Multilocus Analysis of Candidate Genes Involved in Neurogenic Inflammation in Pediatric Asthma and Related Phenotypes: A Case–Control Study

References

• Hunter DD, Undem BJ. Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea. Am J Respir Crit Care Med 1999; 159(6):1943–1948.
   PubMed Web of Science ®Google Scholar
• Nockher WA, Renz H. Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules. J Allergy Clin Immunol 2006; 117(3):583–589.
   PubMed Web of Science ®Google Scholar
• Nockher WA, Renz H. Neurotrophins and asthma: novel insight into neuroimmune interaction. J Allergy Clin Immunol 2006; 117(1):67–71.
   PubMed Web of Science ®Google Scholar
• Prakash Y, Thompson MA, Meuchel L, Pabelick CM, Mantilla CB, Zaidi S, Martin RJ. Neurotrophins in lung health and disease. Expert Rev Respir Med 2010; 4(3):395–411.
   PubMedGoogle Scholar
• Renz H. The role of neurotrophins in bronchial asthma. Eur J Pharmacol. 2001; 429(1–3):231–237.
   PubMed Web of Science ®Google Scholar
• Pouliot P, Turmel V, Gélinas E, Laviolette M, Bissonnette EY. Interleukin-4 production by human alveolar macrophages. Clin Exp Allergy 2005; 35(6):804–810.
   PubMed Web of Science ®Google Scholar
• Caroleo MC, Costa N, Bracci-Laudiero L, Aloe L. Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. J Neuroimmunol 2001; 113(2):193–201.
   PubMed Web of Science ®Google Scholar
• Rost B, Hanf G, Ohnemus U, Otto-Knapp R, Groneberg DA, Kunkel G, Noga O. Monocytes of allergics and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3. Regul Pept 2005; 124(1–3):19–25.
   PubMedGoogle Scholar
• Nassenstein C, Schulte-Herbruggen O, Renz H, Braun A. Nerve growth factor: the central hub in the development of allergic asthma? Eur J Pharmacol 2006; 533(1–3):195–206.
   PubMed Web of Science ®Google Scholar
• Braun A, Lommatzsch M, Mannsfeldt A, Neuhaus-Steinmetz U, Fischer A, Schnoy N, Lewin GR, Renz H. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. Am J Respir Cell Mol Biol 1999; 21(4):537–546.
   PubMed Web of Science ®Google Scholar
• Barouch R, Appel E, Kazimirsky G, Braun A, Renz H, Brodie C. Differential regulation of neurotrophin expression by mitogens and neurotransmitters in mouse lymphocytes. J Neuroimmunol 2000; 103(2):112–121.
   PubMed Web of Science ®Google Scholar
• Braun A, Appel E, Baruch R, Herz U, Botchkarev V, Paus R, Brodie C, Renz H. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol 1998; 28(10):3240–3251.
   PubMed Web of Science ®Google Scholar
• de Vries A, Dessing MC, Engels F, Henricks PA, Nijkamp FP. Nerve growth factor induces a neurokinin-1 receptor- mediated airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med 1999; 159(5 Pt 1):1541–1544.
   PubMed Web of Science ®Google Scholar
• Virchow JC, Julius P, Lommatzsch M, Luttmann W, Renz H, Braun A. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Am J Respir Crit Care Med 1998; 158(6):2002–2005.
   PubMed Web of Science ®Google Scholar
• Joachim RA, Handjiski B, Blois SM, Hagen E, Paus R, Arck PC. Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration: key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions. Am J Pathol 2008; 173(5):1379–1388.
   PubMed Web of Science ®Google Scholar
• Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C, Schulte-Herbruggen O, Gill H, Schuff-Werner P, Virchow JC. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med 2005; 171(2):115–120.
   PubMed Web of Science ®Google Scholar
• Bonini S. Bronchial asthma–no more doubts? Allergy 1996; 51(4):203–205.
   PubMed Web of Science ®Google Scholar
• Olgart Hoglund C, Frossard N. Nerve growth factor and asthma. Pulm Pharmacol Ther 2002; 15(1):51–60.
