280
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Role of the JNK Signaling PathWay in Downregulation of Connexin43 by TNF-α in Human Corneal Fibroblasts

, , , &
Pages 926-932 | Received 17 May 2012, Accepted 18 Apr 2013, Published online: 14 Jun 2013

References

  • Kumar NM, Gilula NB. The gap junction communication channel. Cell 1996;84:381–388
  • Nishida T, Yasumoto K, Otori T, Desaki J. The network structure of corneal fibroblasts in the rat as revealed by scanning electron microscopy. Invest Ophthalmol Vis Sci 1988;29:1887–1890
  • Shibata Y, Kumai M, Nishii K, Nakamura K. Diversity and molecular anatomy of gap junctions. Med Electron Microsc 2001;34:153–159
  • Spanakis SG, Petridou S, Masur SK. Functional gap junctions in corneal fibroblasts and myofibroblasts. Invest Ophthalmol Vis Sci 1998;39:1320–1328
  • Beyer EC, Kistler J, Paul DL, Goodenough DA. Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol 1989;108:595–605
  • Watsky MA. Keratocyte gap junctional communication in normal and wounded rabbit corneas and human corneas. Invest Ophthalmol Vis Sci 1995;36:2568–2576
  • Cordingley FT, Bianchi A, Hoffbrand AV, Reittie JE, Heslop HE, Vyakarnam A, et al. Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies. Lancet 1988;1:969–971
  • Rosenbaum JT, Howes EL, Jr Rubin RM, Samples JR. Ocular inflammatory effects of intravitreally-injected tumor necrosis factor. Am J Pathol 1988;133:47–53
  • Keadle TL, Usui N, Laycock KA, Miller JK, Pepose JS, Stuart PM. IL-1 and TNF-alpha are important factors in the pathogenesis of murine recurrent herpetic stromal keratitis. Invest Ophthalmol Vis Sci 2000;41:96–102
  • Planck SR, Rich LF, Ansel JC, Huang XN, Rosenbaum JT. Trauma and alkali burns induce distinct patterns of cytokine gene expression in the rat cornea. Ocul Immunol Inflamm 1997;5:95–100
  • Thakur A, Xue M, Stapleton F, Lloyd AR, Wakefield D, Willcox MD. Balance of pro- and anti-inflammatory cytokines correlates with outcome of acute experimental Pseudomonas aeruginosa keratitis. Infect Immun 2002;70:2187–2197
  • Leonardi A, Brun P, Tavolato M, Plebani M, Abatangelo G, Secchi AG. Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. Eur J Ophthalmol 2003;13:606–610
  • Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201–211
  • Hao JL, Suzuki K, Lu Y, Hirano S, Fukuda K, Kumagai N, et al. Inhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005;46:1195–1200
  • Kimura K, Nishida T. Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein Connexin43 by TNF-{alpha} in human corneal fibroblasts. Invest Ophthalmol Vis Sci 2010;51:1943–1947
  • Steinberg TH, Civitelli R, Geist ST, Robertson AJ, Hick E, Veenstra RD, et al. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. Embo J 1994;13:744–750
  • Kimura K, Teranishi S, Nishida T. Establishment of human corneal epithelial cells stably expressing human connexin43. Exp Eye Res 2010;90:4–9
  • Vanden Berghe W, Vermeulen L, De Wilde G, De Bosscher K, Boone E, Haegeman G. Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem Pharmacol 2000;60:1185–1195
  • Li HH, Du J, Fan YN, Zhang ML, Liu DP, Li L, et al. The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. Am J Pathol 2011;178:1043–1058
  • Hu J, Cotgreave IA. Differential regulation of gap junctions by proinflammatory mediators in vitro. J Clin Invest 1997;99:2312–2316
  • Mensink A, de Haan LH, Lakemond CM, Koelman CA, Koeman JH. Inhibition of gap junctional intercellular communication between primary human smooth muscle cells by tumor necrosis factor alpha. Carcinogenesis 1995;16:2063–2067
