Immunolocalization of growth factors in the human ciliary body epithelium

References

• Granstein R. D., Staszenski R., Knisely T. L., Zevia E., Nazareno R., Latina M., Albert D. M. Aqueous humor contains transforming growth factor P and a small (< 3500 daltons) inhibitor of thymocyte proliferation. J. Immunol. 1990; 144: 3021–3027
   PubMed Web of Science ®Google Scholar
• Jampel H. D., Roche N., Stark W. J., Roberts A. B. Transforming growth factor beta in human aqueous humor. Curr. Eye Res. 1990; 9: 963–969
   PubMed Web of Science ®Google Scholar
• Cousins S. W., McCabe M. M., Danielpour D., Streilein J. W. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 1991; 32: 2201–2211
   PubMed Web of Science ®Google Scholar
• Tripathi R. C., Borisuth N. S.C., Tripathi B. J. Growth factors in the aqueous humor and their therapeutic implications in glaucoma and anterior segment disorders of the human eye. Drug Dev. Res. 1991; 22: 1–23
   Web of Science ®Google Scholar
• Tripathi R. C., Borisuth N. S.C., Tripathi B. J., Li J. Quantitation of growth modulatory polypeptides in aqueous humor. Invest. Ophthalmol. Vis. Sci. 1992; 33: 821, (Suppl.)
   Web of Science ®Google Scholar
• Tripathi R. C., Millard C. B., Tripathi B. J., Reddy V. A molecule resembling fibroblast growth factor in aqueous humor. Am. J. Ophthalmol. 1988; 106: 230–231
   PubMed Web of Science ®Google Scholar
• Tripathi R. C., Millard C. B., Tripathi B. J. Protein composition of human aqueous humor: SDS—PAGE analysis of surgical and postmortem samples. Exp. Eye Res. 1989; 48: 117–130
   PubMed Web of Science ®Google Scholar
• Tripathi R. C., Borisuth N. S.C., Tripathi B. J. Detection, quantification, and significance of basic fibroblast growth factor in the aqueous humor of man, cat, dog and pig. Exp. Eye Res. 1992; 54: 447–454
   PubMed Web of Science ®Google Scholar
• Sivalingam A., Duker J. S., Brown G. C., Magargal L. E., Kenney J., Donoso L. Aqueous basic fibroblast growth factor level in central retinal artery obstruction. Invest. Ophthalmol. Vis. Sci. 1990; 31: 194, (Suppl.)
   Google Scholar
• Namiki M., Tagami Y., Yamamoto M., Yamanaka A., Itoh M., Kanoh M. Presence of human epidermal growth factor (hEGF), basic fibroblast growth factor (bFGF) in human aqueous. Nippon Ganka Gakhi Zasshi 1992; 96: 652–656
   PubMedGoogle Scholar
• Castro J., Vigo J. F., Larranaga Cordido J., Sabugal J., Dim J. A. Insulin-like growth factor QGF-I) in aqueous humor. Study in non diabetic and diabetic patients. Invest. Ophthalmol. Vis. Sci. 1990; 31: 196, (Suppl.)
