The Evaluation of Human Tenon’s Fibroblasts and Endothelial Cell Responses to Antifibrotics Alone and in Combination with α-Tocopherol

REFERENCES

• Yoon PS, Singh K. Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. Curr Opin Ophthalmol 2004;15:141–146
   PubMedGoogle Scholar
• Goldsberry DH, Epstein RJ, Majmudar PA, Epstein RH, Dennis RF, Holley G, et al. Effect of mitomycin C on the corneal endothelium when used for corneal subepithelial haze prophylaxis following photorefractive keratectomy. J Refract Surg 2007;23:724–727
   Google Scholar
• Avisar R, Avisar I, Bahar I, Weinberger D. Effect of mitomycin C in pterygium surgery on corneal endothelium. Cornea 2008;27:559–561
   Google Scholar
• Werner AB, de Vries E, Tait SW, Bontzer I, Borst J. Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic bak or bax. J Biol Chem 2002;277:22781–22788
   PubMed Web of Science ®Google Scholar
• Rulli E, Biagioli E, Riva I, Gambirasio G, De Simone I, Floriani I, et al. Efficacy and Safety of Trabeculectomy vs Nonpenetrating Surgical Procedures: A Systematic Review and Meta-analysis. JAMA Ophthalmol. 2013; 131:1573--1582
   Google Scholar
• Crowston JG, Akbar AN, Constable PH, Ocleston NL, Daniels JT, Khaw PT. Antimetabolite-induced apoptosis in Tenon’s capsule fibroblasts. Invest Ophthalmol Vis Sci 1998;39:449–454
   PubMed Web of Science ®Google Scholar
• Jampel HD, Moon JI. The effect of paclitaxel powder on glaucoma filtration surgery in rabbits. J Glaucoma 1998;7:170–177
   Google Scholar
• Mac I, Soltau JB. Glaucoma-filtering bleb infections. Curr Opin Ophthalmol 2003;14:91–94
   PubMedGoogle Scholar
• Lehmann OJ, Bunce C, Matheson MM, Maurino V, Khaw PT, Wormald R, et al. Risk factors for development of post-trabeculectomy endophthalmitis. Br J Ophthalmol 2000;84:1349–1353
   Google Scholar
• Mattox C. Glaucoma filtration surgery and antimetabolites. Ophthalmic Surg Lasers 1995;26:473–480
   Google Scholar
• Suzuki R, Nakayama M, Satoh N. Three types of retinal bleeding as a complication of hypotony after trabeculectomy. Ophthalmologica 1999;213:135–138
   Google Scholar
• Seah SK, Prata JA Jr, Minckler DS, Koda RT, Baerveldt G, Lee PP, et al. Mitomycin-C concentration in human aqueous humour following trabeculectomy. Eye 1993;7:652–625
   PubMed Web of Science ®Google Scholar
• Crowston JG, Wang XY, Khaw PT, Zollener H, Healey PR. Human serum reduces mitomycin C cytotoxicity in human Tenon’s fibroblasts. Invest Ophthalmol Vis Sci 2006;47:946–952
   Google Scholar
• Weber T, Dalen H, Andera L, Nègre-Salvayre A, Augé N, Sticha M, et al. Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 2003;42:277–291
   Google Scholar
• Azzi A, Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res 2000;39:231–255
   PubMed Web of Science ®Google Scholar
• Engin KN. Alpha tocopherol: looking beyond an antioxidant. Mol Vis 2009;15:855–860
   PubMed Web of Science ®Google Scholar
• Haas AL, Boscoboinik D, Mojon DS, Bhonke M, Azzi A. Vitamin E inhibits proliferation of human Tenon’s capsule fibroblasts in vitro. Ophthalmic Res 1996;28:171–175
   PubMedGoogle Scholar
• Meyenberg A, Goldblum D, Zingg JM, Azzi A, Nesaretnam K, Kilchenmann M, et al. Tocotrienol inhibits proliferation of human Tenon’s capsule’s fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C. Graefes Arch Clin Exp Ophthalmol 2005;243:1263–1271
   Google Scholar
• Pinilla I, Larrosa JM, Polo V, Honrubia FM. α−Tocopherol derivatives in an experimental model of filtering surgery. Ophthalmic Res 1999;31:440–445
