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Review Article

S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis

, , , , , , & show all
Pages 1146-1157 | Received 23 Sep 2014, Accepted 31 Mar 2015, Published online: 11 Jun 2015

References

  • Kraus JF, McArthur DL. Epidemiology of brain injury. Neurological Trauma 1996;2:3–18
  • Corrigan JD, Selassie AW, Orman JAL. The epidemiology of traumatic brain injury. Journal of Head Trauma Rehabilitation 2010;25:72–80
  • Thornhill S, Teasdale GM, Murray GD, McEwen J, Roy CW, Penny KI. Disability in young people and adults one year after head injury: Prospective cohort study. British Medical Journal 2000;320:1631–1635
  • Borczuk P. Predictors of intracranial injury in patients with mild head trauma. Annals of Emergency Medicine 1995;25:731–736
  • Stein SC, Ross SE. The value of computed tomographic scans in patients with low-risk head injuries. Neurosurgery 1990;26:638–640
  • Smith-Bindman R. Is computed tomography safe. New England Journal of Medicine 2010;363:1–4
  • Reinus WR, Wippold II FJ, Erickson KK. Practical selection criteria for noncontrast cranial computed tomography in patients with head trauma. Annals of Emergency Medicine 1993;22:1148–1155
  • Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M, Fujita M, Izumi T, Maekawa T. Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. Journal of Trauma 2010;69:104–109
  • Gyorgy A, Ling G, Wingo D, Walker J, Tong L, Parks S, Januszkiewicz A, Baumann R, Agoston DV. Time-dependent changes in serum biomarker levels after blast traumatic brain injury. Journal of Neurotrauma 2011;28:1121–1126
  • Ingebrigtsen T, Romner B, Marup-Jensen S, Dons M, Lundqvist C, Bellner J, Alling C, Børgesen SE. The clinical value of serum S-100 protein measurements in minor head injury: A Scandinavian multicentre study. Brain Injury 2000;14:1047–1055
  • Böhmer AE, Oses JP, Schmidt AP, Perón CS, Krebs CL, Oppitz PP, D'Avila TT, Souza DO, Portela LV, Stefani MA. Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery 2011;68:1624–1631
  • Szymanski PT, Kuppast B, Ahmed SA, Khalifa S, Fahmy H. Sarcophine-Diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma B16F10 Cell Line. Marine Drugs 2011;10:1–19
  • Dempsey BR, Shaw GS. Identification of calcium-independent and calcium-enhanced binding between S100B and the dopamine D2 receptor. Biochemistry 2011;50:9056–9065
  • Zongo D, Ribéreau-Gayon R, Masson F, Laborey M, Contrand B, Salmi LR, Montaudon D, Beaudeux JL, Meurin A, Dousset V, Loiseau H, Lagarde E. S100-B protein as a screening tool for the early assessment of minor head injury. Annals of Emergency Medicine 2012;59:209–218
  • Zhang Z, Li W, Mu J, Song J. Increased serum S100B concentration correlates with hippocampal S100B overexpression and cellular damage following chronic cerebral hypoperfusion. Neurology, Psychology & Brain Research 2012;18:114–119
  • Koh SX, Lee JK. S100B as a marker for brain damage and blood–brain barrier disruption following exercise. Sports Medicine 2014;44:369–385
  • Undén J, Romner B. Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: An evidence-based review and meta-analysis. Journal of Head Trauma Rehabilitation 2010;25:228–240
  • Heidari K, Asadollahi S, Jamshidian M, Abrishamchi SN, Nouroozi M. Prediction of neuropsychological outcome after mild traumatic brain injury using clinical parameters, serum S100B protein and findings on computed tomography. Brain Injury 2014;10:1–8
  • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Annals of International Medicine 2009;151:W-65–W-94
