Diverse Regulation of Retinal Pigment Epithelium Phagocytosis of Photoreceptor Outer Segments by Calcium-Independent Phospholipase A₂, Group VIA and Secretory Phospholipase A₂, Group IB

REFERENCES

• Sommer A, Tielsch JM, Katz J et al. Racial differences in the cause-specific prevalence of blindness in east Baltimore. N Engl J Med 1991;325:1412–1417.
   PubMed Web of Science ®Google Scholar
• Klein R, Wang Q, Klein BE et al. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 1995;36:182–191.
   PubMed Web of Science ®Google Scholar
• Klaver CC, Wolfs RC, Vingerling JR et al. Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol 1998;116:653–658.
   PubMed Web of Science ®Google Scholar
• Wang JJ, Foran S, Mitchell P. Age-specific prevalence and causes of bilateral and unilateral visual impairment in older Australians: the Blue Mountains Eye Study. Clin Experiment Ophthalmol 2000;28:268–273.
   PubMed Web of Science ®Google Scholar
• Muñoz B, West SK, Rubin GS et al. Causes of blindness and visual impairment in a population of older Americans: The Salisbury Eye Evaluation Study. Arch Ophthalmol 2000;118:819–825.
   PubMed Web of Science ®Google Scholar
• Weih LM, VanNewkirk MR, McCarty CA et al. Age-specific causes of bilateral visual impairment. Arch Ophthalmol 2000;118:264–269.
   PubMed Web of Science ®Google Scholar
• Rattner A, Nathans J. Macular degeneration: recent advances and therapeutic opportunities. Nat Rev Neurosci 2006;7:860–872.
   PubMed Web of Science ®Google Scholar
• Hogan MJ. Role of the retinal pigment epithelium in macular disease. Trans Am Acad Ophthalmol Otolaryngol 1972;76:64–80.
   PubMedGoogle Scholar
• Rakoczy PE, Zhang D, Robertson T et al. Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am J Pathol 2002;161:1515–1524.
   PubMed Web of Science ®Google Scholar
• Finnemann SC, Leung LW, Rodriguez-Boulan E. The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci USA 2002;99:3842–3847.
   PubMed Web of Science ®Google Scholar
• Bok D, Hall MO. The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J Cell Biol 1971;49:664–682.
   PubMed Web of Science ®Google Scholar
• Seilhamer JJ, Randall TL, Yamanaka M et al. Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA 1986;5:519–527.
   PubMedGoogle Scholar
• Seilhamer JJ, Pruzanski W, Vadas P et al. Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid. J Biol Chem 1989;264:5335–5338.
   PubMed Web of Science ®Google Scholar
• Chen J, Engle SJ, Seilhamer JJ et al. Cloning and characterization of novel rat and mouse low molecular weight Ca(2+)-dependent phospholipase A2s containing 16 cysteines. J Biol Chem 1994;269:23018–23024.
   PubMed Web of Science ®Google Scholar
• Ishizaki J, Suzuki N, Higashino K et al. Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem 1999;274:24973–24979.
   PubMed Web of Science ®Google Scholar
• Suzuki N, Ishizaki J, Yokota Y et al. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. J Biol Chem 2000;275:5785–5793.
   PubMed Web of Science ®Google Scholar
• Valentin E, Singer AG, Ghomashchi F et al. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). Biochem Biophys Res Commun 2000;279:223–228.
   PubMed Web of Science ®Google Scholar
• Valentin E, Ghomashchi F, Gelb MH et al. Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme. J Biol Chem 2000;275:7492–7496.
   PubMed Web of Science ®Google Scholar
• Chen J, Engle SJ, Seilhamer JJ et al. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. J Biol Chem 1994;269:2365–2368.
   PubMed Web of Science ®Google Scholar
• Cupillard L, Koumanov K, Mattéi MG et al. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. J Biol Chem 1997;272:15745–15752.
