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ASTHMA MECHANISMS, GENETICS AND PHYSIOLOGY

Association and Gene-Gene Interactions of Eight Common Single-Nucleotide Polymorphisms with Pediatric Asthma in Middle China

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Pages 238-244 | Published online: 15 Apr 2010

References

  • Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of GINA Dissemination Committee Report. Allergy 2004; 59:469–478.
  • Holgate ST. Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol 1999; 104:1139–1146.
  • Szefler SJ, Apter A. Advances in pediatric and adult asthma. J Allergy Clin Immunol 2005; 115:470–477.
  • McLeish S, Turner SW. Gene–environment interactions in asthma. Arch Dis Child 2007; 92:1032–1035.
  • Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population-based study of 11688 Danish twin pairs. Eur Respir J 1999; 13:8–14.
  • Palmer LJ, Burton PR, James AL, Musk AW, Cookson WO. Familiar aggregation and heritability of asthma-associated quantitative traits in a population-base sample of nuclear families. Eur J Hum Genet 2000; 8:853–860.
  • Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006; 7:95–100.
  • Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich Kautzky E, Schou C, Krishnaswamy G, Beaty TH. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264:1152–1156.
  • CSGA. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 1997; 15:389–392.
  • Yokouchi Y, Nukaga Y, Shibasaki M, Noguchi E, Kimura K, Ito S, Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31–q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 2000; 66:152–160.
  • Xu J, Meyers DA, Ober C, Blumenthal MN, Mellen B, Barnes KC, et al. Collaborative Study on the Genetics of Asthma. Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet 2001; 68:1437–1446.
  • Shek LP, Tay AH, Chew FT, Goh DL, Lee BW. Genetic susceptibility to asthma and atopy among Chinese in Singapore—linkage to markers on chromosome 5q31–33. Allergy 2001; 56:749–753.
  • Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383:247–250.
  • Deichmann KA, Heinzmann A, Forster J, Dischinger S, Mehl C, Brueggenolte E, Hildebrandt F, Moseler M, Kuehr J. Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin Exp Allergy 1998; 28:151–155.
  • Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998; 19:119–120.
  • Howard TD, Koppelman GH, Xu J, Zheng SL, Postma DS, Meyers DA, Bleecker ER. Gene-gene interaction in asthma:IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2002; 70:230–236.
  • Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997; 337:1720–1725.
  • Pernis AB, Rothman PB. JAK-STAT signaling in asthma. J Clin Invest 2002; 109:1279–1283.
  • Duetsch G, Illig T, Loesgen S, Rohde K, Klopp N, Herbon N, Gohlke H, Altmueller J, Wjst M. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet 2002; 11:613–621.
  • Nagarkatti R, B-Rao C, Vijayan V, Sharma SK, Ghosh B. Signal transducer and activator of transcription 6 haplotypes and asthma in the Indian population. Am J Respir Cell Mol Biol 2004; 31:317–321.
  • Kabesch M, Schedel M, Carr D, Woitsch B, Fritzsch C, Weiland SK, von Mutius E. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol 2006; 117:269–274.
  • Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976–983.
  • Koppelman GH, Reijmerink NE, Colin Stine O, Howard TD, Whittaker PA, Meyers DA, Postma DS, Bleecker ER. Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med 2001; 163:965–969.
  • Leung TF, Tang NL, Sung YM, Li AM, Wong GW, Chan IH, Lam CW. The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatr Allergy Immunol 2003; 14:255–260.
  • Heidema AG, Feskens EJ, Doevendans PA, Ruven HJ, van Houwelingen HC, Mariman EC, Boer JM. Analysis of multiple SNPs in genetic association studies: comparison of three multi-locus methods to prioritize and select SNPs. Genet Epidemiol 2007; 31:910–921.
  • Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003; 24:150–157.
  • Motsinger AA, Ritchie MD. Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics 2006; 2:318–328.
  • Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003; 19:376–382.
  • American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152:1107–1136.
  • Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 2005; 15:97–98.
  • Bossé Y, Hudson TJ. Toward a comprehensive set of asthma susceptibility genes. Annu Rev Med 2007; 58:171–184.
  • Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 2000; 9:549–559.
  • Celedón JC, Soto-Quiros ME, Palmer LJ, Senter J, Mosley J, Silverman EK, Weiss ST. Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy 2002; 32:387–390.
  • Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, von Mutius E, Martinez FD. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000; 105:506–513.
  • Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, Björkstén B, Beaty TH, Huang SK. An IL13 coding region variant is associated with a high total serum IgE level and atopy dermatitis in the German Multicenter Atopy Study (MAS-90). J Allergy Clin Immunol 2000; 106:167–170.
  • Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol 2006; 117:1306–1313.
  • Park HW, Lee JE, Kim SH, Kim YK, Min KU, Kim YY, Cho SH. Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: a cross-sectional population-based study in Korea. Respir Med 2009; 103:284–288.
  • Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW. A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy 2001; 31:1515–1521.
  • Savage SA. Genetic association studies: where are we now. Person Med 2006; 3:371–374.
  • Beghé B, Barton S, Rorke S, Peng Q, Sayers I, Gaunt T, Keith TP, Clough JB, Holgate ST, Holloway JW. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy 2003; 33:1111–1117.
  • Risma KA, Wang N, Andrews RP, Cunningham CM, Ericksen MB, Bernstein JA, Chakraborty R, Hershey GK. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. J Immunol 2002; 169:1604–1610.
  • Ober C, Leavitt SA, Tsalenko A, Howard TD, Hoki DM, Daniel R, Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000; 66:517–526.
  • Chan IH, Leung TF, Tang NL, Li CY, Sung YM, Wong GW, Wong CK, Lam CW. Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 2006; 117:127–133.
  • Renauld JC. New insights into the role of cytokines in asthma. J Clin Pathol 2001; 54:577–589.

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