Enhanced local Foxp3 expression in lung tissue attenuates airway inflammation in a mouse model of asthma

References

• Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143–178
   PubMed Web of Science ®Google Scholar
• Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008;118:3546–3556
   PubMed Web of Science ®Google Scholar
• Mazzarella G, Bianco A, Catena E, De Palma R, Abbate GF. Th1/Th2 lymphocyte polarization in asthma. Allergy 2000;55:6–9
   PubMed Web of Science ®Google Scholar
• Boudousquié C, Pellaton C, Barbier N, Spertini F. CD4 + CD25 + T cell depletion impairs tolerance induction in a murine model of asthma. Clin Exp Allergy 2009;39:1415–1426
   PubMedGoogle Scholar
• Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151–1164
   PubMed Web of Science ®Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells. Nat Immunol 2003;4:330–336
   PubMed Web of Science ®Google Scholar
• Klunker S, Chong MMW, Mantel P-Y, Palomares O, Bassin C, Ziegler M, Rückert B, et al. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3 + inducible regulatory T cells. J Exp Med 2009;206:2701–2715
   PubMed Web of Science ®Google Scholar
• Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, et al. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 2012;122:1082–1096
   PubMed Web of Science ®Google Scholar
• Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001;27:20–21
   PubMed Web of Science ®Google Scholar
• Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001;27:68–73
   PubMed Web of Science ®Google Scholar
• Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol 2010;126:845–852.e10
   PubMed Web of Science ®Google Scholar
• Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, O'Sullivan BJ, et al. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Eur Respir J 2011;37:53–64
   PubMed Web of Science ®Google Scholar
• Park SK, Cho MK, Park H-K, Lee KH, Lee SJ, Choi SH, Ock MS, et al. Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4 + CD25 + Foxp3 + T cell recruitment. J Immunol 2009;182:6907–6914
   PubMedGoogle Scholar
• Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari A, Cazareth J, et al. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 2011;4:53–65
   PubMed Web of Science ®Google Scholar
• Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3 + T cells and inhibits allergic asthma in a murine model. J I 2007;178:8081–8089
   Google Scholar
• Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 + CD25– T cells. J Clin Invest 2003;112:1437–1443
   PubMed Web of Science ®Google Scholar
• Moreira-Teixeira L, Resende M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Dy M, et al. Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells. J Immunol 2012;188:624–631
   PubMed Web of Science ®Google Scholar
• Westerman KA, Ao Z, Cohen EA, Leboulch P. Design of a trans protease lentiviral packaging system that produces high titer virus. Retrovirology 2007;4:96
   Google Scholar
• Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766–775
   PubMed Web of Science ®Google Scholar
• Duan W, Chan JHP, Wong CH, Leung BP, Wong WS. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol 2004;172:7053–7059
   PubMed Web of Science ®Google Scholar
• Tian L, Altin JA, Makaroff LE, Franckaert D, Cook MC, Goodnow CC, Dooley J, Liston A. Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood 2011;118:1845–1853
   Google Scholar
• Chapoval SP, Dasgupta P, Smith EP, DeTolla LJ, Lipsky MM, Kelly-Welch AE, Keegan AD. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J Immunol 2011;186:2571–2583
   Google Scholar
• Dao Nguyen X, Robinson DS. Fluticasone propionate increases CD4 + CD25 + T regulatory cell suppression of allergen-stimulated CD4 + CD25 − T cells by an IL-10-dependent mechanism. J Allergy Clin Immunol 2004;114:296–301
   PubMed Web of Science ®Google Scholar
• Francis JN, Till SJ, Durham SR. Induction of IL-10 + CD4 + CD25 + T cells by grass pollen immunotherapy. J Allergy Clin Immunol 2003;111:1255–1261
   PubMed Web of Science ®Google Scholar
• Akdis CA, Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009;123:735–746
   PubMed Web of Science ®Google Scholar
• Barzaghi F, Passerini L, Gambineri E, Ciullini Mannurita S, Cornu T, Kang ES, Choe YH, et al. Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome. J Autoimmun 2012;38:49–58
   Google Scholar
• Dominik H, Barbara K, Alexander TM, Reinhardt D, Nicolai T, Schendel DJ, Griese M, Krauss-Etschmann S. Quantitative and functional impairment of pulmonary CD4 + CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007;119:1258–1266
   Google Scholar
• Vadasz Z HT, Kessel A, Toubi E. B-regulatory cells in autoimmunity and immune mediated inflammation. FEBS Lett 2013;587:2074–2078
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057–1061
   PubMed Web of Science ®Google Scholar
• Khattri R, Cox T, Yasayko S-A, Ramsdell F. An essential role for Scurfin in CD4 + CD25 + T regulatory cells. Nat Immunol 2003;4:337–342
   PubMed Web of Science ®Google Scholar
• Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007;446:685–689
   PubMed Web of Science ®Google Scholar
• Provoost S, Maes T, Van Durme YM, Gevaert P, Bachert C, Schmidt-Weber CB, Brusselle GG, et al. Decreased FOXP3 protein expression in patients with asthma. Allergy 2009;64:1539–1546
   PubMed Web of Science ®Google Scholar
• Vale-Pereira S, Todo-Bom A, Geraldes L, Schmidt-Weber C, Akdis CA, Mota-Pinto A. FoxP3, GATA-3 and T-bet expression in elderly asthma. Clin Exp Allergy 2011;41:490–496
   PubMedGoogle Scholar
• Smyth LJC, Eustace A, Kolsum U, Blaikely J, Singh D. Increased airway T regulatory cells in asthmatic subjects. Chest 2010;138:905–912
   PubMedGoogle Scholar
• Mays LE, Ammon-Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller-Hermelink ES, Grimm M, et al. Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J Clin Invest 2013;123:1216–1228
   PubMed Web of Science ®Google Scholar
• Braciale TJ, Sun J, Kim TS. Regulating the adaptive immune response to respiratory virus infection. Nat Rev Immunol 2012;12:295–305
   PubMed Web of Science ®Google Scholar
• Passerini L, Olek S, Di Nunzio S, Hambleton S, Abinun M, Tommasini A, et al. Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability. Journal of Allergy and Clinical Immunology 2011;128:1376-1379.e1
   Google Scholar
• Kearley J, Barker JE, Robinson DS, Barzaghi F, Hambleton S, Abinun M, Tommasini A, et al. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4 + CD25 +regulatory T cells is interleukin 10 dependent. The J Exp Med 2005;202:1539–1547
   PubMed Web of Science ®Google Scholar
• Koristka S, Cartellieri M, Theil A, Feldmann A, Arndt C, Stamova S, Michalk I, et al. Retargeting of human regulatory T cells by single-chain bispecific antibodies. J Immunol 2012;188:1551–1558
   PubMed Web of Science ®Google Scholar
• Ito T, Hanabuchi S, Wang Y-H, Park WR, Arima K, Bover L, Qin FX, et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity 2008;28:870–880
   PubMed Web of Science ®Google Scholar
• Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, Shevach EM. CD4 + CD25+ regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J Exp Med 2002;196:237–246
   PubMed Web of Science ®Google Scholar