Dorzolamide-induced Relaxation of Intraocular Porcine Ciliary Arteries In Vitro Depends on Nitric Oxide and the Vascular Endothelium

REFERENCES

• Sugrue MF. Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors. Prog Retin Eye Res 2000;19:87–112.
   PubMed Web of Science ®Google Scholar
• Martens-Lobenhoffer J, Banditt P. Clinical pharmacokinetics of dorzolamide. Clin Pharmacokinet 2002;41:197–205.
   Google Scholar
• Kiel JW, Hollingsworth M, Rao R et al. Ciliary blood flow and aqueous humor production. Prog Retin Eye Res 2011;30:1–17.
   PubMed Web of Science ®Google Scholar
• Klemm M, Zeitz O, Reuss J et al. [Therapy of normal tension glaucoma: effect of brinzolamide on ocular haemodynamics]. Klin Monbl Augenheilkd 2003;220:330–333.
   Google Scholar
• Zeitz O, Matthiessen ET, Reuss J et al. Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428]. BMC Ophthalmol 2005;5:6.
   PubMedGoogle Scholar
• Kehler AK, Holmgaard K, Hessellund A et al. Variable involvement of the perivascular retinal tissue in carbonic anhydrase inhibitor induced relaxation of porcine retinal arterioles in vitro. Invest Ophthalmol Vis Sci 2007;48:4688–4693.
   PubMed Web of Science ®Google Scholar
• Torring MS, Holmgaard K, Hessellund A et al. The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition. Invest Ophthalmol Vis Sci 2009;50:345–351.
   PubMed Web of Science ®Google Scholar
• Aamand R, Dalsgaard T, Jensen FB et al. Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation. Am J Physiol Heart Circ Physiol 2009;297:H2068–H2074.
   PubMed Web of Science ®Google Scholar
• Kringelholt S, Simonsen U, Bek T. Dual effect of prostaglandins on isolated intraocular porcine ciliary arteries. Submitted Acta Ophthalmol.2012. Accepted for publication.
   Google Scholar
• Dalsgaard T, Kroigaard C, Bek T, Simonsen U. Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles. Invest Ophthalmol Vis Sci 2009;50:3819–3825.
   PubMedGoogle Scholar
• Josefsson A, Sigurdsson SB, Bang K et al. Dorzolamide induces vasodilatation in isolated pre-contracted bovine retinal arteries. Exp Eye Res 2004;78:215–221.
   PubMed Web of Science ®Google Scholar
• Reitsamer HA, Bogner B, Tockner B et al. Effects of dorzolamide on choroidal blood flow, ciliary blood flow, and aqueous production in rabbits. Invest Ophthalmol Vis Sci 2009;50:2301–2307.
   PubMed Web of Science ®Google Scholar
• El Sherbini M, Gekkieva M, Flammer J et al. Effect of Xalatan® and Cosopt® on the vascular tone of quiescent isolated pig ciliary arteries. Klin Monbl Augenheilkd 2002;219:273–276.
   Google Scholar
• Rassam SM, Patel V, Kohner EM. The effect of acetazolamide on the retinal circulation. Eye (Lond) 1993;7 (Pt 5):697–702.
   Google Scholar
• Fuchsjäger-Mayrl G, Georgopoulos M, Hommer A et al. Effect of dorzolamide and timolol on ocular pressure: blood flow relationship in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 2010;51:1289–1296.
   PubMed Web of Science ®Google Scholar
• Fuchsjäger-Mayrl G, Wally B, Rainer G et al. Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. Br J Ophthalmol 2005;89:1293–1297.
   PubMed Web of Science ®Google Scholar
• Pedersen DB, Koch Jensen P, la Cour M et al. Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels. Graefes Arch Clin Exp Ophthalmol 2005;243:163–168.
   PubMed Web of Science ®Google Scholar
• Siesky B, Harris A, Cantor LB et al. A comparative study of the effects of brinzolamide and dorzolamide on retinal oxygen saturation and ocular microcirculation in patients with primary open-angle glaucoma. Br J Ophthalmol 2008;92:500–504.
   PubMed Web of Science ®Google Scholar
• Grunwald JE, Mathur S, DuPont J. Effects of dorzolamide hydrochloride 2% on the retinal circulation. Acta Ophthalmol Scand 1997;75:236–238.
