Enteral nutrition in patients with severe traumatic brain injury: reasons for intolerance and medical management

References

• Clifton GL, Robertson CS, Grossman RG, Hodge S, Foltz R, Garza C. The metabolic response to severe head injury. J Neurosurg 1984;60(4):687–96.
   PubMed Web of Science ®Google Scholar
• Charrueau C, Belabed L, Besson V, Chaumeil JC, Cynober L, Moinard C. Metabolic response and nutritional support in traumatic brain injury: evidence for resistance to renutrition. J Neurotrauma 2009;26(11):1911–20.
   PubMed Web of Science ®Google Scholar
• Krakau K, Omne-Ponten M, Karlsson T, Borg J. Metabolism and nutrition in patients with moderate and severe traumatic brain injury: a systematic review. Brain Inj 2006;20(4):345–67.
   PubMed Web of Science ®Google Scholar
• Sacks GS, Brown RO, Teague D, Dickerson RN, Tolley EA, Kudsk KA. Early nutrition support modifies immune function in patients sustaining severe head injury. JPEN J Parenter Enteral Nutr 1995;19(5):387–92.
   PubMed Web of Science ®Google Scholar
• Härtl R, Gerber LM, Ni Q, Ghajar J. Effect of early nutrition on deaths due to severe traumatic brain injury. J Neurosurg 2008;109(1):50–6.
   PubMed Web of Science ®Google Scholar
• Perel P, Yanagawa T, Bunn F, Roberts I, Wentz R, Pierro A. Nutritional support for head-injured patients. Cochrane Database Syst Rev 2006;3:CD001530.
   Google Scholar
• McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr 2009;33(3):277–316.
   PubMed Web of Science ®Google Scholar
• McArthur CJ, Gin T, McLaren IM, Critchley J, Oh TE. Gastric emptying following brain injury: effects of choice of sedation and intracranial pressure. Intensive Care Med 1995;21(7):573–6.
   PubMed Web of Science ®Google Scholar
• Norton JA, Ott LG, McClain C, et al. Intolerance to enteral feeding in the brain-injured patient. J Neurosurg 1988;68(1):62–6.
   PubMed Web of Science ®Google Scholar
• Kao CH, ChangLai SP, Chieng PU, Yen TC. Gastric emptying in head-injured patients. Am J Gastroenterol 1998;93(7):1108–12.
   PubMed Web of Science ®Google Scholar
• Dickerson RN, Mitchell JN, Morgan LM, et al. Disparate response to metoclopramide therapy for gastric feeding intolerance in trauma patients with and without traumatic brain injury. JPEN J Parenter Enteral Nutr 2009;33(6):646–55.
   PubMed Web of Science ®Google Scholar
• Mentec H, Dupont H, Bocchetti M, Cani P, Ponche F, Bleichner G. Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Crit Care Med 2001;29(10):1955–61.
   PubMed Web of Science ®Google Scholar
• Saxe JM, Ledgerwood AM, Lucas CE, Lucas WF. Lower esophageal sphincter dysfunction precludes safe gastric feeding after head injury. J Trauma 1994;37(4):581–6.
   PubMedGoogle Scholar
• Chapman M, Fraser R, Vozzo R, et al. Antro-pyloro-duodenal motor responses to gastric and duodenal nutrient in critically ill patients. Gut 2005;54(10):1384–90.
   PubMed Web of Science ®Google Scholar
• Dive A, Miesse C, Jamart J, Evrard P, Gonzalez M, Installe E. Duodenal motor response to continuous enteral feeding is impaired in mechanically ventilated critically ill patients. Clin Nutr 1994;13(5):302–6.
   PubMed Web of Science ®Google Scholar
• Ritz MA, Fraser R, Tam W, Dent J. Impacts and patterns of disturbed gastrointestinal function in critically ill patients. Am J Gastroenterol 2000;95(11):3044–52.
   PubMed Web of Science ®Google Scholar
• Ukleja A. Altered GI motility in critically ill patients: current understanding of pathophysiology, clinical impact, and diagnostic approach. Nutr Clin Pract 2010;25(1):16–25.
