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Current Eye Research Volume 9, 1990 - Issue sup1
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Original Article

The mouse as a model of experimental autoimmune uveoretinitis (EAU)

Rachel R. Caspi National Eye Institute, Bethesda, MD, USA
,
Chi-Chao Chan National Eye Institute, Bethesda, MD, USA
,
Barbara Wiggert National Eye Institute, Bethesda, MD, USA
&
Gerald J. Chader National Eye Institute, Bethesda, MD, USA
Pages 169-174 | Published online: 02 Jul 2009

References

  • Faure J. P. Autoimmunity and the retina. Current Topics in Eye Res. 1980; 2: 215–301
  • Gery I., Mochizuki M., Nussenblatt R. B. Retinal specific antigens and immunopathogenic processes they provoke. Prog. Retinal Res. 1986; 5: 75–109
  • Caspi R. R. Basic mechanisms in immune-mediated uveitic disease. Immunology of Eye Disease, S. L. Lightman. MTP Press Ltd., London 1989; 61–86, Ch. 5
  • Caspi R. R., Roberge F. G., Chan C. C., Wiggert B., Chader G. J., Rozenszajn L. A., Lando Z., Nussenblatt R. B. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 1988; 140: 1490–1495
  • Caspi R. R., Chan C. -C., Leake W. C., Higuchi M., Wiggert B., Chader G. J. Experimental autoimmune uveoretinitis in mice: Induction by a single eliciting event and dependence on quantitative parameters of immunization. J. Autoimm. 1990, in press
  • Hirose S., Kuwabara T., Nussenblatt R. B., Wiggert B., Redmond T. M., Gery I. Uveitis induced in primates by interphotoreceptor retinoidbinding protein. Arch. Ophthalmol. 1986; 104: 1698–1702
  • Fox G. M., Kuwabara T., Wiggert B., Redmond T. M., Hess H. H., Chader G. J., Gery I. Experimental autoimmune uveoretinitis (EAU) induced by retinal interphotoreceptor retinoid-binding protein (IRBP): differences between EAU induced by IRBP and by S-antigen. Clin. Immunol. Immunopathol. 1987; 43: 256–264
  • Broekhuyse R. M., Winkens H. J., Kuhlmann E. D. Induction of experimental autoimmune uveoretinitis and pinealitis by IRBP. Comparison to uveoretinitis induced by S-antigen and opsin. Curr. Eye Res. 1986; 5: 231–240
  • Iwase K., Fuji Y., Nakashima I., Kato N., Fujino Y., Kawashima H., Mochizuki M. A new model for experimental autoimmune uveoretinitis (EAU) in the mouse. Invest. Ophthalmol. Vis. Sci. 1988; 29(Suppl.)39
  • Linthicum D. S., Freilinger J. A. Acute autoimmune encephalomyelitis in mice. II Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. J. Exp. Med. 1982; 155: 35–40

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