  • Viswanathan M, Ansari MT, Berkman ND, Chang S, Hartling L, McPheeters LM, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze A, et al. Agency for Healthcare Research and Quality Methods Guide for Comparative Effectiveness Reviews. Rockville, MC: Quality AfHRa; 2012
  • Vos PE, Battistin L, Birbamer G, Gerstenbrand F, Potapov A, Prevec T, Stepan ChA, Traubner P, Twijnstra A, Vecsei L, et al.; European Federation of Neurological Societies. EFNS guideline on mild traumatic brain injury: Report of an EFNS task force. European Journal of Neurology 2002;9:207–219
  • Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0. The Cochrane Collaboration; 2011 . [2011-03-01]. http://www.cochrane/hand-book.org. accessed 2013
  • Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Medical Research Methodology 2005;5:13
  • Sistrom CL, Mergo PJ. A simple method for obtaining original data from published graphs and plots. American Journal of Roentgenology 2000;174:1241–1244
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. British Medical Journal 2003;327:557--560
  • Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. British Medical Journal 1997;315:629–634
  • Babcock L, Byczkowski T, Wade SL, Ho M, Bazarian JJ. Inability of S100B to predict postconcussion syndrome in children who present to the emergency department with mild traumatic brain injury: A brief report. Pediatric Emergency Care 2013;29:458–461
  • Bazarian JJ, Beck C, Blyth B, von Ahsen N, Hasselblatt M. Impact of creatine kinase correction on the predictive value of S-100B after mild traumatic brain injury. Restorative Neurology & Neuroscience 2006;24:163–172
  • Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Injury 2006;20:759–765
  • Begaz T, Kyriacou DN, Segal J, Bazarian JJ. Serum biochemical markers for post-concussion syndrome in patients with mild traumatic brain injury. Journal of Neurotrauma 2006;23:1201–1210
  • Biberthaler P, Mussack T, Wiedemann E, Gilg T, Soyka M, Koller G, Pfeifer KJ, Linsenmaier U, Mutschler W, Gippner-Steppert C, et al. Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma. Shock 2001;16:97–101
  • Bouvier D, Fournier M, Dauphin JB, Amat F, Ughetto S, Labbé A, Sapin V. Serum S100B determination in the management of pediatric mild traumatic brain injury. Clinical Chemistry 2012;58:1116–1122
  • Calcagnile O, Unden L, Unden J. Clinical validation of S100B use in management of mild head injury. BMC Emergency Medicine 2012;12:13
  • Castellani C, Bimbashi P, Ruttenstock E, Sacherer P, Stojakovic T, Weinberg AM. Neuroprotein s-100B -- a useful parameter in paediatric patients with mild traumatic brain injury? Acta Paediatrica 2009;98:1607–1612
  • de Boussard CN, Lundin A, Karlstedt D, Edman G, Bartfai A, Borg J. S100 and cognitive impairment after mild traumatic brain injury. Journal of Rehabilitation Medicine 2005;37:53–57
  • de Kruijk JR, Leffers P, Menheere PP, Meerhoff S, Twijnstra A. S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with health controls. Acta Neurologica Scandinavica 2001;103:175–179
  • Geyer C, Ulrich A, Grafe G, Stach B, Till H. Diagnostic value of S100B and neuron-specific enolase in mild pediatric traumatic brain injury. Journal of Neurosurgery: Pediatrics 2009;4:339–344
  • Hinkle DA, Baldwin SA, Scheff SW, Wise PM. GFAP and S100beta expression in the cortex and hippocampus in response to mild cortical contusion. Journal of Neurotrauma 1997;14:729–738
  • Ingebrigtsen T, Romner B. Should brain injury markers replace CT in mild head injury? Tidsskr Nors Laegeforen 2012;132:1948–1949
  • Kleinert K, Schleich F, Biasca N, Simmen HP. Is there a correlation between S100 beta and post-concussion symptoms after mild traumatic brain injury? Zentralbl Chir 2010;135:277–278
