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Retina

Retinal Pigment Epithelial Cell Apoptosis is Influenced by a Combination of Macrophages and Soluble Mediators Present in Age-Related Macular Degeneration

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Pages 1235-1244 | Received 08 Aug 2014, Accepted 13 Oct 2015, Published online: 25 Mar 2016

References

  • Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002;120:1435–1442.
  • Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Arch Ophthalmol 1976;60:324–341.
  • Del Priore LV, Kuo YH, Tezel TH. Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci 2002;43:3312–3318.
  • Cruz-Guilloty F, Saeed AM, Echegaray JJ, Duffort S, Ballmick A, Tan Y, et al. Infiltration of proinflammatory M1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. Int J Inflammation 2013;2013: 503725.
  • Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nature Med 2003;9:1390–1397.
  • Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. Plos One 2011;6.
  • Luhmann UFO, Robbie S, Munro PMG, Barker SE, Duran Y, Luong V, et al. The drusenlike phenotype in aging Ccl2-Knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Visual Sci 2009;50:5934–5943.
  • Xu HP, Chen M, Manivannan A, Lois N, Forrester JV. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell 2008;7:58–68.
  • Combadiere C, Feumi C, Raoul W, Keller N, Rodero M, Pezard A, et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 2007;117:2920–2928.
  • Gupta N, Brown KE, Milam AH. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp Eye Res 2003;76:463–471.
  • Yoshida A, Elner SG, Bian ZM, Kindezelskii AL, Petty HR, Elner VM. Activated monocytes induce human retinal pigment epithelial cell apoptosis through caspase-3 activation. Lab Invest 2003;83:1117–1129.
  • Ma WX, Zhao L, Fontainhas AM, Fariss RN, Wong WT. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. Plos One 2009;4.
  • Kramer M, Hasanreisoglu M, Feldman A, Axer-Siegel R, Sonis P, Maharshak I, et al. Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration. Clin Exp Ophthalmol 2012;40:617–625.
  • Oh H, Takagi H, Takagi C, Suzuma K, Otani A, Ishida K, et al. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Visual Sci 1999;40:1891–1898.
  • Roh MI, Kim HS, Song JH, Lim JB, Koh HJ, Kwon OW. Concentration of cytokines in the aqueous humor of patients with naive, recurrent and regressed Cnv associated with Amd after bevacizumab treatment. Retina J Retinal Vitreous Dis 2009;29:523–529.
  • Wan L, Lin HJ, Tsai Y, Lee CC, Tsai CH, Tsai FJ. Tumor necrosis factor-alpha gene polymorphisms in age-related macular degeneration. Retina J Retinal Vitreous Dis 2010;30:1595–1600.
  • Yildirim Z, Ucgun NI, Yildirim F, Sepici-Dincel A. Choroidal neovascular membrane in age-related macular degeneration is associated with increased interleukin-6. Int J Gerontol 2012;6:101–104.
  • Jonas JB, Tao Y, Neumaier M, Findeisen P. Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration. Acta Ophthalmol 2012;90:e381–e388.
  • Faber C, Singh A, Kruger Falk M, Juel HB, Sorensen TL, Nissen MH. Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood. Ophthalmol 2013;120:2310–2316.
  • Suzuki M, Kamei M, Itabe H, Yoneda K, Bando H, Kume N, et al. Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration. Mol Vision 2007;13:772–778.
  • Yamada Y, Ishibashi K, Ishibashi K, Bhutto IA, Tian J, Lutty GA, et al. The expression of advanced glycation endproduct receptors in RPE cells associated with basal deposits in human maculas. Exp Eye Res 2006;82:840–848.
  • Javadzadeh A, Ghorbanihaghjo A, Bahreini E, Rashtchizadeh N, Argani H, Alizadeh S. Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration. Mol Vision 2010;16:2578–2584.
  • Chen M, Muckersie E, Robertson M, Fraczek M, Forrester JV, Xu HP. Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07. Invest Ophthalmol Visual Sci 2008;49:3699–3706.
  • McCarthy CA, Widdop RE, Deliyanti D, Wilkinson-Berka JL. Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system. Clin Exp Pharmacol Phy 2013;40:571–579.
  • Devarajan G, Chen M, Muckersie E, Xu H. Culture and characterization of microglia from the adult murine retina. Sci World J 2014. Article ID: 894368.
  • Zeng H, Ding M, Chen X, Lu Q. Microglial nadph oxidase activation mediates rod cell death in the retinal degeneration in Rd mice. Neuroscience 2014;275:54–61.
  • Elliott JA, Winn WC. Treatment of alveolar macrophages with Cytochalasin-D inhibits uptake and subsequent growth of legionella-pneumophila. Infect Immun 1986;51:31–36.
  • Roque RS, Rosales AA, Jingjing L, Agarwal N, Al-Ubaidi MR. Retina-derived microglial cells induce photoreceptor cell death in vitro. Brain Res 1999;836:110–119.
  • Wardman P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radical Biol Med 2007;43:995–1022.
  • Nussenblatt RB, Ferris F, III. Age-related macular degeneration and the immune response: implications for therapy. Am J Ophthalmol 2007;144:618–626.
  • Dastgheib K, Green WR. Granulomatous reaction to bruchs membrane in age-related macular degeneration. Arch Ophthalmol 1994;112:813–818.
  • Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002;134:411–431.
  • Leung KW, Barnstable CJ, Tombran-Tink J. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol 2009;46:1374–1386.
  • Holtkamp GM, Kijlstra A, Peek R, De Vos AF. Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retinal Eye Res 2001;20:29–48.
  • Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol 1997;15:749–795.
  • Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VA. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462–472.
  • Horiuchi T, Mitoma H, Harashima Si, Tsukamoto H, Shimoda T. Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology 2010;49:1215–1228.
  • Liu B, Wei L, Meyerle C, Tuo J, Sen H, Li Z, et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med 2011;9.
  • Buschini E, Piras A, Nuzzi R, Vercelli A. Age related macular degeneration and drusen: neuroinflammation in the retina. Prog Neurobiol 2011;95:14–25.
  • Zamiri P, Masli S, Streilein JW, Taylor AW. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest Ophthalmol Visual Sci 2006;47:3912–3918.

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