   PubMed Web of Science ®Google Scholar
• Herbert MK, Holzer P. Standardized concept for the treatment of gastrointestinal dysmotility in critically ill patients – current status and future options. Clin Nutr 2008;27(1):25–41.
   PubMed Web of Science ®Google Scholar
• Stengel A, Taché Y. Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight. Annu Rev Physiol 2009;71:219–39.
   PubMed Web of Science ®Google Scholar
• Hang CH, Shi JX, Li JS, Wu W, Li WQ, Yin HX. Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction. World J Gastroenterol 2004;10(6):875–80.
   PubMed Web of Science ®Google Scholar
• Nguyen NQ, Fraser RJ, Chapman MJ, et al. Feed intolerance in critical illness is associated with increased basal and nutrient-stimulated plasma cholecystokinin concentrations. Crit Care Med 2007;35(1):82–8.
   PubMed Web of Science ®Google Scholar
• Jeremitsky E, Omert LA, Dunham CM, Wilberger J, Rodriguez A. The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005;58(1):47–50.
   PubMedGoogle Scholar
• Horowitz M, Jones KL, Wishart JM, Maddox AF, Harding PE, Chatterton BE. Chatterton BE. Relationships between gastric emptying, intragastric meal distribution and blood glucose concentrations in diabetes mellitus. J Nucl Med 1995;36(12):2220–8.
   PubMed Web of Science ®Google Scholar
• Barnett JL. Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology 1988;94(3):739–44.
   PubMed Web of Science ®Google Scholar
• Nguyen N, Ching K, Fraser R, Chapman M, Holloway R. The relationship between blood glucose control and intolerance to enteral feeding during critical illness. Intensive Care Med 2007;33(12):2085–92.
   PubMed Web of Science ®Google Scholar
• Ziebell JM, Morganti-Kossmann MC. Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 2010;7(1):22–30.
   PubMed Web of Science ®Google Scholar
• Nompleggi D, Teo TC, Blackburn GL. Human recombinant interleukin 1 decreases gastric emptying in the rat. Gastroenterology 1988;94(2):326.
   Google Scholar
• Hermann GE, Rogers RC. TNF activates astrocytes and catecholaminergic neurons in the solitary nucleus: implications for autonomic control. Brain Res 2009;1273:72–82.
   PubMed Web of Science ®Google Scholar
• Verdu EF, Bercik P, Collins SM. Effect of probiotics on gastrointestinal function: evidence from animal models. Ther Adv Gastroenterol 2009;2 (Suppl 1):s31–s35.
   PubMedGoogle Scholar
• Husebye E, Hellstrom PM, Sundler F, Chen J, Midtvedt T. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol-Gastrointest L 2001;280(3):368–80.
   PubMed Web of Science ®Google Scholar
• Yu XY, Yin HH, Zhu JC. Increased gut absorptive capacity in rats with severe head injury after feeding with probiotics. Nutrition, in press, Corrected Proof, Available online 3 April 2010.
   Web of Science ®Google Scholar
• Singh G, Harkema JM, Mayberry AJ, Chaudry IH. Severe depression of gut absorptive capacity in patients following trauma or sepsis. J Trauma 1994;36(6):803–9.
   PubMedGoogle Scholar
• Chapman MJ, Fraser RJL, Matthews G, et al. Glucose absorption and gastric emptying in critical illness. Crit Care 2009;13(4):R140.
   PubMed Web of Science ®Google Scholar
• Strack van Schijndel RJM, Wierdsma NJ, Van Heijningen EMB, Weijs PJM, de Groot SDW, Girbes ARJ. Fecal energy losses in enterally fed intensive care patients: an explorative study using bomb calorimetry. Clin Nutr 2006;25(5):758–64.
   PubMed Web of Science ®Google Scholar
• Hang CH, Shi JX, Sun BW, Li JS. Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. J Surg Res 2007;137(1):53–60.
   PubMed Web of Science ®Google Scholar
• Btaiche IF, Chan LN, Pleva M, Kraft MD. Critical illness, gastrointestinal complications, and medication therapy during enteral feeding in critically ill adult patients. Nutr Clin Pract 2010;25(1):32–49.
   PubMed Web of Science ®Google Scholar
• Brinson RR, Kolts BE. Hypoalbuminemia as an indicator of diarrheal incidence in critically ill patients. Crit Care Med 1987;15(5):506–9.