   Google Scholar
• Parelman J. J., Nicolson M., Pepose J. S. Epidermal growth factor in human aqueous humor. Am. J. Ophthalmol. 1990; 109: 603–604
   PubMed Web of Science ®Google Scholar
• Ohashi Y., Motokura M., Kinoshita Y., Mano T., Watanabe H., Kinoshita S., Manabe R., Oshiden K., Yanaihara C. Presence of epidermal growth factor in human tears. Invest. Ophthalmol. Vis. Sci. 1989; 30: 1879–1882
   PubMed Web of Science ®Google Scholar
• Tripathi R. C., Borisuth N. S.C., Tripathi B. J., Fang V. S. Analysis of human aqueous humor for epidermal growth factor. Exp. Eye Res. 1991; 53: 407–409
   PubMed Web of Science ®Google Scholar
• Assoian R. K., Komoriya A., Meyers C. A., Miller D. M., Sporn M. B. Transforming growth factor-beta in human platelets. J. Biol. Chem. 1983; 258: 7155–7160
   PubMed Web of Science ®Google Scholar
• Knisely T. L., Bleicher P. A., Vibbard C. A., Granstein R. D. Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr. Eye Res. 1991; 10: 761–771
   PubMed Web of Science ®Google Scholar
• Helbig H., Kittredge K. L., Coca-Prados M., Davis J., Palestine A. G., Nussenblatt R. B. Mammalian ciliary body epithelial cells in culture produce transforming growth factor-beta. Graefe 's Arch. Clin. Exp. Ophthalmol. 1991; 229: 84–87
   PubMed Web of Science ®Google Scholar
• Wilbanks G. A., Mammolenti M., Streilein J. W. Studies on the induction of anterior chamber—associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta. Eur. J. Immunol. 1992; 22: 165–173
   PubMed Web of Science ®Google Scholar
• Barsotti M. F., Bartels S. P., Freddo T. F., Kamm R. D. The source of protein in the aqueous humor of the normal monkey eye. Invest. Ophthalml. Vis. Sci. 1992; 33: 581–595
   PubMed Web of Science ®Google Scholar
• Lutjen-Drecoll E. Morphological basis for aqueous humor formation. Glaucoma: applied pharmacology in medical treatment, Grune, Stratton, 1984; 23–33
   Google Scholar
• Hagemann G. S., Kirchoff-Rempe M. A., Lewis G. P., Fisher S. K., Anderson D. H. Sequestration of basic fibroblast growth factor in the primate retinal interphotoreceptor matrix. Proc. Natl. Acad. Sci. U.S.A. 1991; 88: 6706–6710
   PubMed Web of Science ®Google Scholar
• Renko M., Quarto N., Morimoto T., Rifkin D. B. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J. Cell. Physiol. 1990; 144: 108–114
   PubMed Web of Science ®Google Scholar
• Tessler S., Neufeld G. Basic fibroblast growth factor accumulates in the nuclei of various bFGF-producing cell types. J. Cell. Physiol. 1990; 145: 310–317
   PubMed Web of Science ®Google Scholar
• Bugler B., Amalric F., Prats H. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Mol. Cell. Biol. 1991; 11: 573–577
   PubMed Web of Science ®Google Scholar
• Vigny M., Ollier-Hartmann M. P., Lavigue M., Fayein N., Jeanny J. C., Laurent M., Courtois Y. Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the E.H.S. tumor. J. Cell. Physiol. 1988; 137: 321–328
   PubMed Web of Science ®Google Scholar
• Soubrane G., Jerdan J., Karpouzas I., Fayein N. A., Glaser B., Coscas G., Courtois Y., Jeanny J. C. Binding of fibroblast growth factor to normal and neovascularized rabbit cornea. Invest. Ophthalmol. Vis. Sci. 1990; 31: 323–333
   PubMed Web of Science ®Google Scholar
• Folkman J., Klagsbrun M., Sasse J., Wadzinski M., Ingber D., Vlodavsky I. A heyjarin-binding angiogenic protein—basic fibroblast growth factor-is stored within basement membrane. Am. J. Pathol. 1988; 130: 393–400
   PubMed Web of Science ®Google Scholar
• Hanneken A., Lutty G. A., McLeod D. S., Robey F., Harvey A. K., Hjelmeland L. M. Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina. J. Cell. Physiol 1989; 138: 115–120
   PubMed Web of Science ®Google Scholar
• Hanneken A., de Juan E., Lutty G. A., Fox G. M., Schiffer S., Hjelmeland L. M. Altered distribution of basic fibroblast growth factor in diabetic retinopathy. Arch. Ophthalmol. 1991; 109: 1005–1011
   PubMedGoogle Scholar
• Vlodavsky J., Folkman J., Sullivan R., Fridman R., Ishai-Michaeli R., Sasse J., Klagsbrun M. Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 2292–2296
   PubMed Web of Science ®Google Scholar
• Yoshitoshi T., Shichi H. Immunosuppressive factors in porcine ciliary body. Jpn. J. Ophthalmol. 1992; 36: 151–157
