1,364
Views
74
CrossRef citations to date
0
Altmetric
Research Article

Neurometabolic and microstructural alterations following a sports-related concussion in female athletes

, , , , , & show all
Pages 1038-1046 | Received 01 Aug 2012, Accepted 07 Apr 2013, Published online: 08 Jul 2013

References

  • Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. Journal of Head Trauma Rehabilitation 2006;21:375–378
  • McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Molloy M, Cantu R. Consensus statement on concussion in sport: The 3rd International Conference on Concussion in Sport Held in Zurich, November 2008. Journal of Athletic Training 2009;44:434–448
  • Echemendia RJ. Sports neuropsychology. New York: Guilford Press; 2006
  • McCrea M, Guskiewicz KM, Marshall S, Barr W, Randolph C, Cantu RC, Onate JA, Yang J, Kelly JP. Acute effects and recovery time following concussion in collegiate football players: The NCAA Concussion Study. Journal of the American Medical Association 2003;290:2556–2563
  • McCrory P, Johnston K, Meeuwisse W, Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Kelly J, Lovell M, Schamasch P. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. British Journal of Sports Medicine 2005;39:196–204
  • Giza CC, Hovda DA. The neurometabolic cascade of concussion. Journal of Athletic Training 2001;36:228–235
  • Covassin T, Swanik CB, Sachs ML. Epidemiological considerations of concussions among intercollegiate athletes. Applied Neuropsychololy 2003;10:12–22
  • Covassin T, Swanik CB, Sachs ML. Sex differences and the incidence of concussions among collegiate athletes. Journal of Athletic Training 2003;38:238–44
  • Gessel LM, Fields SK, Collins CL, Dick RW, Comstock RD. Concussions among United States high school and collegiate athletes. Journal of Athletic Training 2007;42:495–503
  • Hootman JM, Dick R, Agel J. Epidemiology of collegiate injuries for 15 sports: Summary and recommendations for injury prevention initiatives. Journal of Athletic Training 2007;42:311–319
  • Barth JT, Freeman, JR, Broshek DK, Varney RN. Acceleration-deceleration sport-related concussion: The gravity of it all. Journal of Athletic Training 2001;36:253–256
  • Tierney RT, Higgings M, Caswell SV, Brady J, McHardy K, Driban JB, Darvish K. Sex differences in head acceleration during heading while wearing soccer headgear. Journal of Athletic Training 2008;42:578–584
  • Tierney RT, Sitler MR, Swanik CB, Swanik KA, Higgings M, Torg J. Gender differences in head-neck segment dynamic stabilization during head acceleration. Medicine and Science in Sports and Exercise 2005;37:272–279
  • Garces GL, Medina D, Milutinovic L, Garavote P, Guerado E. Normative database of isometric cervical strength in a healthy population. Medicine and Science in Sports and Exercise 2002;34:464–480
  • Barnes BC, Cooper L, Kirkendall DT, McDermott TP, Jordan BD, Garrett WE. Concussion history in elite male and female soccer players. American Journal of Sports Medicine 1998;26:433–438
  • Broshek DK, Kaushik T, Freeman JR, Erlanger D, Webbe F, Barth JT. Sex differences in outcome following sports-related concussion. Journal of Neurosurgery 2005;102:856–863
  • Colvin AC, Mullen J, Lovell M, Vereeke West R, Collins MW, Groh M. The role of concussion history and gender in recovery from soccer-related concussion. American Journal of Sports Medicine 2009;37:1699–1704
  • Preiss-Farzanegan SJ, Chapman B, Wong TM, Wu J, Bazarian JJ. The relationship between gender and postconcussion symptoms after sport-related mild traumatic brain injury. Physical Medicine & Rehabilitation 2009;1:245–53
  • Farace E, Alves WM. Do women fare worse: A metaanalysis of gender differences in traumatic brain injury outcome. Journal of Neurosurgery 2000;93:539–545
  • Covassin T, Elbin RJ, Larson E, Kontos AP. Sex and age differences in depression and baseline sport-related concussion neurocognitive performance and symptoms. Clinical Journal of Sport Medicine 2012;22:98–104
  • Esposito G, Van Horn JD, Weinberger DR, Berman KF. Gender differences in cerebral blood flow as a function of cognitive state with PET. Journal of Nuclear Medicine 1996;37:559–564
  • Rabadi MH, Jordan BD. The cumulative effect of repetitive concussion in sports. Clinical Journal of Sport Medicine 2001;11:194–198
  • Guskiewicz K, Marshall S, Bailes J. Association between recurrent concussion and late-life cognitive impairment in retired professionnal football players. Neurosurgery 2005;57:719–726
  • McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury. Journal of Neuropathology & Experimental Neurology 2009;68:709–735