   PubMed Web of Science ®Google Scholar
• Kassel O, de Blay F, Duvernelle C, Olgart C, Israel-Biet D, Krieger P, Moreau L, Muller C, Pauli G, Frossard N. Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low-dose. Clin Exp Allergy 2001; 31(9):1432–1440.
   PubMed Web of Science ®Google Scholar
• Zeilinger S, Pinto LA, Nockher WA, Depner M, Klopp N, Illig T, von Mutius E, Renz H, Kabesch M. The effect of BDNF gene variants on asthma in German children. Allergy 2009; 64(12):1790–1794.
   PubMed Web of Science ®Google Scholar
• Szczepankiewicz A, Breborowicz A, Skibinska M, Wilkosc M, Tomaszewska M, Hauser J. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic children. Pediatr Allergy Immunol 2007; 18(4):293–297.
   PubMed Web of Science ®Google Scholar
• Szczepankiewicz A, Breborowicz A, Skibinska M, Wilkosc M, Tomaszewska M, Hauser J. Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children. Int Arch Allergy Immunol 2008; 145(1):43–47.
   PubMed Web of Science ®Google Scholar
• Szczepankiewicz A, Rose-Zerilli MJ, Barton SJ, Holgate ST, Holloway JW. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families. Int Arch Allergy Immunol 2009; 149(4):343–349.
   PubMed Web of Science ®Google Scholar
• Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995; 152(3):1107–1136.
   PubMed Web of Science ®Google Scholar
• Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J. Interpretative strategies for lung function tests. Eur Respir J 2005; 26(5):948–968.
   PubMed Web of Science ®Google Scholar
• ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171:912–930.
   PubMed Web of Science ®Google Scholar
• Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16(3):1215.
   PubMed Web of Science ®Google Scholar
• Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001; 69(1):138–147.
   PubMed Web of Science ®Google Scholar
• Hahn C, Islamian AP, Renz H, Nockher WA. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. J Allergy Clin Immunol 2006; 117(4):787–794.
   PubMed Web of Science ®Google Scholar
• Noga O, Hanf G, Gorges D, Dinh QT, Groneberg DA, Suttorp N, Kunkel G. Regulation of NGF and BDNF by dexamethasone and theophylline in human peripheral eosinophils in allergics and non-allergics. Regul Pept 2005; 132(1–3):74–79.
   PubMedGoogle Scholar
• Quarcoo D, Schulte-Herbruggen O, Lommatzsch M, Schierhorn K, Hoyle GW, Renz H, Braun A. Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin Exp Allergy 2004; 34(7):1146–1151.
   PubMed Web of Science ®Google Scholar
• Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, Krug N, Luttmann W, Renz H, Virchow JC Jr. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med 2003; 198(3):455–467.
   PubMed Web of Science ®Google Scholar
• Noga O, Englmann C, Hanf G, Grützkau A, Seybold J, Kunkel G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy 2003; 33(5):649–654.
   PubMed Web of Science ®Google Scholar
• Noga O, Englmann C, Hanf G, Grützkau A, Guhl S, Kunkel G. Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils. Clin Exp Allergy 2002; 32(9):1348–1354.
   PubMed Web of Science ®Google Scholar
• Bonini S, Lambiase A, Lapucci G, Properzi F, Bresciani M, Bracci Laudiero ML, Mancini MJ, Procoli A, Micera A, Sacerdoti G, Bonini S, Levi-Schaffer F, Rasi G, Aloe L. Nerve growth factor and asthma. Allergy 2002; 57(Suppl. 72):13–15.
   PubMedGoogle Scholar
• Ahn NG, Campbell JS, Seger R, Jensen AL, Graves LM, Krebs EG. Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proc Natl Acad Sci U S A 1993; 90(11):5143–5147.