  • Chandross KJ, Spray DC, Cohen RI, Kumar NM, Kremer M, Dermietzel R, Kessler JA. TNF alpha inhibits Schwann cell proliferation, connexin46 expression, and gap junctional communication. Mol Cell Neurosci 1996;7:479–500
  • Eugenin EA, Branes MC, Berman JW, Saez JC. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol 2003;170:1320–1328
  • Kitamura Y, Morita I, Nihei Z, Mishima Y, Murota S. Effect of IL-6 on tumor cell invasion of vascular endothelial monolayers. Surg Today 1997;27:534–541
  • Kumagai N, Fukuda K, Fujitsu Y, Nishida T. Expression of functional ICAM-1 on cultured human keratocytes induced by tumor necrosis factor-alpha. Jpn J Ophthalmol 2003;47:134–141
  • Tran MT, Tellaetxe-Isusi M, Elner V, Strieter RM, Lausch RN, Oakes JE. Proinflammatory cytokines induce RANTES and MCP-1 synthesis in human corneal keratocytes but not in corneal epithelial cells. Beta-chemokine synthesis in corneal cells. Invest Ophthalmol Vis Sci 1996;37:987–996
  • Lu Y, Fukuda K, Nakamura Y, Kimura K, Kumagai N, Nishida T. Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005;46:2346–2352
  • Nagano T, Nakamura M, Nishida T. Differential regulation of collagen degradation by rabbit keratocytes and polymorphonuclear leukocytes. Curr Eye Res 2002;24:240–243
  • Lu Y, Fukuda K, Liu Y, Kumagai N, Nishida T. Dexamethasone inhibition of IL-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture. Invest Ophthalmol Vis Sci 2004;45:2998–3004
  • Lu Y, Fukuda K, Seki K, Nakamura Y, Kumagai N, Nishida T. Inhibition by triptolide of IL-1-induced collagen degradation by corneal fibroblasts. Invest Ophthalmol Vis Sci 2003;44:5082–5088
  • Liu Y, Kimura K, Yanai R, Chikama T, Nishida T. Cytokine, chemokine, and adhesion molecule expression mediated by MAPKs in human corneal fibroblasts exposed to poly(I:C). Invest Ophthalmol Vis Sci 2008;49:3336–3344
  • Nomi N, Kimura K, Nishida T. Release of interleukins 6 and 8 induced by zymosan and mediated by MAP kinase and NF-kappaB signaling pathways in human corneal fibroblasts. Invest Ophthalmol Vis Sci 2010;51:2955–2959
  • Notara M, Shortt AJ, Galatowicz G, Calder V, Daniels JT. IL6 and the human limbal stem cell niche: a mediator of epithelial-stromal interaction. Stem cell research 2010;5:188–200
  • Imanishi J, Kamiyama K, Iguchi I, Kita M, Sotozono C, Kinoshita S. Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 2000;19:113–129
  • Kimura K, Teranishi S, Fukuda K, Kawamoto K, Nishida T. Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB. Invest Ophthalmol Vis Sci 2008;49:565–571
  • Kimura K, Teranishi S, Nishida T. Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells. Invest Ophthalmol Vis Sci 2009;50:597–603
  • Gatzioufas Z, Charalambous P, Thanos S. Reduced expression of the gap junction protein Connexin 43 in keratoconus. Eye (Lond) 2008;22:294–299
  • Suzuki K, Tanaka T, Enoki M, Nishida T. Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing. Invest Ophthalmol Vis Sci 2000;41:2495–2500
  • Petridou S, Masur SK. Immunodetection of connexins and cadherins in corneal fibroblasts and myofibroblasts. Invest Ophthalmol Vis Sci 1996;37:1740–1748
  • Spanakis SG, Petridou S, Masur SK. Functional gap junctions in corneal fibroblasts and myofibroblasts. Invest Ophthalmol Vis Sci 1998;39:1320–1328
  • Grupcheva CN, Laux WT, Rupenthal ID, McGhee J, McGhee CN, Green CR. Improved corneal wound healing through modulation of gap junction communication using connexin43-specific antisense oligodeoxynucleotides. Invest Ophthalmol Vis Sci 2012;53:1130–1138
  • Eugenin EA, Gonzalez HE, Sanchez HA, Branes MC, Saez JC. Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro. Cell Immunol 2007;247:103–110

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.