171
Views
3
CrossRef citations to date
0
Altmetric
Original Article

Molecular and Morphological Evidence for Cadaver Vitreous-stimulated Transformation of Differentiation-competent Retinal Pigment Epithelial Cells into Neuron-like Cells

, , , &
Pages 606-616 | Received 01 Aug 2011, Accepted 03 Feb 2012, Published online: 11 May 2012

REFERENCES

  • Eguchi G, Okada TS. Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: a demonstration of a switch of cell types in clonal cell culture. Proc Natl Acad Sci USA. 1973;70:1495–1499.
  • Spence JR, Madhavan M, Aycinena JC, Del Rio-Tsonis K. Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6. Mol Vis. 2007;13:57–65.
  • Cameron DA. Cellular proliferation and neurogenesis in the injured retina of adult zebrafish. Vis Neurosci. 2000;17:789–797.
  • Fischer AJ, Reh TA. Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens. Dev Biol. 2000;220:197–210.
  • Otteson DC, D’Costa AR, Hitchcock PF. Putative stem cells and the lineage of rod photoreceptors in the mature retina of the goldfish. Dev Biol. 2001;232:62–76.
  • Stone LS. The role of retinal pigment cells in regenerating neural retinae of adult salamander eyes. J Exp Zool. 1950;113:9.
  • Stone LS, Steinitz H. Regeneration of neural retina and lens from retina pigment cell grafts in adult newts. J Exp Zool. 1957;135:301–317.
  • Chiba C, Hoshino A, Nakamura K et al. Visual cycle protein RPE65 persists in new retinal cells during retinal regeneration of adult newt. J Comp Neurol. 2006;495:391–407.
  • Yoshii C, Ueda Y, Okamoto M, Araki M. Neural retinal regeneration in the anuran amphibian Xenopus laevis post-metamorphosis: transdifferentiation of retinal pigmented epithelium regenerates the neural retina. Dev Biol. 2007;303:45–56.
  • Coulombre JL, Coulombre AJ. Regeneration of neural retina from the pigmented epithelium in the chick embryo. Dev Biol. 1965;12:79–92.
  • Orts-Llorca F, Genis-Galvez JM. Experimental production of retinal septa in the chick embryo. Differentiation of pigment epithelium into neural retina. Acta Anat (Basel) 1960;42:31–70.
  • Park CM, Hollenberg MJ. Basic fibroblast growth factor induces retinal regeneration in vivo. Dev Biol. 1989;134:201–205.
  • Zhao S, Thornquist SC, Barnstable CJ. In vitro transdifferentiation of embryonic rat retinal pigment epithelium to neural retina. Brain Res. 1995;677:300–310.
  • Pittack C, Jones M, Reh TA. Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro. Development. 1991;113:577–588.
  • Sakaguchi DS, Janick LM, Reh TA. Basic fibroblast growth factor (FGF-2) induced transdifferentiation of retinal pigment epithelium: generation of retinal neurons and glia. Dev Dyn. 1997;209:387–398.
  • Zhao S, Hung FC, Colvin JS, White A, Dai W, Lovicu FJ, Ornitz DM, Overbeek PA. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 2001;128:5051–5060.
  • Yan RT, Ma WX, Wang SZ. neurogenin2 elicits the genesis of retinal neurons from cultures of nonneural cells. Proc Natl Acad Sci USA. 2001;98:15014–15019.
  • Xie W, Yan RT, Ma W, Wang SZ. Enhanced retinal ganglion cell differentiation by ath5 and NSCL1 coexpression. Invest Ophthalmol Vis Sci. 2004;45:2922–2928.
  • Mao W, Yan RT, Wang SZ. Reprogramming chick RPE progeny cells to differentiate towards retinal neurons by ash1. Mol Vis. 2008;14:2309–2320.
  • Yan RT, Liang L, Ma W, Li X, Xie W, Wang SZ. Neurogenin1 effectively reprograms cultured chick retinal pigment epithelial cells to differentiate toward photoreceptors. J Comp Neurol. 2010;518:526–546.
  • Yan RT, Wang SZ. Expression of an array of photoreceptor genes in chick embryonic retinal pigment epithelium cell cultures under the induction of neuroD. Neurosci Lett. 2000;280:83–86.
  • Liang L, Yan RT, Li X, Chimento M, Wang SZ. Reprogramming progeny cells of embryonic RPE to produce photoreceptors: development of advanced photoreceptor traits under the induction of neuroD. Invest Ophthalmol Vis Sci. 2008;49:4145–4153.
  • Amemiya K, Haruta M, Takahashi M, Kosaka M, Eguchi G. Adult human retinal pigment epithelial cells capable of differentiating into neurons. Biochem Biophys Res Commun. 2004;316:1–5.
  • Vinores SA, Derevjanik NL, Mahlow J et al. Class III beta-tubulin in human retinal pigment epithelial cells in culture and in epiretinal membranes. Exp Eye Res. 1995;60:385–400.
  • Hausman RE. Ocular extracellular matrices in development. Prog Retin Eye Res. 2007;26:162–188.
  • Khera S, Tiwari A, Srinivasan R, Gupta A, Luthra-Guptasarma M. Expression of granulocyte colony stimulating factor and its receptor by retinal pigment epithelial cells: a role in maintaining differentiation-competent state. Curr Eye Res. 2011;36:469–480.
  • Wiese C, Rolletschek A, Kania G et al. Nestin expression–a property of multi-lineage progenitor cells? Cell Mol Life Sci. 2004;61:2510–2522.
  • McKay R. Stem cells in the central nervous system. Science. 1997;276:66–71.
  • Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992;255:1707–1710.
  • Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci. 1992;12:4565–4574.
  • Moeller ML, Dimitrijevich SD. A new strategy for analysis of phenotype marker antigens in hollow neurospheres. J Neurosci Methods. 2004;139:43–50.
  • Engelhardt M, Bogdahn U, Aigner L. Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res. 2005;1040:98–111.
  • Gao BB, Chen X, Timothy N, Aiello LP, Feener EP. Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy. J Proteome Res. 2008;7:2516–2525.
  • van Deemter M, Pas HH, Kuijer R, van derWorp RJ, Hooymans JM, Los LI. Enzymatic breakdown of type II collagen in the human vitreous. Invest Ophthalmol Vis Sci. 2009;50:4552–4560.
  • Mandelcorn MS, Machemer R, Fineberg E, Hersch SB. Proliferation and metaplasia of intravitreal retinal pigment epithelium cell autotransplants. Am J Ophthalmol. 1975;80:227–237.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.