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Original Article

Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK herpes simplex virus experimental keratitis

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Pages 139-142 | Received 13 Aug 1990, Accepted 04 Dec 1990, Published online: 02 Jul 2009

References

  • De Clercq E., Holy A., Rosenberg I., Sakuma T., Balzarini J., Maudgal P. C. A novel, selective broad-spectrum anti-DNA virus agent. Nature 1986; 323: 464–467
  • De Clercq E., Sakuma T., Baba M., Pauwels R., Balzarini J., Rosenberg I., Holy A. Antiviral activity of phosphonylmethoxy-alkyl derivatives of purine and pyrimidines. Antiviral Res. 1987; 8: 261–272
  • Snoeck R., Sakuma T., De Clercq E., Rosenberg I., Holy A. (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 1988; 32: 1839–1844
  • Votruba I., Bernaerts R., Sakuma T., De Clercq E., Merta A., Rosenberg I., Holy A. Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis. Mol. Pharmacol. 1987; 32: 524–529
  • Lin J. C., De Clercq E., Pagano J. S. Novel acyclic adenosine analogs inhibit Epstein Barr virus replication. Antimicrob. Agents Chemother. 1987; 31: 1431–1433
  • Osterhaus A. D.M.E., Green J., De Clercq E. Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil on seal herpes-virus (phocid herpesvirus 1) infection in vitro. Antiviral Res. 1987; 7: 221–226
  • Gil-Fernandez C., De Clercq E. Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African Swine fever virus replication in vitro. Antiviral Res. 1987; 8: 273–282
  • Pauwels R., Balzarini J., Schols D., Baba M., Desmyter J., Rosenberg I., Holy A., De Clercq E. Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agent. Antimicrob. Agents Chemother. 1988; 32: 1025–1030
  • Neyts J., Snoeck R., Schols D., Balzarini J., De Clercq E. Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3- hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)- HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG). Virology 1990, (in press)
  • Maudgal P. C., De Clercq E., Huyghe P. Efficacy of (S)-HPMPA against thymidine kinase deficient herpes simplex virus keratitis. Invest. Ophthalmol. Vis. Sci. 1987; 28: 243–245
  • Maudgal P. C., De Clercq E., Descamps J., Missotten L. Comparative evaluation of BVDU [(E)-5-(2-bromovinyl)-2′-deoxyuridine] and IDU (5-iodo-2′-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits. Bull. Soc. Beige Ophtalmol. 1979; 186: 109–118
  • Maudgal P. C., Missotten L., De Clercq E., Descamps J., De Meuter E. Efficacy of (E)-5-(2-bromovinyl)-2′ -deoxyuridine in the topical treatment of herpes simplex keratitis. Graefes Arch. Clin. Exp. Ophthalmol. 1981; 216: 261–268
  • Maudgal P. C., De Clercq E., Descamps J., Missotten L., Wijnhoven J. Experimental stromal herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine. Arch. Ophthalmol. 1982; 100: 653–656
  • Maudgal P. C., Uyttebroeck W., De Clercq E., Missotten L. Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine. Arch. Ophthalmol. 1982; 100: 1337–1340
  • De Clercq E., Descamps J., Verhelst G., Walker R. T., Jones A. S., Torrence P. F., Shugar D. Comparative efficacy of different antiherpes drugs against different strains of herpes simplex virus. J. Infect. Dis. 1980; 141: 563–574
  • De Clercq E., Holy A., Rosenberg I. Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrob. Agents Chemother. 1989; 33: 185–191
  • Gangemi D. J., Cozens R. M., De Clercq E., Balzarini J., Hochkeppel H.-K. 9-(2-phosphonyl-methoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. Antimicrob. Agents Chemother. 1989; 33: 1864–1868
  • Egberink H., Borst M., Niphuis H., Balzarini J., Neu H., Schellekens H., De Clercq E., Horzinek M., Koolen M. Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethylJadenine. Proc. Natl. Acad. Sci. USA 1990; 87: 3087–3091
  • Balzarini J., Naesens L., Herdewijn P., Rosenberg I., Holy A., Pauwels R., Baba M., Johns D. G., De Clercq E. Marked in vivo antiretrovirus activity of 9-(2-phosphonyl-methoxyethyl)adeine, a selective anti-human immunodeficiency virus agent. Proc. Natl. Acad. Sci. USA 1989; 86: 332–336

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