  • Leidel BA, Bogner V, Zock M, Kanz KG. Serological determination of protein S100B. Significance in emergency diagnosis of adults with mild craniocerebral trauma--meta-analysis. Der Unfallchirurg 2012;115:903–912
  • Lima DP, Simao Filho C, Abib Sde C, de Figueiredo LF. Quality of life and neuropsychological changes in mild head trauma. Late analysis and correlation with S100B protein and cranial CT scan performed at hospital admission. Injury 2008;39:604–611
  • Metting Z, Wilczak N, Rodiger LA, Schaaf JM, van der Naalt J. GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology 2012;78:1428–1433
  • Morochovic R, Rácz O, Kitka M, Pingorová S, Cibur P, Tomková D, Lenártová R. Serum S100B protein in early management of patients after mild traumatic brain injury. European Journal of Neurology 2009;16:1112–1117
  • Müller K, Ingebrigtsen T, Wilsgaard T, Wikran G, Fagerheim T, Romner B, Waterloo K. Prediction of time trends in recovery of cognitive function after mild head injury. Neurosurgery 2009;64:698–704
  • Nygren De Boussard C, Fredman P, Lundin A, Andersson K, Edman G, Borg J. S100 in mild traumatic brain injury. Brain Injury 2004;18:671–683
  • Ruan S, Noyes K, Bazarian JJ. The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumatic brain injury. Journal of Neurotrauma 2009;26:1655–1664
  • Savola O, Hillbom M. Early predictors of post-concussion symptoms in patients with mild head injury. European Journal of Neurology 2003;10:175–181
  • Shima K. Clinical standard of neurosurgical disorder. (2) Management of mild traumatic brain injury. No Shinkei Geka 2009;37:95–104
  • Sojka P, Stalnacke BM, Bjornstig U, Karlsson K. One-year follow-up of patients with mild traumatic brain injury: Occurrence of post-traumatic stress-related symptoms at follow-up and serum levels of cortisol, S-100B and neuron-specific enolase in acute phase. Brain Injury 2006;20:613–620
  • Stalnacke BM, Bjornstig U, Karlsson K, Sojka P. One-year follow-up of mild traumatic brain injury: Post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase. Journal of Rehabilitation Medicine 2005;37:300–305
  • Stapert S, de Kruijk J, Houx P, Menheere P, Twijnstra A, Jolles J. S-100B concentration is not related to neurocognitive performance in the first month after mild traumatic brain injury. European Neurology 2005;53:22–26
  • Stranjalis G, Korfias S, Papapetrou C, Kouyialis A, Boviatsis E, Psachoulia C, Sakas DE. Elevated serum S-100B protein as a predictor of failure to short-term return to work or activities after mild head injury. Journal of Neurotrauma 2004;21:1070–1075
  • Talypov AE, Puras IuV, Godkov MA, Sharifullin FA, Kuksova NS, Sosnovskiĭ EA, Krylov VV. Levels of S100beta protein in patients with mild traumatic brain injury. Journal of Trauma and Acute Care Surgery 2010;110:4–8
  • Topolovec-Vranic J, Pollmann-Mudryj MA, Ouchterlony D, Klein D, Spence J, Romaschin A, Rhind S, Tien HC, Baker AJ. The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. Journal of Trauma 2011;71(5 Suppl 1):S478–S486
  • Wolf H, Frantal S, Pajenda GS, Salameh O, Widhalm H, Hajdu S, Sarahrudi K. Predictive value of neuromarkers supported by a set of clinical criteria in patients with mild traumatic brain injury: S100B protein and neuron-specific enolase on trial: Clinical article. Journal of Neurosurgery 2013;118:1298–1303
  • Beaudeux JL. S100B protein: A novel biomarker for the diagnosis of head injury. Annals of Pharmaceutiques Francaises 2009;67:187–194
  • Beharier O, Kahn J, Shusterman E, Sheiner E. S100B - a potential biomarker for early detection of neonatal brain damage following asphyxia. Journal of Maternal-Fetal & Neonatal Medicine 2012;25:1523–1538
