98
Views
71
CrossRef citations to date
0
Altmetric
Original Article

Dexamethasone induced ultrastructural changes in cultured human trabecular meshwork cells

, , &
Pages 783-793 | Received 06 Jan 1993, Accepted 24 Aug 1993, Published online: 02 Jul 2009

References

  • Armaly M. F. Effect of corticosteroids on intraocular pressure and fluid dynamics. I. The effect of dexamethasone in the normal eye. Arch. Ophthalmol. 1963; 70: 482–491
  • Miller D., Peczon J. D., Whitworth C. G. Corticosteroids and functions in the anterior segment of the eye. Am. J. Ophthalmol. 1965; 59: 31–34
  • Bernstein N. H., Schwartz B. Effects of long-term systemic steroids on ocular pressure and tonographic values. Arch. Ophthalmol. 1962; 68: 742–753
  • Francois J. Cortisone et tension oculaire. Ann. Ocul. 1954; 187: 805–816
  • Goldmann H. Cortisone glaucoma. Arch. Ophthalmol. 1962; 68: 621–626
  • Becker B., Mills D. W. Corticosteroids and intraocular pressure. Arch. Ophthalmol. 1963; 70: 500–507
  • Kass M. A., Johnson T. Corticosteroid-induced glaucoma. The Glaucomas, R. Ritch, M. B. Shields, T. Krupin. The C. V. Mosby Co., St. LouisUSA 1989; 1161–1168
  • Rohen J. W., Linner E., Witmer R. Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid-glaucoma. Exp. Eye Res. 1973; 17: 19–31
  • Rohen J. W., Lutjen-Drecoll E. Morphology of aqueous outflow pathways in normal and glaucomatous eyes. The Glaucomas, R. Ritch, M. B. Sheilds, T. Krupin. The C.V. Mosby Co., St. LouisUSA 1989; 41–74
  • Rohen J. W. Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations. Ophthalmology 1983; 90: 758–765
  • Neumann G. O.H., Apple D. J. Pathology of the Eye. Springer-Verlag, New York 1986; 771–847
  • Knepper P. A., Collins J. A., Frederick R. Effect of dexamethasone, progesterone and testosterone on IOP and GAGS in the rabbit eye. Invest. Ophthalmol. Vis Sci. 1985; 26: 1093–1100
  • Knepper P. A., Hvizd M. G., Goosens W., Higbee R. G., Gum G. G., Palmberg P. F. GAG profile of human TM in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 1989; 30: 224
  • Weinreb R. N., Bloom E., Baxter J. D., Alvarado J., Lan N., O'Donnell J., Polansky J. R. Detection of glucocorticoid receptors in cultured trabecular cells. Invest. Ophthalmol. Vis. Sci. 1981; 21: 403–407
  • Hernandez M. R., Wenk E. J., Weinstein B. I., Abumohor P., Podos S. M., Dunn M. W., Southren A. L. Glucocorticoid target cells in human outflow pathway, Autopsy and surgical specimens. Invest. Ophthalmol. Vis. Sci. 1983; 24: 1612–1616
  • Shirato S., Bloom E., Polansky J., Alvarado J., Stiwell L. Phagocytic properties of confluent human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1988; 29: 125, (Suppl.)
  • Polansky J. R., Kurtz R. M., Fauss D. J., Kim R. Y., Bloom E. In vitro correlates of glucocorticoid effects on intraocular pressure. Glaucoma Update IV, G. K. Krieglstein. Springer-Verlag, Berlin 1991; 20–29
  • Snyder R. W., Stamer W. D., Limstrom S. A., Seftor R. E.B., Jahnke J. C., Hunts J. Corticosteroid treatment regulates trabecular meshwork fibrinolytic enzymes. Invest. Ophthalmol. Vis. Sci. 1992; 33: 1119, (Suppl.)
  • Alexander J. P., Fisk A., Acott T. S., Samples J. R. Antagonism of interleukin-1 and phorbol ester induced metalloproteinase production by dexamethasone: time course studies. Invest. Ophthalmol. Vis. Sci. 1992; 33: 1120, (Suppl.)
  • Patridge C. A., Weinstein B. I., Southern A. L., Gerritsen M. E. Dexamethasone induces specific proteins in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1989; 30: 1843–1847
  • Polansky J. R., Fauss D. J., Nguyen T. D., Huang W., Alvarado J. Isolation of mRNAs and secreted proteins following dexamethasone treatment of cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1989; 30: 223, (Suppl.)
  • Tripathi B. J., Tripathi R. C., Hewson H. S. Hydrocortisone-induced DNA endoreplication in human trabecular cells in vitro. Exp. Eye Res. 1989; 49: 259–270