   PubMed Web of Science ®Google Scholar
• Gelb MH, Valentin E, Ghomashchi F et al. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. J Biol Chem 2000;275:39823–39826.
   PubMed Web of Science ®Google Scholar
• Kramer RM, Roberts EF, Manetta J et al. The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells. J Biol Chem 1991;266:5268–5272.
   PubMed Web of Science ®Google Scholar
• Pickard RT, Strifler BA, Kramer RM et al. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. J Biol Chem 1999;274:8823–8831.
   PubMed Web of Science ®Google Scholar
• Chiba H, Michibata H, Wakimoto K et al. Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2δ, induced in psoriatic skin. J Biol Chem 2004;279:12890–12897.
   PubMed Web of Science ®Google Scholar
• Ohto T, Uozumi N, Hirabayashi T et al. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){δ}, {ϵ}, and {ζ}, which form a gene cluster with cPLA(2){β}. J Biol Chem 2005;280:24576–24583.
   PubMed Web of Science ®Google Scholar
• Larsson PK, Claesson HE, Kennedy BP. Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. J Biol Chem 1998;273:207–214.
   PubMed Web of Science ®Google Scholar
• Mancuso DJ, Jenkins CM, Gross RW. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). J Biol Chem 2000;275:9937–9945.
   PubMed Web of Science ®Google Scholar
• Jenkins CM, Mancuso DJ, Yan W et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004;279:48968–48975.
   PubMed Web of Science ®Google Scholar
• Tjoelker LW, Wilder C, Eberhardt C et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 1995;374:549–553.
   PubMed Web of Science ®Google Scholar
• Hattori K, Adachi H, Matsuzawa A et al. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. J Biol Chem 1996;271:33032–33038.
   PubMed Web of Science ®Google Scholar
• Hattori M, Adachi H, Tsujimoto M et al. The catalytic subunit of bovine brain platelet-activating factor acetylhydrolase is a novel type of serine esterase. J Biol Chem 1994;269:23150–23155.
   PubMed Web of Science ®Google Scholar
• Hattori M, Adachi H, Aoki J et al. Cloning and expression of a cDNA encoding the β-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase. J Biol Chem 1995;270:31345–31352.
   PubMed Web of Science ®Google Scholar
• Adachi H, Tsujimoto M, Hattori M et al. cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase γ-subunit and its mRNA expression in human tissues. Biochem Biophys Res Commun 1995;214:180–187.
   PubMed Web of Science ®Google Scholar
• Kolko M, Rodriguez de Turco EB, Diemer NH et al. Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. Neurosci Lett 2003;338:164–168.
   PubMed Web of Science ®Google Scholar
• Granata F, Petraroli A, Boilard E et al. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 2005;174:464–474.
   PubMed Web of Science ®Google Scholar
• Ancian P, Lambeau G, Mattéi MG et al. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J Biol Chem 1995;270:8963–8970.
   PubMed Web of Science ®Google Scholar
• Femling JK, Nauseef WM, Weiss JP. Synergy between extracellular group IIA phospholipase A2 and phagocyte NADPH oxidase in digestion of phospholipids of Staphylococcus aureus ingested by human neutrophils. J Immunol 2005;175:4653–4661.
   PubMed Web of Science ®Google Scholar
• Balestrieri B, Hsu VW, Gilbert H et al. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J Biol Chem 2006;281:6691–6698.
   PubMed Web of Science ®Google Scholar
• Lennartz MR, Lefkowith JB, Bromley FA et al. Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase. J Leukoc Biol 1993;54:389–398.
   PubMed Web of Science ®Google Scholar
• Irschick EU, Sgonc R, Böck G et al. Retinal pigment epithelial phagocytosis and metabolism differ from those of macrophages. Ophthalmic Res 2004;36:200–210.
   PubMed Web of Science ®Google Scholar
• Kolko M, Wang J, Zhan C et al. Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci 2007;48:1401–1409.
