Advanced search
Publication Cover
International Journal of Hyperthermia Volume 13, 1997 - Issue 2
Submit an article Journal homepage
113
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Bioluminescence imaging of metabolites in a human tumour xenograft after treatment with hyperthermia and/or the radiosensitizer pimonidazole

P. Tamulevicius Institut für Med. Strahlenbiologie, Universitätsklinikum Essen, Hufelandstr, 55 45122, Essen, Germany
&
C. Streffer Institut für Med. Strahlenbiologie, Universitätsklinikum Essen, Hufelandstr, 55 45122, Essen, Germany
Pages 235-245 | Received 21 Mar 1996, Accepted 21 Oct 1996, Published online: 09 Jul 2009

References

  • Jain R. K. Determinants of tumor blood flow: a review. Cancer Research 1988; 48: 2641–2658
  • Kallinowski F., Vaupel P., Runkel S., Berg G., Fortmeyer H. P., Baessler K. H., Wagner K., Müller‐Klieser W., Walenta S. Glucose uptake, lactate release, ketone body turn‐over, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude mice. Cancer Research 1988; 48: 7264–7272
  • Kelleher D. K., Engel T., Vaupel P. W. Changes in microregional perfusion, oxygenation, ATP and lactate distribution in subcutaneous rat tumours upon water‐filtered IR‐A hyperthermia. International Journal of Hyperthermia 1995; 11: 241–255
  • Konerding M. A., van Ackern C., Hinz S., Steinberg F., Streffer C. Ultrastructural studies of tumour angiogenesis in human xenotransplanted tumours. International Journal of Radiation Biology 1991; 60: 49–53
  • Lee S. Y., Ryu K. H., Kang M. S., Song C. W. Effect of hyperthermia on the lactic acid and β‐hydroxybutyrate acid content in tumour. International Journal of Hyperthermia 1986; 2: 213–222
  • Müller‐Klieser W., Krüger M., Walenta S., Rofstad E. K. Comparative imaging of structure and metabolites in tumours. International Journal of Radiation Biology 1991; 60: 147–159
  • Müller‐Klieser W., Schaefer C., Walenta S., Rofstad E. K., Fenton B. M., Sutherland R. M. Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic spectroscopy, and cryospectrophotometry. Cancer Research 1990; 50: 1681–1685
  • Müller‐Klieser W., Walenta S. Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging. Histochemical Journal 1993; 25: 407–420
  • Müller‐Klieser W., Walenta S., Paschen W., Kallinowski F., Vaupel P. Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. Journal of the National Cancer Institute 1988; 80: 842–848
  • Reinhold H. S., Endrich B. Tumour microcirculation as a target for hyperthermia. International Journal of Hyperthermia 1986; 2: 111–137
  • Schaefer C., Mayer W. ‐K., Krüger W., Vaupel P. Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon hyperthermia and/or hyperglycaemia. Journal of Cancer Research and Clinical Oncology, 119: 599–608
  • Streffer C. Metabolic changes during and after hyperthermia. International Journal of Hyperthermia 1985; 1: 305–319
  • Streffer C. Aspects of metabolic changes after hyperthermia. Recent Results in Cancer Research 1988; 107: 7–16
  • Streffer C., Tamulevicius P. Metabolic effects of hypoxic cell sensitizers. In Selective Activation of Drugs by Redox Processes, G. E. Adams, A. Breccia, E. M. Fielden, P. Wardman. Plenum, New York 1990; 159–164
  • Streffer C., Tamulevicius P. Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers. International Journal of Radiation Oncology, Biology and Physics 1994; 29: 571–575
  • Tamulevicius P., George K. C., Rucker A., Streffer C. Effects of local hyperthermia on the tissue levels and toxicity of three radiosensitizers in mice. International Journal of Hyperthermia 1992; 8: 321–328
  • Tamulevicius P., Luscher G., Streffer C. Effects on intermediary metabolism in mouse tissues by Ro‐03–8799. British Journal of Cancer 1987; 56: 315–320
  • Tamulevicius P., Streffer C. Metabolic imaging in tumours by means of bioluminescence. British Journal of Cancer 1995; 12: 1102–1112
  • Vaupel P., Kallinowski F. Physiological effects of hyperthermia. Recent Results in Cancer Research 1987; 104: 71–109
  • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Research 1989; 49: 6449–6465
  • Vaupel P., Okunieff P., Neuringer L. J. In vivo 31‐P‐NMR spectroscopy of murine tumours before and after localized hyperthermia. International Journal of Hyperthermia 1990; 6: 15–31
  • Walenta S., Dellian N., Goetz A. E., Kuhnle G. E. H., Muller‐Klieser W. Pixel‐to‐pixel correlations between images of absolute ATP concentrations and blood flow in tumours. British Journal of Cancer 1992; 66: 1099–1102

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.