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Current Eye Research Volume 9, 1990 - Issue sup1
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Original Article

Multiple, spatially distinct T cell epitopes within a pathogenic 123 residue cyanogen bromide peptide of bovine retinal S-antigen

Steven P. Fling Departments of Microbiology, University of Minnesota, Minneapolis, MN, USA
,
Dale S. Gregerson Departments of Microbiology, University of Minnesota, Minneapolis, MN, USA; Ophthalmology, University of Minnesota, Minneapolis, MN, USA
,
Wesley F. Obritsch Ophthalmology, University of Minnesota, Minneapolis, MN, USA
,
Michael Boyce-Jacino Departments of Microbiology, University of Minnesota, Minneapolis, MN, USA
,
Carmen F. Merryman Department of Biochemistry and Molecular Biology, Thomas Jefferson University
&
Larry A. Donoso Wills Eye Hospital, Philadelphia, PA, USA
Pages 111-117 | Published online: 02 Jul 2009

References

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  • Gregerson D. S., Obritsch W. F., Fling S. P., Cameron J. D. S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J. Immunol. 1986; 136: 2875–2882
  • Caspi R. R., Roberge F. G., McAllister C. G., ElSaied M., Kuwabara T., Gery I., Hanna E., Nussenblatt R. B. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J. Immunol. 1986; 136: 928–933
  • Wacker W. B., Donoso L. A., Kalsow C. M., Yankeelov J. A., Jr., Organisciak D. T. Experimental allergic uveitis. Isolation, characterization and localization of a soluble uveitopathogenic antigen from bovine retina. J. Immunol. 1977; 119: 1949–1958
  • Gregerson D. S., Fling S. P., Wohlhueter R. M. Characterization of immunologically active cyanogen bromide peptide fragments of bovine and human retinal S-antigen. Exp. Eye Res. 1986; 43: 803–818
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  • Gregerson D. S., Obritsch W. F., Fling S. P. Identification of a uveitogenic cyanogen bromide peptide fragment of bovine retinal S-antigen and preparation of a uveitogenic, peptide-specific T cell line. Eur. J. Immunol. 1987; 17: 405–411
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  • Mannie M. D., Paterson P. Y., U'Prichard D. C., Flouret G. Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: Delineation of antigenic determinants for encephalitogenicity, in vitro activation of cellular transfer, and proliferation of lymphocytes. Proc. Natl. Acad. Sci. USA 1985; 87: 5515–5519
  • Mannie M. D., Paterson P. Y., U'Prichard D. C., Flouret G. Encephalitogenic and proliferative responses of Lewis rat lymphocytes distinguished by position 75- and 80-substituted peptides of myelin basic protein. J. Immunol. 1989; 142: 2608–2616
  • Gregerson D. S., Fling S. P., Obritsch W. F., Merryman C. F., Donoso L. A. Identification of T cell recognition sites in S-antigen: Dissociation of proliferative and pathogenic sites. Cell. Immunol. 1989; 123: 427–440
  • Gregerson D. S., Fling S. P., Obritsch W. F., Merryman C. F., Donoso L. A. Functional dissociation of T cell sites; immunogenic, antigenic and pathogenic sites. Molecular Biology and Autoimmune Disease. AthensGreece April 16–20, 1989, NATO Advanced Research Workshop on In Press
  • Gregerson D. S., Putterman G. J. Preparation, isolation, and immunochemical studies of the cyanogen bromide peptides from a retinal photoreceptor cell autoantigen, S-antigen. J. Immunol. 1984; 133: 843–848
  • Shinohara T., Dietzschold B., Craft C. M., Wistow G., Early J. J., Donoso L. A., Horwitz J., Tao R. Primary and secondary structure of bovine retinal S-antigen (48KDA protein). Proc. Natl. Acad. Sci. USA 1987; 84: 6975–6979
  • Knospe V., Donoso L. A., Banga J. P., Kasp E., Gregerson D. S. Epitope mapping of S-antigen with monoclonal antibodies. Curr. Eye Res. 1988; 7: 1137–1147

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