   PubMed Web of Science ®Google Scholar
• Kolko M, Prause JU, Bazan NG et al. Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases. Acta Ophthalmol Scand 2007;85:317–323.
   PubMedGoogle Scholar
• Gorovetz M, Schwob O, Krimsky M et al. MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2. Front Biosci 2008;13:1917–1925.
   PubMed Web of Science ®Google Scholar
• Silliman CC, Moore EE, Zallen G et al. Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Am J Physiol, Cell Physiol 2002;283:C1102–C1113.
   Web of Science ®Google Scholar
• Fonteh AN, Atsumi G, LaPorte T et al. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. J Immunol 2000;165:2773–2782.
   PubMed Web of Science ®Google Scholar
• Sparrow JR, Nathan C, Vodovotz Y. Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture. Exp Eye Res 1994;59:129–139.
   PubMed Web of Science ®Google Scholar
• Bao S, Miller DJ, Ma Z et al. Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. J Biol Chem 2004;279:38194–38200.
   Google Scholar
• Schraermeyer U, Stieve H. A newly discovered pathway of melanin formation in cultured retinal pigment epithelium of cattle. Cell Tissue Res 1994;276:273–279.
   PubMed Web of Science ®Google Scholar
• Hall MO. Phagocytosis of light- and dark-adapted rod outer segments by cultured pigment epithelium. Science 1978;202:526–528.
   PubMed Web of Science ®Google Scholar
• Kolko M, Kiilgaard JF, Wang J et al. Calcium-independent phospholipase A2 regulates retinal pigment epithelium proliferation and may be important in the pathogenesis of retinal diseases. Exp Eye Res 2009;89:383–391.
   PubMed Web of Science ®Google Scholar
• Karimi K, Gemmill TR, Lennartz MR. Protein kinase C and a calcium-independent phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells. J Leukoc Biol 1999;65:854–862.
   PubMed Web of Science ®Google Scholar
• McNally AK, Anderson JM. Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol 2005;79:126–135.
   PubMed Web of Science ®Google Scholar
• Hazen SL, Stuppy RJ, Gross RW. Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids. J Biol Chem 1990;265:10622–10630.
   PubMed Web of Science ®Google Scholar
• Song H, Ramanadham S, Bao S et al. A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols. Biochemistry 2006;45:1061–1073.
   PubMed Web of Science ®Google Scholar
• Pérez R, Balboa MA, Balsinde J. Involvement of group VIA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide-treated U937 cells. J Immunol 2006;176:2555–2561.
   PubMed Web of Science ®Google Scholar
• Mishra RS, Carnevale KA, Cathcart MK. iPLA2β: front and center in human monocyte chemotaxis to MCP-1. J Exp Med 2008;205:347–359.
   PubMed Web of Science ®Google Scholar
• Collins FD, Love RM, Morton RA. Studies in rhodopsin. V. Chemical analysis of retinal material. Biochem J 1952;51:669–673.
   PubMed Web of Science ®Google Scholar
• Fleischer S, McConnell DG. Preliminary observations on the lipids of bovine retinal outer segment disks. Nature 1966;212:1366–1367.
   PubMed Web of Science ®Google Scholar
• Atsumi G, Murakami M, Kojima K et al. Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2α inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+-independent phospholipase A2 augments spontaneous fatty acid release. J Biol Chem 2000;275:18248–18258.
   PubMed Web of Science ®Google Scholar
• Wilt SD, McLaughlin BJ. Is another mannose receptor-like lectin present in retinal pigment epithelium? Curr Eye Res 1999;19:1–3.
   PubMed Web of Science ®Google Scholar
• Cupillard L, Mulherkar R, Gomez N et al. Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor. J Biol Chem 1999;274:7043–7051.
   PubMed Web of Science ®Google Scholar
• Lio YC, Dennis EA. Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta 1998;1392:320–332.
   PubMed Web of Science ®Google Scholar