  • Bennet L, Booth L, Gunn AJ. Potential biomarkers for hypoxic-ischemic encephalopathy. Seminars in Fetal & Neonatal Medicine 2010;15:253–260
  • Berger R. Biomarkers or neuroimaging in central nervous system injury: Will the real “gold standard” please stand up? Pediatric Critical Care Medicine 2003;4:391–392
  • Bramanti V, Tomassoni D, Avitabile M, Amenta F, Avola R. Biomarkers of glial cell proliferation and differentiation in culture. Frontiers in Bioscience (Scholar Edition) 2010;2:558–570
  • Cata JP, Abdelmalak B, Farag E. Neurological biomarkers in the perioperative period. British Journal of Anaesthesia 2011;107:844–858
  • Einav S, Kaufman N, Algur N, Kark JD. Modeling serum biomarkers S100 beta and neuron-specific enolase as predictors of outcome after out-of-hospital cardiac arrest: An aid to clinical decision making. Journal of the American College of Cardiology 2012;60:304–311
  • Fenton K. Sepsis and the BBB: Brain injury, biomarkers, and the bedside. Critical Care Medicine 2006;34:2022–2023
  • Finnoff JT, Jelsing EJ, Smith J. Biomarkers, genetics, and risk factors for concussion. Physical Medicine & Rehabilitation 2011;3(10 Suppl 2):S452–459
  • Graham MR, Myers T, Evans P, Davies B, Cooper SM, Bhattacharya K, Grace FM, Baker JS. Direct hits to the head during amateur boxing is associated with a rise in serum biomarkers for brain injury. International Journal of Immunopathology & Pharmacology 2011;24:119–125
  • Laskowitz DT, Kasner SE, Saver J, Remmel KS, Jauch EC, Group BS. Clinical usefulness of a biomarker-based diagnostic test for acute stroke: The Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study. Stroke 2009;40:77–85
  • Liao CW, Fan CK, Kao TC, Ji DD, Su KE, Lin YH, Cho WL. Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infectious Diseases 2008;8:84
  • Lo TY, Jones PA, Minns RA. Combining coma score and serum biomarker levels to predict unfavorable outcome following childhood brain trauma. Journal of Neurotrauma 2010;27:2139–2145
  • Massaro AN, Chang T, Kadom N, Tsuchida T, Scafidi J, Glass P, McCarter R, Baumgart S, Vezina G, Nelson KB. Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia. Journal of Pediatrics 2012;161:434–440
  • Michetti F, Corvino V, Geloso MC, Lattanzi W, Bernardini C, Serpero L, Gazzolo D. The S100B protein in biological fluids: More than a lifelong biomarker of brain distress. Journal of Neurochemistry 2012;120:644–659
  • Neselius S, Brisby H, Theodorsson A, Blennow K, Zetterberg H, Marcusson J. CSF-biomarkers in Olympic boxing: Diagnosis and effects of repetitive head trauma. PLoS One 2012;7:e33606
  • Niyonkuru C, Wagner AK, Ozawa H, Amin K, Goyal A, Fabio A. Group-based trajectory analysis applications for prognostic biomarker model development in severe TBI: A practical example. Journal of Neurotrauma 2013;30:938–945
  • Palmio J, Huuhka M, Laine S, Huhtala H, Peltola J, Leinonen E, Suhonen J, Keränen T. Electroconvulsive therapy and biomarkers of neuronal injury and plasticity: Serum levels of neuron-specific enolase and S-100b protein. Psychiatry Research 2010;177:97–100
  • Petzold A, Stiefel D, Copp AJ. Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. Journal of Neurochemistry 2005;95:594–598
  • Ramaswamy V, Horton J, Vandermeer B, Buscemi N, Miller S, Yager J. Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatric Neurology 2009;40:215–226
  • Redl H, Pelinka L, Bahrami S. To be or not to be--a biomarker of brain damage in sepsis. Pediatric Critical Care Medicine 2008;9:337–339
  • Risso FM, Sannia A, Gavilanes DA, Vles HJ, Colivicchi M, Ricotti A, Li Volti G, Gazzolo D. Biomarkers of brain damage in preterm infants. Journal of Maternal-Fetal & Neonatal Medicine 2012;25(Suppl 4):101–104
