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Original Article

Effects of sorbinil treatment in rats with chronic streptozotocin-diabetes; changes in lens and in substance P and catecholamines in the iris

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Pages 357-363 | Received 19 Aug 1988, Accepted 22 Feb 1989, Published online: 02 Jul 2009

References

  • Kinoshita J. H., Merola L. O., Sato K., Dimak E. Osmotic changes caused by the accumulation of dulcitol in the lenses of rats fed with galactose. Nature 1962; 194: 1085
  • Gonzalez A.-M., Sochor M., McLean P. The effect of an aldose reductase inhibitor (sorbinil) on the level of metabolites in lenses of diabetic rats. Diabetes 1983; 22: 482–485
  • Beyer-Mears A., Cruz E. Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes 1985; 34: 15–21
  • Gonzalez A.-M., Sochor M., Hothersall J. S., McLean P. Effect of aldose reductase inhibitor (sorbinil) on integration of polyol pathway, pentose phosphate pathway, and glycolytic route in rat lens. Diabetes 1986; 35: 200–205
  • MacGregor L. C., Matchinsky F. M. Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats. J. Clin. Invest. 1985; 76: 887–889
  • Cunha-Vaz J. C., Mota C, Leite E. C., Abreu J. R.F., Ruas M. A. Effect of sorbinil on blood-retinal barrier in early diabetic retinopathy. Diabetes 1986; 35: 574–578
  • Hreidarsson A. B. Pupil motility in long-term diabetes. Diabetologia 1979; 17: 145–150
  • Hreidarsson A. B. Pupil size in insulin-dependent diabetes. Diabetes 1982; 31: 442–448
  • Hreidarsson A. B., Gundersen H. J.G. The pupillary response to light in Type I (insulin-dependent) diabetes. Diabetologia 1985; 28: 815–821
  • Willars G. B., Townsend J., Tomlinson D. R., Compton A. M., Churchill R. D. Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil. Metabolism 1988, in press
  • Pernow B. Substance P. Pharmacol. Rev. 1983; 35: 85–141
  • Kessler J. A., Bell W. O., Black I. B. Substance P levels differ in sympathetic target organ terminals and ganglion perikarya. Brain Res. 1983; 258: 144–146
  • Rasch R. Control of blood glucose levels in the streptozotocin diabetic rat using a long-acting heat-treated insulin. Diabetologia 1979; 16: 185–190
  • Mayer J. H., Tomlinson D. R. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats. Diabetologia 1983; 25: 433–438
  • Harmar A., Schofield J. G., Keen P. Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia. Nature 1980; 284: 267–269
  • Robinson J. P., Willars G. B., Tomlinson D. R., Keen P. Axonal transport and tissue contents of substance P in rats with long-term streptozotocin-diabetes. Effects of the aldose reductase inhibitor —Statil—. Brain Res. 1987; 426: 339–348
  • Tomlinson D. R., Robinson J. P., Willars G. B., Keen P. Deficient axonal transport of substance P in streptozocin-induced diabetic rats. Diabetes 1988; 37: 488–493

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