Expression of the Th1-Specific Cell-Surface Protein Tim-3 Increases in a Murine Model of Atopic Asthma

References

• Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348–2357.
   PubMed Web of Science ®Google Scholar
• Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17:138–146.
   PubMedGoogle Scholar
• Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787–793.
   PubMed Web of Science ®Google Scholar
• Reiner SL. Development in motion: Helper T cells at work. Cell 2007; 129:33–36.
   PubMed Web of Science ®Google Scholar
• O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000; 10:542–550.
   PubMed Web of Science ®Google Scholar
• Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 1992; 10:385–409.
   PubMed Web of Science ®Google Scholar
• Paul WE, Seder RA. Lymphocytes responses and cytokines. Cell. 1994; 76:241–251.
   PubMed Web of Science ®Google Scholar
• Liblau RS, Singer SW, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995; 16:34–38.
   PubMedGoogle Scholar
• Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298–304.
   PubMed Web of Science ®Google Scholar
• Shimbara A, Christodoulopoulos P, Soussi-Gounni A, Olivenstein R, Nakamura Y, Levitt RC, Nicolaides NC, Holroyd KJ, Tsicopoulos A, Lafitte JJ, Wallaert B, Hamid QA. IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma. J Allergy Clin Immunol 2000; 105:108–115.
   PubMed Web of Science ®Google Scholar
• Kroegel C, Julius P, Matthys H, Virchow JC Jr, Luttmann W. Endobronchial secretion of interleukin-13 following local allergen challenge in atopic asthma: Relationship to interleukin-4 and eosinophil counts. Eur Respir J 1996; 9:899–904.
   PubMed Web of Science ®Google Scholar
• Lack G, Renz H, Saloga J, Bradley KL, Loader J, Leung DY, Larsen G, Gelfand EW. Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J Immunol 1994; 152:2546–2554.
   PubMed Web of Science ®Google Scholar
• Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995; 3:397–405.
   PubMed Web of Science ®Google Scholar
• Woodruff PG, Fahy JV. Asthma: Prevalence, pathogenesis, and prospects for novel therapies. JAMA 2001; 286:395–398.
   PubMed Web of Science ®Google Scholar
• Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002; 415(6871):536–541.
   PubMed Web of Science ®Google Scholar
• Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 2003; 4:1093–1101.
   PubMed Web of Science ®Google Scholar
• Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 2003; 4:1102–1110.
   PubMed Web of Science ®Google Scholar
• Geng H, Zhang G-M, Li D, Zhang H, Yuan Y, Zhu H-G, Xiao H, Han L-F, Feng Z-H. Soluble form of T cell Ig mucin 3 is aninhibitory molecule in T cell-mediated immune response. J Immunol 2006; 176:1411–1420.
   PubMed Web of Science ®Google Scholar
• Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol 2004; 172:7169–7176.
   PubMed Web of Science ®Google Scholar
• Yang L, Anderson DE, Kuchroo J, Hafler DA. 2008. Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol 180:4409–4414.
   PubMed Web of Science ®Google Scholar
• Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005; 6:1245–1252.
   PubMed Web of Science ®Google Scholar
• McMillan SJ, Bishop B, Townsend MJ, McKenzie AN, Lloyd CM. The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. J Exp Med 2002; 195:51–57.
   PubMed Web of Science ®Google Scholar
• Choudhry MA, Fazal N, Goto M, Gamelli RL, Sayeed MM. Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury. Am J Physiol Gastrointest Liver Physiol 2002; 282:G937–947.
   PubMed Web of Science ®Google Scholar
• Yokoyama A, Hamazaki T, Ohshita A, Kohno N, Sakai K, Zhao GD, Katayama H, Hiwada K. Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. Int Arch Allergy Immunol 2000; 123:327–332.
   PubMed Web of Science ®Google Scholar
• Sakai K, Yokoyama A, Kohno N, Hamada H, Hiwada K. Prolonged antigen exposure ameliorates airway inflammation but not remodeling in a mouse model of bronchial asthma. Int Arch Allergy Immunol 2001; 126:126–134.
   PubMed Web of Science ®Google Scholar
• Sakai K, Yokoyama A, Kohno N, Hiwada K. Effect of different sensitizing doses of antigen in a murine model of atopic asthma. Clin Exp Immunol 1999; 118:9–15.
   PubMed Web of Science ®Google Scholar
• Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005; 202:1539–1547.
   PubMed Web of Science ®Google Scholar
• Kearley J, McMillan SJ, Lloyd CM. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. J Exp Med 2007; 204:1289–1294.
   PubMed Web of Science ®Google Scholar