REFERENCES
- Ambati BK, Nozake M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993–997.
- Cursiefen C, Chen L, Saint-Geniez M, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006;103:11405–11410.
- Chang JI, Gabison EE, Kato T, et al. Corneal neovascularization. Curr Opin Opthalmol. 2001;12:242–249.
- Philips GD, Stone AM, Jones BD, et al. Vascular endothelial growth factor (rhVEGF165) stimulates direct angiogenesis in the rabbit cornea. In Vivo. 1994;8:961–966.
- Amano R, Rohan R, Kuroki M, et al. Requirement for vascular endothelial growth factor in wound-and inflammation-related corneal neovascularization. Invest Opthalmol Vis Sci. 1998;39:18–22.
- Miller JW, Adamis AP, Shima DT, et al. Vascular endothelial growth factor/vascular permeabilitu factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol.1994;145:574–584.
- Uno K, Hayashi H, Kuroki M, et al. Thrombospondin-1 accelarates wound healing of corneal epithelia. Biochem Biophys Res Commun. 2004;315:928–934.
- Armstrong LC, Bornstein P. Thrombospondin-1 and -2 function as inhibitors of angiogenesis. Matrix Biol. 2003;22:63–71.
- Bazan HEP, Ottino P. The role of platelet-activating factor in the corneal response to injury. Prog Ret Eye Res. 2002;21:449–464.
- Bazan HEP. Cellular and molecular events in corneal wound healing: Significance of lipid signaling. Exp Eye Res. 2005;4:453–463.
- Izumi T, Shimizu T. Platelet-activating factor receptor: Gene expression and signal transduction. Biochem Biophys Acta. 1995;1259:317–333.
- Chandrasekher G, Ma X, Lallier TE, et al. Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor. Invest Ophthal Vis Sci. 2002;43:1422–1428.
- Tao Y, Bazan HEP, Bazan NG. Platelet-activating factor induces the expression of metalloproteinases-1 and -9, but not -2 or -3, in the corneal epithelium. Invest Ophthal Vis Sci. 1995;36:345–354.
- Bazan HEP, Tao Y, Bazan NG. Platelet-activating factor induces collagenase expression in corneal epithelial cells. Proc Natl Acad Sci U S A. 1993;90:8678–8682.
- Ma X, Ottino P, Bazan HEP, et al. Platelet-activating factor (PAF) induces corneal neovascularization and upregulates vascular endothelial growth factor (VEGF) expression in endothelial cells. Invest Ophthalmol Vis Sci. 2004;45:2915–2921.
- Jester JV, Petroll WM, Cavanagh HD. Corneal stromal wound healing in refractive surgery: The role of myofibroblasts. Prog Retin Eye Res. 1999;18:311–356.
- Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999;18:529–551.
- Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodeling. Nat Rev Mol Cell Biol. 2002;3:349–363.
- He J, Bazan HEP. Synergistic effect of platelet-activating factor and tumor necrosis factor-α on corneal myofibroblast apoptosis. Invest Ophthalmol Vis Sci. 2006;47:883–891.
- Ottino P, He J, Axelrod TW, et al. PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. Invest Opthalmol Vis Sci. 2005;46:487–496.
- He J, Bazan HEP. Epidermal growth factor synergisms with TNF-beta1 via PI-3 kinase activity in corneal keratocyte differentiation. Invest Opthalmol Vis Sci. 2008;49:2936–2945.
- Masur SK, Dewal HS, Dinh TT, et al. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci U S A. 1996;93:4219–4223.
- Ellenberg D, Azar D, Hallak JA, et al. Novel aspects of corneal angiogenic and lymphoangiogenic privilege. Prog Ret Eye Res. 2010; 29:208–248.
- McCracken JS, Burger PC, Klintworth GK. Morphologic observations on experimental corneal vascularization in the rat. Lab Invest.1979;41:519–530.
- Inomata H, Smelser GK, Polack FM. Corneal vascularization in experimental uveitis and graft rejection. Invest Opthalmol. 1971;10:840–850.
- Burger PC, Chandler DB, Klintworth GK. Corneal neovascularization as studied by scanning electron microscopy of vascular casts. Lab Invest. 1983;48:169–180.
- Cursiefen C, Hofman-Rummelt C, Kuchle M, et al. Pericyte recruitment in human corneal angiogenesis: An ultrastructural study with clinicopathological correlation. Brit J Opthalmol. 2003;87:101–106.
- Nakayasu K, Hayashi N, Okisaka S, et al. Formation of capillary-like tubes by vascular endothelial cells cocultivated with keratocytes. Invest Ophthal Vis Sci. 1992;33:3050–3057.
- Bazan HEP, Reddy STK, Lin N. Platelet-activating factor (PAF) accumulation correlates with injury in the cornea. Exp Eye Res. 1991;52:481–491.
- Onguchi T, Han KY, Chang JH, et al. Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization. Am J Pathol. 2009;174:1564–1571.
- Sounni NE, Roghi C, Chabottaux V, et al. Up-regulation of vascular endothelial growth factor-A by active membrane type-1 matrix metalloproteinase through activation of Src-tyrosine kinases. J Biol Chem. 2004;279:13564–13574.
- Cursiefen C, Masli S, Ng TF, et al. Roles of trombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Opthalmol Vis Sci. 2004;45:1117–1124.
- Jimenez B, Volpert OV, Crawford SE et al Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med. 2000;6:41–18.
- Kilarski WW, Samolov B, Peterson L, et al. Biomechanical regulation of blood vessel growth during tissue vascularization. Nat Med. 2009;15:657–665.
- Bahar I, Kaiserman I, McAllum P, et al. Subconjunctival bevacizumab injection for corneal neovascularization. Cornea. 2008;27;142–147.
- Yoeruek E, Ziemssen F, Henke-Fahele S, et al. Safty, penetration and efficacy of topically applied bevacizumab: Evaluation of eyedrops in corneal neovascularization after chemical burn. Acta Opthalmol. 2008;86:322–328.
- Bock F, Konig Y, Kruse F, et al. Bevacizumab (avastin) eye drops inhibit corneal neovascularization. Graefes Arch Clin Exp Opthalmol. 2008;246:281–284.
- Kim SW, Ha BJ, Kim EK, et al. The effect of topical bevacizumab on corneal neovascularization. Ophthalmology. 2008;115:e33–e38.
- Galor A, Yoo SH. Corneal melt while using topical bevacizumab eye drops. Opthalmic Surg Lasers Imaging. 2010;9:1–3.
- He J, Bazan NG, Bazan HE. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Opthalmol. 2006;124:70–78.