  • Sanfilippo F, Li Volti G, Ristagno G, Murabito P, Pellis T, Astuto M, Gullo A. Clinical biomarkers in brain injury: A lesson from cardiac arrest. Frontiers in Biosciences (Scholar Edition) 2010;2:623–640
  • Seco M, Edelman JJ, Wilson MK, Bannon PG, Vallely MP. Serum biomarkers of neurologic injury in cardiac operations. Annals of Thoracic Surgery 2012;94:1026–1033
  • Shirasaki Y, Edo N, Sato T. Serum S-100b protein as a biomarker for the assessment of neuroprotectants. Brain Research 2004;1021:159–166
  • Taira BR. Annals of Emergency Medicine Journal Club. Biomarkers revisited: Study design, validity and STARD. Will S100-B impact computed tomography use in head injury patients? Annals of Emergency Medicine 2012;59:221–222
  • Taira BR, Schriger DL. Annals of Emergency Medicine Journal Club. Biomarkers revisited: Study design, validity, and STARD: Will S100-B affect computed tomography use in head injury patients?: Answers to the March 2012 Journal Club questions. Annals of Emergency Medicine 2012;60:236–240
  • Tasker RC. Validating serologic biomarkers of brain injury for cardiac arrest research. Pediatric Critical Care Medicine 2009;10:529–530
  • Undén J, Strandberg K, Malm J, Campbell E, Rosengren L, Stenflo J, Norrving B, Romner B, Lindgren A, Andsberg G. Explorative investigation of biomarkers of brain damage and coagulation system activation in clinical stroke differentiation. Journal of Neurology 2009;256:72–77
  • Ingebrigtsen T, Waterloo K, Jacobsen EA, Langbakk B, Romner B. Traumatic brain damage in minor head injury: Relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioral outcome. Neurosurgery 1999;45:468–475
  • Mussack T, Biberthaler P, Wiedemann E, Kanz KG, Englert A, Gippner-Steppert C, Jochum M. S-100b as a screening marker of the severity of minor head trauma (MHT)--a pilot study. Acta Neurochirurgica Supplement 2000;76:393–396
  • Romner B, Ingebrigtsen T, Kongstad P, Borgesen SE. Traumatic brain damage: Serum S-100 protein measurements related to neuroradiological findings. Journal of Neurotrauma 2000;17:641–647
  • Herrmann M. High serum S100B levels for trauma patients without head injuries. Neurosurgery 2001;49:1272–1273
  • de Kruijk J, Leffers P, Menheere P, Meerhoff S, Rutten J, Twijnstra A. Prediction of post-traumatic complaints after mild traumatic brain injury: Early symptoms and biochemical markers. Journal of Neurology, Neurosurgery & Psychiatry 2002;73:727–732
  • Mussack T, Biberthaler P, Kanz KG, Heckl U, Gruber R, Linsenmaier U, Mutschler W, Jochum M. Immediate S-100B and neuron-specific enolase plasma measurements for rapid evaluation of primary brain damage in alcohol-intoxicated, minor head-injured patients. Shock 2002;18:395–400
  • Savola O, Hillbom M. Early predictors of post-concussion symptoms in patients with mild head injury. European Journal of Neurology 2003;10:175–181
  • Poli-de-Figueiredo LF, Biberthaler P, Simao Filho C, Hauser C, Mutschler W, Jochum M. Measurement of S-100B for risk classification of victims sustaining minor head injury--first pilot study in Brazil. Clinics (Sao Paulo) 2006;61:41–46
  • Stranjalis G, Korfias S, Psachoulia C, Kouyialis A, Sakas DE, Mendelow AD. The prognostic value of serum S-100B protein in spontaneous subarachnoid haemorrhage. Acta Neurochirurgica (Wien) 2007;149:231–237
  • Schultke E, Sadanand V, Kelly ME, Griebel RW, Juurlink BH. Can admission S-100beta predict the extent of brain damage in head trauma patients? Canadian Journal of Neurological Sciences 2009;36:612–616
  • Muller B, Evangelopoulos DS, Bias K, Wildisen A, Zimmermann H, Exadaktylos AK. Can S-100B serum protein help to save cranial CT resources in a peripheral trauma centre? A study and consensus paper. Emergency Medicine Journal 2011;28:938–940
