Interleukin-6 prevents NMDA-induced neuronal Ca²⁺ overload via suppression of IP3 receptors

References

• Gadient RA, Otten UH. Interleukin-6 (IL-6) – a molecule with both beneficial and destructive potentials. Progress in Neurobiology 1997;52:379–390
   PubMed Web of Science ®Google Scholar
• Gruol DL, Nelson TE. Physiological and pathological roles of interleukin-6 in the central nervous system. Molecular Neurobiology 1997;15:307–339
   PubMed Web of Science ®Google Scholar
• Benveniste EN. Cytokine actions in the central nervous system. Cytokine & Growth Factor Reviews 1998;9:259–275
   PubMed Web of Science ®Google Scholar
• Van Wagoner NJ, Benveniste EN. Interleukin-6 expression and regulation in astrocytes. Journal of Neuroimmunology 1999;100:124–139
   PubMed Web of Science ®Google Scholar
• Ali C, Nicole O, Docagne F, Lesne S, MacKenzie ET, Nouvelot A, Buisson A, Vivien D. Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. Journal of Cerebral Blood Flow & Metabolism 2000;20:956–966
   PubMed Web of Science ®Google Scholar
• Baker DG, Ekhator NN, Kasckow JW, Hill KK, Zoumakis E, Dashevsky BA, Chrousos GP, Geracioti TD Jr. Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation 2001;9:209–217
   PubMed Web of Science ®Google Scholar
• Mutlu LK, Woiciechowsky C, Bechmann I. Inflammatory response after neurosurgery. Best Practice & Research Clinical Anaesthesiology 2004;18:407–424
   PubMedGoogle Scholar
• Nakamachi T, Tsuchida M, Kagami N, Yofu S, Wada Y, Hori M, Tsuchikawa D, Yoshikawa A, Imai N, Nakamura K, Arata S, Shioda S. IL-6 and PACAP receptor expression and localization after global brain ischemia in mice. Journal of Molecular Neuroscience 2012;48:518--525. Available online at: http://www.springerlink.com/10.1007/s12031-012-9819-0, accessed 6 June 2012
   Google Scholar
• Penkowa M, Giralt M, Carrasco J, Hadberg H, Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 2000;32:271–285
   PubMed Web of Science ®Google Scholar
• Herrmann O, Tarabin V, Suzuki S, Attigah N, Coserea I, Schneider A, Vogel J, Prinz S, Schwab S, Monyer H, et al. Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 2003;23:406–415
   PubMed Web of Science ®Google Scholar
• Spittau B, Zhou X, Ming M, Krieglstein K. IL6 protects MN9D cells and midbrain dopaminergic neurons from MPP+-induced neurodegeneration. Neuromolecular Medicine 2012;14:317--327. Available online at: http://www.springerlink.com/10.1007/s12017-012-8189-7, accessed 8 July 2012
   Google Scholar
• Bensadoun JC, de Almeida LP, Dreano M, Aebischer P, Deglon N. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington’s syndrome. European Journal of Neuroscience 2001;14:1753–1761
   PubMed Web of Science ®Google Scholar
• Inomata Y, Hirata A, Yonemura N, Koga T, Kido N, Tanihara H. Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage. Biochemical & Biophysical Research Communications 2003;302:226–232
   PubMed Web of Science ®Google Scholar
• Peng YP, Qiu YH, Lu JH, Wang JJ. Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neuroscience Letters 2005; 374:192–196
   PubMed Web of Science ®Google Scholar
• Wang XQ, Peng YP, Lu JH, Cao BB, Qiu YH. Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK. Neuroscience Letters 2009;450:122–126
   PubMed Web of Science ®Google Scholar
• Liu Z, Qiu YH, Li B, Ma SH, Peng YP. Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms. Neurotoxicity Research 2011;19:484–495
   PubMed Web of Science ®Google Scholar
• Suzuki S, Tanaka K, Suzuki N. Ambivalent aspects of interleukin-6 in cerebral ischemia: Inflammatory versus neurotrophic aspects. Journal of Cerebral Blood Flow & Metabolism 2009;29:464–479
   PubMed Web of Science ®Google Scholar
• Spooren A, Kolmus K, Laureys G, Clinckers R, De Keyser J, Haegeman G, Gerlo S. Interleukin-6, a mental cytokine. Brain Research Reviews 2011;67:157–183
   PubMed Web of Science ®Google Scholar
• Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003;34:325–337
   PubMed Web of Science ®Google Scholar
• Qiu Z, Gruol DL. Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons. Journal of Neuroimmunology 2003;139:51–57
   PubMed Web of Science ®Google Scholar
• Cucchiaroni ML, Viscomi MT, Bernardi G, Molinari M, Guatteo E, Mercuri NB. Metabotropic glutamate receptor 1 mediates the electrophysiological and toxic actions of the cycad derivative beta-N-methylamino-L-alanine on substantia nigra pars compacta DAergic neurons. Journal of Neuroscience 2010;30:5176–5188
   PubMed Web of Science ®Google Scholar
• Wang XC, Qiu YH, Peng YP. Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity. Sheng Li Xue Bao 2007;59:150–156
   PubMedGoogle Scholar
