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Original Article

The use of a hypoxic cell radiosensitizer AK-2123 gave no improvement in thermoradiotherapy combined with hydralazine

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Pages 771-777 | Received 12 Feb 1996, Accepted 05 Jun 1996, Published online: 09 Jul 2009

References

  • Eighth International Conference on Chemical Modifiers of Cancer Treatment (Kyoto, Japan). 1993, 1993, Abstracts
  • Chaplin D. J., Olive P. L., Durand R. L. Intermittent blood flow in a murine tumor: Radiobiological effects. Cancer Research 1987; 47: 597–601
  • Dewhirst M. W. Future directions in hyperthermia biology. International Journal of Hyperthermia 1994; 10: 339–345
  • Field S. B., Burney I. A., Needham S., Maxwell R. J., Griffiths J. R. From hydralazine to CGRP to man. International Journal of Hyterthermia 1994; 10: 451–455
  • Gerweck L. E., Nygaard T. G., Burlett M. Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Research 1979; 39: 966–972
  • Gerweck L. E. Effect of microenvironmental factors on the response of cells to single and fractionated heat treatments. National Cancer Institute Monograph 1982; 61: 19–26
  • Horsman M. R., Chaplin D. J., Overgaard J. Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells. Cancer Research 1990; 50: 7430–7436
  • Horsman M. R., Lindegaard J. C., Overgaard J. Interaction of hyperthermia and radiation in solid tumors in vivo. Radiation Research: A Twentieth-Century Perspec tive. Volume II: Congress Proceedings, W. C. Dewey, M. Edington, R. J. M. Fry, E. J. Hall, G. F. Whitmore. Academic Press, Inc., San Diego, New York, Boston, London, Sydney, Tokyo and Toronto 1992; 1033–1038
  • Horsman M. R., Overgaard J. Overcoming tumour radiation resistance resulting from acute hypoxia. European Journal of Cancer 1992; 28A: 717–718
  • Kozin S. V., Hasegawa T., Ha-Kawa S. K., Akagi K., Tanaka Y. Hydralazine at thermoradiotherapy: Tumor size and blood flow effects. International Journal of Radiation Oncology, Biology and Physics 1994; 29: 505–510
  • Kozin S. V., Volenec K., Zaitsev A. V., Borisov M. B., Yarmonenko S. P. Hydralazine for enhancement of thermoradiotherapy efficacy. Radiosensitization Newsletter 1992; 11(4)2–4
  • Kozin S. V., Zaitsev A. V., Yarmonenko S. P. Antitumor effect of irradiation followed by hyperglycemia and hyperthermia: The dependence on tumor size and blood flow. International Journal of Hyperthermia 1996; 12: 147–156
  • Kunugita N., Norimura T., Tsuchiya T. Experimental study of the effects of AK-2123 in multimodal treatment. Eighth International Conference on Chemical Modifiers of Cancer Treatment (Kyoto, Japan, 1993) 1993; 231–232
  • Oleson J. R., Calderwood S. K., Coughlin C. T., Dewhirst M. W., Gerweck L. E., Gibbs F. A., Kapp D. S. Biological and clinical aspects of hyperthermia in cancer therapy. American Journal of Clinical Oncology (CCT) 1988; 11: 368–380
  • Osinsky S., Kelleher D. K. Changes of laser Doppler flowmetry in rat tumors following AK-2123 application (preliminary communication). Radiosensitization Newsletter 1992; 11(3)2–4
  • Osinsky S. P., Bubnovskaya L. N., Ganusevich I. I. In vivo thermochemosensitiz ing activity and pathophysiological effects of hypoxic radiosensitizer AK-2123. Experi mental Oncology 1994; 16: 61–66
  • Overgaard J. The current and potential role of hyperthermia in radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 535–549
  • Overgaard J., Grau C., Lindegaard J. C., Horsman M. R. The potential of using hyperthermia to eliminate radioresistant hypoxic cells. Radiotherapy and Oncology 1991; 20(Suppl)113–116
  • Tanaka M., Kagiya V. T. (1991) Effect of hydralazine as a vasodilator on pharmokinetics of AK-2123 and efficacy of radiation treatment in vivo. 7th International Conference on Chemical Modifiers of Cancer Treatment (Clearwater, Florida, USA). 1991, 60–61
  • Yarmonenko S. P., Kozin S. V. Radiobiological approaches to enhancement of thermoradiotherapy efficacy. Radiation Research: A Twentieth-Century Perspective. Volume II: Congress Proceedings, W. C. Dewey, M. Edington, R. J. M. Fry, E. J. Hall, G. F. Whitmore. Academic Press, Inc., San Diego, New York, Boston, London, Sydney, Tokyo and Toronto 1992; 1016–1020

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