The Association Between Aqueous Connective Tissue Growth Factor and the Severity of Age-related Cataracts as Graded by the Lens Opacities Classification System III

REFERENCES

• West S. Epidemiology of cataract: accomplishments over 25 years and future directions. Ophthalmic Epidemiol 2007;14:173–178
   PubMed Web of Science ®Google Scholar
• Abraham AG, Condon NG, West Gower E. The new epidemiology of cataract. Ophthalmol Clin North Am 2006;19:415–425
   PubMedGoogle Scholar
• Gordon-Thomson C, de Iongh RU, Hales AM, Chamberlain CG, McAvoy JW. Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci 1998;39:1399–1409
   PubMed Web of Science ®Google Scholar
• Lee EH, Joo CK. Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol Vis Sci 1999;40:2025–2032
   PubMed Web of Science ®Google Scholar
• Wormstone IM. Posterior capsule opacification: a cell biological perspective. Exp Eye Res 2002;74:337–347
   PubMed Web of Science ®Google Scholar
• Weston BS, Wahab NA, Mason RM. CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol 2003;14:601–610
   PubMed Web of Science ®Google Scholar
• Kothapalli D, Grotendorst GR. CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts. J Cell Physiol 2000;182:119–126
   PubMed Web of Science ®Google Scholar
• Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999;20:189–206
   PubMed Web of Science ®Google Scholar
• Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab 2000;71:276–292
   PubMed Web of Science ®Google Scholar
• Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002;4:599–604
   PubMed Web of Science ®Google Scholar
• Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR. The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem 2002;277:44187–44194
   PubMed Web of Science ®Google Scholar
• Furlong F, Crean J, Thornton L, O'Leary R, Murphy M, Martin F. Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose. Am J Physiol Renal Physiol 2007;292:F1691–700
   PubMedGoogle Scholar
• Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997;8:171–179
   PubMedGoogle Scholar
• Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Grotendorst GR, Takehara K. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J Invest Dermatol 1995;105:280–284
   PubMed Web of Science ®Google Scholar
• Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 1996;106:729–733
   PubMed Web of Science ®Google Scholar
• Hinton DR, He S, Jin ML, Barron E, Ryan SJ. Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye 2002;16:422–428
   PubMed Web of Science ®Google Scholar
• Chylack LT, Jr Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, et al. The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol 1993;111:831–836
   PubMed Web of Science ®Google Scholar
• Karbassi M, Khu PM, Singer DM, Chylack LT. Jr Evaluation of lens opacities classification system III applied at the slitlamp. Optom Vis Sci 1993;70:923–928
   PubMed Web of Science ®Google Scholar
• Kuiper EJ, de Smet MD, van Meurs JC, Tan HS, Tanck MW, Oliver N, et al. Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye. Arch Ophthalmol 2006;124:1457–1462
   PubMed Web of Science ®Google Scholar
• Ho SL, Dogar GF, Wang J, Crean J, Wu QD, Oliver N, et al. Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Br J Ophthalmol 2005;89:169–173
   PubMed Web of Science ®Google Scholar
• Junglas B, Yu AH, Welge-Lussen U, Tamm ER, Fuchshofer R. Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells. Exp Eye Res 2009;88:1065–1075
   PubMed Web of Science ®Google Scholar
• de Iongh RU, Wederell E, Lovicu FJ, McAvoy JW. Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs 2005;179:43–55
   PubMed Web of Science ®Google Scholar
• Zhao G, Wojciechowski MC, Jee S, Boros J, McAvoy JW, Lovicu FJ. Negative regulation of TGF-beta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. Exp Eye Res 2015;132:9–16
   PubMed Web of Science ®Google Scholar
• Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, Chen YE. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem 2001;276:45888–45894
   PubMed Web of Science ®Google Scholar
• Lovicu FJ, Schulz MW, Hales AM, Vincent LN, Overbeek PA, Chamberlain CG, McAvoy JW. TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract. Br J Ophthalmol 2002;86:220–226
   PubMed Web of Science ®Google Scholar
• Ma B, Kang Q, Qin L, Cui L, Pei C. TGF-beta2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF. Biochem Biophys Res Commun 2014;447:689–695
   PubMed Web of Science ®Google Scholar
• Rea, LM, Parker, RA. Designing & conducting survey research: a comprehensive guide (3rd Edition). San Francisco, CA: Jossey-Bass; 2005
   Google Scholar
• Gui T, Sun Y, Shimokado A, Muragaki Y. The roles of mitogen-activated protein kinase pathways in TGF-beta-induced epithelial-mesenchymal transition. J Signal Transduct 2012;2012:289243
   PubMedGoogle Scholar
• Hashida N, Ping X, Nishida K. MAPK activation in mature cataract associated with Noonan syndrome. BMC Ophthalmol 2013;13:70
   PubMed Web of Science ®Google Scholar
• Xie L, Santhoshkumar P, Reneker LW, Sharma KK. Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFbeta2-induced lens epithelial-to-mesenchymal cell transition. Invest Ophthalmol Vis Sci 2014;55:4731–4740
   PubMed Web of Science ®Google Scholar
• Shin EH, Basson MA, Robinson ML, McAvoy JW, Lovicu FJ. Sprouty is a negative regulator of transforming growth factor beta-induced epithelial-to-mesenchymal transition and cataract. Mol Med 2012;18:861–873
   PubMed Web of Science ®Google Scholar