   Google Scholar
• Larrosa JM, Polo V, Ramirez T, Pinilla I, Pablo LE, Honrubia FM. α-Tocopherol derivatives and wound healing in an experimental model of filtering surgery. Ophthalmic Surg Lasers 2000;31:131–135
   Google Scholar
• Chakrabarty S, Huang S. Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression. J Exp Ther Oncol 1996;1:218–221
   PubMedGoogle Scholar
• Spencer W, Kwon H, Crepieux P, Leclerc N, Lin R, Hiscott J. Taxol selectively blocks microtubule dependent NF-κB activation by phorbol ester via inhibition of IκBα phosphorylation and degradation. Oncogene 1999;18:495–505
   Google Scholar
• Kammerer C, Czermak I, Getoff N, Kodym R. Enhancement of mitomycin C efficiency by vitamin C, E-acetate and beta-carotene under irradiation. A study in vitro. Anticancer Res 1999;19:5319–5321
   Google Scholar
• Engin KN, Kocabora SM, Erdem-Kuruca S, Akgün-Dar K, Dayı-Erol Ö. Method description for obtaining primary fibroblast cultures from human Tenon’s capsule. Turkiye Klinikleri J Ophthalmol 2009;18:108–112
   Google Scholar
• Hughes P, Marshall D, Reid Y, Parkes H, Gelber C. The costs of using unauthenticated, over-passaged cell lines: how much more data do we need? BioTechniques 2007;43:575–586
   PubMed Web of Science ®Google Scholar
• Khaw PT, Ward S, Porter A, Grierson I, Hitchings RA, Rice NS. The long-term effects of 5-fluorouracil and sodium butyrate on human Tenon’s fibroblasts. Invest Ophthalmol Vis Sci 1992;33:2043–2052
   PubMed Web of Science ®Google Scholar
• Lan YQ, Song X, Xiao JH, Zhuo YH, Guo H, Zhang C, et al. The inhibitive effects of 5-fluorouracil-loaded polylactic acid nanoparticles on human Tenon’s capsule fibroblast in vitro. Zhonghua Yan Ke Za Zhi 2009;45:26–31
   Google Scholar
• Oliveira-Ferrer L, Hauschild J, Fiedler W, Bokemeyer C, Nippgen J, Celik I, et al. Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway. J Exp Clin Cancer Res 2008;27:86
   PubMed Web of Science ®Google Scholar
• Packer L. Protective role of vitamin E in biological systems. Am J Clin Nutr 1991;53:1050S–1055S
   PubMed Web of Science ®Google Scholar
• Smith S, D'Amore PA, Dreyer EB. Comparative toxicity of mitomycin C and 5-fluorouracil in vitro. Am J Ophthalmol 1994;118:332–337
   PubMed Web of Science ®Google Scholar
• Seki Y, Toba K, Fuse I, Sato N, Niwano H, Takahashi H, et al. In vitro effect of cyclosporin A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells. Thromb Res 2005;115:219–228
   PubMed Web of Science ®Google Scholar
• Brown J, Reading SJ, Jones S, Fitchett CJ, Howl J, Martin A, et al. Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer derived epithelial cell line T24/83. Lab Invest 2000;80:37–45
   PubMed Web of Science ®Google Scholar
• Chang SW. Early corneal edema following topical application of mitomycin-C. J Cataract Refract Surg 2004;30:1742–1750
   PubMed Web of Science ®Google Scholar
• Suárez F, Jockovich ME, Hernandez E, Feuer W, Parel JM, Murray TG. Paclitaxel in the treatment of retinal tumors of LH beta-tag murine transgenic model of retinoblastoma. Invest Ophthalmol Vis Sci 2007;48:3437–3440
   PubMed Web of Science ®Google Scholar
• Lattanzio FA Jr, Sheppard JD Jr, Allen RC, Baynham S, Samuel P, Samudre S. Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment? J Ocul Pharmacol Ther 2005;21:223–235
   Google Scholar
• Shikano M, Onimura K, Fukai Y, Hori M, Fukazawa H, Mizuno S, et al. 1α-Docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase. Biochem Biophys Res Commun 1998;248:858–863