   PubMed Web of Science ®Google Scholar
• Peng B., Shichi H. Ciliary body in experimental autoimmun uveitis: tissue repair and immunoreactivity of extracellular matrix substances. Curr. Eye Res. 1992; 11: 1087–1097
   PubMed Web of Science ®Google Scholar
• Baudouin C., Fredj-Reygrobellet D., Camelle J.-P., Barritault D., Gastaud P., Lapalus P. Acidic fibroblast growth factor distribution in normai human eye and possible implications in ocular pathogenesis. Ophthalmic Res. 1990; 22: 73–81
   PubMed Web of Science ®Google Scholar
• Pasquale L. R., Dorman-Pease M. E., Lutty G. A., Quigley H. A., Jampel H. D. Immunolocalization of TGF-β1, TGF-β2, and TGF-β3 in the anterior segment of the human eye. Invest. Ophthalmol. Vis. Sci. 1993; 34: 23–30
   PubMed Web of Science ®Google Scholar
• Wakefield L. M., Smith D. M., Flanders K. C., Sporn M. B. Latent transforming growth factor-β from human platelets. A high molecular weight complex containing precursor sequences. J. Biol. Chem. 1988; 263: 7646–7654
   PubMed Web of Science ®Google Scholar
• Roberts A. B., Sporn M. B. Transforming growth factor beta. Adv. Cancer Res. 1988; 51: 107–144
   PubMed Web of Science ®Google Scholar
• Grant M., Russell B., Fitzgerald C., Merimee T. J. Insulin-like growth factors in vitreous: studies in control and diabetic subjects with neovascularization. Diabetes 1986; 35: 416–420
   PubMed Web of Science ®Google Scholar
• Connor T. B., Roberts A. B., Sporn M. B., Danielpour D., Dart L. L., Michels R. G., Bustros S., Enger C., Kato H., Lansing M., Hayashi H., Glaser B. M. Correlation of fibrosis and transforming growth factor beta type 2 levels in the eye. J. Clin. Invest. 1989; 83: 1661–1666
   PubMed Web of Science ®Google Scholar
• Sivalingam A., Kenny J., Brown G. C., Benson W. E., Donoso L. Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch. Ophthalmol. 1990; 108: 869–872
   PubMed Web of Science ®Google Scholar
• Borisuth N. S.C., Tripathi R. C., Morse P. H., Tripathi B. J., El-Asrar A. M.A., Fang V. S. Quantification of TGF-β, EGF, and bFGF in the vitreous of patients with proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 1991; 32: 1028, (Suppl.)
   Web of Science ®Google Scholar
• Schweigerer L., Ferrara N., Haaparanta T., Neufeld G., Gospodarowicz D. Basic fibroblast growth factor: expression in cultured cells derived from corneal endothelium and lens epithelium. Exp. Eye Res. 1988; 46: 71–80
   PubMed Web of Science ®Google Scholar
• Plouet J., Gospodarowicz D. Iris-derived melanocytes contain a growth factor that resembles basic fibroblast growth factor. Exp. Eye Res. 1990; 51: 519–529
   PubMed Web of Science ®Google Scholar
• Schweigerer L., Malerstein B., Neufeld G., Gospodarowicz D. Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 1987; 143: 934–940
   PubMed Web of Science ®Google Scholar
• Ishigooka H., Aotaki-Keen A. E., Hjelmeland L. M. Subcellular localization of bFGF in human retinal pigment epithelium in vitro. Exp. Eye Res. 1992; 55: 203–214
   PubMed Web of Science ®Google Scholar
• Waldbillig R. J., Pfeffer B. A., Schoen T. J., Adler A. A., Shen-Orr Z., Scavo L., LeRoith D., Chader G. J. Evidence for an insulin-like growth factor autocrine—paracrine system in the retinal photoreceptor—pigment epithelial cell complex. J. Neurochem. 1991; 57: 1522–1533
   PubMed Web of Science ®Google Scholar
• Martin D. M., Yee D., Feldman E. L. Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells. Mol. Brain Res. 1992; 12: 181–186
   PubMedGoogle Scholar
• Connor T., Roberts A., Sporn M., Davis J., Glaser B. RPE cells synthesize and release transforming growth factor-β, a modulator of endothelial cell growth and wound healing. Invest. Ophthalmol. Vis. Sci. 1988; 29: 307, (Suppl.)
   Google Scholar
• Tanihara H., Yoshida M., Matsumoto M., Yoshimura N. Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 1993; 34: 413–419
   PubMed Web of Science ®Google Scholar
• Lutty G. A., Merges C., Threlkeld A. B., Crone S., McLeod D. S. Heterogeneity in localization of isoforms of TGF-β in human retina, vitreous, and choroid. Invest. Ophthalmol. Vis. Sci. 1993; 34: 477–487
   PubMed Web of Science ®Google Scholar