   PubMed Web of Science ®Google Scholar
• Guenter PA, Settle RG, Perlmutter S, Marino PL, DeSimone GA, Rolandelli RH. Tube feeding-related diarrhea in acutely ill patients. JPEN J Parenter Enteral Nutr 1991;15(3):277–80.
   PubMed Web of Science ®Google Scholar
• Ford EG, Jennings LM, Andrassy RJ. Serum albumin (oncotic pressure) correlates with enteral feeding tolerance in the pediatric surgical patient. J Pediatr Surg 1987;22(7):597–9.
   PubMed Web of Science ®Google Scholar
• Nguyen NQ, Chapman M, Fraser RJ, Bryant LK, Burgstad C, Holloway RH. Prokinetic therapy for feed intolerance in critical illness: one drug or two? Crit Care Med 2007;35(11):2561–7.
   PubMed Web of Science ®Google Scholar
• Gottschlich MM, Warden GD, Michel M, et al. Diarrhea in tube-fed burn patients: incidence, etiology, nutritional impact, and prevention. JPEN J Parenter Enteral Nutr 1988;12(4):338–45.
   PubMed Web of Science ®Google Scholar
• Luft VC, Beghetto MG, de Mello ED, Polanczyk CA. Role of enteral nutrition in the incidence of diarrhea among hospitalized adult patients. Nutrition 2008;24(6):528–35.
   PubMed Web of Science ®Google Scholar
• Bankhead R, Boullata J, Brantley S, et al. Enteral nutrition practice recommendations. JPEN J Parenter Enteral Nutr 2009;32(2):122–67.
   Google Scholar
• Bengmark S, Andersson R, Mangiante G. Uninterrupted perioperative enteral nutrition. Clin Nutr 2001;20(1):11–19.
   PubMed Web of Science ®Google Scholar
• Fruhwald S, Holzer P, Metzler H. Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact. Intensive Care Med 2007;33(1):36–44.
   PubMed Web of Science ®Google Scholar
• Kompan L, Vidmar G, Spindler-Vesel A, Pecar J. Is early enteral nutrition a risk factor for gastric intolerance and pneumonia? Clin Nutr 2004;23(4):527–32.
   PubMed Web of Science ®Google Scholar
• Martindale RG, Maerz LL. Management of perioperative nutrition support. Curr Opin Crit Care 2006;12(4):290–4.
   PubMed Web of Science ®Google Scholar
• Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003;27(5):355–73.
   PubMed Web of Science ®Google Scholar
• Kreymann KG, Berger MM, Deutz NEP, et al. ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 2006;25(2):210–23.
   PubMed Web of Science ®Google Scholar
• Marino LV, Kiratu EM, French S, Nathoo N. To determine the effect of metoclopramide on gastric emptying in severe head injuries: a prospective, randomized, controlled clinical trial. Br J Neurosurg 2003;17(1):24–8.
   PubMed Web of Science ®Google Scholar
• Nursal T, Erdogan B, Noyan T, Cekinmez M, Atalay B, Bilgin N. The effect of metoclopramide on gastric emptying in traumatic brain injury. J Clin Neurosci 2007;14(4):344–8.
   PubMed Web of Science ®Google Scholar
• Reignier J, Dimet J, Martin-Lefevre L, et al. Before–after study of a standardized ICU protocol for early enteral feeding in patients turned in the prone position. Clin Nutr 2010;29(2):210–16.
   PubMed Web of Science ®Google Scholar
• Berne JD, Norwood SH, McAuley CE, et al. Erythromycin reduces delayed gastric emptying in critically ill trauma patients: a randomized, controlled trial. J Trauma 2002;53(3):422–5.
   PubMedGoogle Scholar
• Meissner W, Dohrn B, Reinhart K. Enteral naloxone reduces gastric tube reflux and frequency of pneumonia in critical care patients during opioid analgesia. Crit Care Med 2003;31(3):776–80.
   PubMed Web of Science ®Google Scholar
• Food and Agriculture Organization of the United Nations and World Health Organization. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. World Health Organization Web site. http://www. who.int/foodsafety/publications/fs_management/en/probiotics.pdf . Accessed October 2001.
