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Original Article

The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes

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Pages 645-650 | Received 07 Nov 1983, Accepted 10 Jan 1984, Published online: 02 Jul 2009

References

  • Laibson P. R. Cornea and Sclera. Arch. Ophthalmol. 1972; 88: 553–574
  • Fisher E., Allen J. H. Corneal ulcers produced by cell free extracts of P. aeruginosa. Am. J. Ophthalmol. 1958; 46: 21–27
  • Kawaharajo K., Abe C., Homma J. Y., Kawano M., Gotoh E., Tanaka N., Morihara K. Corneal ulcers caused by protease and elastase from P. aeruginosa. Jpn. J. Exp. Med. 1974; 44: 435–442
  • Kreger A. S., Gray L. D. Purification of P aeruginosa proteases and microscopic characterization of Pseudomonal protease induced rabbit corneal damage. Infect. Immun. 1978; 19: 630–648
  • Brown S. I., Bloomfield S. E., Tam W. ‐FI. The cornea destroying enzyme of Pseudomonas aeruginosa. Invest. Ophthalmol. 1974; 13: 174–180
  • Kessler E., Kennah H., Brown S. I. Pseudomonas protease. Purification, partial characterization and its effect on collagen, proteoglycan and rabbit corneas. Invest. Ophthalmol. Vis. Sci. 1977; 16: 488–497
  • Wilson L. A. Chelation in experimental Pseudomonas keratitis. Brit. J. Ophthalmol. 1970; 54: 587–593
  • Bohigian G., Valenton M., Okumoto M., Caraway B. L. Collagenase inhibitors in Pseudomonas keratitis. Arch. Ophthalmol. 1974; 91: 52–56
  • Mondino B. J., Kessler E., Gipson L. L., Brown S. I. Effects of zine sulfate on Pseudomonas aeruginosa infections and protease in rabbit corneas. Arch. Ophthalmol. 1976; 94: 2149–2152
  • Kessler E., Israel M., Landshman N., Chechick A., Blumberg S. In vitro inhibition of Pseudomonas elastase by metalchelating peptide derivatives. Infect. Immun. 1982; 38: 716–723
  • Kessler E., Spierer A., Blumberg S. Specific inhibition of P. aeruginosa elastase injected intracorneally in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 1983; 24: 1093–1097
  • Blumberg S., Tauber Z. Inhibition of metalloendopeptidases by 2‐mercaptoacetyl dipeptides. Eur. J. Biochem. 1983; 136: 151–154
  • Ohman D. E., Burns R. P., Iglewski B. H. Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa. J. Infect. Dis. 1980; 142: 547–555
  • Hyndiuk R. A. Experimental Pseudomonas keratitis. Tr. Am. Ophthalmol. Soc. 1981; 79: 541–624
  • Kessler E., Mondino B. J., Brown S. I. The corneal response to Pseudomonas aeruginosa: histopathological and enzymatic characterization. Invest. Ophthalmol. Vis. Sci. 1977; 16: 116–125
  • Kessler E., Safrin M. Growth of Pseudomonas aeruginosa and secretion of protease in the presence of the protease inhibitors. Metabol. Pediat. System. Ophthalmol. 1982; 6: 331–336

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