   Google Scholar
• Mosseri M, Fingert HJ, Varticovski L, Chokshi S, Isner JM. In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase c-mediated vasoconstriction of vascular smooth muscle. Cancer Res 1993;53:3028–3033
   PubMed Web of Science ®Google Scholar
• Yu W, Park SK, Jia L, Tiwary R, Scott WW, Li J, et al. RRR-γ-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Lett 2008;259:165–176
   Google Scholar
• Khveuja KL, Kumar S, Varma N, Varma SC, Avti PK, Pathak CM. Enhancement in α−tocopherol succinate-induced apoptosis by all-trans-retinoic acid in primary leukemic cells: role of antioxidant defense, Bax and c-myc. Mol Cell Biochem 2008;319:133–139
   Google Scholar
• Ronco MT, de Alvarez ML, Monti J, Carrillo MC, Pisani G, Lugano MC, et al. Modulation of balance between apoptosis and proliferation by lipid peroxidation (LPO) during rat liver regeneration. Mol Med 2002;8:808–817
   PubMed Web of Science ®Google Scholar
• Shah SJ, Sylvester PW. Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochem Cell Biol 2005;83:86–95
   Google Scholar
• Chen ZL, Tao J, Yang J, Yuan ZL, Liu XH, Jin M, et al. Vitamin E modulates cigarette smoke extract-induced cell apoptosis in mouse embryonic cells. Int J Biol Sci 2011;7:927–936
   Google Scholar
• Wilankar C, Khan NM, Checker R, Sharma D, Patwardhan R, Gota V, et al. γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways. Curr Pharm Des 2011;171:2176–2189
   Google Scholar
• Ezzoukhry Z, Louandre C, François C, Saidak Z, Godin C, Mazière JC, et al. The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL. Mol Pharmacol 2011;79:997–1004
   Google Scholar
• Mailloux A, Grenet K, Bruneel A, Bénéteau-Burnat B, Vaubourdolle M, Baudin B. Anticancer drugs induce necrosis of human endothelial cells involving both oncosis and apoptosis. Eur J Cell Biol 2001;80:442–449
   PubMed Web of Science ®Google Scholar
• Engin KN, Erdem-Kuruca S, Özcan-Arıcan G, Çetin B, Arıcan E, Serbes U, et al. In vitro evaluation of apoptotic effects of single and combined use of current antifibrotic agents on human endothelial cells. TUR Glokom-Katarakt 2009;4:93–99
   Google Scholar
• Sumide T, Nishida K, Yamato M, Ide T, Hayashida Y, Watanabe K, et al. Functional human corneal endothelial cell sheets harvested from temperature-responsive culture surfaces. FASEB J 2006;20:392–394
   PubMed Web of Science ®Google Scholar
• Neuwirth-Lux O, Billson F. Vitamin E and rabbit corneal endothelial cell survival. Aust NZJ Ophthalmol 1987;15:309–314
   PubMedGoogle Scholar
• Liu CJ, Tsei CC, Chou JC, Liu JH. Combined trabeculectomy and extracapsular cataract extraction with mitomycin C. Zhonghua Yi Xue Za Zhi 1997;60:205–212
   Google Scholar
• Garweg JG, Wegmann-Burns M, Goldblum D. Effects of daunorubicin, mitomycin C, azathioprine and cyclosporin A on human retinal pigmented epithelial, corneal endothelial and conjunctival cell lines. Graefes Arch Clin Exp Ophthalmol 2006;244:382–389
   PubMed Web of Science ®Google Scholar
• Tappeiner C, Meyenberg A, Goldblum D, Mojon D, Zingg JM, Nesaretnam K, et al. Antifibrotic effects of tocotrienols on human Tenon’s fibroblasts. Graefes Arch Clin Exp Ophthalmol 2010;248:65–71
   Google Scholar
• Kinhult S, Albertsson M, Eskilsson J, Cvikiel M. Effects of probucol on endothelial damage by 5-fluorouracil. Acta Oncol 2003;42:304–308
   PubMed Web of Science ®Google Scholar