Preliminary findings on biomarker levels from extracerebral sources in patients undergoing trauma surgery: Potential implications for TBI outcome studies

References

• Biberthaler P, Linsenmeier U, Pfeifer KJ, Kroetz M, Mussack T, Kanz KG, Hoecherl EF, Jonas F, Marzi I, Leucht P, et al.Serum S- 100B concentration provides additional information for the indication of computed tomography in patients after minor head injury: a prospective multicenter study. Shock 2006;25:446–453.
   PubMed Web of Science ®Google Scholar
• Wolf H, Frantal S, Pajenda GS, Salameh O, Widhalm H, Hajdu S, Sarahrudi K. Predictive value of neuromarkers supported by a set of clinical criteria in patients with mild traumatic brain injury: S100B protein and neuron- specific enolase on trial. Journal of Neurosurgery 2013;118:1298–1303.
   PubMed Web of Science ®Google Scholar
• Brophy GM, Mondello S, Papa L, Robicsek SA, Gabrielli A, Tepas J 3rd, Buki A, Robertson C, Tortella FC, Hayes RL, et al.Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids. Journal of Neurotrauma 2011;28:861–870.
   PubMed Web of Science ®Google Scholar
• Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M, Fujita M, Izumi T, Maekawa T. Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. Journal of Trauma 2010;69:104–109.
   PubMed Web of Science ®Google Scholar
• Papa L, Lewis LM, Falk JL, Zhang Z, Silvestri S, Giordano P, Brophy GM, Demery JA, Dixit NK, Ferguson I, et al.Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Annals of Emergency Medicine 2012;59:471–483.
   PubMed Web of Science ®Google Scholar
• Cao F, Yang XF, Liu WG, Hu WW, Li G, Zheng XJ, Shen F, Zhao XQ, Lv ST. Elevation of neuron-specific enolase and S-100beta protein level in experimental acute spinal cord injury. Journal of Clinical Neuroscience 2008;15:541–544.
   PubMed Web of Science ®Google Scholar
• Marquardt G, Setzer M, Theisen A, Tews DS, Seifert V. Experimental subacute spinal cord compression: correlation of serial S100B and NSE serum measurements, histopathological changes, and outcome. Neurological Research 2011;33:421–426.
   PubMed Web of Science ®Google Scholar
• Marquardt G, Setzer M, Szelenyi A, Seifert V, Gerlach, R. Prognostic relevance of serial S100b and NSE serum measurements in patients with spinal intradural lesions. Neurological Research 2009;31:265–269.
   PubMed Web of Science ®Google Scholar
• Savola O, Pyhtinen J, Leino TK, Siitonen S, Niemelä O, Hillbom M. Effects of head and extracranial injuries on serum protein S100B levels in trauma patients. Journal of Trauma 2004;56:1229–1234.
   PubMed Web of Science ®Google Scholar
• Undén J, Bellner J, Eneroth M, Alling C, Ingebrigtsen T, Romner B. Raised serum S100B levels after acute bone fractures without cerebral injury. Journal of Trauma 2005;58:59–61.
   PubMedGoogle Scholar
• Benneker LM, Leitner C, Martinolli L, Robert K, Zimmermann H, Exadaktylos AK. Isolated vertebral fractures give elevated serum protein S-100B levels. Scandinavian Journal of Trauma, Resuscitation & Emergency Medicine 2008;16:13.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Kim CW, Lee KJ, Choe JW, Kim SE, Oh JH, Park YS. Elevated serum S100B levels in acute spinal fracture without head injury. Emergency Medicine Journal 2010;27:209–212.
   PubMed Web of Science ®Google Scholar
• Vajtr D, Benada O, Kukacka J, Průsa R, Houstava L, Toupalík P, Kizek R. Correlation of ultrastructural changes of endothelial cells and astrocytes occurring during blood brain barrier damage after traumatic brain injury with biochemical markers of BBB leakage and inflammatory response. Physiological Research 2009;58:263–268.
   PubMed Web of Science ®Google Scholar
• Bellander BM, Olafsson IH, Ghatan PH, Bro Skejo HP, Hansson LO, Wanecek M, Svensson MA. Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B. Acta Neurochirurgica (Wien) 2011;153:90–100.
   PubMed Web of Science ®Google Scholar
• Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M. Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. Journal of Neuroscience 2015;35:518–526.
   PubMed Web of Science ®Google Scholar
• Pelinka LE, Szalay L, Jafarmadar M, Schmidhammer R, Redl H, Bahrami S. Circulating S100B is increased after bilateral femur fracture without brain injury in the rat. British Journal of Anaesthesia 2003;91:595–597.
   PubMed Web of Science ®Google Scholar
• Pelinka LE, Jafarmadar M, Redl H, Bahrami S. Neuron-specific-enolase is increased in plasma after hemorrhagic shock and after bilateral femur fracture without traumatic brain injury in the rat. Shock 2004;22:88–91.
   PubMed Web of Science ®Google Scholar
• Marquardt G, Setzer M, Szelenyi A, Seifert V, Gerlach R. Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy. Acta Neurochirurgica (Wien) 2009;151:1439–1443.
   PubMed Web of Science ®Google Scholar
• Wolf H, Krall C, Pajenda G, Leitgeb J, Bukaty AJ, Hajdu S, Sarahrudi K. Alterations of the biomarker S-100B and NSE in patients with acute vertebral spine fractures. Spine Journal 2014;14:2918–2922.
   PubMed Web of Science ®Google Scholar
• Meric E, Gunduz A, Turedi S, Cakir E, Yandi M. The prognostic value of neuron-specic enolase in head trauma patients. Journal of Emergency Medicine 2010;38:297–301.
   PubMed Web of Science ®Google Scholar
• Goyal A, Failla MD, Niyonkuru C, Amin K, Fabio A, Berger RP, Wagner AK. S100b as a prognostic biomarker in outcome prediction for patients with severe traumatic brain injury. Journal of Neurotrauma 2013;30:946–957.
   PubMed Web of Science ®Google Scholar
• Takala RS, Posti JP, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzen J, Ala-Seppäla H, Kyllönen A, Maanpää HR, et al.GFAP and UCH-L1 as outcome predictors in traumatic brain injury. World Neurosurgery 2015; Nov.4. pii: S1878-8750(15)01484–9. [Epub ahead of print].
   Google Scholar
• Gradisek P, Osredkar J, Korsic M, Kremzar B. Multiple indicators model of long-term mortality in traumatic brain injury. Brain Injury 2012;26:1472–1481.
   PubMed Web of Science ®Google Scholar
• Lesko MM, O’Brien SJ, Childs C, Bouamra O, Rainey T, Lecky F. Comparison of several prognostic tools in traumatic brain injury including S100B. Brain Injury 2014;28:987–994.
   PubMed Web of Science ®Google Scholar
• Al Nimer F, Thelin E, Nyström H, Dring AM, Svenningsson A, Piehl F, Nelson DW, Bellander BM. comparative assessment of the prognostic value of biomarkers in traumatic brain injury reveals an independent role for serum levels of neurofilament light. PLoS One 2015;10:e0132177.
   PubMed Web of Science ®Google Scholar
• Aebi M, Nazarian S. [Classification of injuries of the cervical spine]. Orthopade 1987;16:27–36.
   PubMed Web of Science ®Google Scholar