochemical Pharmacology 1980; 29: 3169–3173

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