Inhibitory Activity of Fenoterol on Dermatophagoides-, Parietaria-, Tetanus-Toxoid-, and Candida albicans-Stimulated Blood Mononuclear Cells: Differences in β₂-Adrenoreceptor Stimulation but Not in Cell Apoptosis

References

• Barnes B J. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995; 152: 828
   Google Scholar
• Nelson H S. p-adrenergic bronchodilators. N Engl J Med 1995; 333: 499
   PubMed Web of Science ®Google Scholar
• Butchers P R, Vardley C J, Johnson M. Salmeterol: a potent and long-acting inhibitor of inflammatory release from human lung. Br] Pharmacol 1991; 104: 672
   PubMed Web of Science ®Google Scholar
• Yukawa T, Ukena D, Chanez P, Dent G, Chung K F, Barnes P J. Beta-adrenergic receptors on eosinophils: binding and functional studies. Am Rev Respir Dis 1990; 141: 1446
   PubMedGoogle Scholar
• Pedersen B, Dahl R, Larsen B B, Venge P. The effects of salmeterol on the early- and late-phase reaction to bronchial allergen and postchallenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein and serum eosinophil protein X. Allergy 1993; 48: 377
   PubMed Web of Science ®Google Scholar
• Seldon P M, Barnes P J, Giembycz M A. Phosphodiesterase IV inhibitors and B2-adrenoreceptor agonists suppress lipopolysaccharide-induced tumour necrosis factor-generation by human peripheral blood monocytes. Br J Pharmacol 1994; 112: 215P
   Google Scholar
• Bishopric N H, Cohen H J, Lefkowitz R J. Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol 1980; 65: 29
   PubMed Web of Science ®Google Scholar
• Conolly M E, Greenacre J K. The lymphocyte b-adrenoreceptor in normal subjects and patients with asthma: the effect of different forms of treatment on receptor function. J Clin Invest 1976; 58: 1307
   PubMed Web of Science ®Google Scholar
• Feldman R D, Hunninghake G W, McArdle W L. β2 - adrenergic receptor-mediated suppression of in-terleukin 2 receptors in human lymphocytes. J Immunol 1987; 139: 3355
   PubMed Web of Science ®Google Scholar
• Oddera S, Silvestri M, Scarso L, Testi R, Rossi G A. Salmeterol inhibits the allergen-induced mononuclear cell proliferation and downregulates GM-CSF release and HLA-DR expression by monocytes. Pulmon Pharmacol 1997; 10: 43
   Google Scholar
• Oddera S, Silvestri M, Lantero S, Sacco O, Rossi G A. Downregulation of the expression of intercellular adhesion molecule (ICAM)-l on bronchial epithelial cells by a betaradrenoceptor agonist: fenoterol. J Asthma 1998; 35(5)401
   Web of Science ®Google Scholar
• Wyllie A H, Kerr J F, Currie A R. Cell death: the significance of apoptosis. Int Rev Cytol 1980; 68: 251
   PubMedGoogle Scholar
• Arends M J, Morris R G, Wyllie A H. Apoptosis. The role of endonuclease. Am J Pathol 1990; 236: 593
   Google Scholar
• McConkey D J, Orrenius S, Jondal M. Cellular signalling in programmed cell death (apoptosis). Immunol Today 1990; 11: 120
   PubMedGoogle Scholar
• McConkey D J, Orrenius S, Jondal M. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J Immunol 1990; 145: 1227
   PubMed Web of Science ®Google Scholar
• Johnson K W, Davis B H, Smith K A. cAMP antagonizes interleukin 2-promoted T cell cycle progression at a discrete point in early Gl. Proc Natl Acad Sci USA 1988; 85: 6072
   PubMedGoogle Scholar
• Rossi G A, Zocchi E, Sacco O, Balbi B. Alveolar macrophage stimulation of T-cell proliferation in autologous mixed lymphocyte reaction. Role of HLA-DR antigens. Am Rev Respir Dis 1986; 133: 78
   Google Scholar
• Burastero S E, Fenoglio D, Crimi E, Brusasco V, Rossi G A. Frequency of allergen-specific T-lymphocytes in blood and bronchial response to allergen in asthma. J Allergy Clin Immunol 1993; 91: 1075