  • Alvarado J. A., Franse-Carman L., Murphy C. G., McHolm G., Epstein D. Biological effects of glucocorticoid treatment on cultured human trabecular meshwork (HTM) cells: decreased fluid flow. Invest. Ophthalmol. Vis. Sci. 1992; 33: 1120, (Suppl.)
  • Underwood J. L., Alvarado J. A., Franse-Carman L., Wood I., Murphy C. G., Anderson J. M., Epstein D. L. Steroids induce tight junction formation, narrowing of paracellular routes and decreased hydraulic conductivity. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1140, (Suppl.)
  • Clark A. F., Wilson K., McCartney M. D., Miggans S. T., Kunkel M., Howe W. Glucocorticoid-induced cross-linked actin networks (CLANS) in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1993, (in press)
  • Steely H. T., Browder S., Julian M. B., Miggins S. T., Wilson K. L., Clark A. F. The effects of dexamethasone on fibronectin expression in cultured trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 1992; 33: 2242–2250
  • Yun A. J., Murphy C. G., Polansky J. R., Newsome D. A., Alvarado J. A. Proteins secreted by human trabecular cells. Invest. Ophthalmol. vis. Sci. 1989; 30: 2012–2022
  • Hajek A. S., Sossi N., Sossi G., Palmberg P. Dexamethasone phosphate increases the accumulation of collagen in the cell layer of cultured human trabecular endothelial cells. Invest. Ophthalmol. Vis. Sci. 1983; 24: 136, (Suppl.)
  • Tripathi B. J., Millard C. B., Tripathi R. C. Corticosteroids induce a sialated glycoprotein (Cort-GP) in trabecular cells in vitro. Exp. Eye Res. 1990; 51: 735–737
  • Tripathi R. C., Tripathi B. J. Human trabecular endothelium, corneal endothelium, keratocytes, and scleral fibroblasts in primary cell culture. A comparative study of growth characteristics, morphology, and phagocytic activity by light and scanning electron microscopy. Exp. Eye Res. 1982; 35: 611–624
  • Beato M. Gene regulation by steroid hormones. Cell 1989; 56: 335–344
  • Swarovsky B., Steinhilber W., Scheele G. A., Kern H. F. Coupled induction of proteins and intercellular compartments involved in the secretory pathway in AR4–2J cells by glucocorticoids. Eur. J. Cell Biol. 1988; 47: 101–111
  • Steffen M., Scheridin V., Duvigneau C., Holzel F. Glucocorticoid-induced alterations of morphology and growth of fibrosarcoma cells derived from 7, 12 dimethyl-benz (a) anthracene rat mammary tumor. Cancer Res. 1988; 48: 7212–7218
  • Hay E. D., Svoboda K. K. Extracellular matrix interaction with the cytoskeleton. Cell Shape, W. D. Stein, F. Bronner. Academic Press, Inc., New York 1989; 147–172
  • DeSantis L., Garthwaite C., Knepper P. A. Dexamethasone-induction of ocular hypertension in the primate. Invest. Ophthalmol. Vis. Sci. 1990; 31: 488, (Suppl.)
  • Lorenzetti O. J. Effects of corticosteroids on ocular dynamics in rabbits. J. Pharmacol. Exp. Therap. 1970; 175: 763–772
  • Francois J., Benozzi G., Victoria-Trancoso V., Bohyn W. Ultrastructural and morphometric study of corticosteroid in rabbits. Ophthalmic Res. 1984; 16: 168–178
  • Zhan G-L., Miranda O. C., Bito L. Z. Steroid glaucoma, corticosteroid-induced ocular hypertension in cats. Exp. Eye Res. 1992; 54: 211–218
  • Clark A. F., Wilson K., deKater A. W., Allingham R. R. Dexamethasone induced ocular hypertension in perfusion cultured human eyes. Invest. Ophthalmol. Vis. Sci. 1991; 32: 599, (Suppl.)
  • Rodrigues M. M., Katz S. I., Foidart J-M., Spaeth G. L. Collagen, factor VIII antigen and immunoglobulin in the human aqueous drainage channels. Ophthalmology 1980; 87: 337–345
  • Babizhayev M. A., Brodskaya M. V. Fibronectin detection in drainage outflow system of human eyes in ageing and progression of open-angle glaucoma. Mech. Ageing Dev. 1989; 47: 145–157

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.