199
Views
7
CrossRef citations to date
0
Altmetric
Genetics

SPINK5 and ADRB2 haplotypes are risk factors for asthma in Mexican pediatric patients

, MD, PhD, , MD, MSc, , MD, MSc, , PhD, , MD, PhD & , PhD
Pages 232-239 | Received 14 May 2014, Accepted 14 Sep 2014, Published online: 08 Oct 2014

References

  • Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, et al. Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet 1998;7:1393–1398
  • Sengler C, Lau S, Wahn U, Nickel R. Interactions between genes and environmental factors in asthma and atopy: new developments. Respir Res 2002;3:7
  • Denham S, Koppelman GH, Blakey J, Wjst M, Ferreira MA, Hall IP, Sayers I. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Res 2008;9:38
  • Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, et al. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol 2010; 125:321–327
  • Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genome wide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000;67:1154–1162
  • Shek LP, Tay AH, Chew FT, Goh DL, Lee BW. Genetic susceptibility to asthma and atopy among Chinese in Singapore-linkage to markers on chromosome 5q31-33. Allergy 2001;56:749–753
  • Noguchi E, Yokouchi Y, Zhang J, Shibuya K, Shibuya A, Bannai M, Tokunaga K, et al. Positional identification of an asthma susceptibility gene on human chromosome 5q33. Am J Respir Crit Care Med 2005;172:183–188
  • Ryu HJ, Jung HY, Park JS, Ryu GM, Heo JY, Kim JJ, Moon SM, et al. Gene-based single nucleotide polymorphisms and linkage disequilibrium patterns of asthma candidate genes in the chromosome 5q31-33 region in Koreans. Int Arch Allergy Immunol 2006;139:209–1206
  • Weir TD, Mallek N, Sandford AJ, Bai TR, Awadh N, Fitzgerald JM, Cockcroft D, et al. Beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 1998;158:787–791
  • Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, et al. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med 2006;174:101–109
  • Vladich FD, Brazille SM, Stern D, Peck ML, Ghittoni R, Vercelli D. IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest 2005;115:747–754
  • Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213–1214
  • Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, et al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med 2005;171:563–570
  • Lee YL, Wang ST, Tsai CH, Guo YL. Associations of beta2-adrenergic receptor genotypes and haplotypes with wheezing illness in Taiwanese schoolchildren. Allergy 2009;64:1451–1457
  • Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010;125:328–335
  • Murk W, Walsh K, Hsu LI, Zhao L, Bracken MB, Dewan AT. Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum Hered 2011;71:97–105
  • Lee GR, Fields PE, Griffin TJ, Flavell RA. Regulation of the Th2 cytokine locus by a locus control region. Immunity 2003; 19:145–153
  • Mújica-López KI, Flores-Martínez SE, Ramos-Zepeda R, Castañeda-Ramos SA, Gazca-Aguilar A, García-Pérez J, Sánchez-Corona J. Association analysis of polymorphisms in the interleukin-4 receptor (alpha) gene with atopic asthma in patients from western Mexico. Eur J Immunogenet 2002;29:375–378
  • López KI, Martínez SE, Moguel MC, Romero LT, Figueroa CS, Pacheco GV, Ibarra B, Corona JS. Genetic diversity of the IL-4, IL-4 receptor and IL-13 loci in mestizos in the general population and in patients with asthma from three subpopulations in Mexico. Int J Immunogenet 2007;34:27–33
  • Aas K, Belin L. Standardization of diagnostic work in allergy. Int Arch Allergy Appl Immunol 1973;45:57–60
  • Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, London SJ. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 2009;64:629–635
  • Jiménez Morales S, Velázquez Cruz R, Ramírez-Bello J, Bonilla-González E, Romero-Hidalgo S, Escamilla-Guerrero G, Cuevas F, et al. Tumor necrosis factor–α is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population. Immunology 2009;70:251–256
  • Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, eds. Bioinformatics methods and protocols: methods in molecular biology. Totowa, NJ: Humana Press; 2000:365–386
  • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263–265
  • Del-Rio-Navarro B, Del Rio-Chivardi JM, Berber A, Sienra-Monge JJ, Rosas-Vargas MA, Baeza-Bacab M. Asthma prevalence in children living in North Mexico City and a comparison with other Latin American cities and world regions. Allergy Asthma Proc 2006;27:334–340
  • McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001;2:1109–1116
  • Muñoz B, Magaña JJ, Romero-Toledo I, Juárez-Pérez E, López-Moya A, Leyva-García N, López-Campos C, et al. The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico. Environ Toxicol Pharmacol 2012;33:226–232
  • Kim WK, Kwon JW, Seo JH, Kim HY, Yu J, Kim BJ. Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children. J Allergy Clin Immunol 2012;130:421–426
  • Andiappan AK, Yeo WS, Parate PN, Anantharaman R, Suri BK, Wang de Y, Chew FT. Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese. BMC Med Genet 2011;12:39
  • Kim JH, Cheong HS, Park BL, Bae JS, Jung S, Yoon SH, Park JS, et al. A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. J Hum Genet 2010;55:358–365