   PubMed Web of Science ®Google Scholar
• Anderson K L, Anderson G, Michell R H, Jenkinson E J, Owen J JT. Intracellular signaling pathways involved in the induction of apoptosis in immature T lymphocytes. J Immunol 1996; 256: 4083
   Google Scholar
• Lomo J, Blomhoff H K, Beiske K, Stokke T, Smeland E B. TGF-ftt and cyclic AMP promote apoptosis in resting human B lymphocytes. J Immunol 1995; 154: 1634
   PubMed Web of Science ®Google Scholar
• Wag T, Sheppard J R, Foker J E. Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis. Science 1978; 202: 155
   Google Scholar
• Oddera S, Silvestri M, Testi R, Rossi G A. Salmeterol enhances the inhibitory activity of dexamethasone on allergen-induced blood mononuclear cell activation. Respiration 1998; 65: 199
   Google Scholar
• Hall I P. β2-adrenoceptor polymorphisms: are they clinically important. Thorax 1996; 51: 351
   PubMedGoogle Scholar
• Mary D, Aussel C, Ferrua B, Fehlmann M. Regulation of interleukin-2 synthesis by cAMP in human T-cells. J Immunol 1987; 139: 1179
   PubMed Web of Science ®Google Scholar
• Kahn M M, Sansoni P, Silverman E D, Engleman E G, Melmon K L. Beta-adrenergic receptors on human suppressor, helper and cytolytic lymphocytes. Bio-chem Pharmacol 1986; 35: 1137
   Google Scholar
• Andersson U, Andersson J, Lindfors A, Wagner K, Møller G, Heusser C H. Simultaneous production of interleukin 2, interleukin 4 and interferon-Y by activated human blood lymphocytes. Eur J Immunol 1990; 20: 1591
   PubMedGoogle Scholar
• Fowlkes B J, Schwartz R H, Pardoll D M. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature 1988; 334: 620
   PubMed Web of Science ®Google Scholar
• Hoshi S, Furatani-Seiki M, Seto M, Tada T, Asano Y. Prevention of TCR-mediated apoptosis by the elevation of c AMP. Int Immunol 1994; 6: 1081
   Google Scholar
• Newman S P, Miller A B, Lennard-Jones T R, Moren F, Clarke S W. Improvement of pressurized aerosol deposition with Nebuhaler spacer device. Thorax 1984; 39: 935
   PubMed Web of Science ®Google Scholar
• Newman S P. Therapeutic aerosols. Aerosol and the Lung in Clinical and Experimental Aspects, S W Clarke, D Pavia. Butterworths, London 1984; 197–224
   Google Scholar
• Kerrebijn K F. Beta agonists. Asthma: Its Pathology and Treatment, M A Kaliner, P J Barnes, C GA Persson. Marcel Dekker Inc., New York 1991; 523–545
   Google Scholar
• Masclans J R, Barberà JA, MacNee W, Pavia I, Piera C, Lomena F, Chung K F, Roca J, Rodriguez-Roisin R. Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. Am J Respir Crit Care Med 1996; 149: 529
   Google Scholar
• Kahn M M, Sansoni P, Silverman E D, Engleman E G, Melmon K L. Beta-adrenergic receptors on human suppressor, helper and cytolytic lymphocytes. Bio-chem Pharmacol 1986; 35: 1137
   Google Scholar
• Taylor I K, O'Shaughnessy K M, Choudry N B, Adachi M, Palmer J BD, Fuller R W. A comparative study in atopic subject with asthma of effects of salmeterol and salbutamol on allergen-induced bronchocon-striction, increase in airway reactivity and increase in urinary leukotriene E4 excretion. J Allergy Clin Immunol 1992; 89: 574
   Google Scholar
• Laitinen L A, Laitinen A, Haahtela T. A comparative study of the effects of inhaled corticosteroid, bude-sonide, and of a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma. J Allergy Clin Immunol 1992; 90: 32
   PubMed Web of Science ®Google Scholar
• Gardiner P V, Ward C, Booth H, Allison A, Hendrick D J, Walter E H. Effects of eight weeks of treatment with salmeterol on bronchoalveolar lavage on inflammatory indices in asthmatics. Am J Respir Crit Care Med 1994; 150: 1006
   PubMed Web of Science ®Google Scholar