Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

References

• Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976;197:517–532.
   PubMed Web of Science ®Google Scholar
• Matsumoto R. Sigma receptors: historical perspective and background. In: Matsumoto RR, Bowen WD, Su TP (Eds). Sigma receptors: chemistry, cell biology and clinical implications. New York: Springer Science; 2007.
   Google Scholar
• Schoenwald RD, Barfknecht CF, Xia E, Newton RE. The presence of sigma-receptors in the lacrimal gland. J Ocul Pharmacol 1993;9:125–139.
   PubMedGoogle Scholar
• Schoenwald RD, Barfknecht CF, Shirolkar S, Xia E, Ignace CC. Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. Adv Exp Med Biol 1994;350:141–146.
   PubMedGoogle Scholar
• Bucolo C, Campana G, Di Toro R, Cacciaguerra S, Spampinato S. Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure. J Pharmacol Exp Ther 1999;289:1362–1369.
   PubMed Web of Science ®Google Scholar
• Senda T, Matsuno K, Mita S. The presence of sigma receptor subtypes in bovine retinal membranes. Exp Eye Res 1997;64:857–860.
   PubMed Web of Science ®Google Scholar
• Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A 1996;93:8072–8077.
   PubMed Web of Science ®Google Scholar
• Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V. Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1). Biochem Biophys Res Commun 1996;229:553–558.
   PubMed Web of Science ®Google Scholar
• Seth P, Leibach FH, Ganapathy V. Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun 1997;241:535–540.
   PubMed Web of Science ®Google Scholar
• Seth P, Fei YJ, Li HW, Huang W, Leibach FH, Ganapathy V. Cloning and functional characterization of a sigma receptor from rat brain. J Neurochem 1998;70:922–931.
   PubMed Web of Science ®Google Scholar
• Ha Y, Saul A, Tawfik A, Williams C, Bollinger K, Smith R, et al. Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigmaR1). Invest Ophthalmol Vis Sci 2011;52:7749–7760.
   PubMed Web of Science ®Google Scholar
• Mavlyutov TA, Nickells RW, Guo LW. Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor. Mol Vision 2011;17:1034–1043.
   PubMed Web of Science ®Google Scholar
• Ha Y, Shanmugam AK, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell Tiss Res 2014;356:15–27.
   PubMed Web of Science ®Google Scholar
• Mori T, Hayashi T, Hayashi E, Su TP. Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One 2013;8:e76941.
   Google Scholar
• Rybczynska AA, Elsinga PH, Sijbesma JW, Ishiwata K, de Jong JR, de Vries EF, et al. Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats. Eur J Nuc Med Mol Imag 2009;36:1167–1175.
   PubMed Web of Science ®Google Scholar
• Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 2009;323:934–937.
   PubMed Web of Science ®Google Scholar
• Johannessen M, Fontanilla D, Mavlyutov T, Ruoho AE, Jackson MB. Antagonist action of progesterone at sigma-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol 2011;300:C328–C337.
   PubMed Web of Science ®Google Scholar
• Ola MS, Moore P, El-Sherbeny A, Roon P, Agarwal N, Sarthy VP, et al. Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina. Brain Res Mol Brain Res 2001;95:86–95.
   PubMedGoogle Scholar
• Jiang G, Mysona B, Dun Y, Gnana-Prakasam JP, Pabla N, Li W, et al. Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci 2006;47:5576–5582.
   PubMed Web of Science ®Google Scholar
• Liu LL, Wang L, Zhong YM, Yang XL. Expression of sigma receptor 1 mRNA and protein in rat retina. Neuroscience 2010;167:1151–1159.
   PubMed Web of Science ®Google Scholar
• Shirolkar S, Schoenwald RD, Barfknecht CF, Xia E, Cheng B, Iwai Y, et al. Lacrimal secretion stimulants: sigma receptors and drug implications. J Ocul Pharmacol 1993;9:211–227.
   PubMedGoogle Scholar
• Sun X, Cheng F, Meng B, Yang B, Song W, Yuan H. Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension. Mol Biol Rep 2012;39:6607–6614.
   PubMed Web of Science ®Google Scholar
• Campana G, Bucolo C, Murari G, Spampinato S. Ocular hypotensive action of topical flunarizine in the rabbit: role of sigma 1 recognition sites. J Pharmacol Exp Ther 2002;303:1086–1094.
   PubMed Web of Science ®Google Scholar
• Martin PM, Ola MS, Agarwal N, Ganapathy V, Smith SB. The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Brain Res Mol Brain Res 2004;123:66–75.
   PubMedGoogle Scholar
• Dun Y, Thangaraju M, Prasad P, Ganapathy V, Smith SB. Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. Invest Ophthalmol Vis Sci 2007;48:4785–4794.
   PubMed Web of Science ®Google Scholar
• Bucolo C, Drago F, Lin LR, Reddy VN. Sigma receptor ligands protect human retinal cells against oxidative stress. Neuroreport 2006;17:287–291.
   PubMed Web of Science ®Google Scholar
• Tchedre KT, Yorio T. Sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation. Invest Ophthalmol Vis Sci 2008;49:2577–2588.
