242
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Neuroprotective Effect of Small Interfering RNA Targeted to Caspase-3 on Rat Retinal Ganglion Cell Loss Induced by Ischemia and Reperfusion Injury

, , , &
Pages 907-913 | Received 23 Nov 2011, Accepted 08 Apr 2012, Published online: 29 May 2012

REFERENCES

  • Daugeliene L, Niwa M, Hara A et al. Transient ischemic injury in the rat retina caused by thrombotic occlusion-thrombolytic reperfusion. Invest Ophthalmol Vis Sci 2000;41:2743–2747.
  • Harada T, Harada C, Nakamura K et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest 2007;117:1763–1770.
  • Woo SJ, Kim JY, Kim DM et al. Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma. Eye (Lond) 2009;23:17–24.
  • Takahashi K, Lam TT, Edward DP et al. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol 1992;110:862–870.
  • Büchi ER. Cell death in rat retina after pressure-induced ischaemia-reperfusion insult: electron microscopic study. II. Outer nuclear layer. Jpn J Ophthalmol 1992;36:62–68.
  • Rosenbaum DM, Rosenbaum PS, Gupta A et al. Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Res 1997;37:3445–3451.
  • Lam TT, Abler AS, Tso MO. Apoptosis and caspases after ischemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci 1999;40:967–975.
  • Zhang C, Rosenbaum DM, Shaikh AR et al. Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Invest Ophthalmol Vis Sci 2002;43:3059–3066.
  • Katai N, Yoshimura N. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci 1999;40:2697–2705.
  • Parone PA, James D, Martinou JC. Mitochondria: regulating the inevitable. Biochimie 2002;84:105–111.
  • Produit-Zengaffinen N, Pournaras CJ, Schorderet DF. Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. Mol Vis 2009;15:2101–2110.
  • Tezel G, Wax MB. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci 1999;40:2660–2667.
  • Zimmermann TS, Lee AC, Akinc A et al. RNAi-mediated gene silencing in non-human primates. Nature 2006;441:111–114.
  • Lingor P, Koeberle P, Kügler S et al. Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain 2005;128:550–558.
  • Zheng GY, Zhang C, Li ZG. Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice. Chin Med J 2004;117:717–721.
  • Morrison JC, Jia L, Cepurna W et al. Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats. Invest Ophthalmol Vis Sci 2009;50:2802–2808.
  • Lee EJ, Park KH, Kim DM et al. Assessing intraocular pressure by rebound tonometer in rats with an air-filled anterior chamber. Jpn J Ophthalmol 2008;52:500–503.
  • Germain F, Calvo M, de la Villa P. Rabbit retinal ganglion cell survival after optic nerve section and its effect on the inner plexiform layer. Exp Eye Res 2004;78:95–102.
  • Simon P, Thanos S. Combined methods of retrograde staining, layer-separation and viscoelastic cell stabilization to isolate retinal ganglion cells in adult rats. J Neurosci Methods 1998;83:113–124.
  • Kaneda K, Kashii S, Kurosawa T et al. Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina. Brain Res 1999;815:11–20.
  • Tsuchiya F, Kano R, Sano J et al. Apoptosis of canine mammary tumor cells induced by small interfering RNA (siRNA) against Bcl-xL gene. J Vet Med Sci 2006;68:1199–1201.
  • Minakuchi Y, Takeshita F, Kosaka N et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res 2004;32:e109.
  • Contreras JL, Vilatoba M, Eckstein C et al. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. Surgery 2004;136:390–400.
  • Takeda H, Kitaoka Y, Hayashi Y et al. Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity. Brain Res 2007;1184:306–315.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.