• Qiu Z, Parsons KL, Gruol DL. Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. Journal of Neuroscience 1995;15:6688–6699
   PubMed Web of Science ®Google Scholar
• Qiu Z, Sweeney DD, Netzeband JG, Gruol DL. Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons. Journal of Neuroscience 1998;18:10445–10456
   PubMed Web of Science ®Google Scholar
• Verkhratsky A, Petersen OH. The endoplasmic reticulum as an integrating signaling organelle: From neuronal signaling to neuronal death. European Journal of Pharmacology 2002;447:141–154
   PubMed Web of Science ®Google Scholar
• Sun XM, Lu JH, Qiu YH, Liu Z, Wang XQ, Peng YP. Interleukin-6 reduces NMDA-induced Ca2+ overload via prevention of Ca2+ release from intracellular store. International Journal of Neuroscience 2011;121:423–429
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using Real-Time quantitative PCR and the 2-ΔΔCt method. Methods 2001;25:402–408
   PubMed Web of Science ®Google Scholar
• Hagar RE, Burgstahler AD, Nathanson MH, Ehrlich BE. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998;396:81–84
   PubMed Web of Science ®Google Scholar
• Yang J, Mcbride S, Mark DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor (Ca2+) release channels. Proceedings of the National Academy of Sciences USA 2002;99:7711–7716
   PubMed Web of Science ®Google Scholar
• Bootman MD, Berridge MJ, Roderick HL. Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate. Proceedings of the National Academy of Sciences USA 2002;99:7320–7322
   PubMed Web of Science ®Google Scholar
• Kasri NN, Holmes AM, Bultynck G, Parys JB, Bootman MD, Rietdorf K, Missiaen L, McDonald F, De Smedt H, Conway SJ, et al. Regulation of InsP3 receptor activicity by neuronal Ca2+-binding proteins. EMBO Journal 2004;23:312–321
   PubMed Web of Science ®Google Scholar
• Popescu AT, Saghyan AA, Nagy FZ, Paré D. Facilitation of corticostriatal plasticity by the amygdala requires Ca2+-induced Ca2+ release in the ventral striatum. Journal of Neurophysiology 2010;104:1673–1680
   PubMed Web of Science ®Google Scholar
• Gruol DL, Netzeband JG, Nelson TE. Somatic Ca2+ signaling in cerebellar Purkinje neurons. Journal of Neuroscience Research 2010;88:275–289
   PubMed Web of Science ®Google Scholar
• Nakata H, Nakamura S. Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling. FEBS Letters 2007;581:2047–2054
   PubMed Web of Science ®Google Scholar
• Turovskaya MV, Turovsky EA, Zinchenko VP, Levin SG, Godukhin OV. Interleukin-10 modulates [Ca2+]i response induced by repeated NMDA receptor activation with brief hypoxia through inhibition of InsP(3)-sensitive internal stores in hippocampal neurons. Neuroscience Letters 2012;516:151–155
   PubMed Web of Science ®Google Scholar
• Moriyoshi K, Masu M, Ishii T, Shigemono R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature 1991;354:31–37
   PubMed Web of Science ®Google Scholar
• Resink A, Villa M, Boer GJ, Möhler H, Balázs R. Agonist-induced down regulation of NMDA receptors in cerebellar granule cell cultures. European Journal of Neuroscience 1995;7:1700–1706
   PubMed Web of Science ®Google Scholar
• Resink A, Villa M, Benke D, Hidaka H, Möhler H, Balázs R. Characterization of agonist-induced down regulation of NMDA receptors in cerebellar granule cell cultures. Journal of Neurochemistry 1996;66:369–377
   PubMed Web of Science ®Google Scholar
• Brandoli C, Sanna A, De Bernardi MA, Follesa P, Brooker G, Mocchetti I. Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. Journal of Neuroscience 1998;18:7953–7961
   PubMed Web of Science ®Google Scholar
• Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature 1992;358:36–42
   PubMed Web of Science ®Google Scholar
• Monyer H, Sprengel R, Schoepfer R, Herb A, Higuci M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 1992;256:1217–1221
   PubMed Web of Science ®Google Scholar
• Hollmann M, Heinemann H. Cloned glutamate receptors. Annual Review of Neuroscience 1994;17:31–108
   PubMed Web of Science ®Google Scholar
• Genazzani AA, Carafoli E, Guerini D. Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. Proceedings of the National Academy of Science USA 1999;96:5797–5801
   PubMed Web of Science ®Google Scholar
• Gruol DL, Puro A, Hao C, Blakely P, Janneke E, Vo K. Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6. Journal of Neuroimmunology 2011;239:28–36
   PubMed Web of Science ®Google Scholar
• Mhyre TR, Maine DN, Holliday J. Calcium-induced calcium release from intracellular stores is developmentally regulated in primary cultures of cerebellar granule neurons. Journal of Neurobiology 2000;42:134–147
   PubMedGoogle Scholar