  • Kim JH, Cha JY, Cheong HS, Park JS, Jang AS, Uh ST, Kim MK, et al. KIF3A, a cilia structural gene on chromosome 5q31, and its polymorphisms show an association with aspirin hypersensitivity in asthma. J Clin Immunol 2011;31:112–121
  • Toncheva AA, Suttner K, Michel S, Klopp N, Illig T, Balschun T, Vogelberg C, et al. Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol 2012;23:636–641
  • Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L, Foster PS, Hogan SP, et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 2002;195:1433–1444
  • Ulitsky I, Laurent LC, Shamir R. Towards computational prediction of microRNA function and activity. Nucleic Acids Res 2010;38:e160
  • Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009;136:642–655
  • Kabesch M, Carr D, Weiland SK, von Mutius E. Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. Clin Exp Allergy 2004;34:340–345
  • Jongepier H, Koppelman GH, Nolte IM, Bruinenberg M, Bleecker ER, Meyers DA, te Meerman GJ, Postma DS. Polymorphisms in SPINK5 are not associated with asthma in a Dutch population. J Allergy Clin Immunol 2005;115:486–492
  • Liu Q, Xia Y, Zhang W, Li J, Wang P, Li H, Wei C, Gong Y. A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population. BMC Med Genet 2009;10:59
  • Parate PN, Wang de Y, Chew FT. Linkage disequilibrium pattern in asthma candidate genes from 5q31-q33 in the Singapore Chinese population. Ann Hum Genet 2010;74:137–145
  • Birben E, Sackesen C, Turgutoğlu N, Kalayci O. The role of SPINK5 in asthma related physiological events in the airway epithelium. Respir Med 2012;106:349–355
  • Polikepahad S, Knight JM, Naghavi AO, Oplt T, Creighton CJ, Shaw C, Benham AL, et al. Proinflammatory role for let-7 microRNAS in experimental asthma. J Biol Chem 2001;285:30139–30149
  • Qian F, Zhang Q, Zhou L, Ma G, Jin G, Huang Q, Yin K. Association between polymorphisms in IL17F and male asthma in a Chinese population. J Investig Allergol Clin Immunol 2012;22:257–263
  • Yang J, Lu MM, Lu YW, Feng CC, Leng RX, Pan HF, Ye DQ. Sex-specific differences in the relationship between the single-nucleotide polymorphism rs2298804 of FCER1A and the susceptibility to systemic lupus erythematosus in a Chinese Han population. Clin Exp Dermatol 2013;38:410–416
  • Jiménez-Morales S, Martínez-Aguilar N, Gamboa-Becerra R, Jiménez-Ruíz JL, López-Ley D, Lou H, Saldaña-Alvarez Y, et al. Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients. Hum Immunol 2013;74:998–1002
  • Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213–1214
  • Dewar JC, Wheatley AP, Venn A, Morrison JF, Britton J, Hall IP. Beta2- adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin Exp Allergy 1998;28:442–448
  • Munakata M, Harada Y, Ishida T, Saito J, Nagabukuro A, Matsushita H, Koga N, et al. Molecular-based haplotype analysis of the beta 2-adrenergic receptor gene (ADRB2) in Japanese asthmatic and non-asthmatic subjects. Allergol Int 2006;55:191–198
  • Isaza C, Sepúlveda-Arias JC, Agudelo BI, Arciniegas W, Henao J, Porras GL, Beltrán L. β(2) –adrenoreceptor polymorphisms in asthmatic and non-asthmatic schoolchildren from colombia and their relationship to treatment response. Pediatr Pulmonol 2012;47:848–855
  • Fu WP, Zhao ZH, Zhong L, Sun C, Fang LZ, Liu L, Zhang JQ, et al. Relationship between polymorphisms in the 5′ leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China. Respirology 2011;16:1221–1227
  • Salama MS, Ashaat NA, Hamad AA. Genetic association between common beta-2 adrenoreceptor polymorphism and asthma severity in school-age children. Egyptian J Med Human Genet 2011;12:151–156
  • Carroll CL, Sala KA, Zucker AR, Schramm CM. β2-adrenergic receptor haplotype linked to intubation and mechanical ventilation in children with asthma. J Asthma 2012;49:563–568
  • Lee YL, Wang ST, Tsai CH, Guo YL. Associations of beta2-adrenergic receptor genotypes and haplotypes with wheezing illness in Taiwanese schoolchildren. Allergy 2009;64:1451–1457
  • Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, Li J, et al. Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell 2012;11:1094–1101
  • Tsai CJ, Sauna ZE, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM, Nussinov R. Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima. J Mol Biol 2008;383:281–291
  • Tellechea ML, Muzzio DO, Iglesias Molli AE, Belli SH, Graffigna MN, Levalle OA, Frechtel GD, Cerrone GE. Association between β2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. Clin Endocrinol (Oxf) 2012;78:600–606
  • Bhatnagar P, Gupta S, Guleria R, Kukreti R. Beta2-adrenergic receptor polymorphisms and asthma in the North Indian population. Pharmacogenomics 2005;6:713–719
  • Ma L, Wu DD, Ma SL, Tan L, Chen X, Tang NL, Yao YG. Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia. J Psychiatr Res 2014;57:84–89
  • SIGMA Type 2 Diabetes Consortium, Estrada K, Aukrust I, Bjørkhaug L, Burtt NP, Mercader JM, García-Ortiz H, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA 2014;311:2305–2314
  • Panebra A, Schwarb MR, Glinka CB, Liggett SB. Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5′ sequence. Am J Respir Cell Mol Biol 2007;36:654–660

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.