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Retina and Uvea

Immunohistochemical Detection of CTGF in the Human Eye

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Pages 1571-1579 | Received 18 May 2015, Accepted 10 Jan 2016, Published online: 23 Jun 2016

References

  • Ponticos M. Connective tissue growth factor (CCN2) in blood vessels. Vascul Pharmacol 2013;58(3):189–193.
  • Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002;14(5):608–616.
  • Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003;130(12):2779–2791.
  • Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, et al. Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn 2004;231(3):542–550.
  • Shi-Wen X, Leask A, Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 2008;19(2):133–144.
  • Gressner OA, Gressner AM. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int 2008;28(8):1065–1079.
  • Ollivier FJ, Brooks DE, Schultz GS, Blalock TD, Andrew SE, Komaromy AM, et al. Connective tissue growth factor in tear film of the horse: detection, identification and origin. Graefes Arch Clin Exp Ophthalmol 2004;242(2):165–171.
  • van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor (CTGF) in human tear fluid: preliminary results. Acta Ophthalmol Scand 2003;81(1):51–53.
  • Kothary PC, Badhwar J, Weng C, Del Monte MA. Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration. Adv Exp Med Biol 2010;664:419–428.
  • Kuiper EJ, de Smet MD, van Meurs JC, Tan HS, Tanck MW, Oliver N, et al. Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye. Arch ophthalmol 2006;124(10):1457–1462.
  • Razzaque MS, Foster CS, Ahmed AR. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Visual Sci 2003;44(5):1998–2003.
  • Yang H, Huang Y, Chen X, Liu J, Lu Y, Bu L, et al. The role of CTGF in the diabetic rat retina and its relationship with VEGF and TGF-beta(2), elucidated by treatment with CTGFsiRNA. Acta Ophthalmol 2009;88(6):652–659.
  • Kuiper EJ, Witmer AN, Klaassen I, Oliver N, Goldschmeding R, Schlingemann RO. Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol 2004;88(8):1082–1087.
  • Matsuda S, Gomi F, Katayama T, Koyama Y, Tohyama M, Tano Y. Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. Jpn J Ophthalmol 2006;50(3):229–234.
  • Watanabe D, Takagi H, Suzuma K, Oh H, Ohashi H, Honda Y. Expression of connective tissue growth factor and its potential role in choroidal neovascularization. Retina 2005;25(7):911–918.
  • Tikellis C, Cooper ME, Twigg SM, Burns WC, Tolcos M. Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology 2004;145(2):860–866.
  • He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, et al. Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Visual Sci 2008;49(9):4078–4088.
  • Junglas B, Kuespert S, Seleem AA, Struller T, Ullmann S, Bosl M, et al. Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am J Pathol 2012;180(6):2386–2403.
  • van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor in human aqueous humor. Ophthalmic Res 2002;34(5):306–308.
  • Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O’Brien CJ, et al. Connective Tissue Growth Factor is increased in Pseudoexfoliation Glaucoma. Invest Ophthalmol Visual Sci 2011;52(6):3660–3666.
  • Leask A, Abraham DJ. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006;119(Pt 23):4803–4810.
  • Yeger H, Perbal B. The CCN family of genes: a perspective on CCN biology and therapeutic potential. J Cell Commun Signal 2007;1(3–4):159–164.
  • Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 2009;41(4):771–783.
  • Wallace DM, Murphy-Ullrich JE, Downs JC, O’Brien CJ. The role of matricellular proteins in glaucoma. Matrix Biol 2014;37:174–182.
  • Secker GA, Shortt AJ, Sampson E, Schwarz QP, Schultz GS, Daniels JT. TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling. Exp Cell Res 2008;314(1):131–142.
  • Raghunathan VK, Dreier B, Morgan JT, Tuyen BC, Rose BW, Reilly CM, et al. Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells. PLoS One 2014;9(10):e109811.
  • Abu El-Asrar AM, Al-Kharashi SA, Missotten L, Geboes K. Expression of growth factors in the conjunctiva from patients with active trachoma. Eye (Lond) 2006;20(3):362–369.
  • Phanish MK, Winn SK, Dockrell ME. Connective tissue growth factor-(CTGF, CCN2)–a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 2009;114(3):e83–e92.
  • Gibson DJ, Pi L, Sriram S, Mao C, Petersen BE, Scott EW, et al. Conditional knockout of CTGF affects corneal wound healing. Invest Ophthalmol Visual Sci 2014;55(4):2062–2070.
  • Chang Y, Wu XY. JNK1/2 siRNA inhibits transforming-growth factor-beta1-induced connective tissue growth factor expression and fibrotic function in THSFs. Mol Cell Biochem 2009;335(1–2):83–89.
  • Sriram S, Robinson P, Pi L, Lewin AS, Schultz G. Triple combination of siRNAs targeting TGFbeta1, TGFbetaR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. Invest Ophthalmol Visual Sci 2013;54(13):8214–8223.