   Google Scholar
• Bengmark S. Pre-, pro-and synbiotics. Curr Opin Clin Nutr Metab Care 2001;4(6):571–9.
   PubMed Web of Science ®Google Scholar
• Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 2008;8(6):411–20.
   PubMed Web of Science ®Google Scholar
• Lesniewska V, Rowland I, Laerke HN, Grant G, Naughton PJ. Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo. Exp Physiol 2006;91(1):229–37.
   PubMed Web of Science ®Google Scholar
• Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. J Pediatr 2008;152(6):801–6.
   PubMed Web of Science ®Google Scholar
• Soeters PB. Probiotics: did we go wrong, and if so, where? Clin Nutr 2008;27(2):173–8.
   PubMed Web of Science ®Google Scholar
• Besselink MGH, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371(9613):651–9.
   PubMed Web of Science ®Google Scholar
• Whelan K, Myers CE. Safety of probiotics in patients receiving nutritional support: a systematic review of case reports, randomized controlled trials, and nonrandomized trials. Am J Clin Nutr 2010;91(3):687–03.
   PubMed Web of Science ®Google Scholar
• Elia M, Engfer MB, Green CJ, Silk DBA. Systematic review and meta-analysis: the clinical and physiological effects of fibre-containing enteral formulae. Aliment Pharmacol Therapeut 2008;27(2):120–45.
   PubMed Web of Science ®Google Scholar
• Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354(9193):1851–8.
   PubMed Web of Science ®Google Scholar
• Metheny NA, Clouse RE, Chang YH, Stewart BJ, Oliver DA, Kollef MH. Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med 2006;34(4):1007–15.
   PubMed Web of Science ®Google Scholar
• Cook DJ, Meade MO, Hand LE, McMullin JP. Toward understanding evidence uptake: semirecumbency for pneumonia prevention. Crit Care Med 2002;30(7):1472–7.
   PubMed Web of Science ®Google Scholar
• Grap MJ, Munro CL, Hummel RS III, Elswick RK Jr, McKinney JL, Sessler CN. Effect of backrest elevation on the development of ventilator-associated pneumonia. Am J Crit Care 2005;14(4):325–32.
   PubMed Web of Science ®Google Scholar
• Lee JSW, Kwok T, Chui PY, et al. Can continuous pump feeding reduce the incidence of pneumonia in nasogastric tube-fed patients? A randomized controlled trial. Clin Nutr 2010; 29(4):453–8.
   PubMed Web of Science ®Google Scholar
• Williams TA, Leslie GD. A review of the nursing care of enteral feeding tubes in critically ill adults.I. Intens Crit Care Nurs 2004;20(6):330–43.
   PubMedGoogle Scholar
• Hacker R, Harvey-Banchik LP. Prospective randomized control trial of intermittent versus continuous gastric feeds for critically ill trauma patients. Nutr Clin Pract 2008;23(5):564–5.
   Web of Science ®Google Scholar
• Chen YC, Chou SS, Lin LH, Wu LF. The effect of intermittent nasogastric feeding on preventing aspiration pneumonia in ventilated critically ill patients. J Nurs Res 2006;14(3):167–80.
   PubMedGoogle Scholar
• Kozar RA, McQuiggan MM, Moore EE, Kudsk KA, Jurkovich GJ, Moore FA. Postinjury enteral tolerance is reliably achieved by a standardized protocol. J Surg Res 2002;104(1):70–5.
   PubMed Web of Science ®Google Scholar
• Rice TW, Swope T, Bozeman S, Wheeler AP. Variation in enteral nutrition delivery in mechanically ventilated patients. Nutrition 2005;21(7–8):786–92.
   PubMed Web of Science ®Google Scholar
• Petros S, Engelmann L. Enteral nutrition delivery and energy expenditure in medical intensive care patients. Clin Nutr 2006;25(1):51–9.
   PubMed Web of Science ®Google Scholar
• Kuo P, Rayner CK, Jones KL, Horowitz M. Pathophysiology and management of diabetic gastropathy: a guide for endocrinologists. Drugs 2007;67(12):1671–87.
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345(19):1359–67.
   PubMed Web of Science ®Google Scholar