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Current Eye Research Volume 5, 1986 - Issue 1
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Original Article

Recovery of a latent HSV-1 thymidine kinase negative strain following iontophoresis and co-cultivation in the ocularly-infected rabbit model

J. W. Caudill Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA
,
E. Romanowski Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA
,
T. Araullo-cruz Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA
&
Y. J. Gordon Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA
Pages 41-45 | Received 03 Sep 1985, Accepted 05 Dec 1985, Published online: 02 Jul 2009

References

  • Field H. J., Wildy P. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. J. of Hygiene (Cambridge) 1978; 81: 267–277
  • Tenser R. B., Dunstan M. E. Herpes simplex virus thymidine fcinase expression in infection of the trigeminal ganglion. Virology 1979; 99: 417–422, 1979
  • Klein R. J., Friedman-Kien A. E., DeStefano E. Pathogenesis of experimental skin infections induced by drug-resistant herpes simplex virus mutants. Inf. & Imm. 1981; 34: 693–701
  • Price R. W., Khan A. Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity. Inf. & Immun. 1981; 34: 571–580
  • Gordon Y. J., Gilden D. M., Becker Y. HSV-1 thymidine kinase promotes virulence and latency in the mouse. Invest. Ophthalmol. Vis. Sci. 1983; 24: 599–602
  • Field H. J., Darby G. Pathogenicity in mice strains of herpes simplex virus which are resistant to acyclovir in intro and in vivo. Antimicrob. Agents and Chemo. 1980; 17: 209–216
  • Tenser R. B., Killer R. L., Rapp F. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus. Science 1979; 205: 915–917
  • Gordon Y. J., Rao H., Araullo-Cruz T. Immunosuppression promotes ocular virus replication and CNS neurovirulence following corneal inoculation with an avirulent herpes simplex type 1 thymidine kinase negative mutant. Cur. Eye. Res. 1984; 3: 651–657
  • Shimomura Y., Gangarosa L. P., Kataoka M., Hill J. M. HSV-1 shedding by iontophoresis of 6-hydroxydopamine followed by topical epinephrine. Invest. Ophthalmol. Vis. Sci. 1983; 24: 1588–1594
  • Tenser R. B., Jones J. C., Ressel S. J., Fralish F. A. Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpes viruses. J. Clin. Microbiol. 1983; 17: 122–127
  • Easty D. L., Carter C. Mechanisms of resistance and hypersensitivity in herpes simplex keratitis. Trans. Ophthal. Soc, U.K. 1979; 99: 126–133
  • Sears A. E., Meignier B., Roizman. Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase gene. J. of Virology 1985; 55: 410–416
  • Tenser R. B., Ressel S., Dunstan M. E. Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: Correlation of the enzyme activity with ganglion virus titer and evidence of in vivo complementation. Virology 1981; 112: 328–341
  • Kwon B. S., Gangarosa L. P., Burch K. D., deBack J., Hill J. M. Induction of ocular herpes simplex virus shedding by iontophoresis of epinephrine into rabbit cornea. Invest. Ophthalmol. Vis. Sci. 1981; 21: 442–449
  • Tullo A. B., Shimild C, Blyth W. A., Hill T. J., Easty D. L. Spread of virus and distribution of latent immune infection following ocular herpes simplex in the non-immune and immune mouse. J. Gen. Virol. 1982; 63: 95–101
  • Willey D. E., Trousdale M. D., Nesburn A. B. Reactivation of latent ocular HSV infection in mice by epinephrine iontophoresis. Invest. Ophthalmol. Vis. Sci. 1984; 25: 945–950
  • Gordon Y. J., Romanowski E., Ruziczka L., Balouris C. An improved mouse iontophoresis latency model using a clinical isolate, HSV-1 W strain. Inv. Ophthalmol. Vis. Sci., submitted
  • Rawls W. E., Inamoto K., Adam E., Melnick J. L. Measurement of Antibodies to Herpesvirus types 1 and 2 in Human Sera. J. Immunol. 1970; 104: 599–606

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