441
Views
15
CrossRef citations to date
0
Altmetric
Original Article

Implication of Smad2 and Smad3 in Transforming Growth Factor-β-induced Posterior Capsular Opacification of Human Lens Epithelial Cells

, , &
Pages 386-397 | Received 18 Nov 2013, Accepted 12 May 2014, Published online: 09 Jun 2014

References

  • Marcantonio JM, Syam PP, Liu CS, Duncan G. Epithelial transdifferentiation and cataract in the human lens. Exp Eye Res 2003;77:339–346
  • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Investigation 2009;119:1420–1428
  • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Investigation 2003;112:1776–1784
  • Saika S, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Sumioka T, et al. Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis. Endocr Metab Immune Disord Drug Targets 2008;8:69–76
  • Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. BioEssays 2001;23:912–923
  • Eldred JA, Dawes LJ, Wormstone IM. The lens as a model for fibrotic disease. Philos Trans R Soc Lond Sers B, Biol Sci 2011;366:1301–1319
  • Zhang XH, Sun HM, Yuan JQ. Extracellular matrix production of lens epithelial cells. J Cataract Refractive Surgery 2001;27:1303–1309
  • S Saika, T Miyamoto, I Ishida, K Shirai, Y Ohnishi, A Ooshima, et al. TGFβ-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol 2002;86:1428–1433
  • de Iongh RU, Wederell E, Lovicu FJ, McAvoy JW. Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs 2005;179:43–55
  • Saika S, Miyamoto T, Kawashima Y, Okada Y, Yamanaka O, Ohnishi Y, et al. Immunolocalization of TGF-beta1, -beta2, and -beta3, and TGF-beta receptors in human lens capsules with lens implants. Graefe's Arch Clin Exp Ophthalmol 2000;238:283–293
  • Zheng D, Song T, Zhongliu X, Wu M, Liang J, Liu Y. Downregulation of transforming growth factor-β type II receptor prohibit epithelial-to-mesenchymal transition in lens epithelium. Mol Vision 2012;18:1238–1246
  • Wormstone IM, Tamiya S, Anderson I, Duncan G. TGF-β2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Investigative Ophthalmol Visual Sci 2002;43:2301–2308
  • Wormstone IM, Tamiya S, Eldred JA, Lazaridis K, Chantry A, Reddan JR, et al. Characterisation of TGF-β2 signalling and function in a human lens cell line. Exp Eye Res 2004;78:705–714
  • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577–84
  • Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753–791
  • Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J cellular Biochem 2007;101:9–33
  • Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, Dockrell ME. The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Biochem J 2006;393:601–607
  • Li J, Tang X, Chen X. Comparative effects of TGF-beta2/Smad2 and TGF-beta2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res 2011;92:173–179
  • Oft M, Heider K-H, Beug H. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998;8:1243–1252
  • Kim SG, Kim HA, Jong HS, Park JH, Kim NK, Hong SH, et al. The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3. Mol Biol Cell 2005;16:4672–4683
  • Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, et al. Comparative analysis of TGF-beta/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PloS One 2013;8:e72252
  • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002;4:487–494
  • Kitase Y, Shuler CF. Microtubule disassembly prevents palatal fusion and alters regulation of the E-cadherin/catenin complex. Int J Dev Biol 2013;57:55–60
  • Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, Szaszi K, et al. Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol 2010;188:383–399
  • Masszi A, Kapus A. Smaddening complexity: the role of Smad3 in epithelial-myofibroblast transition. Cells Tissues Organs 2011;193:41–52
  • Robertson JV, Nathu Z, Najjar A, Dwivedi D, Gauldie J, West-Mays JA. Adenoviral gene transfer of bioactive TGFβ1 to the rodent eye as a novel model for anterior subcapsular cataract. Mol Vision 2007;13:457–469
  • Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Investigation 2003;112:1486–1494
  • Lakos G, Takagawa S, Chen S-J, Ferreira AM, Han G, Masuda K, et al. Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. AmJ Pathol 2004;165:203–217
  • Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004;85:47–64

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.