   PubMed Web of Science ®Google Scholar
• Cantarella G, Bucolo C, Di Benedetto G, Pezzino S, Lempereur L, Calvagna R, et al. Protective effects of the sigma agonist Pre-084 in the rat retina. Br J Ophthalmol 2007;91:1382–1384.
   PubMed Web of Science ®Google Scholar
• Smith SB, Duplantier J, Dun Y, Mysona B, Roon P, Martin PM, et al. In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Invest Ophthalmol Vis Sci 2008;49:4154–4161.
   PubMed Web of Science ®Google Scholar
• Hellewell SB, Bowen WD. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res 1990;527:244–253.
   PubMed Web of Science ®Google Scholar
• Hornick JR, Xu J, Vangveravong S, Tu Z, Mitchem JB, Spitzer D, et al. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Mol Cancer 2010;9:298.
   PubMed Web of Science ®Google Scholar
• Mach RH, Smith CR, al-Nabulsi I, Whirrett BR, Childers SR, Wheeler KT. Sigma 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 1997;57:156–161.
   Google Scholar
• Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, et al. Sigma-2 receptors as a biomarker of proliferation in solid tumours. Br J Cancer 2000;82:1223–1232.
   PubMed Web of Science ®Google Scholar
• Huang YS, Lu HL, Zhang LJ, Wu Z. Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy. Med Res Rev 2014;34:532–566.
   PubMed Web of Science ®Google Scholar
• Mach RH, Zeng C, Hawkins WG. The sigma2 receptor: a novel protein for the imaging and treatment of cancer. J Med Chem 2013;56:7137–7160.
   PubMed Web of Science ®Google Scholar
• Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, et al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2011;2:380.
   PubMed Web of Science ®Google Scholar
• Abate C, Niso M, Infantino V, Menga A, Berardi F. Elements in support of the “non-identity” of the PGRMC1 protein with the sigma receptor. Eur J Pharmacol 2015;758:16–23.
   PubMed Web of Science ®Google Scholar
• Ruoho AE, Guo LW, Hajipour AR, Karaoglu K, Mavlyutov TA, Chu UB, Yang J. (2012) Will the true sigma-2 receptor please stand up. Soc Neurosci Abstr 2012;631:08/U17.
   Google Scholar
• Rohe HJ, Ahmed IS, Twist KE, Craven RJ. PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. Pharmacol Ther 2009;121:14–19.
   PubMed Web of Science ®Google Scholar
• Nolte I, Jeckel D, Wieland FT, Sohn K. Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins. Biochim Biophys Acta 2000;1543:123–130.
   PubMed Web of Science ®Google Scholar
• Ahmed IS, Rohe HJ, Twist KE, Craven RJ. Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity. J Biol Chem 2010;285:24775–24782.
   PubMed Web of Science ®Google Scholar
• Zeng C, Vangveravong S, Xu J, Chang KC, Hotchkiss RS, Wheeler KT, et al. Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res 2007;67:6708–6716.
   PubMed Web of Science ®Google Scholar
• Losel RM, Besong D, Peluso JJ, Wehling M. Progesterone receptor membrane component 1—many tasks for a versatile protein. Steroids 2008;73:929–934.
   PubMed Web of Science ®Google Scholar
• Ahmed IS, Rohe HJ, Twist KE, Mattingly MN, Craven RJ. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J Pharmacol Exp Ther 2010;333:564–573.
   PubMed Web of Science ®Google Scholar
• Cenedella RJ, Sexton PS, Zhu XL. Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein. Invest Ophthalmol Vis Sci 1999;40:1452–1459.
   PubMed Web of Science ®Google Scholar
• Zhu XL, Sexton PS, Cenedella RJ. Characterization of membrane steroid binding protein mRNA and protein in lens epithelial cells. Exp Eye Res 2001;73:213–219.
   PubMed Web of Science ®Google Scholar
• Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res 2009;198:472–476.
   PubMed Web of Science ®Google Scholar
• Umapathy NS, Li W, Mysona BA, Smith SB, Ganapathy V. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Muller cells. Invest Ophthalmol Vis Sci 2005;46:3980–3987.
   PubMed Web of Science ®Google Scholar
• Shanmugam A, Wang J, Markand S, Perry RL, Tawfik A, Zorrilla E. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIPγ, MIP2, MIP3α and IL12(p40/p70) by retinal Müller glial cells. J Neurochem 2015 ( In Press).
   Google Scholar
• Ola MS, Moore P, Maddox D, El-Sherbeny A, Huang W, Roon P, et al. Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice. Brain Res Mol Brain Res 2002;107:97–107.
   PubMedGoogle Scholar
• Ha Y, Saul A, Tawfik A, Zorrilla EP, Ganapathy V, Smith SB. Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. Mol Vision 2012;18:2860–2870.
   PubMed Web of Science ®Google Scholar
• Palmer CP, Mahen R, Schnell E, Djamgoz MB, Aydar E. Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. Cancer Res 2007;67:11166–11175.
   PubMed Web of Science ®Google Scholar
• Gebreselassie D, Bowen WD. Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. Eur J Pharmacol 2004;493:19–28.
   PubMed Web of Science ®Google Scholar