   PubMed Web of Science ®Google Scholar
• Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, Richesson DA, Bojesen SE, Nordestgaard BG, Axelsson CK, Arias JI, Milne RL, Ribas G, González-Neira A, Benítez J, Zamora P, Brauch H, Justenhoven C, Hamann U, Ko YD, Bruening T, Haas S, Dörk T, Schürmann P, Hillemanns P, Bogdanova N, Bremer M, Karstens JH, Fagerholm R, Aaltonen K, Aittomäki K, von Smitten K, Blomqvist C, Mannermaa A, Uusitupa M, Eskelinen M, Tengström M, Kosma VM, Kataja V, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X; Australian Ovarian Cancer Management Group; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Devilee P, van Asperen CJ, Jacobi CE, Tollenaar RA, Huijts PE, Klijn JG, Chang-Claude J, Kropp S, Slanger T, Flesch-Janys D, Mutschelknauss E, Salazar R, Wang-Gohrke S, Couch F, Goode EL, Olson JE, Vachon C, Fredericksen ZS, Giles GG, Baglietto L, Severi G, Hopper JL, English DR, Southey MC, Haiman CA, Henderson BE, Kolonel LN, Le Marchand L, Stram DO, Hunter DJ, Hankinson SE, Cox DG, Tamimi R, Kraft P, Sherman ME, Chanock SJ, Lissowska J, Brinton LA, Peplonska B, Klijn JG, Hooning MJ, Meijers-Heijboer H, Collee JM, van den Ouweland A, Uitterlinden AG, Liu J, Lin LY, Yuqing L, Humphreys K, Czene K, Cox A, Balasubramanian SP, Cross SS, Reed MW, Blows F, Driver K, Dunning A, Tyrer J, Ponder BA, Sangrajrang S, Brennan P, McKay J, Odefrey F, Gabrieau V, Sigurdson A, Doody M, Struewing JP, Alexander B, Easton DF, Pharoah PD. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet 2008; 4(4):e1000054.
   Web of Science ®Google Scholar
• Dai L, Gast A, Horska A, Schrappe M, Bartram CR, Hemminki K, Kumar R, Bermejo JL. A case-control study of childhood acute lymphoblastic leukaemia and polymorphisms in the TGF-beta and receptor genes. Pediatr Blood Cancer 2009; 52(7):819–823.
   PubMed Web of Science ®Google Scholar
• Williams SM, Ritchie MD, Phillips JA 3rd, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, Moore JH. Multilocus analysis of hypertension: a hierarchical approach. Hum Hered 2004; 57(1):28–38.
   PubMed Web of Science ®Google Scholar
• Cho YM, Ritchie MD, Moore JH, Park JY, Lee KU, Shin HD, Lee HK, Park KS. Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. Diabetologia 2004; 47(3):549–554.
   PubMed Web of Science ®Google Scholar
• Coffey CS, Hebert PR, Ritchie MD, Krumholz HM, Gaziano JM, Ridker PM, Brown NJ, Vaughan DE, Moore JH. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics 2004; 5:49.
   PubMed Web of Science ®Google Scholar
• Chan IH, Leung TF, Tang NL, Li CY, Sung YM, Wong GW, Wong CK, Lam CW. Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 2006; 117(1):127–133.
   PubMed Web of Science ®Google Scholar
• Leung TF, Chan IH, Wong GW, Li CY, Tang NL, Yung E, Lam CW. Association between candidate genes and lung function growth in Chinese asthmatic children. Clin Exp Allergy 2007; 37(10):1480–1486.
   PubMed Web of Science ®Google Scholar
• Park HW, Shin ES, Lee JE, Kwon HS, Chun E, Kim SS, Chang YS, Kim YK, Min KU, Kim YY, Cho SH. Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction. Thorax. 2007; 62(3):265–269.
   PubMed Web of Science ®Google Scholar
• Franklin RA, Tordai A, Mazer B, Terada N, Lucas J, Gelfand EW. Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. Biochem Biophys Res Commun 1995; 209(3):1111–1118.
   PubMed Web of Science ®Google Scholar
• Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003; 24(2):150–157.
   PubMed Web of Science ®Google Scholar