  • Liang Y, Li C, Guzman VM, Evinger AJ, 3rd, Protzman CE, Krauss AH, et al. Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. J Biol Chem 2003;278(29):27267–27277.
  • Hutchinson AJ, Coons SC, Chou CL, Xu W, Stamer WD, Woodward DF, et al. Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. Curr Eye Res 2010;35(5):408–418.
  • Bachmann B, Birke M, Kook D, Eichhorn M, Lutjen-Drecoll E. Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model. Invest Ophthalmol Visual Sci 2006;47(5):2011–2020.
  • Burgess JK, Ge Q, Poniris MH, Boustany S, Twigg SM, Black JL, et al. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. Am J Physiol Lung Cell Mol Physiol 2006;290(1):L153–L161.
  • Luo X, Ding L, Chegini N. CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium: inverse association with TGF-beta and regulation by TGF-beta in leiomyoma and myometrial smooth muscle cells. Mol Hum Reprod 2006;12(4):245–256.
  • De Falco M, Staibano S, D’Armiento FP, Mascolo M, Salvatore G, Busiello A, et al. Preoperative treatment of uterine leiomyomas: clinical findings and expression of transforming growth factor-beta3 and connective tissue growth factor. J Soc Gynecol Investig 2006;13(4):297–303.
  • Kita T, Hata Y, Kano K, Miura M, Nakao S, Noda Y, et al. Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor. Diabetes 2007;56(1):231–238.
  • Brigstock DR. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 2002;5(3):153–165.
  • Praidou A, Androudi S, Brazitikos P, Karakiulakis G, Papakonstantinou E, Dimitrakos S. Angiogenic growth factors and their inhibitors in diabetic retinopathy. Curr Diabetes Rev 2010;6(5):304–312.
  • Ma B, Kang Q, Qin L, Cui L, Pei C. TGF-beta2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF. Biochem Biophys Res Commun 2014;447(4):689–695.
  • Lee EH, Joo CK. Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol Visual Sci 1999;40(9):2025–2032.
  • Wunderlich K, Pech M, Eberle AN, Mihatsch M, Flammer J, Meyer P. Expression of connective tissue growth factor (CTGF) mRNA in plaques of human anterior subcapsular cataracts and membranes of posterior capsule opacification. Curr Eye Res 2000;21(2):627–636.
  • Fuchshofer R, Yu AH, Welge-Lussen U, Tamm ER. Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Visual Sci 2007;48(2):715–726.
  • Kuespert S, Junglas B, Braunger BM, Tamm ER, Fuchshofer R. The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells. J Cell Mol Med 2015;19(5):1010–1020.
  • Klaassen I, van Geest RJ, Kuiper EJ, van Noorden CJ, Schlingemann RO. The role of CTGF in diabetic retinopathy. Exp Eye Res 2015;133:37–48.
  • Liu SC, Chuang SM, Hsu CJ, Tsai CH, Wang SW, Tang CH. CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis 2014;5:e1485.
  • He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol 2003;121(9):1283–1288.
  • Kirwan RP, Leonard MO, Murphy M, Clark AF, O’Brien CJ. Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. Glia 2005;52(4):309–324.
  • Ogden TE. Nerve fiber layer astrocytes of the primate retina: morphology, distribution, and density. Invest Ophthalmol Visual Sci 1978;17(6):499–510.
  • Hauck SM, Gloeckner CJ, Harley ME, Schoeffmann S, Boldt K, Ekstrom PA, et al. Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach. Mol Cell Proteomics: MCP 2008;7(7):1349–1361.
  • Wallace DM, Pokrovskaya O, O’Brien CJ. The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma. J Ocul Pharmacol Ther: Off J Assoc Ocul Pharmacol Ther 2015;31(7):386–395.
  • Weston BS, Wahab NA, Mason RM. CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol 2003;14(3):601–610.
  • Junglas B, Yu AH, Welge-Lussen U, Tamm ER, Fuchshofer R. Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells. Exp Eye Res 2009;88(6):1065–1075.
  • Iyer P, Maddala R, Pattabiraman PP, Rao PV. Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. Invest Ophthalmol Visual Sci 2012;53(8):4952–4962.
  • Fuchshofer R, Kuespert S, Junglas B, Tamm ER. The prostaglandin f2alpha analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular meshwork cells. J Ocul Pharmacol Ther: Off J Assoc Ocul Pharmacol Ther 2014;30(2–3):237–245.
  • Su Y, Cheng J, Liu H, Wang F, Zhao S. Adenovirus conducted connective tissue growth factor on extracellular matrix in trabecular meshwork and its role on aqueous humor outflow facility. Mol Biol Rep 2013;40(11):6091–6096.
  • Wallace DM, Clark AF, Lipson KE, Andrews D, Crean JK, O’Brien CJ. Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells. Invest Ophthalmol Visual Sci 2013;54(13):7836–7848.
  • Wu CK, Wang YC, Lee JK, Chang SN, Su MY, Yeh HM, et al. Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. Eur J Heart Fail 2014;16(2):163–172.
  • Weinreb RN, Toris CB, Gabelt BT, Lindsey JD, Kaufman PL. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol 2002;47(Suppl 1):S53–S64.

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