  • Omalu B, Bailes J, Hamilon RL, Kamboh MI, Hammers J, Case M, Fitzsimmons R. Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes. Neurosurgery 2011;69:173–183
  • Tremblay S, De Beaumont L, Henry LC, Boulanger Y, Evans AC, Bourgoin P, Poirier J, Théoret H, Lassonde M. Sports concussions and aging: A neuroimaging investigation. Cerebral Cortex 2012; 23: 1159--1166
  • De Beaumont L, Théoret H, Mongeon D, Messier J, Leclerc S, Tremblay S, Ellemberg D, Lassonde M. Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood. Brain 2009;132:695–708
  • Gao S, Hendrie HC, Hall KS, Hui S. The relationships between age, sex, and the incidence of dementia and Alzheimer Disease. Archives of General Psychiatry 1998;55:809–815
  • Henry LC, Tremblay S, Leclerc S, Khiat A, Boulanger Y, Ellemberg D, Lassonde M. Metabolic changes in concussed American football players during the acute and chronic post-injury phases. BMC Neurology 2011;11:105–114
  • Vagnozzi R, Signoretti S, Tavazzi B, Floris R, Ludovici A, Marziali S, Tarascio G, Amorini AM, Di Pietro V, Delfini R, et al. Temporal window of metabolic brain vulnerability to concussion: A pilot 1H-magnetic resonance spectroscopic study in concussed athletes - part III. Neurosurgery 2008;62:1286–1295
  • Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgro E, Ria A, Marziale S, Zoccatelli G, Tavazzi B, et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain 2010;133:3232–3243
  • Toga AW, Mazziotta JC. Brain mapping: The methods. 2nd ed. San Diego, CA: Academic Press; 2002
  • Badar-Goffer RS, Ben-Yoseph O, Bachelard HS, Morris PG. Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. study. Biochemical Journal 1992;282:225–230
  • Xu S, Zhuo J, Racz J, Shi D, Roys S, Fiskum G, Gullapalli R. Early microstructural and metabolic changes following controlled cortical impact injury in rat: A magnetic resonance imaging and spectroscopy study. Journal of Neurotrauma 2011;28:2091–2102
  • Castillo M, Smith JK, Kwock L. Correlation of myo-inositol levels and grading of cerebral astrocytomas. AJNR American Journal of Neuroradioloy 2000;21:1645–1649
  • Henry LC, Tremblay J, Tremblay S, Lee A, Brun C, Lepore N, Theoret H, Ellemberg D, Lassonde M. Acute and chronic changes in diffusivity measures after sports concussion. Journal of Neurotrauma 2011;28:2049–2059
  • Cubon VA, Putukian M, Boyer C, Dettwiler A. A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. Journal of Neurotrauma 2011;28:189–201
  • Zhang K, Johnson B, Pennell D, Ray W, Sebastianelli W, Slobounov S. Are functional deficits in concussed individuals consistent with white matter structural alterations: Combined FMRI & DTI study. Experimental Brain Research 2010;204:57–70
  • Shenton ME, Hamoda HM, Schneiderman JS, Brouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, et al. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior 2012;6:137–192
  • Dupuis F, Johnston KM, Lavoie M, Lepore F, Lassonde M. Concussions in athletes produce brain dysfunction as revealed by event-related potentials. NeuroReport 2000;11:4087–4092
  • Gaetz M, Weinberg H. Electrophysiological indices of persistent post-concussion symptoms. Brain Injury 2000;14:815–832
  • Chen JK, Johnston KM, Collie A, McCrory P, Ptito A. A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI. Journal of Neurology, Neurosurgery and Psychiatry 2007;78:1231–1238
  • Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: An fMRI study. NeuroImage 2004;22:68–82
  • Chen JK, Johnston KM, Petrides M, Ptito A. Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Archives of General Psychiatry 2008;65:81–89
  • Jantzen, KJ, Anderson B, Steinberg FL, Kelso JA. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR American Journal of Neuroradioloy 2004;25:738–745
  • Lovell MR, Pardini JE, Welling J, Collins MW, Bakal J, Lazar N, Roush R, Eddy WF, Becker JT. Functional brain abnormalities are related to clinical recovery and time to return-to-play in athletes. Neurosurgery 2007;61:352–359
  • Barr M. The human nervos system: An anatomical viewpoint. 8th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2005
  • Kandel E, Schwartz J, Jessell, T. Principles of neuroscience. 4th ed. New York: McGraw-Hill; 2000
  • Ducreux D, Huynh I, Fillard P, Renoux J, Petit-Lacour MC, Marsot-Dupuch K, Lasjaunias P. Brain MR diffusion tensor imaging and fibre tracking to differentiate between two diffuse axonal injuries. Neuroradiology 2005;47:604–608