   PubMedGoogle Scholar
• Pillunat LE, Böhm AG, Köller AU et al. Effect of topical dorzolamide on optic nerve head blood flow. Graefes Arch Clin Exp Ophthalmol 1999;237:495–500.
   PubMed Web of Science ®Google Scholar
• Bergstrand IC, Heijl A, Harris A. Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double-masked study. Acta Ophthalmol Scand 2002;80:176–182.
   PubMedGoogle Scholar
• Simsek T, Yanik B, Conkbayir I et al. Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma. J Ocul Pharmacol Ther 2006;22:79–85.
   Google Scholar
• Tamaki Y, Araie M, Muta K. Effect of topical dorzolamide on tissue circulation in the rabbit optic nerve head. Jpn J Ophthalmol 1999;43:386–391.
   PubMedGoogle Scholar
• Kaup M, Plange N, Niegel M et al. Effects of brinzolamide on ocular haemodynamics in healthy volunteers. Br J Ophthalmol 2004;88:257–262.
   PubMed Web of Science ®Google Scholar
• Kerty E, Hørven I, Dahl A et al. Ocular and cerebral blood flow measurements in healthy subjects. A comparison of blood flow velocity and dynamic tonometry measurements before and after acetazolamide. Acta Ophthalmol (Copenh) 1994;72:401–408.
   Google Scholar
• Sampaolesi J, Tosi J, Darchuk V et al. Antiglaucomatous drugs effects on optic nerve head flow: design, baseline and preliminary report. Int Ophthalmol 2001;23:359–367.
   PubMedGoogle Scholar
• Stefánsson E, Jensen PK, Eysteinsson T et al. Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors. Invest Ophthalmol Vis Sci 1999;40:2756–2761.
   PubMed Web of Science ®Google Scholar
• Martínez A, Sánchez-Salorio M. A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients. J Ocul Pharmacol Ther 2009;25:239–248.
   PubMed Web of Science ®Google Scholar
• Barnes GE, Li B, Dean T et al. Increased optic nerve head blood flow after 1 week of twice daily topical brinzolamide treatment in Dutch-belted rabbits. Surv Ophthalmol 2000;44 Suppl 2:S131–S140.
   Google Scholar
• Reber F, Gersch U, Funk RW. Blockers of carbonic anhydrase can cause increase of retinal capillary diameter, decrease of extracellular and increase of intracellular pH in rat retinal organ culture. Graefes Arch Clin Exp Ophthalmol 2003;241:140–148.
   PubMed Web of Science ®Google Scholar
• Peng HL, Jensen PE, Nilsson H et al.. Effect of acidosis on tension and [Ca2+]i in rat cerebral arteries: is there a role for membrane potential? Am J Physiol 1998;274:H655–H662.
   Google Scholar
• Koss MC. Functional role of nitric oxide in regulation of ocular blood flow. Eur J Pharmacol 1999;374:161–174.
   PubMed Web of Science ®Google Scholar
• Pellanda N, Flammer J, Haefliger IO. L-NAME- and U 46619-induced contractions in isolated porcine ciliary arteries versus vortex veins. Klin Monbl Augenheilkd 2001;218:366–369.
   Web of Science ®Google Scholar
• Schmetterer L, Polak K. Role of nitric oxide in the control of ocular blood flow. Prog Retin Eye Res 2001;20:823–847.
   PubMed Web of Science ®Google Scholar
• Boedtkjer E, Praetorius J, Matchkov VV et al. Disruption of Na+,HCO3+ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca2+ sensitivity, and hypertension development in mice. Circulation 2011;124:1819–1829.
   Google Scholar
• Tuettenberg J, Heimann A, Kempski O. Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study. Neurosci Lett 2001;315:65–68.
   PubMed Web of Science ®Google Scholar
• Sato E, Sakamoto T, Nagaoka T et al. Role of nitric oxide in regulation of retinal blood flow during hypercapnia in cats. Invest Ophthalmol Vis Sci 2003;44:4947–4953.
   PubMed Web of Science ®Google Scholar
• Loftsson T, Jansook P, Stefánsson E. Topical drug delivery to the eye: dorzolamide. Acta Ophthalmol 2012 Jan 23. doi: 10.1111/j.1755-3768.2011.02299.x. [Epub ahead of print] PMID: 22269010 [PubMed - as supplied by publisher].
   Google Scholar
• Fabrizi F, Mincione F, Somma T et al. A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology. J Enzyme Inhib Med Chem 2012;27:138–147.
   PubMed Web of Science ®Google Scholar