  • Egea-Guerrero JJ, Revuelto-Rey J, Murillo-Cabezas F, Muñoz-Sánchez MA, Vilches-Arenas A, Sánchez-Linares P, Domínguez-Roldán JM, León-Carrión J. Accuracy of the S100beta protein as a marker of brain damage in traumatic brain injury. Brain Injury 2012;26:76–82
  • Zongo D, Ribéreau-Gayon R, Masson F, Laborey M, Contrand B, Salmi LR, Montaudon D, Beaudeux JL, Meurin A, Dousset V, Loiseau H, Lagarde E. S100-B protein as a screening tool for the early assessment of minor head injury. Annals of Emergency Medicine 2012;59:209–218
  • Müller K, Townend W, Biasca N, Undén J, Waterloo K, Romner B, Ingebrigtsen T. S100B serum level predicts computed tomography findings after minor head injury. Journal of Trauma & Acute Care Surgery 2007;62:1452–1456
  • Bazarian JJ, Blyth BJ, He H, Mookerjee S, Jones C, Kiechle K, Moynihan R, Wojcik SM, Grant WD, Secreti LM, et al. Classification accuracy of serum Apo A-I and S100B for the diagnosis of mild traumatic brain injury and prediction of abnormal initial head computed tomography scan. Journal of Neurotrauma 2013;30:1747–1754
  • Stranjalis G, Korfias S, Psachoulia C, Kouyialis A, Sakas D, Mendelow A. The prognostic value of serum S-100B protein in spontaneous subarachnoid haemorrhage. Acta Neurochirurgica (Wien) 2007;149:231–238
  • De Boussard C, Fredman P, Lundin A, Andersson K, Edman G, Borg J. S100 in mild traumatic brain injury. Brain Injury 2004;18:671–683
  • Cervellin G, Benatti M, Carbucicchio A, Mattei L, Cerasti D, Aloe R, Lippi G. Serum levels of protein S100B predict intracranial lesions in mild head injury. Clinical Biochemistry 2012;45:408–411
  • Bechtel K, Frasure S, Marshall C, Dziura J, Simpson C. Relationship of serum S100B levels and intracranial injury in children with closed head trauma. Pediatrics 2009;124:e697–e670104
  • Asadollahi S, Heidari K, Hatamabadi H, Jamshidian M, Vafaee A, Manoochehri M, Mohammad Seidabadi A, Habibzade Shojaee A, Nezafat T. Reducing head computed tomography after mild traumatic brain injury: Screening value of clinical findings and S100B protein levels. Manuscript submitted for publication. 2014
  • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine 2009;151:264–269
  • Müller K, Townend W, Biasca N, Undén J, Waterloo K, Romner B, Ingebrigtsen T. S100B serum level predicts computed tomography findings after minor head injury. Journal of Trauma 2007;62:1452–1456
  • Jagoda AS, Bazarian JJ, Bruns JJ Jr., Cantrill SV, Gean AD, Howard PK, Ghajar J, Riggio S, Wright DW, Wears RL, et al. Clinical policy: Neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting. Journal of Emergency Nursing 2009;35:e5–e40
  • Hall EJ, Brenner DJ. Cancer risks from diagnostic radiology. British Journal of Radiology 2008;81:362–378
  • Kuppermann N, Holmes JF, Dayan PS, Hoyle JD Jr., Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, et al. Identification of children at very low risk of clinically-important brain injuries after head trauma: A prospective cohort study. The Lancet 2009;374:1160–1170
  • Papa L, Ramia MM, Kelly JM, Burks SS, Pawlowicz A, Berger RP. Systematic review of clinical research on biomarkers for pediatric traumatic brain injury. Journal of Neurotrauma 2013;30:324–338
  • Filippidis AS, Papadopoulos DC, Kapsalaki EZ, Fountas KN. Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury. Neurosurgical Focus 2010;29:E2
  • Bouvier D, Castellani C, Fournier M, Dauphin JB, Ughetto S, Breton M, Labbé A, Weinberg AM, Sapin V. Reference ranges for serum S100B protein during the first three years of life. Clinical Biochemistry2011;44:927–929

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