  • Wilde EA, McCauley SR, Hunter JV, Bigler ED, Chu Z, Wang ZJ, Hanten GR, Troyanskaya M, Yallampalli R, Li X, et al. Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology 2008;70:948–955
  • Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine 1993;3:672–679
  • Zimmerman ME, Pan JW, Heterington HP, Katz MJ, Verghese J, Buschke H, Derby CA, Lipton RB. Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology 2008;70:1594–1600
  • King KG, Glodzik L, Liu S, Babb JS, de Leon MJ, Gonen O. Anteroposterior hippocampal metabolic heterogeneity: Three-dimensional multivoxel proton 1H MR spectroscopic imaging–initial findings. Radiology 2008;249:242–250
  • Szentkuti A, Guderian S, Schiltz K, Kaufmann J, Munte TF, Heinze HJ, Duzel E. Quantitative MR analyses of the hippocampus: Unspecific metabolic changes in aging. Journal of Neurology 2004;251:1345–1353
  • Geurts JJ, Barkhof F, Castelijns JA, Uitdehaag BM, Polman CH, Pouwels PJ. Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: Metabolite concentrations, quantification precision, and reproducibility. Journal of Magnetic Resonance Imaging 2004;20:366–371
  • Braun CM, Boulanger Y, Labelle M, Khiat A, Dumont M, Mailloux C. Brain metabolic differences as a function of hemisphere, writing hand preference, and gender. Laterality 2002;7:97–113
  • Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, et al. Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–1505
  • Smith SM, Jenkinson M, Woolrich MW, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23:S208–219
  • Smith SM. Fast robust automated brain extraction. FMRIB Centre, Oxford, United Kingdom. Human Brain Mapping 2002;17:143–155
  • Andersson JLR, Jenkinson M, Smith S. Non-linear optimization. FMRIB technical report TR07JA9. 2007. FMRIB Centre, Oxford, United Kingdom. Available online at: www.fmrib.ox.ac.uk/analyis/techrep, [last accessed 8 Oct 2011]
  • Andersson JLR, Jenkinson M, Smith S. Non-linear registration, aka Spatial normalization. FMRIB technical report TR07JA2. FMRIB Centre, Oxford, United Kingdom. 2007. Available online at: www.fmrib.ox.ac.uk/analysis/techrep, [last accessed 8 Oct 2011]
  • Rueckert D, Sonoda LI, Hayes C, Hill DL, Leach MO, Hawkes DJ. Nonrigid registration using free-form deformations: Application to breast MR images. IEEE Transactions in Medical Imaging 1999;18:712–721
  • Hofer S, Frahm J. Topography of the human corpus callosum revisited–comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage 2006;32:989–994
  • Bear MF, Connors BW, Paradiso MA. Neuroscience: Exploring the brain. 3rd ed. Baltimore, MD: Lippincott Williams and Wilking; 2007
  • Venkatachalam MA, Buja M. Cellular injury and cellular death. In: Cotran RS, Kumar V, Robbins SL, Schoen FJ, editors. Robbins pathologic basis of disease. Philadelphia, PA: WB Saunders; 1994. p 1–34
  • Messe A, Caplain S, Paradot G, Garrigue D, Mineo JF, Soto Ares G, Ducreux D, Vignaud F, Rozec G, Desal H, et al. Diffusion tensor imaging and white matter lesions at the subacute stage in mild traumatic brain injury with persistent neurobehavioral impairment. Human Brain Mapping 2010;32:999–1011
  • Inglese M, Makani S, Johnson G, Cohen BA, Silver JA, Gonen O, Grossman RI. Diffuse axonal injury in mild traumatic brain injury: A diffusion tensor imaging study. Journal of Neurosurgey 2005;103:298–303
  • Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637–648
  • Lipton ML, Gellella E, Lo C, Gold T, Ardekani BA, Shifteh K, Bello JA, Branch CA. Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: A voxel-wise analysis of diffusion tensor imaging. Journal of Neurotrauma 2008;25:1335–1342
  • Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ. Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 2010;133:528–539
  • Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR in Biomedicine 2002;15:435–455
  • Bayly PV, Cohen TS, Leister EP, Ajo D, Leuthardt E, Genin GM. Deformation of the human brain induced by mild acceleration. Journal of Neurotrauma 2005;22:845–856
  • Kraus MF, Susmaras T, Caughlin BP, Walker CJ, Sweeney JA, Little DM. White matter integrity and cognition in chronic traumatic brain injury: A diffusion tensor imaging study. Brain 2007;130:2508–2519
  • Sabet AA, Christoforou E, Zatlin B, Genin GM, Bayly PV. Deformation of the human brain induced by mild angular head acceleration. Journal of Biomechanics 2008;41:307–315
  • Bazarian JJ, Zhu T, Blyth B, Borrino A, Zhong J. Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion. Magnetic Resonance Imaging 2012;30:171–180

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.